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Multiple-Drugs-Related Osteonecrosis of the Jaw in a Patient Affected by Multiple Myeloma: A Case Report.

A 60-year-old woman suffering from multiple myeloma (MM) was treated with zoledronic acid (bisphosphonate), dexamethasone (corticosteroid), bortezomib (a chemotherapeutic agent), and lenalidomide (thalidomide analog) for about a year and with lenalidomide alone as maintenance therapy for almost two years and developed stage three medication-related osteonecrosis of the jaws (MRONJ) in the upper left dental arch approximately two weeks after tooth extraction, which was treated with a medical nonoperative conservative approach until reversion to stage one. The present case report describing the

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… Necrotizing Fasciitis as a Rare Complication of Osteonecrosis of the Jaw in a Patient with Multiple Myeloma Treated with Lenalidomide: Case Report and Review of the Literature. Springerplus. 2014;3:123. doi: 10.1186/2193-1801-3-123. 42. …

Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus.

OBJECTIVE: This study aims to examine the value of two-dimensional (2D) ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: According to the diabetic peripheral neuropathy (DPN) diagnostic criteria, 60 patients with T2DM were enrolled and divided into 35 T2DM patients without DPN (non-DPN group) and 25 T2DM patients with DPN (DPN group). The control group consisted of another 15 healthy volunteers. The width, thickness, cross-sectional area

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… Investigation of the acute plantar fasciitis with contrast-enhanced ultrasound and shear wave elastography–first results . Clin Hemorheol Micro. ( 2017 ) 67 : 415 – 23 . 10.3233/CH-179222 28885209 10. Frankewycz B Penz A Weber J Da Silva N Freimoser F Bell R . …

Hemoadsorption as a Supportive Strategy for Severe Toxicity Associated With Chimeric Antigen Receptor T-Cell Therapy: A Case Series.

RATIONALE & OBJECTIVE: To describe the use and effects of extracorporeal blood purification with hemoadsorption in managing severe complications after treatment with chimeric antigen receptor T-cells (CAR-T). STUDY DESIGN: Retrospective analysis of a case series. SETTING & PARTICIPANTS: Hematological department and intensive care unit from a single institution. Patients with hematological cancer who underwent CAR-T therapy between 2021 and 2023, developed severe toxicity, and were treated with hemoadsorption based on clinical indications. RESULTS: Of 48 patients, extracorporeal blood purifi

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… the CytoSorb cartridge, which consists of highly biocompatible porous polymer beads that are capable of extracting molecules up to a size of 65 kDa. 24 Originally developed for the management of septic shock, 25 CytoSorb has since been applied across a spectrum of conditions, including necrotizing fasciitis …

Monoclonal Antibodies Approved for Cancer Therapy

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Others : non-GI fistula, RPLS, IR, CHF, hypertension, arterial/venous thromboembolism, eye disorders, proteinuria, neutropenia/infections, ONJ | Systemic : pulmonary events, epistaxis, headache, rectal hemorrhage, dry skin, necrotizing fasciitis, taste alteration, lacrimation disorder, ovarian failure … Mucocutaneous diseases provoked by panitumumab contribute to an extensive range of clinical manifestations including erythema, rash, pruritus, skin exfoliation, acneiform dermatitis, xerosis, paronychia, and skin fissures as well as life-threatening infectious complications such as necrotizing fasciitis …

Effects of Acetylcholine on Endothelial Function and Nitric Oxide Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Sham-Controlled Study.

BACKGROUND: Peripheral neuropathy is a prevalent neurological disorder with multiple etiologies. Nerve damage frequently occurs due to prolonged high blood sugar levels and diabetes. Peripheral nerve fiber impairment, mediated mainly through dysregulation of Nitric Oxide Synthase (NOS) activity, induces irreversible structural damage. Acetylcholine induces vasodilation by stimulating endothelial nitric oxide (NO) production, which relaxes smooth muscle, and by triggering a nerve axon reflex. This reflex releases neuropeptides like substance P, which further dilate vessels and prompt histamine

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… 13 Iontophoresis is a non-invasive technique that enables the transdermal delivery of ionized chemical agents through the skin by using a low-intensity electrical current applied via two adhesive electrodes. 14 This method has been examined as a potential treatment for conditions such as plantar fasciitis …

Клинические характеристики и прогностические факторы инфекции Клостридий перфрингенов, осложненные массовым внутриваскулярным гемолизом у пациентов с гематологическими заболеваниями: ретроспективное тематическое исследование.

С пищевым отравлением и газовой гангреной обычно ассоциируются анаэробные бактерии с положительным гравием Clostridium perfringens (CP). В редких случаях он может вызывать смертельный массовый внутриваскулярный гемолиз (MIH) — состояние, связанное с чрезвычайно высокой смертностью, которое создает серьезную клиническую проблему. Ретроспективный анализ был проведен с использованием смертельного случая T-лимфоболической лимфомы/лейкемии, осложненной острым гемолизом, связанным с ХП, который лечился в нашем центре в ноябре 2024 , а также сообщения о связанных с КП MIG пациентах-гематологах с янва

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… Successful treatment of necrotizing fasciitis in an upper extremity caused by Clostridium perfringens after bone marrow transplantation. Intern Med. (2011) 50:2213–7. 10.2169/internalmedicine.50.5829 41. Guo Z, Yue N, Chen M, Li J, Lv R, Wang J, et al. …

Реальный опыт использования озанимода у взрослых с множественной скlerозом.

AIM: Ozanimod — фингозин второго поколения. 1-phosphate Модулятор рецептора (S1PR), утвержденный для лечения повторного склероза (MS). Данные об использовании озанимодов в реальной клинической практике отсутствуют. Цель этого исследования состоит в том, чтобы определить характеристики людей, у которых MS (PwMS) предписан озанимод, а также стойкость, терпимость, безопасность и эффективность по отношению к ним. one Год. МЕТОДЫ: Ретроспективно собирались данные по взрослым с синдромом MS или клинически изолированным синдромом, которые получали озанимод two Высшие центры MS. Результаты: Мы определ

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… One pwMS developed necrotizing fasciitis, which led to discontinuation of ozanimod. Discontinuation pattern of ozanimod. *9 pwMS with new T2 hyperintense or enhancing brain lesions. **7 pwMS with elevated liver function tests. 1 with lymphopenia. …

Pilot Study: Human Adipose Tissue Allograft for Fat Pad Defects in Patients With Preulcerative Lesions.

BackgroundLoss or displacement of a fat pad on the foot increases plantar pressure, leading to pain and plantar ulcers. These ulcers, especially in patients with diabetic neuropathy, have high recurrence rates, often resulting in amputations. Standard of care focuses on reducing plantar pressure with shoe padding or orthotic devices, leaving the restoration of the fat pad as an unmet medical need. To address this, a human cryopreserved adipose tissue (hCAT) allograft has been developed to repair adipose tissue defects.MethodsScientific characterization of hCAT included assessments of its struc

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… Autologous fat grafting for plantar fasciitis. J Cutan Aesthet Surg. 2022;15:97–98. 29. Bus SA, Maas M, Cavanagh PR, et al. Plantar fat-pad displacement in neuropathic diabetic patients with toe deformity: a magnetic resonance imaging study. Diabetes Care. 2004;27:2376–2381. 30. …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

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… For example, Streptococcus pyogenes , or Group A Streptococcus , can cause acute pharyngitis ( 40 ) and necrotizing fasciitis ( 41 ). Enterococcus faecalis infection may be involved in the progression of chronic pancreatitis and eventually lead to the development of pancreatic cancer ( 42 ). …

Insights Into Late-Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets.

Late-onset rheumatoid arthritis (LORA) is defined as rheumatoid arthritis (RA) manifesting after the age of 65 years, although the terminology remains somewhat ambiguous. With the advent of a super-aging society and extended life expectancies, a significant increase in the incidence of LORA is anticipated. In comparison to young-onset RA (YORA), LORA is predominantly characterized by a higher incidence of acute onset, augmented disease activity and constitutional symptoms, a propensity for systemic manifestations, increased erythrocyte sedimentation rate at disease onset, reduced seropositivit

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… Palmar fasciitis, linked to ovarian and breast cancers, causes rapid flexion contractures and painful hand swelling. MRI shows fascial and tendon thickening, especially in muscles like the flexor carpi ulnaris (Figure 2 ). … Palmar fasciitis with polyarthritis (PFPA) associated with ovarian cancer. A 68‐year‐old woman with a 4‐month history of spontaneous left‐hand digital contractures. …

Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States.

BackgroundManagement of chronic inflammatory demyelinating polyneuropathy (CIDP) is challenged by heterogeneity in severity, comorbidities, potential adverse effects, and treatment accessibility. This study aimed to elucidate treatment utilization among patients with CIDP in the United States (US) to identify potential unmet needs.MethodsAdult patients with CIDP were identified using Komodo Health's Healthcare Map™ (January 2016-December 2020). Descriptive statistics related to utilization of CIDP treatments over 1-year post-index were analyzed. Among patients who used immunoglobulin (Ig), chr

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… dermatomyositis, fibromyalgia, Guillain-Barre syndrome, familiar neuropathy, human immunodeficiency virus, immune thrombocytopenic purpura, inclusion body myositis, bone marrow transplant, Kawasaki disease, multifocal motor neuropathy, multiple myeloma, multiple sclerosis, myasthenia gravis, necrotizing fasciitis …

Could kinesiology taping help mitigate pain, breathlessness and abdominal-related symptoms in cancer?

We present the case of a woman who was an amateur athlete diagnosed with primary breast cancer, and 10 years later with terminal metastatic cancer. This case report was prepared posthumously in co-operation with her next of kin (husband). The patient first presented to a sports physiotherapist (AR) for her pain-management and to help maintain physical fitness so that she could continue with sports and an active lifestyle. The patient continued with physiotherapy for several months to enable her to be active. However, when her health deteriorated significantly due to advancing cancer, the treat

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… has no immediate effect on reducing low back pain and disability; small effect for neck pain reduction which may not be clinically relevant | Morris et al 12 n=6; MSK pain, ROM, disability, function n=1; cancer-related lymphedema n=1; stroke-related spasticity *limited evidence for short-term plantar fasciitis-related …

Inpatient Medicine

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High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease.

AimTo determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD).Methods50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria. The presence of vitiligo, alopecia, xerosis, nail changes, and dyspigmentation was

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… Diagnostic skin manifestations of cGVHD are poikiloderma, lichen planus-like eruptions, lichen-sclerosus-like lesions, morphea-like sclerosis, and deep sclerosis/fasciitis and therefore there is no need for a biopsy to establish the diagnosis ( 2 ). …

Injected corticosteroids for treating plantar heel pain in adults.

BACKGROUND: Plantar heel pain, commonly resulting from plantar fasciitis, often results in significant morbidity. Treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), orthoses, physical therapy, physical agents (e.g. extracorporeal shock wave therapy (ESWT), laser) and invasive procedures including steroid injections. OBJECTIVES: To assess the effects (benefits and harms) of injected corticosteroids for treating plantar heel pain in adults. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of C…

Imatinib and dasatinib as salvage therapy for sclerotic chronic graft-vs-host disease.

AimTo assess the toxicity, tolerance, steroid-sparing capacity, effectiveness, and response rate to imatinib and dasatinib for the treatment of severe sclerotic chronic graft-vs-host disease (scGVHD).MethodsThis retrospective study analyzed 8 consecutive patients with severe refractory scGVHD who received salvage therapy with imatinib. Patients intolerant and/or refractory to imatinib received dasatinib treatment.Results7 patients discontinued imatinib treatment (1 achieved complete response, 5 were resistant and/or intolerant, and 1 developed grade IV neutropenia) and 1 patient achieved prolo

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… At the first response assessment, three months after the start of imatinib, his sclerotic features started improving and by six months he had achieved partial response with objective improvement in erythema due to fasciitis, joint stiffness, and photographic range of motion. …

Морфологическое исследование ячеек HLA-DR-иммунопозитивных клеток в множестве склерозов и их последствий для патогенеза

Фон: Множественный склероз (MS) характеризуется обезвоживанием белой материи, которое может быть классифицировано как активный, хронически активный или хронически неактивный в зависимости от степени обезвоживания, клетчатости и воспаления. Ключевую роль в этих процессах играют микроглии и макрофаги. Цель этого исследования заключалась в изучении морфологических характеристик клеток HLA-DR-иммунопозитивных клеток в этих досках, с тем чтобы улучшить наше понимание роли этих клеток в досках MS. Методы: Это исследование представляет собой ретроспективное исследование гистопатологического характера

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… The causes of death in these cases varied: one case involved drowning, three cases involved sudden unexpected death in epilepsy (SUDEP), one case involved sudden death with no identifiable cause or brain pathology, and one case involved necrotizing fasciitis with no significant pathological alterations …

Prostate-specific membrane antigen (PSMA)-ligand positron emission tomography and radioligand therapy (RLT) of prostate cancer.

From a clinical perspective, prostate-specific membrane antigen (PSMA) is a valuable target for both diagnosis and radioligand therapy (RLT) of prostate cancer. The term 'specific' has been used to characterize a histologic hallmark of overexpression in the membrane of most prostate cancer. Many PSMA ligands have been developed since the previous decade and have been used in several clinical trials and clinical studies. However, procedure, specification, protocol, interpretation criteria, radiation dose, and cost-effectiveness of PSMA ligands have not been fully explained. Regardless of worldw

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… submandibular gland Abdomen | Liver, spleen, kidney, small bowel, ureter Pelvis | Urinary bladder, myometrium Other | Sympathetic ganglia (cervical, celiac, sacral ganglia) Benign condition or disease Granuloma | Granulation tissue, keroid, sarcoidosis, active tuberculosis, anthracosis Inflammation | Nodular fasciitis …

Current trends of infectious complications following hematopoietic stem cell transplantation in a single center.

This study was to analyze the infectious complications after hematopoietic stem cell transplantation (HSCT) according to the recent changes of HSCT. Medical records of 379 adult patients who underwent HSCT consecutively at Catholic HSCT Center from January 2001 to December 2002 were reviewed retrospectively. Allogeneic HSCT accounted for 75.7% (287/379) and autologous HSCT for 24.3% (92/379). During pre-engraftment period, bacterial infection was predominant, and E. coli was still the most common organism. After engraftment, viral infection was predominant. The incidence of invasive fungal inf

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… In the late-recovery period, the mortality rate was 26.9% (91/338), and 59.3% (54/91) of these deaths were related to infection; 42 patients with pneumonia, 7 with septic shock, 1 with necrotizing fasciitis, 1 with cerebral aspergillosis, and 3 with fulminant hepatitis B. …

Риск заражения иммунной контрольной точкой: систематический обзор и метаанализ.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Относительный риск (RR) инфекции для пациентов, прошедших курс лечения с ингибиторами для иммунных контрольно-пропускных пунктов (ИПК), неизвестен. ЦЕЛИ: В этом исследовании была проведена оценка риска инфицирования пациентов с твердыми опухолями, проходящих курс лечения в рамках ИКИ, на основе систематического обзора и метаанализа. ПАТИЕНТЫ И МЕТОДЫ: Были проведены обыски баз данных библиотеки Кокрана, ЭМБАСЕ и Пубмеда 1 декабрь 2020. Включены случайные испытания, сравнивающие любой ICI в одиночку с химиотерапией (CT) или с другими агентами против плацебо, КТ или других

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… Sunitinib 432 vs. 429 | 0.23 vs. 1.17 | Pneumonia, sepsis, urinary tract infection necrotizing fasciitis | NA | NA | 0.23 vs. 1.17 | Low Rizvi 2020 [ 38 ] | III | 1118 | NSCLC | Durva or durva + tremelimumab vs. …