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Distress Screening among Patients with Hematological Malignancies: A Descriptive Cross-sectional Study.

IntroductionDistress is a major concern during diagnosis and treatment of hematological malignancies. The Distress Thermometer is a commonly used screening tool to detect distress. The objectives of this study was to know the prevalence and identify distress score among patients with hematological malignancies in Nepal.MethodsA descriptive cross sectional study was carried out at the Hematology Unit of Civil Service Hospital after obtaining an ethical approval from the Institutional Review Committee (reference number 931/076/077). A convenient sampling technique was used for this study. Statis

Spiritual well-being of terminally ill patients and next-of-kin caregivers in hospice care: A quantitative and qualitative approach.

BackgroundTerminal cancer patients often endure significant distress, impacting their quality of life. Spiritual well-being provides peace and meaning during this challenging period.Objectives. This study explored the spiritual well-being of terminally ill patients and their next-of-kin caregivers in hospice care, focusing on factors influencing their spiritual experiences.MethodsThis mixed-methods study included 30 terminally ill patients and 17 next-of-kin caregivers in hospice care. Spiritual well-being was assessed using the Functional Assessment of Chronic Illness Therapy - Spiritual Well

Patterns of multimorbidity in older adults with multiple myeloma: An analysis of SEER-Medicare.

OBJECTIVE: Multimorbidity influences the management of symptoms, treatment, and health outcomes for older adults with multiple myeloma. Our study characterized patient profiles defined by discrete chronic condition patterns and examined the distribution of their sociodemographic factors in older adults at time of diagnosis with multiple myeloma. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) Program database linked with Medicare insurance claims (2007-2017), we examined 11,926 individuals diagnosed with multiple myeloma at age ≥ 65 years. Hierarchical cluster analysis wa

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… Front Public Health . 2023 ; 11 : 1081518 . doi: 10.3389/fpubh.2023.1081518 37050950 PMC10084932 30 Roso-Llorach A , Violán C , Foguet-Boreu Q , Rodriguez-Blanco T , Pons-Vigués M , Pujol-Ribera E , et al . … BMJ Open . 2021 ; 11 ( 11 ):e049334. doi: 10.1136/bmjopen-2021-049334 34782339 PMC8593730 36 Guisado-Clavero M , Roso-Llorach A , López-Jimenez T , Pons-Vigués M , Foguet-Boreu Q , Muñoz MA , et al . Multimorbidity patterns in the elderly: a prospective cohort study with cluster analysis . …

AYAs' online information and eHealth needs: A comparison with healthcare professionals' perceptions.

BackgroundAdolescents and young adults (AYAs) diagnosed with cancer fulfill their cancer-related information needs often via the Internet. Healthcare professionals (HCPs) have a crucial role in guiding patients in finding appropriate online information and eHealth sources, a role that is often overlooked. Misperceptions of AYAs' needs by HCPs may lead to suboptimal guidance. We aimed to examine the extent to which AYAs' online information and eHealth needs corresponded with HCPs' perceptions of these needs.MethodsTwo cross-sectional online surveys (AYAs, n = 299; HCP, n = 80) on online informa

Psychological Distress Among Cancer Patients During COVID-19 Pandemic in the World: A Systematic Review.

Aim: Patients with malignancies, experience high rates of psychological distress. Fear of Corona-infection combined with the interruptions in some treatment programs might affect the psychological health of cancer patients. This review study was conducted to investigate the psychological distress among cancer patients during COVID-19 pandemic to offer system-adapted individual solutions. Materials and methods: To identify the psychological distress of cancer patients, a comprehensive search was carried out in PubMed, Web of Science, and Scopus. English language and original articles were inclu

Exercise barriers and facilitators during hematopoietic stem cell transplantation: a qualitative study.

ObjectiveAlthough exercise is beneficial in patients undergoing hematopoietic stem cell transplantation (HSCT), motivating patients to exercise is challenging. We aimed to understand exercise barriers and facilitators during HSCT treatment while participating in a daily unsupervised exercise programme.ParticipantsPatients scheduled to have HSCT.Study design6 participants were included in this descriptive qualitative study during HSCT treatment while participating in an exercise programme to identify perceived barriers and facilitators of the exercise. An average of three semi-structured interv

Sense of coherence and its relationship to participation, cancer-related fatigue, symptom burden, and quality of life in women with breast cancer participating in the OptiTrain exercise trial.

Abstract Purpose This study examined the Sense of Coherence (SOC) of patients participating in the randomized controlled ‘Optimal Training for Women with Breast Cancer’ (OptiTrain) study and assessed how patient characteristics were associated with SOC. Secondary aims were to assess the association between SOC and patients’ participation in this study and to determine whether SOC moderates the effect of the 16-week exercise intervention on fatigue, quality of life (QoL), and symptom burden in women with breast cancer undergoing chemotherapy. Methods Modified Poisson regression analyses were co

Risk of Suicide After Cancer Diagnosis in England.

ImportanceA diagnosis of cancer carries a substantial risk of psychological distress. There has not yet been a national population-based study in England of the risk of suicide after cancer diagnosis.ObjectivesTo quantify suicide risk in patients with cancers in England and identify risk factors that may assist in needs-based psychological assessment.Design, setting, and participantsPopulation-based study using data from the National Cancer Registration and Analysis Service in England linked to death certification data of 4 722 099 individuals (22 million person-years at risk). Patients (aged

A prospective observational study to assess clinical decision-making, prognosis, quality of life and satisfaction with care in patients with relapsed/refractory multiple myeloma: the CLARITY study protocol.

BACKGROUND: Treatment decision-making in patients with relapsed/refractory multiple myeloma (RRMM) is challenging for a number of reasons including, the heterogeneity of disease at relapse and the number of possible therapeutic approaches. This study broadly aims to generate new evidence-based data to facilitate clinical decision-making in RRMM patients. The primary objective is to investigate the prognostic value of patient self-reported fatigue severity for overall survival. METHODS: This multicenter prospective observational study will consecutively enroll 312 patients with multiple myelom

Factors affecting the quality of life of cancer patients undergoing chemotherapy: A questionnaire study.

ObjectiveThis descriptive and cross-sectional study was undertaken to determine the factors affecting cancer patients' quality of life.MethodsWe collected data from 352 chemotherapy patients of an Outpatient Chemotherapy Unit in a state hospital. We included volunteered chemotherapy patients with a signed informed consent and at least 50 Karnofsky Performance Scale points. We gathered data by Personal Information Form and Nightingale Symptom Assessment Scale (N-SAS) and analyzed via basic descriptive statistics and linear regression analysis.ResultsPatients were women (54.8%), married (83.5%),

Запугивание MOGAD в форме контактных изъятий.

MOGAD — это демиелинизирующий синдром с наличием антител против миелина олигодендроцита гликпротеина, который, рядом с множественным склерозом и спектром нейромиелита, является одним из проявлений демиелионирующего процесса, более распространенным среди педиатрического населения. MOGAD может принимать различные клинические формы: острый распространённый энцефаломиэлит (ADEM), ретробуллярный оптический нейрит, часто бинокльный (ON), поперечный миелит (TM), или курс, похожий на NMOSD (неевромиэлитный спектральный расстройства), менее часто энцефалопатия. Курс может быть монофазным (40-50%) или п

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… The largest change area measures 19 × 14 mm and is located in the right middle cerebellar peduncle, which merges with changes observed in the pons. …

Voices of Survivorship: The Unmet Needs of Italian Cancer Survivors. A Qualitative Study.

BackgroundThe increasing number of cancer survivors (CSs) globally highlights the critical need for healthcare systems to address their unmet needs. These needs span physical, psychosocial, spiritual, informational, and practical dimensions and, if unaddressed, can impact quality of life and healthcare satisfaction.AimsThis study aimed to identify and understand the unmet needs of CSs in Italy to guide the development of patient-centered survivorship care services.MethodsA cross-sectional qualitative study was conducted between April 2023 and January 2024 at the Comprehensive Cancer Centre of

State of the art biology, progression, and clinical management of monoclonal B-cell lymphocytosis (MBL): consensus report from the Intercepting Blood Cancers Workshop Committee.

In March 2023 and 2024, a panel of international experts convened at the first and second Intercepting Blood Cancers (IBC) Workshops, with the aim of better appreciating the diagnostic challenges, pathophysiology, and potential therapeutic interventions for precursor malignant hematology conditions. Here, we report a summary of the proceedings from the sessions focused on monoclonal B-cell lymphocytosis (MBL)/chronic lymphocytic leukemia (CLL). We highlight four main content areas: biology of MBL, clinical implications of MBL, progression of MBL and transformation from indolent CLL to aggressi

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… Oliva-Ariza G, Fuentes-Herrero B, Carbonell C, Lecrevisse Q, Perez-Pons A, Torres-Valle A, et al. High frequency of low-count monoclonal B-cell lymphocytosis in hospitalized COVID-19 patients. Blood 2023;141:309–14. 31. Parikh SA, Achenbach SJ, Rabe KG, Norman AD, Boddicker NJ, Olson JE, et al. … Oliva-Ariza G, Fuentes-Herrero B, Lecrevisse Q, Carbonell C, Perez-Pons A, Torres-Valle A, et al. Immune cell kinetics and antibody response in COVID-19 patients with low-count monoclonal B-cell lymphocytosis. Am J Hematol 2023;98:1909–22. 33. …

Staff- and service-level factors associated with organisational readiness to implement a clinical pathway for the identification, assessment, and management of anxiety and depression in adults with cancer.

BackgroundOrganisational readiness is recognised as a key factor impacting the successful translation of research findings into practice. Within psycho-oncology, measuring organisational readiness and understanding factors impacting organisational readiness is crucial as it is often challenging to implement evidence-based findings into routine cancer care. In this quantitative study, we examined the level of organisational readiness of cancer services preparing to implement a clinical pathway for the screening, assessment, and management of anxiety and depression in adult cancer patients (the

Factors associated with palliative care symptoms in cancer patients in Palestine.

Palliative care is critical to redundancy in cancer patients seeking to improve their quality of life. Evaluation should be incorporated int … re symptoms (score > 4) were obtained using ESAS-R. The survey consisted of 271 patients, with a response rate of 95%. The average age of the patients was 47 ± 17.7 years, ranging from 18 to 84 years. The male-to-female ratio was approximately 1:1, 59.4% of the patients were outpatients, and 153 (56.5%) had hematologic malignancies. Fatigue (62.7%) and …

Early palliative care for solid and blood cancer patients and caregivers: Quantitative and qualitative results of a long-term experience as a case of value-based medicine.

IntroductionCancer patients and their caregivers have substantial unmet needs, that negatively impact the clinical outcome and quality of life. However, interventions aimed to address such needs are still suboptimal, failing to answer the recent healthcare call for the adoption of value-based models of care. In the case of incurable oncologic and hematologic cancers, a value-based model of care should plan advanced care on patients' needs and include the quality of death as an outcome. The integration of early palliative care into standard oncologic care for patients with advanced cancers repr

Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experiences and Expectations.

BackgroundNew cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. Although long-term monitoring of HRQoL has been shown to improve survival, integration of HRQoL into everyday practice remains poorly documented.ObjectiveThis study describes experiences and expectations of patients treated with ICIs regarding a discussion of HRQoL with health care professionals (HCPs) in cancer management.MethodsThis cross-sectional study was conducted in an online patient community (Carenity) in France. Patient

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… Pons-Tostivint E, Latouche A, Vaflard P, Ricci F, Loirat D, Hescot S, Sablin M, Rouzier R, Kamal M, Morel C, Lecerf C, Servois V, Paoletti X, Le Tourneau C. … Psychooncology. 2010 May;19(5):490–9. doi: 10.1002/pon.1579. http://europepmc.org/abstract/MED/19449348 . 39. Mouillet G, Fritzsch J, Paget-Bailly S, Pozet A, Es-Saad I, Meurisse A, Vernerey D, Mouyabi K, Berthod D, Bonnetain F, Anota A, Thiery-Vuillemin A. …

Screening supportive care needs, compliance with exercise program, quality of life, and anxiety level during the COVID-19 pandemic in individuals treated with hematopoietic stem cell transplantation.

PurposeThe primary aim was to assess supportive care needs, compliance with home exercise program, quality of life level (QOL), and anxiety level during the COVID-19 pandemic in individuals treated with hematopoietic stem cell transplantation (HSCT). The secondary aim was to investigate demographic and medical factors associated with the recorded outcomes.MethodsThe present study included individuals treated with HSCT and previously referred to physical therapy. The data were collected by interviews with the participants on the phone. Supportive care needs were assessed using the Supportive Ca

An Integrated Process and Outcome Evaluation of a Web-Based Communication Tool for Patients With Malignant Lymphoma: Randomized Controlled Trial.

BackgroundThe complex nature of the medical dialogue and the often emotional context in cancer care present challenges to health care professionals (HCPs) and patients. Patients are increasingly expected to be informed participants and to be able to make conscious decisions, which they often find very difficult. In an attempt to support patients with malignant lymphoma in clinical communication, we developed a stand-alone, Web-based intervention called "PatientTIME." The development of PatientTIME was based on a participatory intervention mapping framework. Its primary aim is to boost patients

Когда уши болеют больше: отомастоидитные двусторонние краниальные Neurophies в иммунокомпрометированном пациенте.

Отомастоидит — это инфекция и воспаление как отитной среды (мидлушное ухо), так и мастоидной воздушной клетки. Если инфекция проходит мимо среднего уха, чтобы повлиять на прилежащие структуры, то могут быть задействованы мастоидные воздушные элементы. Фунгальный мастоидит очень редкий и почти исключительно наблюдается у иммунокомпромиссированных пациентов. Мы представляем необычный случай типа 2 диабетик с грибковым отомастоидитом, проявляющимся как боль в левом ухе, а также нейропатия левого черепного нерва VII и правого черепного нерва III. Хотя паралич лицевого нерва часто объясняется идиоп

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… CN VII is supplied by four nuclei found in the pons, medulla, and upper cervical spinal cord. It passes into the internal acoustic meatus and temporal bone close to the inner and middle ear, before exiting the skull via the stylomastoid foramen. …