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A novel "turn-on" fluorescence probe for chromium(III) sensing: experimental validation and theoretical insights.

CONTEXT: Trivalent chromium exhibits a dual nature. It acts as a necessary micronutrient for lipid and carbohydrate metabolism at low levels in the body, but causes dangerous genotoxic harm at higher thresholds. Hence, precise tracking of trace trivalent chromium is absolutely essential. Compounding this, its intracellular detection remains highly obstructed by paramagnetic fluorescence quenching and a deficiency in selective probes. Addressing this material and analytical challenge, this work reports the development of an ultrasensitive "turn-on" fluorogenic chemosensor utilizing a novel azo-

Soil conditioners promote cadmium reduction and selenium enrichment in rice: formulation process, effects, and mechanisms.

Excessive accumulation of cadmium (Cd) in rice from a selenium (Se)-enriched area is a global environmental issue. Due to its widespread presence and potential transfer through the food chain, it poses a significant threat to human health. Se, as an essential micronutrient for humans, reduces the Cd uptake of rice and mitigates the toxicity of Cd. The application of optimized soil conditioners has emerged as a promising agronomic strategy to mitigate Cd accumulation in rice grains while enhancing Se biofortification, leveraging the interactive mechanisms of Se-Cd antagonism in the soil-rice sy

Nutrient intake and diet quality in individuals with hyperuricemia: a matched population study.

BACKGROUND: Dietary factors influence hyperuricemia; however, comprehensive evaluations integrating nutrient intake, dietary patterns, and overall diet quality remain limited. This study aimed to address this gap by assessing nutrient intake using the Korean Dietary Reference Intakes (KDRIs) and diet quality using the Korean Healthy Eating Index (KHEI). METHODS: In this cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data, 24,026 Korean adults were eligible prior to matching, stratified by sex, and then classified according to hyperuricemia status

Mediterranean Diet Adherence and Vitamin Intake Adequacy in Spanish University Students: Associations with Body Composition and Physical Activity.

BACKGROUND/OBJECTIVES: This study examined the relationship between adherence to the Mediterranean diet (MD), dietary and vitamin intake, physical activity, and body composition in young adults. METHODS: A total of 145 Spanish university students (34 women and 111 men) were included in this cross-sectional study, with a mean body mass index (BMI) of 23 kg/m2. MD adherence was assessed using the Mediterranean Diet Adherence Screener (MEDAS). Dietary intake was evaluated through a three-day food record, physical activity using the International Physical Activity Questionnaire (IPAQ), and body c

Dietary diversity among reproductive aged women attending urban and rural healthcare facilities, Middle Delta, Egypt.

BACKGROUND: Proper nutrition is essential for women of reproductive age (WRA) as it promotes hormonal balance, fertility, and healthy pregnancy and lactation. Dietary diversity (DD) is an important component of diet quality and Minimum dietary diversity has been widely used as a proxy indicator for micronutrient adequacy. There is a notable lack of studies in Egypt addressing dietary diversity among WRA. This study investigated the dietary diversity among those who attended an urban and a rural health care facilities in Egypt. METHODS: A cross-sectional study was carried out between January 20

Planetary health diet adherence and risk of cognitive-behavioral disorders in children and adolescents: a retrospective cohort study.

BACKGROUND: Mental and behavioral disorders are a major public health concern and represent the most prevalent psychiatric conditions among youth. Although the Planetary Health Diet (PHD) was developed to promote both human and planetary health, the role of sustainable dietary patterns in neurodevelopment remains unclear. This retrospective cohort study investigated the association between adherence to a child-adapted PHD index (PHDI-C) and cognitive-behavioral health among children and adolescents. METHODS: Data from 1,744 participants aged 7-18 years in the 2013-2016 Nutrition and Health Su

Early Prediction of Standing at Discharge in Moderate-to-Severe Traumatic Brain Injury: A Clinical Machine Learning Model Integrating Modifiable and Nonmodifiable Factors.

OBJECTIVE: To develop and internally validate a machine learning model to predict favorable standing ability at hospital discharge in patients with moderate-to-severe traumatic brain injury, incorporating both modifiable and nonmodifiable clinical factors. DESIGN: Retrospective cohort study. SETTING: A tertiary academic medical center in Taiwan. PARTICIPANTS: A total of 248 adults with moderate-to-severe traumatic brain injuries admitted between 2019 and 2024 who received standard acute care and had complete discharge functional outcome data. INTERVENTIONS: Not applicable. MAIN OUTCOME ME

Evaluation of the nutrition quality of meals served in small-scale public foodservice for the elderly in Korea by foodservice operation type-focused on proportion over chronic disease risk reduction intake and nutrient adequacy ratio: a cross-sectional study.

OBJECTIVES: Although delivery-based contract-managed operations have recently increased in small-scale foodservice facilities serving older adults, studies investigating the nutrient adequacy of meals and chronic disease risk reduction intake remain limited. This study aimed to evaluate nutrient intake levels, nutrient intake adequacy, and their chronic disease risk, and to compare differences between self-operation and contract-managed foodservice. METHODS: Nutrient intakes of 777 participants were assessed for lunch and snack in 18 small-scale foodservice settings serving older adults in Ko

Effects of Different Selenium Concentrations on Agronomic Traits, Antioxidant Defense, and Leaf Metabolome in Blueberry (Vaccinium corymbosum L. 'Brigitta').

Selenium (Se) is an important micronutrient that is required in very small amounts and plays a significant role in enhancing plant growth, stress resistance, and fruit quality. In this study, we investigated the effects of different sodium selenite concentrations (CK, 0 mg/L; Se1, 0.50 mg/L; Se2, 1.00 mg/L, Se3, 2.00; and Se4, 3.00 mg/L) on the growth, nutrient absorption, antioxidant capacity, and leaf metabolome of blueberry (Vaccinium corymbosum L. 'Brigitta') in hydroponic culture. Our results showed that moderate Se concentration (1.00 mg/L, Se2) had noticeable enhancements in key traits

Impact of bovine respiratory disease on tissue-specific regulation of Zn and vitamin a metabolism and apparent absorption and retention of trace minerals.

This study aimed to characterize trace mineral and vitamin A metabolism and redistribution during clinical and subclinical respiratory infection in beef on dairy crossbred steers (n = 29; BW = 230 ± 2.14 kg). Steers were assigned to one of four groups encompassing days -6 to -1, 0 to 5, 5 to 10, and 10 to 15 of an experimental viral-bacterial respiratory challenge. Steers were adapted to metabolism crates for 5 d prior to a 5-d total urine and fecal collection period and necropsied at the end of the period. On day 0, steers were inoculated with bovine respiratory syncytial virus strain 375 fol

Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis.

BACKGROUND: Tuberculosis remains a major global health challenge, with emerging evidence suggesting that micronutrient deficiencies may contribute to susceptibility to infection through impaired immune function. Iron deficiency anemia (IDA) is the most common nutritional deficiency worldwide; however, its association with tuberculosis risk remains inadequately characterized across diverse populations. We examined the relationship between IDA and incident tuberculosis in a large multinational cohort. METHODS: This retrospective matched cohort study used data from the TriNetX Research Network s

Malleolar Stress Fracture as the First Manifestation of Undiagnosed Crohn's Disease: A Case Report.

INTRODUCTION: Stress fractures (SFs) typically result from repetitive high-impact activities in athletes or military personnel. Their occurrence in young, non-athletic individuals without significant mechanical overload is uncommon and warrants investigation for underlying systemic conditions. Although Crohn's disease (CD) is associated with increased fracture risk due to chronic inflammation, malabsorption, and nutritional deficiencies, SFs as the initial manifestation of clinically silent CD are rarely documented. To the best of our knowledge, this represents the first reported case of a med

Состояние питания, способность к антиоксидантам в рационе питания и разнообразие рациона питания у пациентов с недавно диагностированными гематологическими отклонениями: тематическое исследование.

ППОЗ: Состояние питания и способность к антиоксидантам в рационе питания являются важными факторами, определяющими клиническую устойчивость к раку; однако данные о гематологических заболеваниях по-прежнему ограничены. Мы поставили перед собой цель сравнить состояние питания, общий потенциал рациона питания с антиоксидантами (DTAC) и разнообразие рациона питания между пациентами с недавно диагностированными гематологическими отклонениями и здоровыми средствами контроля. МЕТОДЫ: Это тематическое исследование включало 34 больные с недавно диагностированными гематологическими заболеваниями12 лимфо

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… Dietary records were analyzed using the Nutrition Information System (BEBİS 9.0, Pasifik Company, 2016) to estimate mean daily energy and macro- and micronutrient intakes. … Micronutrient inadequacies were also evident, particularly for zinc, vitamin E, and folate, nutrients essential for immune function, redox balance, and cellular metabolism [ 35 – 37 ]. Lower intake of these micronutrients may further compromise antioxidant defense and immune competence. …

PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis.

UNLABELLED: Porcine epidemic diarrhea virus (PEDV), a member of the Alphacoronavirus genus, causes severe enteric disease with up to 100% mortality in suckling piglets. Iron is an essential micronutrient for the replication of various pathogens, including viruses, which hijack host iron resources to support their proliferation. SLC40A1 encodes ferroportin (FPN), the only known iron exporter in mammals and a key target for pathogens to manipulate host iron homeostasis. However, whether coronaviruses exploit this mechanism remains unknown. Here, we demonstrate that PEDV infection disrupts host i

Assessment of Dry Eye Disease Symptoms in Health Science University Students: A Combined Approach Using CVS-Q and Schirmer Tear Test to Evaluate the Influence of Digital Devices.

INTRODUCTION: GLP-1 receptor agonists (GLP-1 RAs) are among the fastest-growing pharmacological classes globally. Alopecia has emerged as a clinically relevant adverse effect signal, yet pooled quantitative estimates of risk by subtype and agent are lacking. The objective of this study was to estimate the pooled risk of alopecia associated with GLP-1 RA use, stratified by subtype, agent, and follow-up duration, and to synthesize mechanistic and management evidence. METHODS: PubMed/MEDLINE, Embase, Cochrane Central, Web of Science, and Scopus were searched from inception to March 31, 2026, wit

Outcomes of a Novel Surgery: Gastrojejunal-Ileal Interposition with Bipartition and Sleeve Gastrectomy for Type 2 Diabetes and Obesity.

Background/Objectives: Gastrojejunal-ileal interposition with bipartition and sleeve gastrectomy (GJIB-SG) is a novel metabolic procedure developed to combine functional foregut exclusion with hindgut stimulation while preserving duodenal continuity and endoscopic biliary access. This study evaluated the medium-term glycemic, weight-loss, and nutritional safety outcomes of GJIB-SG in patients with obesity and long-standing type 2 diabetes (T2D). Methods: A retrospective single-center cohort of 30 consecutive patients with obesity and T2D who underwent GJIB-SG between January 2016 and August 20

An Inflammation-Adjusted Framework for Nutritional Assessment in Multimorbid Patients with Advanced Neurological Diseases.

Background and Objectives: Laboratory parameters associated with nutritional and metabolic status may be substantially influenced by inflammatory activity, complicating their interpretation in patients with advanced neurological diseases. This study aimed to characterize within-patient changes in inflammatory biomarkers and laboratory parameters related to nutritional and metabolic status in multimorbid patients receiving long-term enteral nutrition, with particular emphasis on differences between infectious and clinically non-infectious periods. A secondary objective was to propose a conceptu

High Prevalence of Pseudo-Pelger-Huët Anomaly and Neutrophil Dysplasia in Children with Celiac Disease: A Retrospective Case-Control Study.

Background/Objectives: Celiac disease (CD) is a chronic immune-mediated disorder associated with a broad spectrum of extraintestinal manifestations, including hematological abnormalities. Although anemia and micronutrient deficiencies are well recognized, neutrophil morphological abnormalities have not been systematically investigated in pediatric CD; this study aimed to evaluate peripheral blood smear findings in children with CD compared with healthy controls. Methods: This retrospective case-control study included 70 children with CD and 74 healthy controls; demographic characteristics, ant

Identifying populations with high prevalence of non-malarial febrile illnesses across different demographic groups in Malawi.

BACKGROUND: Malaria remains a major cause of febrile illness in Malawi; however, the epidemiology of non-malarial febrile illnesses (NMFIs) is less well characterized. Understanding the distribution and determinants of NMFIs across demographic groups is essential for improving case management in malaria-endemic settings. OBJECTIVES: This study aimed to characterized the distribution and predictors of NMFIs among preschool-aged children (PSC), school-aged children (SAC), women of reproductive age (WRA), and men in Malawi. METHODS: Secondary data from the 2015-2016 Malawi Micronutrient Survey

Serum homocysteine is a biomarker for hearing loss associated with or without cardiovascular risk: a cross-sectional study in men.

PURPOSE: Hearing loss (HL) represents a major health problem worldwide, and increasingly so due to population ageing and new leisure activities, such as video gaming or virtual reality experiences. HL has a multifactorial origin including both genetic and environmental issues with nutrition status emerging as a new contributing factor. In fact, certain micronutrient deficiencies, along with excessive consumption of specific macronutrients, have been related to HL This study aimed to examine the association of HL with dietary fat intake, nutritional status biomarkers, and serum metabolic signat