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Bilateral optic disk swelling plus.

A 64-year-old woman presented with bilateral optic neuropathy leading to a diagnosis of Sjögren syndrome. She improved with high-dose corticosteroids and oral azathioprine and was subsequently found to have asymptomatic bilateral iridocyclitis. Although central nervous system manifestations of Sjögren syndrome are documented in the literature, they are not widely recognized in clinical practice. Associated optic neuritis often mimics demyelinating disease such as multiple sclerosis. Treatment of CNS disease related to Sjögren syndrome is highly controversial. Uveitis is an uncommon finding ass…

Familial exudative vitreoretinopathy (FEVR) associated with infantile osteoporosis: case report.

Familial exudative vitreoretinopathy (FEVR) is an inherited blinding condition characterized by abnormal development of the retinal vasculature. The authors describe a rare case of the disease associated with severe infantile osteoporosis in a young female patient. The patient was submitted to multiple vitreoretinal procedures in both eyes due to tractional macular detachments. The case was complicated by diffuse uveitis of difficult control in one eye, which stimulated proliferative vitreoretinopathy and retinal redetachment. The inflammatory potential of drugs used in the control of the oste…

The painful eye.

Emergency physicians are required to diagnose and treat patients who have a painful eye on a regular basis. This article focuses on ophthalmologic emergencies that range in presentation from mild to severe symptomatology and include vision and eye-threatening ailments. The etiology, pathophysiology, physical examination, and treatment of the following conditions are discussed: acute angle closure glaucoma, scleritis, anterior uveitis, optic neuritis, keratitis, and corneal abrasion. This article should provide the necessary information to allow for rapid diagnosis and initiation of appropriate…

Acute retinal pigment epithelial detachment secondary to pamidronate administration.

Bisphosphonates are associated with an important number of inflammatory ocular side-effects including but not limited to conjunctivitis, episcleritis, scleritis, uveitis, and optic neuritis. The intravenous bisphosphonates appear to be linked with more severe ocular inflammation than the orally administered ones. These eye complications tend to resolve with the bisphosphonate discontinuation and can re-occur with its re-challenge. We present here the first case of an acute retinal pigment epithelial detachment associated with pamidronate infusion in a 59-year-old patient with metastatic prosta…

[Retinal neovascularization in a traumatic microhyphema].

CLINICAL CASE: This is a case of retinal ischaemia with subsequent neovascularization, in a 13 year-old boy who sustained a traumatic hyphema after blunt trauma. DISCUSSION: Hyphemas can occur after blunt trauma, intraocular surgery, spontaneously and in association with the use of substances that alter platelet or thrombin function (aspirin, ethanol). Associated injuries are traumatic anterior uveitis, iridodialysis, optic atrophy, secondary hemorrhage and a traumatic cataract. This case illustrates the formation of retinal neovascularization in association with a microhyphema and the need f…

Reactivation of ocular toxoplasmosis in fellow unaffected eye.

PURPOSE: To report a case of reactivation of ocular toxoplasmosis in fellow unaffected eye. METHODS: Case report. RESULTS: A 15 year old girl, known to have right ocular toxoplasmosis previously, has presented with one week history of sudden left visual deterioration and pan uveitis. Her condition was improved on intensive steroid treatment. CONCLUSIONS: Reactivation of such lesion in fellow unaffected eye is quite rare. Various choices of treatment are available and there are also different techniques to treat. A review of treatment based on this pathology is briefly discussed.

[Severe retinal phlebitis in ocular bartonellosis].

PURPOSE/METHODS: To report the clinical case of a 34-year-old male with atypical ophthalmic manifestations of cat-scratch disease (ocular ba … isease. The authors recommend considering this condition in the differential diagnosis of posterior uveitis in young patients.

Glaucoma drainage devices: pros and cons.

Glaucoma drainage devices are an option in the management of complicated glaucomas that carry a high risk of failure from conventional filtering surgery. Examples include the glaucomas associated with aphakia or pseudophakia, neovascular glaucoma, and glaucomas associated with trauma, uveitis, epithelial downgrowth, iridocorneal endothelial syndrome, vitreoretinal disorders, and penetrating keratoplasty. Modifications in the various implant designs have been developed to limit the occurrence of postsurgical complications such as hypotony, serous and hemorrhagic choroidal detachment, tube and p…

Tuberculous choroiditis and acquired immunodeficiency syndrome.

Tuberculosis is a common illness among patients with acquired immunodeficiency syndrome (AIDS), and therefore, choroidal tubercles are expected to be found in these patients. Nevertheless, this association (AIDS-induced choroidal tuberculosis) is infrequently reported in the literature. We report four cases of patients with AIDS and tuberculosis who did not have any visual complaints and in whom a routine funduscopic examination disclosed the presence of choroidal nodules. These lesions were not accompanied by vitritis, iridocyclitis, or any sign of uveitis as has been reported in cases of tub…

Exogenous Nocardia asteroides endophthalmitis following cataract surgery.

We present a case of Nocardia asteroides endophthalmitis following cataract surgery. It is the second to be reported and the first in which vision has been preserved. Symptoms commenced 5 days after surgery and there followed a chronic relapsing anterior uveitis which lasted for 4 months. Nocardia asteroides was finally cultured from an aqueous aspirate and a combination of specific antimicrobial treatment and surgery resulted in a satisfactory visual outcome. Exogenous nocardial intraocular infection is rare and must be distinguished from fungal infection as the organism is resistant to antif…

Papilloedema in Behçet's disease: value of MRI in diagnosis of dural sinus thrombosis.

Behçet's disease is a multisystem disease characterised by the clinical triad of oral ulcers, genital ulcers and uveitis. Nervous system involvement is frequent and occasionally precedes other manifestations. Behcet's disease is not frequently considered in the differential diagnosis of papilloedema. We report four cases of Behcet's disease in which papilloedema occurred with or without dural sinus thrombosis. MRI is of great value in the investigation of such patients as it can demonstrate venous sinus thrombosis non-invasively or suggest the diagnosis by showing the associated parenchymal le…

[Clinical aspects of Behcet's syndrome].

Behçet's syndrome is characterized by the recurrent ulceration of the genitals, aphthous lesions of the mouth, uveitis, or iridocyclitis followed by hypopyon. Morbidity is increasing in the regions of the Central and North Europe. The disease is endemic in the region of Mediterranean Sea and Japan. Clinical course of Behçet's syndrome in WHO classification in 4 patients in discussed. Aphthous stomatitis, ulceration of the genitals and iridocyclitis dominated in the symptomatology. Several laboratory tests including complement, immunoglobulins and HLA B-27 were carried out. No abnormal values w…

[Intraocular malignant lymphoma].

The paper in devoted to a rare condition difficult to diagnose, intraocular lymphoma. Five patients with a disease history of 2 to 6 years were examined. The authors describe clinical features of the condition and histologic and electron microscopic findings. The clinical pattern of malignant intraocular lymphoma in polymorphous, therefore virtually every case with a sluggish uveitis or posterior scleritis resistant to common therapy has to be verified. A hematologist should take part in examination of such patients. Since the involvement is local, as our findings evidence, a course of polyche…

Sodium hyaluronate in perspective: experiences from a four-year clinical trial.

Analysis of the safety from the use of 1 per cent sodium hyaluronate (Healonid) is presented in terms of postoperative ocular hypertension, uveitis, visual acuity and endothelial cell loss. The results of a four-year clinical trial confirm that this product is safe and effective. There was no significant difference in the short term visual results from its use, however on assessment of comparative endothelial cell studies, it was found that incidences of severe cell loss tend to be excluded by the use of Healonid so improving the surgeons confidence in difficult surgical situations.

Антитела против вируса кори в анкилосовом спондилите.

Измерения игг-диапазона против вируса кори были произведены с помощью твердофазного радиоиммуномассы в образцах сыворотки, взятых из 31 пациента с подтвержденным ангилозирующим спондилитом (АС), 8 пациентов с симптомами и признаками, напоминающими АО, и 39 пациентов, госпитализированных по различным нерегуматологическим расстройствам. Пациенты, имеющие AS и не имеющие аритма/увеита, имели в своих образцах сыворотки в 4 раза больше антител кори по сравнению с пациентами-контролями (p менее 0,01). Пациенты АО с иритом и пациенты с симптомами и признаками АО были в этом отношении аналогичны пацие

Совпадение в аннотации оригинала
IgG antibodies to measles virus were measured by a solid-phase radio-immunoassay in serum specimens from 31 patients with confirmed ankylosing spondylitis (AS), from 8 patients with symptoms and signs resembling AS and from 39 patients hospitalized for various non-rheumatological disorders. The patients with AS and without iritis/uveitis had a 4-fold increas…

Exogenous Nocardia asteroides endophthalmitis associated with malignant glaucoma.

A 42-year-old man sustained a penetrating corneal wound with a soil-contaminated wire and developed Nocardia asteroides endophthalmitis. A month delay in diagnosis occurred while topical and systemic steroids were prescribed for persistent anterior uveitis, but the diagnosis was finally established by separate aqueous and vitreous aspirates. The patient's course was complicated by a form of malignant glaucoma that was relieved by vitreous aspiration and reformation of the anterior chamber. Surgical intervention, followed by intensive topical and systemic sulfonamide therapy, has resulted in po…

[Behçet's disease and the gastrointestinal tract (author's transl)].

Behçet's disease is characterized by the triad of aphteous stomatitis, genital ulcerations and uveitis. This syndrome is thought to be a systemic disease with various unspecific manifestations, which may arise in other organs as well in a considerable number of cases. More than 50% of all patients do have gastrointestinal symptoms; erosive and ulcerative lesions are found primarily in the jejunum and colon. Case reports are given of 3 patients with Behçet's disease and gastrointestinal involvement; one of these patients died. All patients did have unspecific changes of esophageal motility.

Real-World Anatomical Outcomes of Suprachoroidal Triamcinolone Acetonide Injections in a Large Retinal Practice over a 4-Year Period.

PURPOSE: To evaluate the clinical role, durability, anatomical response, and safety for suprachoroidal triamcinolone acetonide (SCTA) (Xiper … eived 340 SCTA injections for macular edema associated with an underlying diagnosis of intermediate uveitis (10%), pseudophakic cystoid macular edema (31%), and posterior uveitis (59%). The time between first and second injection was approximately 5 months [SD ± 72.5; median 144 (min 35, max 427)]. From baseline to follow-up, mean CRT decreased by 103 µm …

Association between anti-TNF and NSAID therapy and choroidal and macular thickness in ankylosing spondylitis: an OCT-based study.

This prospective, cross-sectional study aimed to evaluate the association between non-steroidal anti-inflammatory drugs (NSAIDs) and anti–tumor necrosis factor-α (anti-TNF-α) therapy and retinal and choroidal thickness in patients with ankylosing spondylitis (AS) without uveitis, and to compare these findings with healthy controls. A total of 65 AS patients and 30 age- and sex-matched healthy controls were included. Macular thickness, retinal nerve fiber layer (RNFL) thickness, and subfoveal choroidal thickness were measured using spectral-domain optical coherence tomography (SD-OCT). Patients…

Smoking and Risk of Vision Threatening Complications: A Global Database Analysis.

PURPOSE: To investigate the association between smoking and the incidence of vision-threatening conditions, including cataract, glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vascular occlusion, uveitis, and ischemic optic neuropathy (ION) in a large real-world database to provide quantitative risk estimates to inform smoking cessation counseling. METHODS: A retrospective cohort study was conducted using the TriNetX electronic health records platform, analyzing 12,183,254 patients. Patients were categorized into smokers (n = 304,823) and non-smokers (n = …