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Lighting Up Mislocalized Proteins: Quantum Dot Probes for Multiplexed Cytoplasm-Selective Cell Profiling in Neurodegeneration.

Semiconductor quantum dots (QDs) provide unique stability, brightness, and multiplexed capacity for biomarker detection in complex diseases; … oring, and early biomarker discovery, with potential applications in translational neuroscience and precision medicine.

Recent advances of microbial medicine to prevent and treat cardiovascular disease.

Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with standard pharmacological interventions often failing to fully address their complex pathophysiology. Recent advances in microbial medicine highlight the human gut microbiome as a critical regulator of cardiovascular health. Gut microbial metabolites such as short-chain fatty acids (SCFAs), trimethylamine-N-oxide (TMAO), and indole derivatives play pivotal roles in modulating inflammation, lipid metabolism, immune function, and vascular homeostasis. Dysbiosis, or microbial imbalance, has been strongly associated w

Organoids: Current Applications and Future Directions.

Organoids are three-dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug discovery, precision medicine, and regenerative medicine. However, current organoid models are limited by incomplete maturation, insufficient vascularization, inadequate immune and neural integration, and poor reproducibility, restricting their physiol…

Screening strategies for colorectal cancer: adjusting for individual risk factors.

INTRODUCTION: Colorectal cancer (CRC) is a common cause of cancer-related mortality. While overall incidence has declined, certain populatio … C risk must become increasingly more nuanced to adequately serve, screen, and surveil our patients. Precision medicine offers a pathway to accomplish this, but will require significant research to accurately measure risk, and the ability to adapt risk models as our data evolves. This undertaking grows evermore relevant as medicine becomes increasingly personalized a …

Clinical Genetics in Reproductive Medicine: Variant Classification, Medically Actionable Genes, and Carrier Screening.

As genomic sequencing becomes more prevalent in reproductive medicine, clinicians must remain knowledgeable about the purpose of each ordere … nsanguinity or significant family history. While technical genomic advances enhance the delivery of precision medicine, they introduce challenges, including higher rates of uncertain findings and the need for more careful clinical interpretation.

First-in-human to proof-of-concept: why experimental medicine studies remain essential in human physiology and drug development.

Experimental medicine studies, small, mechanistically focused investigations, have historically driven key discoveries in human physiology and pharmacology. Despite their foundational role, these studies are increasingly marginalised in today's drug development environment due to economic pressures, regulatory conservatism, and an overemphasis on statistical endpoints from large-scale trials. This article traces the historical roots and enduring value of experimental medicine, distinguishes it from current early phase drug development studies, and explores the structural forces behind its decl

Oculomics: advances and perspectives from traditional Chinese medicine to modern multimodal biomarkers.

Oculomics, the study of the relationship between ophthalmic biomarkers (changes or abnormalities in the eye) and systemic health or disease … the new concept of oculomics. This multimodal approach exhibits significant potential for advancing precision medicine, ultimately improving patient outcomes through early detection and personalized treatment strategies.

[Interpretation of effect measures in clinical research: A practical guide for the clinician].

Modern medical practice faces an ever-growing volume of information that demands accurate statistical interpretation to guide clinical decision-making. Effect measures are essential tools for quantifying the true magnitude of an intervention and assessing its clinical impact. However, limited understanding of these measures among healthcare professionals often hinders the effective translation of evidence into everyday practice. This article's objective is to provide a clear and didactic overview of the principal effect measures used in clinical research, emphasizing their relevance to evidenc

The potential of bioengineered exosomes in regenerative medicine: a next generation therapy.

The limitations of conventional drug delivery systems and synthetic nanocarriers have spurred the search for advanced therapeutic platforms in regenerative medicine. Bioengineered exosomes/sEV, natural extracellular vesicles with inherent biocompatibility and targeting capabilities, have emerged as a groundbreaking solution. This review explores the fabrication of these nanovesicles as precision drug delivery vehicles through strategies such as parent-cell modification, direct cargo loading (via sonication, electroporation, and extrusion), and surface functionalization. Critically, the synergy

Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.

Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and tissue repair. Traditionally considered passive regenerative cells, ISCs are now recognized as active environmental sensing hubs that integrate microbial, immune, metabolic, mechanical, and neural signals from the intestinal microenvironment. Through intrinsic sensing mechanisms and interactions with niche components, ISCs translate environmental cues into distinct fate decisions, including proliferative regeneration, defensive differentiation, injury-induced plasticity, and, under chronic stress, stem cell e

Collecting Eggs, Not Killing Chickens: Why Stem Cell Secretome and Exosomes Are Redefining Regenerative Medicine for Healthspan Extension.

Regenerative medicine is becoming more widely integrated with longevity-oriented and preventive care as populations age and chronic degenerative diseases burden healthcare systems. Mesenchymal stem cell (MSC) therapies have progressed from experimental interventions to approved products, yet scalability, safety, cost, and regulatory complexity constrain widespread implementation in medical wellness contexts. The predominant therapeutic effects of MSCs are mediated via paracrine mechanisms, leading to cell-free approaches based on the MSC secretome-a complex mixture of bioactive factors includi

Primary cell cultures versus immortalized cell lines: critical comparative insights into biological fidelity and translational applications.

In vitro cell culture models are fundamental to biomedical research, yet the choice between primary cell cultures and immortalized cell line … te in vitro models, highlighting the translational significance of primary cells in drug discovery, precision medicine, and biomedical research.

Genetically Modified and Gene-Edited Organisms-Objectives, Public Perception and Applications.

Genetic modification and genome editing have become important tools in agriculture, animal production, biotechnology, and human medicine, but their safety and societal acceptance remain subjects of debate. This review examines genetically modified (GM) and gene-edited organisms, distinguishing transgenesis from precision genome editing technologies, including CRISPR/Cas9, base editing, and prime editing. Representative applications in crops, livestock, pharmaceutical production, and xenotransplantation are discussed, together with their regulatory framework and public perception. Current scien

Deciphering the Molecular Mechanisms of Polycystic Ovary Syndrome and Flaxseed Therapy Through Transcriptomics and Machine Learning.

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder characterised by heterogeneous clinical and molecular pheno … ental studies and support the development of flaxseed-based therapeutic strategies for PCOS through precision medicine frameworks.

Establishing a Net-Zero Emissions Kidney Care Center: A Model Proposal for Taiwan.

Green nephrology has emerged as a crucial strategy to address the health care sector's role in the climate crisis, particularly due to the high carbon intensity of dialysis-related services. Aligned with global net-zero commitments, sustainable kidney care can reduce environmental impact while maintaining high standards of patient care. This viewpoint paper proposes a net-zero carbon emissions kidney care center model to address global climate change challenges and advance health care sustainability goals. Based on the United Nations Sustainable Development Goals, we developed a 4D framework:

The use of laser therapy in fetal medicine: a narrative review.

INTRODUCTION: Fetal therapy has evolved into an established clinical specialty in fetal medicine, offering life-saving interventions for conditions with high intrauterine morbidity and mortality. Among various approaches, laser therapy has played a significant role in advancing fetal procedures. CONTENT: The most established application of laser is fetoscopic laser coagulation for twin-twin transfusion syndrome, which significantly reduces perinatal mortality and neurological complications. Other indications include twin anemia-polycythemia sequence and, as an intrafetal application, twin rev

Достижения в области терапевтических исследований в области демиелинизирующих заболеваний.

Болезни демиелина представляют собой группу хронических и изнурительных неврологических расстройств, при этом разрушение миелинской оболочки служит основной патологической отличительной чертой. Центральный патогенез связан с иммунно-посредованным повреждением олигодендроцитов (Оль) и миелинового распада, сопровождающимся порочным циклом нейроинфламмации и нарушенным эпигенетическим восстановлением. Нынешние терапевтические стратегии, включая традиционные иммунодуляторные агенты, направленные против моноклонных антител, эффективно контролируют рецидивы заболеваний, но демонстрируют ограниченную

Совпадение в аннотации оригинала
Demyelinating diseases comprise a group of chronic and debilitating neurological disorders, with the destruction of the myelin sheath servin … , and difficulties in translating findings from preclinical models. Future efforts should emphasize precision medicine, multi-target synergistic therapies, and the development of intelligent delivery systems, with the ultimate goal of achieving a paradigm shift from delaying disability progression to functional neural reconstruction.

Familial and hereditary pancreatic cancer in Japan.

As in Western countries, familial pancreatic cancer accounts for 5-7% of pancreatic cancer (PC) in Japan. Opportunities for diagnosing hereditary pancreatic cancer (HPC) are increasing owing to the coverage of companion diagnostics and cancer genomic profiling by national health insurance in patients with unresectable or recurrent PC refractory to standard chemotherapies. HPC is recognized in 7% of PCs and 15% of familial pancreatic cancer, including germline variants of BRCA1/2, ATM, PALB2, APC, and mismatch repair genes. Individuals with 5-fold or greater inherited risks of PC are recommende

In Situ Array Microextraction and Metabolic Profiling of Small Extracellular Vesicles to Guide and Monitor Maternal Delivery.

The advantages of small extracellular vesicles (sEV) in disease management have become increasingly prominent, with the main challenge lying in meeting the demands of large-scale extraction and high-throughput analysis, a crucial aspect in the realm of precision medicine. To overcome this challenge, an engineered on-plate aptamer array (16×24 spots) is developed for continuous scale-up microextraction of plasma sEV and their in situ metabolic analysis using mass spectrometry. With this integrated array strategy, metabolic profiles of sEV are acquired from the plasma of 274 antenatal or postpar…

Biomarkers in Psoriasis: The Future of Personalised Treatment.

Psoriasis is a chronic and complex immune-mediated papulosquamous disease affecting almost 2% of the world population. The interaction betwe … data validating their routine use in clinical practice and the progress so far made in the field of precision medicine for psoriasis.