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Engineering cell ring organoids for efficient establishment of patient-derived orthotopic xenotransplantation (r-PDOX) model in sarcoma.

Patient-derived orthotopic xenotransplantation (PDOX) models have recently emerged as a potential approach for experimental therapeutics and precision medicine in malignant disease. However, the clinical application of PDOX models was restricted by the varying success rate of the animal models, long generation time, limited number of patient tumor cells and distinct stromal environments. To address this critical barrier, we developed an innovative patient-derived cell ring organoid platform using scaffold-free tumor cell rings. By co-culturing primary sarcoma cells with human skin fibroblasts …

Genotoxicity and Proteotoxicity of Arsenic: Mechanisms, Clinical Implications, and Therapeutic Challenges.

INTRODUCTION: Arsenic is a ubiquitous environmental metalloid with dual characteristics-acting as both a potent toxin and an effective thera … ssion rates exceeding 90% in APL by degrading the PML-RARα oncoprotein. Emerging nanotechnology and precision medicine approaches enhance drug delivery, reduce systemic toxicity, and support targeted therapy. DISCUSSION: Arsenic's paradoxical behavior is dose- and context-dependent. While chronic lowlevel exposure drives carcinogenesis, controlled pharmacologic use …

Recent advances in MR neuroimaging: toward quantitative and AI-driven brain and spinal cord imaging.

Magnetic resonance neuroimaging is undergoing a major paradigm shift from traditional qualitative anatomical mapping toward integrated, quan … ented precision tools and translational potential for both basic neuroscience research and clinical precision medicine. Across these domains, AI contributes not only to acceleration and reconstruction but also to segmentation, quality control, quantitative parameter extraction, and multiparametric pattern recognition that can support diagnostic interpretation. The q …

Advances in the role of house dust mite allergen components in the pathogenesis of allergic diseases.

House dust mites (HDMs) represent one of the most prevalent indoor aeroallergens globally and are closely associated with type 2 immune-medi … sely, component-resolved diagnosis (CRD) and allergen immunotherapy (AIT) present novel avenues for precision medicine. This review systematically delineates the classification, structural characteristics, and immunopathogenic mechanisms of HDM allergen components in allergic diseases. It further summarizes recent advances in precision diagnostics and targeted inter …

Urinary Tract Infections: Molecular Determinants of Uropathogenicity and Their Translation into Contemporary Clinical Practice.

Urinary tract infections (UTIs) represent a major global health burden, traditionally defined as microbial invasion of a sterile urinary tra … tegrated molecular, clinical, and therapeutic approaches, with future advancements likely driven by precision medicine and artificial intelligence.

Deep Learning for the Diagnosis and Treatment of Thyroid Cancer: A Review.

OBJECTIVE: In recent years, the application of deep learning (DL) technology in the thyroid field has expanded rapidly, driving substantial … achieving meaningful improvements in thyroid cancer care and realizing the full potential of DL in precision medicine. CONCLUSION: DL techniques are advancing the precision diagnosis and treatment of thyroid cancer and hold the potential to enhance diagnostic accuracy and improve therapeutic outcomes for patients.

Analyte-Induced pKa-Tunable Hemicyanine Dual-Locked Molecular Platform for In Vivo Tumor Precision Imaging.

Dual-locked probes that precisely visualize the tumor microenvironment (TME) are poised to close a critical detection gap in personalized medicine. However, traditional dual-locked systems are still constrained by sluggish response kinetics, low sensitivity, intricate design, and limited generality. To overcome these challenges, we introduce a general "analyte-induced pKa-tunable" (AIPT) hemicyanine dual-locked platform (pKa-RH) for in vivo tumor precision imaging. Interestingly, the pKa of pKa-RH can be readily modulated by adjusting the electron-donating ability of the optically tunable site

CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment.

Cardiovascular diseases (CVDs) remain a significant global health challenge, with many current treatments addressing symptoms rather than th … treat but also potentially cure genetically driven cardiovascular diseases, heralding a new era in precision medicine for cardiovascular health.

Integrative bioinformatics and deep learning to identify common genetic pathways in Crohn's disease and ischemic cardiomyopathy.

Crohn's disease (CD) and ischemic cardiomyopathy (ICM) share inflammatory characteristics, yet their common genetic underpinnings remain und … ified CDEGs, miRNAs, and TFs hold promise as therapeutic targets and biomarkers, paving the way for precision medicine approaches in managing CD and its cardiovascular complications. Future experimental validation and cohort expansion could further elucidate these shared mechanisms, enhancing their translational impact.

The role of double-negative B cells in the pathogenesis of systemic lupus erythematosus.

B cells are essential to the pathophysiology of systemic lupus erythematosus (SLE), a chronic autoimmune illness. IgD-CD27-double negative B … t target B cells have proven effective in managing SLE; nevertheless, a significant breakthrough in precision medicine for SLE may come from targeting DNB cells specifically. Despite growing interest in DNB cells, their precise characteristics, developmental trajectories, and regulatory mechanisms remain incompletely defined, posing significant challenges to the fie …

Night shift work and breast cancer: from etiopathology to precision risk analysis.

The increasing prevalence of night shift work (NSW) in our current professional landscape has raised significant public health concerns, par … erstanding of the strength and nature of the relationship between NSW and BC, but also to support a precision medicine framework. This integrated approach is essential for improving individual risk stratification, guiding occupational health policies, and developing targeted preventive strategies for high-risk workers.

Цель CD20 для разрушения клеток B в аутоиммунной почечной болезни: следующее поколение.

АнтиCD20 моноколональные антитела приобретают клиническое значение в нефрологическом сообществе благодаря их продемонстрированной эффективности и благоприятным характеристикам безопасности в краткосрочной, среднесрочной и долгосрочной перспективе. В настоящее время в рамках более широкого спектра аутоиммунных заболеваний, включая гломерулопатии, как с сопутствующей, так и без сопутствующей подоцитопатией, изучается лечение истощения клеток В. Последние достижения привели к разработке новых антиCD20 агентов, которые используются не только в качестве потенциальных альтернатив кортикостероидам, н

Совпадение в аннотации оригинала
Anti-CD20 monoclonal antibodies are gaining clinical relevance in the nephrology community due to their demonstrated efficacy and favorable … action, along with the potential for resistance and therapeutic failure, is essential for advancing precision medicine in this field. This review provides a molecular and clinical overview, incorporating pharmacokinetic and pharmacodynamic insights into the most widely used and emerging anti-CD20 monoclonal antibodies in nephrology. It serves as a practical guide to …

Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study.

Alcohol use disorder (AUD) is a disorder of clinical and public health significance requiring novel and improved therapeutic solutions. Both … he current diagnostic and statistical manual of mental disorders (DSM)-based intervention to propel precision medicine forward.

Polymeric Microneedle Drug Delivery Systems: Mechanisms of Treatment, Material Properties, and Clinical Applications-A Comprehensive Review.

Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their trans … an innovative strategy that steers drug concentration to specific targets, offering a paradigm for precision medicine. A thorough analysis of the clinical applications of polymeric microneedle systems is presented, highlighting their adaptability and impact across a spectrum of therapeutic domains. This review also accentuates the systems' promise to bolster patien …

Debate: Intermittent Hemodialysis versus Continuous Kidney Replacement Therapy in the Critically Ill Patient: The Argument for CKRT.

Continuous kidney replacement therapy (CKRT) is well entrenched as one of the dominant KRT modalities in modern critical care practice. Since its introduction four decades ago, there have been considerable innovations in CKRT machines that have improved precision, safety, and simplicity. CKRT is the preferred KRT modality for critically ill patients with hemodynamic instability. Early physical therapy and rehabilitation can be feasibly and safely provided to patients connected to CKRT, thus obviating concerns about immobility. Although randomized clinical trials have not shown a mortality diff

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019.

Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic and biological information in order to optimise the therapeutic benefit relative to the possibility of side-effects for each individual. Recent clinical trials have shown that higher blood eosinophil counts are associated with a greater efficacy of inhaled corticosteroids (ICSs) in chronic obstructive pulmonary disease (COPD) patients. Blood eosinophil counts are a biomarker with potential to be used in clinical practice, to help target ICS treatment with more precision in COPD patients with a hist…

Erythropoietin in tissue engineering and beyond: a multifunctional macromolecule with emerging roles in organoids, immune modulation, and cancer research.

Erythropoietin (EPO), a glycoprotein hormone conventionally associated with erythropoiesis, has emerged as a versatile macromolecule with su … eper understanding of its effects on tumor growth and immunity. Future advances in biomaterials and precision medicine could optimize EPO-based delivery systems to enable personalized therapeutic solutions. EPO stands poised to revolutionize tissue engineering, thus bridging laboratory innovation and clinical applications.

Breast Cancer: Challenges in the Treatment and Prodrug Strategies.

Breast cancer (BC) remains a leading cause of mortality worldwide, with treatment complicated by tumor heterogeneity, drug resistance, and t … bioavailability. Combining prodrugs with other therapeutic modalities, including immunotherapy and precision medicine, is actively being investigated to overcome drug resistance and enhance treatment response. Nevertheless, challenges remain, including the complexity of designing prodrugs that can be efficiently activated within the TME, as well as scalability and …

Microfragmented Adipose Tissue in Pain Management: Bridging Regenerative Biology and Clinical Therapeutics.

Regenerative medicine has emerged as a transformative paradigm in contemporary healthcare, shifting the therapeutic focus from symptomatic m … lity randomized evidence. Finally, future perspectives are explored, emphasizing the integration of precision medicine approaches, biomarker-driven patient stratification, and combinatorial regenerative strategies to optimize therapeutic outcomes.

[The Oral Microecological Theory of Dental Caries].

The microecological theory represents the current understanding of dental caries etiology, emphasizing that the dynamic balance of the structure and function of the oral microbial community plays a central role in the initiation and progression of caries. This theory posits that dental caries is not caused by a single specific pathogen, but rather results from dysbiosis-an imbalance-of the entire oral microecosystem. By redefining caries from an "infectious disease" to an "ecological imbalance disorder," the microecological theory offers a novel perspective for caries prevention, early interve