Результаты поиска

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… For severe erysipelas with fevers and chills , consider ceftriaxone 1 g IV q24h or cefazolin 1–2 g IV q8h × 5–14 days Specific Entities NECROTIZING FASCIITIS types — type 1 (polymicrobial infections including Enterococci, E. coli , non-group A Streptococcus , Klebsiella , anaerobes. … Plain X-ray to check for gas with type 1 necrotizing fasciitis. CT or MRI maybe useful. Early deep incisional biopsy is gold standard treatments —urgent surgical debridement of all necrotic tissue. Consider IVIG if significant hypotension in Group A S treptococcus necrotizing fasciitis. …

Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations.

Dear Editor, cutaneous chronic graft versus host disease (cGVHD) is a pathological process consisting of donor-derived T-cells aimed at the antigens of the recipient. It exhibits a large range of clinical presentations resembling morphea and deep sclerosis/fasciitis, all characterized by both inflammation and progressive dermal and hypodermic fibrosis (1). Although classic scleroderma-like lesions in cGVHD are nummular or irregular plaques and linear bundles associated with hypo- or hyperpigmentation (2), we report an atypical case with ulcerative presentation. No other case-reports of morphea…

Imaging of abdominal and pelvic infections in the cancer patient.

Infections are the most commonly encountered complications in patients with cancer. The classical signs and symptoms of infections are often not present in this patient population, which makes the diagnosis more challenging. Host factors play a major role in the development and prognosis of infections in cancer patients; these can be related to the underlying type of malignancy (solid organ versus hematological), tumor burden, anatomic obstruction, altered integrity of barriers (skin or mucosa), treatment-related factors (from chemotherapy, radiation treatment, surgery, interventional procedur

Совпадение в полном тексте источника
… SSTIs include cutaneous infections in addition to deeper subcutaneous, muscular, and fascial infections such as cellulitis, necrotizing fasciitis, and pyomyositis. … The presence of subcutaneous gas on non-contrast CT that spreads along fascial planes is usually worrisome for necrotizing fasciitis, requiring early and aggressive management with drainage and surgical debridement. …

Атипичные презентации Acolovir-Resistant Herpes Simplex Virus в иммунокомпромиссированных пациентах: Серия дел.

Инфекции, связанные с вирусом герпеса (HSV), у иммунокомпромиссированных пациентов могут иметь атипичные представления - от грануломатных до линейных эрозийных повреждений - и превращаться в рефракторную и стандартную терапию. Мы сообщаем three :: случаи некротизации категорической инфекции HSV у иммунокомпромиссированных пациентов с гематологическими малигнациями или предшествующими химиотерапиями, все из которых имеют нетипичные и рефракторные проявления заболевания. One дело касалось 53-year-old :: пациентка с реанимацией/рефрактом острой миэлоидной лейкемией (АМЛ), разработавшая некротизир

Совпадение в полном тексте источника
… HSV: Herpes simplex virus As her infection persisted with worsening gluteal myositis and concerns for necrotizing fasciitis (Figure 6 ), the antimicrobial regimen was escalated to meropenem and linezolid. … Figure 6 As the patient’s infection persisted with worsening gluteal myositis and concerns for necrotizing fasciitis, the antimicrobial regimen was escalated on Day 9 to meropenem and linezolid. …

International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.

As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the number of HCTs performed annually continues to rise. Parallel improvements in HCT techniques and supportive care entails more patients surviving long term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary to pretransplantation, peritransplantation, and post-transplantation exposures and other underlying risk factors. Guidelines for screening and preventive practices for HCT survivors were originally p

Совпадение в полном тексте источника
… Fasciitis and polymyositis are cGVHD manifestations [ 206 , 208 , 209 ]. … Along with cGVHD treatment, patients with fasciitis may benefit from a multidisciplinary rehabilitation program to control edema and preserve range of motion. Polymyositis usually presents with moderate to severe proximal muscle weakness and myalgia [ 202 ]. …

Unusual Prostate-Specific Membrane Antigen (PSMA) Splenic Uptake in a Patient With Prostate Cancer.

There are many benefits to early detection of prostate cancer, including improved survival rates, less invasive treatment options, and better quality of life. Apart from traditional tests and imaging (including the prostate-specific antigen (PSA) test, digital rectal exam, biopsy, computed tomography (CT), and magnetic resonance imaging (MRI)), an imaging technique called prostate-specific membrane antigen positron emission tomography (PSMA PET) is more specific and sensitive, targeting PSMA expressed by prostate cancer cells on their surface. This case report describes a 62-year-old male with

Совпадение в полном тексте источника
… Published case reports show PSMA uptake in inflammatory and infectious diseases such as neurocysticercosis, tuberculosis, sarcoidosis, osteomyelitis, and nodular fasciitis; benign tumors such as meningioma, schwannoma, neurofibromas, thyroid and parathyroid adenomas, angiolipoma, hemangiomas, thymomas …

Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature.

IntroductionInfection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.Case descriptionWe present a case of a 43-year-old male with a history of excessive alcohol consumption who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bul

Совпадение в полном тексте источника
… Purpura fulminans secondary to Capnocytophaga bacteraemia was likely, but due to static CRP (175 mg l −1 [171 mg l −1 ]) with worsening white cell count (WCC 24.8×10 9 l −1 [21.3×10 9 l −1 ], Nt 19.1×10 9 l −1 [16.5×10^ 9 l −1 ]) an underlying necrotising fasciitis was considered. … The patient had further fevers, but the rash had not progressed by morning, so it was felt to not be in keeping with necrotising fasciitis. …

The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges.

The frequency of chronic cutaneous wounds are sharply increasing in aging populations. Patients with age-related diseases, such as diabetes, tumors, renal failure and stroke are prone to soft tissue and skin injury, compounded by slowed healing in aging. Imbalance of wound inflammation, loss of growth factor secretion, and impairment of tissue repair abilities are all possible reasons for failed healing. Therefore, it is vital to explore novel approaches to accelerate wound healing. Platelet-rich plasma (PRP) as a cell therapy has been widely applied for tissue repair and regeneration. PRP pro

Совпадение в полном тексте источника
… In our previous reports, diabetic patients with acute necrotizing fasciitis and refractory diabetic foot benefited from treatment with au-PRP ( Deng et al., 2016 ; Jiang et al., 2020 ). … Recently, we published a report on a severely infective diabetic patient with foot necrotising fasciitis and gaseous gangrene, who successfully recovered and underwent limb salvage after a combination of clinical interventions that included PRP ( Deng et al., 2016 ). …

Construction and validation of a risk prediction model for perianal infection in HSCT patients: a retrospective cohort study.

BackgroundPerianal infection is a frequent and detrimental complication in patients undergoing hematopoietic stem cell transplantation (HSCT), leading to significant morbidity and extended hospital stays. Despite its clinical significance, a substantial gap remains in our ability to proactively identify high-risk individuals. However a validated predictive model is actually lacking and it is still unclear how to identify these patients before the onset of infection.ObjectiveThis study aimed to develop and to validate a risk prediction model for the accurate assessment of perianal infection ris

Совпадение в полном тексте источника
… According to the pathological stage, perianal infection may manifest as perianal abscess, anal fistula, and even necrotizing fasciitis, causing significant swelling, defecation disorders, severe pain, and even systemic infection, which may become life-threatening ( 4 ). … Notably, the cohort included 38 cases of perianal soft tissue infection, 8 cases of perianal abscess, 1 case of anal fistula, and 1 case of anal fistula combined with necrotizing fasciitis. …

Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study.

This retrospective and single-center study in Reunion Island (Indian Ocean) assessed frequency, mortality, causative pathogens of severe necrotizing skin, and necrotizing skin and soft tissue infections (NSSTIs) admitted in intensive care unit (ICU). Sixty-seven consecutive patients were included from January 2012 to December 2018. Necrotizing skin and soft tissue infection represented 1.06% of total ICU admissions. We estimate the incidence of NSSTI requiring ICU at 1.21/100,000 person/years in Reunion Island. Twenty (30%) patients were receiving nonsteroidal anti-inflammatory drugs (NSAIDs)

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

Совпадение в полном тексте источника
… Necrotizing fasciitis is a rare complication of Streptococcus infection; however, S. aureus or anaerobic bacteria may be involved. Fournier’s gangrene is a severe perineal or genitoanal variant of necrotizing fasciitis with a high mortality rate. … The differential diagnosis is with other diseases that present with fibrosis (scleromyxedema, systemic sclerosis, eosinophilia-myalgia syndrome, toxic oil syndrome, and eosinophilic fasciitis). 12 Oxalosis: it is a rare disease and comprises two forms: primary and secondary oxalosis. …

Editorial: Bio-Pathological Markers in the Diagnosis and Therapy of Cancer.

Identifying novel biomarkers with diagnostic, prognostic and predictive value in terms of therapeutic response is a current topic in the clinical practice of oncologists, pathologists and medical researchers in general [...].

Совпадение в полном тексте источника
… WT1) immunoreactivity could represent a strong diagnostic tool to distinguish dermatofibrosarcoma protuberans from other dermal/subcutaneous bland-looking mesenchymal spindle cell lesions, such as dermatofibromas, deep fibrous histiocytomas, neurofibromas, spindle cell lipomas, dermal scars, nodular fasciitis …

DREAMM-11, Part 2: Japanese phase I trial of belantamab mafodotin combination therapies in relapsed/refractory multiple myeloma.

DREAMM-11 (NCT03828292) was a Phase 1, open-label, dose-escalation study of belantamab mafodotin in Japanese patients with relapsed/refractory multiple myeloma (RRMM). In Part 1, belantamab mafodotin monotherapy (2.5 or 3.4 mg/kg every 3 weeks) was tolerated and demonstrated clinical activity and a manageable safety profile. Part 2 investigated the tolerability, safety, clinical activity and pharmacokinetics of belantamab mafodotin (2.5 mg/kg on Day [D]1 of each 21-day cycle) plus bortezomib and dexamethasone (Arm A; N = 3) or belantamab mafodotin (2.5 mg/kg on D1 of the first 28-day cycle; 1.

Совпадение в полном тексте источника
… 0) 0 (0) Ingrowing nail 0 (0) 0 (0) 1 (25) 0 (0) Liver injury 0 (0) 0 (0) 1 (25) 1 (25) Nasopharyngitis 0 (0) 0 (0) 1 (25) 0 (0) Nausea 0 (0) 0 (0) 1 (25) 0 (0) Oral mucosa erosion 0 (0) 0 (0) 1 (25) 0 (0) Peripheral neuropathy 0 (0) 0 (0) 1 (25) 0 (0) Periodontitis 0 (0) 0 (0) 1 (25) 0 (0) Plantar fasciitis … Liver injury | 0 (0) | 0 (0) | 1 (25) | 1 (25) Nasopharyngitis | 0 (0) | 0 (0) | 1 (25) | 0 (0) Nausea | 0 (0) | 0 (0) | 1 (25) | 0 (0) Oral mucosa erosion | 0 (0) | 0 (0) | 1 (25) | 0 (0) Peripheral neuropathy | 0 (0) | 0 (0) | 1 (25) | 0 (0) Periodontitis | 0 (0) | 0 (0) | 1 (25) | 0 (0) Plantar fasciitis …

Group A Streptococcus Meningitis, United States, 1997-2022.

Group A Streptococcus (GAS) causes a variety of diseases in humans but is not widely appreciated as a cause of meningitis. During 1997-2022, ten sites participating in the Active Bacterial Core Surveillance network in the United States identified GAS meningitis cases. We calculated annual incidence and case-fatality rates (CFRs) for 320 of those cases and determined antimicrobial resistance by whole-genome sequencing. Annual incidence of GAS meningitis ranged from 0.02 to 0.07 cases/100,000 persons. Children <1 year of age had the highest average annual incidence, 0.23 cases/100,000 children.

Совпадение в полном тексте источника
… Clinical manifestations of iGAS disease include cellulitis, bacteremia, pneumonia, necrotizing fasciitis, and streptococcal toxic shock syndrome (STSS) ( 1 , 2 ). … ABCs defines iGAS as GAS isolated from a normally sterile site, or from a wound culture if accompanied by a diagnosis of necrotizing fasciitis or STSS, in a resident of a surveillance area ( 13 ). …

Oral Graft-Versus-Host Disease: A Pictorial Review and a Guide for Dental Practitioners.

IntroductionGraft-versus-host disease (GVHD) is a complication of haematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred. GVHD affects multiple organs, including the oral tissues.ObjectiveThis pictorial review provides a background of GVHD to dental practitioners, describes the most common oral manifestations of GVHD and highlights the main treatment modifications needed to deliver dental care to patients with GVHD.MethodsA narrative review enhanced with clinical photographs.ResultsAcute GVHD

Совпадение в полном тексте источника
… children) Liver | | | | • Total bilirubin, alkaline phosphatase > 2 × upper normal limit | | | | • ALT> 2 × upper normal limit Lung | • Bronchiolitis obliterans diagnosed with biopsy | • Air trapping and bronchieactasis on chest CT | • Cryptogenic organising pneumonia | Muscles, fascia, joints | • Fasciitis … | • Myositis or polymyositis | • Restrictive lung disease | | • Joint stiffness or contractures secondary to fasciitis or sclerosis | | • Oedema | | | | • Muscle cramps | | | | • Arthralgia or arthritis | Haematopoietic and immune | | | • Thrombocytopenia | | | | • Eosinophilia | …

Belantamab mafodotin, carfilzomib, lenalidomide и дексаметазон для рецидива или рефракта множественной миеломы.

Резюме Belantamab mafodotin (Belamaf), антитела-наркотики, направленные против антигена ячеек B-клеток, продемонстрировало активность одного агента в повторной/охлажденной миеломе (RRMM), но связано с окулярной токсичностью. Это фазы 1/2 в ходе исследования была проведена оценка безопасности и предварительной эффективности использования беналафа 8 Недели в сочетании с карфилзомидом, линалидомидом и дексаметасоном (KRd-b) у пациентов с RRMM. Пациенты, имеющие право на получение помощи, по крайней мере, 1 :: предыдущая терапия и не продвинулась по полной дозе леналидомида. На стадии &quot; доза-

Совпадение в полном тексте источника
… . † COVID-19, metapneumovirus, and necrotizing fasciitis. ‡ Hypogammaglobulinemia, seasonal allergies, chest congestion, immune thrombocytopenia, and immunoglobulin deficiency. § Petechiae, painless bumps on inside of lips, skin peeling on hands, rosacea, and skin graft for cellulitis. … hematologic events, stroke, and other nonhematologic events that occurred in at least 10% of patients. ∗ Double vision, cloudy vision, ocular pruritus, bilateral crusting, redness, stye, moderate corneal striae and edema, Fuchs dystrophy, and epitheliopathy. † COVID-19, metapneumovirus, and necrotizing fasciitis …

Эффективность неконцентрированных действий Координирующие Шоковые Волны в сочетании с ботулинумтоксином на спасти у пациентов с умом.

Спастичность — это обычное осложнение у пациентов с неврологическими расстройствами, возрастающей инвалидностью и ухудшающей качество жизни. Было продемонстрировано, что комбинированная обработка с сфокусированными ударными волнами (FESWT) и ботулиновым токсином (BONT-A) повышает эффективность и продолжительность воздействия BONT-A на спасти у пациентов с травмами мозга. Мы изучили эффективность сочетания неконцентрированных ударных волн (uESWT) и BONT-A по спастисти. Это перспективное исследование с систематической случайностью включает в себя 24 :: пациенты с травмой мозга, небольшой размер

Совпадение в полном тексте источника
… uESWT has been used to treat pathologies such as plantar fasciitis [ 27 ]; however, in spasticity, we only have evidence with fESWT and radial extracorporeal shock wave therapy (rESWT). …

Invasive group A streptococcal infections in children and adolescents in Denmark during 2022-23 compared with 2016-17 to 2021-22: a nationwide, multicentre, population-based cohort study.

BACKGROUND: A historic increase in paediatric invasive group A streptococcal (iGAS) infections was reported globally in 2022. iGAS infections can lead to severe manifestations (eg, pleural empyema, necrotising fasciitis, toxic shock syndrome, osteomyelitis, septic arthritis, and meningitis). We aimed to compare the incidence and severity of iGAS infections overall, for distinct clinical phenotypes, and for GAS emm variants in Denmark in 2022-23 with reference to the previous six seasons (ie, 2016-17, 2017-18, 2018-19, 2019-20, 2020-21, and 2021-22). METHODS: In this nationwide, multicentre, p…

Evidence for the use of intravenous immunoglobulins--a review of the literature.

Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel

Совпадение в полном тексте источника
… deterioration renal function [ 66 ] Case report IVIg 1 g/kg for 2 days 56-year-old man with HSP and severe digestive manifestations The patient's purpura and abdominal syndrome improved dramatically Mixed connective tissue disease (MCTD) [ 67 ] Case report IVIg 0.4 g/kg for 5 days A woman with MCTD and fasciitis … function [ 66 ] | Case report | IVIg 1 g/kg for 2 days | 56-year-old man with HSP and severe digestive manifestations | The patient's purpura and abdominal syndrome improved dramatically Mixed connective tissue disease (MCTD) | [ 67 ] | Case report | IVIg 0.4 g/kg for 5 days | A woman with MCTD and fasciitis …

Human Amniotic Membrane Dressing as a Non-Surgical Alternative for Extensive Chronic Ulcers: A Comparative Case Study.

Chronic wound management remains a significant clinical challenge, requiring adaptive therapeutic approaches to achieve wound closure that nonetheless frequently prove fruitless. Balancing the initial pro-inflammatory response with debris removal and tissue rebuilding remains elusive in most cases, leading to pain, drastic quality-of-life deterioration, and, eventually, amputation. Meanwhile, patient adherence is an overarching theme. Furthermore, non-surgical alternatives that effectively promote tissue rebuilding are essential for patients seeking to avoid further invasive procedures. We rep

Совпадение в полном тексте источника
… An adult male patient with a 60 cm 2 gluteal ulcer (post-injection fasciitis, 1-month VAC) was referred while undergoing chemotherapy for multiple myeloma. To defer surgery per patient request, a comparative treatment was applied to two ulcer regions: commercial BCM vs. hAM-pe. …