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Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment for a range of medical conditions. However, the procedure carries with it a significant risk of chronic graft-versus-host disease (cGVHD), which can have a considerable impact on patients’ quality of life and clinical outcomes. In recent years, there has been a marked shift in treatment strategies for this condition, with greater emphasis being placed on novel targeted therapies and cell therapies that target specific pathways. This shift in approach signifies a more profound comprehension of the pa

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… the 2014 NIH consensus criteria, cGVHD manifestations are classified into diagnostic features (e.g., poikiloderma, lichen planus-like features, sclerotic features, lichen sclerosus-like features, esophageal web, sicca syndrome), distinctive manifestations requiring confirmation (e.g., depigmentation, fasciitis … Consequently, these effects exert a therapeutic and reversal effect on cGVHD, particularly cutaneous and fasciitis [ 143 ]. …

Primary tumours of the calcaneus.

The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system. The majority of patients with benign tumours h

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… In general, symptoms and physical examinations are nonspecific, potentially resulting in misdiagnosis including plantar fasciitis, chronic ankle sprain, os-trigonum syndrome, calcaneal apophysitis, retained foreign bodies and fractures ( 2 , 26 , 30 , 32 , 64 , 121 ). …

Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.

PTA is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. It is considered a complication of a … ey include parapharyngeal abscess (PPA), upper airway obstruction, Lemierre´s syndrome, necrotizing fasciitis, mediastinitis, erosion of the internal carotid artery, brain abscess, and streptococcal toxic shock syndrome. The treatment consists of abscess drainage and antimicrobial therapy. There are three accepted methods of surgical intervension: needle as …

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.

Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, a

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… Acute generalized exanthematous pustulosis in a child with fasciitis. Pediatr Int. 2019;61(9):938. doi: 10.1111/ped.13967. 20. Villani A, Baldo A, De Fata SG, Desiato V, Ayala F, Donadio C. …

Management and Clinical Outcomes of Scleredema Diabeticorum: A Scoping Review.

Background/objectivesThe objective of this scoping review was to systematically map the available evidence for the management of scleredema diabeticorum (SD) to summarize the documented clinical outcomes with the aim to inform clinical practice and identify research gaps.MethodsWe conducted a scoping review identifying studies published in English from January 2005 to July 2025 through a comprehensive search of Scopus, MEDLINE, and the Cochrane Library. Eligible studies included randomized controlled trials, observational studies, case series, and case reports on treatment interventions and cl

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… Eosinophilic fasciitis also presents with skin induration and is often associated with peripheral eosinophilia but differs in histological appearance. Scleromyxedema, commonly linked to monoclonal gammopathy, is characterized by papular skin lesions and distinct histopathological features. …

Polymyalgia rheumatica: An update (Review).

Polymyalgia rheumatica (PMR) is a chronic inflammatory disease which affects the connective vascular tissue, characterized by pain accompanied by morning stiffness, predominantly of the neck muscles, hip and shoulder girdle. Usually, patients with this disease are >50 years of age and biological inflammatory syndrome is present with an increase in both the erythrocyte sedimentation rate and C-reactive protein levels, aspects similar to giant cell arteritis. The aim of the present review was to depict the current pathogenic hypothesis, diagnostic and treatment approach for patients with PMR, an

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… On three occasions, fasciitis was also observed. In individuals diagnosed with PMR, age, CRP levels, or an overall PMR PET score were not linked to muscle involvement detected by PET ( 79 ). …

The CoV-2 outbreak: how hematologists could help to fight Covid-19.

COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). Hematologists are confident with these situations requiring a prompt therapeutic approach for switching off the uncontrolled cytokine release; here, we discuss pros and cons of drugs that are already employed in hematology in

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… Moreover, clinical manifestations, especially of the aGVHD, are similar to those observed in COVID-19: skin rash, diarrhea, elevated bilirubin, infections, pulmonary leak syndrome, eye and mouth damage and, in the chronic form, also fasciitis, myositis and fibrosis that mimic the systemic scleroderma …

Влияние краткосрочной прогрессивной физической тренировки на активность заболевания у пациентов с подозрительной множественной миеломой и моноклональной гамма-патологией неопределенного значения: односторонний пилотный исследование.

ОБЪЕКТ: Высокий уровень физической активности связан с уменьшением риска развития крови опухоли множественной миеломы (ММ). ММ предшествует асимптоматическим стадиям моноклональной гамма-патологии неопределенного значения (MGUS) и дымящей множественной миеломы (SMM), которые клинически управляются методом наблюдения. Случайный исследователь (N = 1) бывшего высшего спортсмена в возрасте 44 лет показал, что многофакторная программа физических упражнений обратила активность SMM. С учетом результатов этого предыдущего тематического исследования в настоящем экспериментальном исследовании сначала ра

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… A grade one adverse event that was unlikely related to the exercise programme– due to the presence of other risk factors– was onset of symptoms consistent with plantar fasciitis ( N = 1 participant). …

How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… arthralgia" OR "Aseptic necrosis"OR "Baker's cyst" OR "Bunion" OR "Calcaneal spur" OR "Chondromalacia of patella" OR "knee* derangement" OR "Hallux rigidus" OR "Hallux valgus" OR "Hammer toe" OR "Iliotibial band syndrome" OR "Knee effusion" OR "Metatarsalgia" OR "Pes anserinus tendinitis" OR "Plantar fasciitis …

SGLT2 Inhibitors: From Structure-Effect Relationship to Pharmacological Response.

SGLT2 inhibitors have become increasingly used due to their effectiveness in improving not only type 2 diabetes but also cardiovascular, renal and hepatic diseases, as well as the obesity found in metabolic syndrome. Starting from the structure of gliflozins, modifications of the carbohydrate part, aglycone, and also the glycosidic bond between them can determine variations in pharmacokinetic and pharmacodynamic properties. SGLT2 inhibitors, in addition to reducing blood glucose levels, improve alterations in lipid metabolism by diverting excessively accumulated lipids in tissues towards mobil

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… Another concern is dedicated to Fournier’s gangrene (FG), an infectious necrotizing fasciitis of the perineum and genitals in a fulminant form, found associated with SGLT2 inhibitors in the context of glycosuria [ 226 , 227 ]. …

Current Therapeutic Options for the Main Monogenic Autoinflammatory Diseases and PFAPA Syndrome: Evidence-Based Approach and Proposal of a Practical Guide.

Monogenic autoinflammatory diseases are rare conditions caused by genetic abnormalities affecting the innate immunity. Previous therapeutic strategies had been mainly based on results from retrospective studies and physicians' experience. However, during the last years, the significant improvement in their genetic and pathogenic knowledge has been accompanied by a remarkable progress in their management. The relatively recent identification of the inflammasome as the crucial pathogenic mechanism causing an aberrant production of interleukin 1β (IL-1β) in the most frequent monogenic autoinflamm

Reversing Autoimmunity Combination of Rituximab and Intravenous Immunoglobulin.

In this concept paper, the authors present a unique and novel protocol to treat autoimmune diseases that may have the potential to reverse autoimmunity. It uses a combination of B cell depletion therapy (BDT), specifically rituximab (RTX) and intravenous immunoglobulin (IVIg), based on a specifically designed protocol (Ahmed Protocol). Twelve infusions of RTX are given in 6-14 months. Once the CD20+ B cells are depleted from the peripheral blood, IVIg is given monthly until B cells repopulation occurs. Six additional cycles are given to end the protocol. During the stages of B cell depletion,

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

The Clinical Application of Ozonetherapy

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… Fig. 9.1 The amazing results obtained in one patient with necrotizing fasciitis treated with parenteral ( EBOO ) and topical (ozonized water and oil) treatments. Extensive necrotic lesions were present between the buttocks, on the legs and heels. … Before ( left ) and after ( right ) the treatments Fig. 9.1 The amazing results obtained in one patient with necrotizing fasciitis treated with parenteral ( EBOO ) and topical (ozonized water and oil) treatments. Extensive necrotic lesions were present between the buttocks, on the legs and heels. …

Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment.

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune response, with an imbalance between pro-inflammatory and anti-inflammatory mediators, leading to neutrophil-driven inflammatory damage. Several immunosuppressants and immunomodulatory drugs are currently available for the treatment of PG, in combination with topical therapies, wound management and pain control strategies. Systemic corticosteroids and cyclospor

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… In these cases, differentiating post-operative PG from necrotizing fasciitis is crucial, as wound debridement could worsen a PG-like eruption due to pathergy phenomenon [ 7 ]. …

Molecular targeted therapy for anticancer treatment.

Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistanc

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… Severe toxicities, such as colitis, digestive perforation, toxic cardiomyopathy, pneumonitis/interstitial lung disease, acute respiratory distress syndrome, posterior reversible encephalopathy syndrome, necrotizing fasciitis, acute renal failure, and hypersensitivity, have been observed in patients receiving …

Integumentary System

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Abstracts cont.

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Ход работы сессии 28th Европейский конгресс педиатрической ремуматологии (ПСР) 2022) Прага, Чешская Республика. 20-23 сентябрь 2022.

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Radiotherapy based management during Covid-19 pandemic - A systematic review of presented consensus and guidelines.

Treatment management of cancer patients in the radiation oncology departments during the current COVID-19 pandemic is challenging. A systematic review of published consensus/guidelines on the role of radiotherapy prioritization, suggested treatment protocols, and set up management was undertaken based on the PRISMA protocol and through PubMed/PMC, Scopus, Google Scholar, Web of Science databases until 01/20/2021. One hundred and sixty-eight publications or regional consensus were included. Summary of recommendations contained: (1) using hypo-fractionated (Hypo-F) regimens for therapeutic/palli

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… 5 frs (in the favorable subgroup) MSCC: 8 Gy / 1 fr ( Counago et al., 2020 ) Symptomatic bone metastases: 8 Gy/1 fr ( Kwek et al., 2021 ) Benign Disease Keloid, heterotopic Ossification, Actinic Keratosis Benign Disease, Pituitary Adenoma, Fibromatosis Other: Actinic Keratosis, Recurrent/Refractory Fasciitis …