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Diffuse midline glioma treated with epigenetic agent-based immunotherapy.

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… Dear Editor , Diffuse midline glioma, H3K27-altered (DMG), is a pediatric-type high-grade diffuse glioma that preferentially localizes to the brainstem or pons, thalamus, and spinal cord. Surgical resection is challenging and biopsy is often performed in most cases. …

Randomized controlled trial of emotion regulation therapy versus cognitive behavioral therapy to address distress in cancer caregivers

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Development and psychometric properties of a general cancer stigma scale.

Cancer stigma negatively impacts diagnosis, quality of life, and survival outcomes, yet stigma reduction efforts are hindered by the lack of a valid and universal scale to measure cancer stigma. This study aimed to develop and validate a global cancer stigma scale, the Cross-Cultural Oncology Measure for Perception and Awareness of Stigma Scale (COMPASS), which measures internalized, anticipated, and enacted stigma. The scale was developed using mixed methods in two phases: (1) feedback from experts and people with cancer on an initial pool of items, and (2) psychometric validation with people

Baseline Characteristics of Participants in the Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study: A Wake-Up Call for Action.

Background: Alberta Cancer Exercise (ACE) is a hybrid effectiveness-implementation study evaluating a cancer-specific community-based exercise program across urban sites in Alberta, Canada. The purpose of this paper is to describe the baseline characteristics of participants. Methods: Adults with any type and stage of cancer, who were undergoing cancer treatment or up to three years post treatment completion, were eligible. ACE was delivered in person at 18 sites across 7 cities in Alberta, with video conferencing introduced during the COVID-19 pandemic. Participants took part in 60 min of mil

Может ли дополнение антиоксидантами улучшить когнитивные функции у пациентов с множественным склерозом? Обзор литературы.

Множественный склероз (MS) — хроническое нервно-воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), имеющее сложную и многофакторную патофизиологию. Хотя эти механизмы еще не полностью прояснились, установлено, что окислительный стресс (ОС) играет ключевую роль в вождении нейродегенерации в MS. Эти патологические механизмы способствуют возникновению широкого круга симптомов, включая моторные и сенсорные расстройства, а также когнитивное расстройство. Дефекты когнитивных функций могут создавать для этих пациентов тяжелое бремя и существенно влиять на качество их

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… Studies have reported lower plasma PON activity in RRMS patients during relapse compared with remission and also in the remission phase of RRMS compared with healthy individuals [ 48 , 49 ] , suggesting it may play a role in MS activity. … In a recent study, two months of NAC supplementation significantly increased CBF in regions involved in attention, memory, and executive function, such as the pons, midbrain, hippocampus, frontal lobe, temporal lobe, and thalamus [ 88 ] . …

Perceptions of Older Adults with Hematological Cancer on Diet and Exercise Behavior and Its Role in Navigating Daily Tasks.

Diet and exercise are associated with the maintenance of physical function, independence and better health-related quality of life in cancer survivors. Adherence to healthy diet and exercise guidelines, however, remains low. The aim of this study was to explore the perceptions of hematological cancer survivors (HCS, ≥50 years) on the role of diet and exercise in navigating daily tasks using a qualitative descriptive research method. Eligible HCS completed an online survey gathering demographic information including physical functioning, exercise frequency, malnutrition and frailty risk. Follow

Correlates of physical activity in a population-based sample of kidney cancer survivors: an application of the theory of planned behavior.

BackgroundOver half of kidney cancer survivors (KCS) are completely inactive and only a quarter are meeting physical activity (PA) guidelines. This highlights the need to identify and understand the determinants of PA in this understudied population. The purpose of this study is to determine the social cognitive correlates of PA intention and behavior in KCS using the Theory of Planned Behavior (TPB).MethodsAll 1,985 KCS diagnosed between 1996 and 2010 in Alberta, Canada were mailed a self-report survey that consisted of the Godin Leisure Time Exercise Questionnaire and standard TPB items for

Mechanisms of Chemotherapy-Induced Neurotoxicity.

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment either alone or as an adjuvant therapy before and after surgery. Although the use of chemotherapeutic drugs improved the survival of cancer patients, these drugs are notorious for causing many severe side effects that significantly reduce the efficacy of anti-cancer treatment and patients' quality of life. Many widely used chemotherapy drugs including platinum-based agents, taxanes, vinca alkaloids, proteasome inhibitors, and thalidomide ana

A Qualitative Study of the Initial Diagnosis and Treatment Experience of Black Patients with Newly Diagnosed Acute Myeloid Leukemia.

PURPOSE: Black patients with acute myeloid leukemia (AML) experience disparate outcomes, and factors such as structural racism and differential treatment access have been implicated. We sought to understand the experience of Black patients with newly diagnosed AML to gain insight into their unique experience. METHODS: We interviewed Black patients ≥18 years of age with newly diagnosed AML (diagnosed from 7/1/2021 to 7/31/2022) over Zoom. Interviews were conducted by the same interviewer, with concordance in race between the interviewer and interviewees. A rapid qualitative content analysis wa

Cancer Patients' Age-Related Benefits from Mobile Neurofeedback-Therapy in Quality of Life and Self-efficacy: A Clinical Waitlist Control Study.

Electroencephalographic neurofeedback (EEG NF) can improve quality of life (QoL) and reduce distress by modifying the amplitude of selected brain frequencies. This study aims to investigate the effects of NF therapy on QoL and self-efficacy in cancer patients and to explore age-related reactions. In a waitlist control paradigm, psychometric data (EORTC QLQ-C30, General Self-Efficacy Scale) of 20 patients were collected at three different time points, each five weeks apart. An outpatient 10-session NF intervention (mobile) was conducted between the second and third measurement point. QoL and se

Validation study of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 for the Portuguese population.

BackgroundCancer-related cognitive impairment is a common and potentially debilitating symptom experienced by patients with non-central nervous system (CNS) cancers, with negative impact on their quality of life. The Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 (FACT-Cog-v3) is the most extensively used instrument specifically developed to evaluate cognitive complaints in adult cancer patients. Nevertheless, this self-report measure is not yet validated for the Portuguese population. Therefore, the purpose of this study was to evaluate the psychometric properties of the

Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study).

BACKGROUND: Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2-4 years after diagnosis. METHODS: Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised

Understanding what matters most to people with multiple myeloma: a qualitative study of views on quality of life.

BACKGROUND: Multiple myeloma is an incurable haematological cancer that affects physical, psychological and social domains of quality of life (QOL). Treatment decisions are increasingly guided by QOL issues, creating a need to monitor QOL within clinical practice. The development of myeloma-specific QOL questionnaires has been limited by a paucity of research to fully characterise QOL in this group. Aims of the present study are to (1) explore the issues important to QOL from the perspective of people with multiple myeloma, and (2) explore the views of patients and clinical staff on existing Q

Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review.

Health related quality of life (HRQoL) is increasingly assessed in oncology research and routine care, which has led to the inclusion of HRQoL in prediction models. This review aims to describe the current state of oncological prediction models incorporating HRQoL. A systematic literature search for the inclusion of HRQoL in prediction models in oncology was conducted. Selection criteria were a longitudinal study design and inclusion of HRQoL data in prediction models as predictor, outcome, or both. Risk of bias was assessed using the PROBAST tool and quality of reporting was scored with an ad

Development of a Mindfulness-Based Stress Reduction Program for Hematologic Malignancy Patients: A Delphi Study.

PurposeHematologic malignancies (HM) are a group of malignant clonal diseases that pose significant treatment challenges and adversely impac … 15 psychology experts participated in the Delphi expert consultations, with a 100% questionnaire response rate achieved in both rounds. The results of the expert consultations indicated a progressive convergence of expert opinions, with calculated Expert Judgment Basis, Familiarity with Content, and Expert Authority Coefficient values of 0.882, 0.809, …

Mapping the Unmet Informational Needs of Young Portuguese Female Cancer Survivors: Psychometric Validation of a Multidimensional Scale.

Background/Objectives: Young female cancer survivors often face specific informational needs related to the physical and emotional effects o … ung female cancer survivors. Its clinical use may promote earlier, personalized, and emotionally responsive communication-supporting psychological well-being, informed decision-making, and long-term survivorship care.

The Role of Nurse on the Treatment Decision Support for Older People with Cancer: A Systematic Review.

Background: The number of older adults with cancer is increasing worldwide. The role of nurses in supporting patients' decision-making is expanding, as this process is fraught with complexity and uncertainty due to comorbidities, frailty, cognitive decline, etc., in older adults with cancer. The aim of this review was to examine the contemporary roles of oncology nurses in the treatment decision-making process in older adults with cancer. Methods: A systematic review of PubMed, CINAHL, and PsycINFO databases was conducted in accordance with PRISMA guidelines. Results: Of the 3029 articles scre

Seroprevalence study prior and post vaccination in cancer patients in principality of Andorra (COVONCO study).

BackgroundCOVID-19 serologic response in patients with cancer may be lower than in the general population and may be influenced by the type of tumor or anticancer treatment. This study aims to analyze serological response prior and after vaccination of COVID-19 within the oncological population in Andorra. We set out to identify risk factors for a higher or lower serological response.Patients and methodsObservational, unicentric, prospective cohort study of oncologic patients in Andorra. We calculated the seroprevalence of antibodies against SARS-CoV-2 (May 2020-June 2021) and analyzed the mai…

Validity of a single-item indicator of treatment side effect bother in a diverse sample of cancer patients.

PURPOSE: With higher efficacy of cancer therapies, the numbers and types of side effects experienced by patients have also increased, eviden … Italy, Spain, the UK and the USA, covering 10 cancer sites. We examined correlations between GP5 responses and varied measures of patient-reported global health and the number of side effects experienced. We explored whether more advanced patients and those with worse Eastern Cooperative Oncology Group Performance Status Rating (ECOG PSR) reported grea …

Ethical considerations for hematologic precursor conditions.

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