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Проблемы с диагностикой и оказанием неотложной медицинской помощи в случае быстро прогрессирующего заболевания лёгких, вторичного и многократного заболевания миеломой.

Одновременное представление множественной миеломы (ММ) и межститиальной болезни легких (МЛ) остается исключительно редким, при этом ограниченная литература описывает оптимальные стратегии управления для этой двойной патологии. Мы сообщаем о сложном случае 62-year-old Мужчина с недавно поставленным диагнозом MM с цитогенетикой промежуточного риска (del13q, набирающий 1q), который одновременно представил быстро прогрессирующий ILD, демонстрирующий обычную интерститальную пневмонию (МСАГВ). Пациентка 6-month Клинический курс был отмечен участием многих организаций, периодическими инфекциями, тром

Совпадение в аннотации оригинала
The concurrent presentation of multiple myeloma (MM) and interstitial lung disease (ILD) remains exceptionally rare, with limited literature … rent infections, thromboembolic complications, and multiple cardiopulmonary crises culminating in a fatal outcome. This case illustrates the profound diagnostic and therapeutic challenges when dual malignancy and progressive pulmonary fibrosis coexist, highlighting the need for aggressive multidisciplinary management, heightened awareness of infection risk, and …

Acute hemorrhagic leukoencephalitis with gradual symptom onset: Case Report and literature review.

This report highlights an atypical case of acute hemorrhagic Leukoencephalitis (AHLE) in a 73-year-old male, contributing valuable insights into the disease's progression in older adults. AHLE, a rare and often fatal central nervous system disorder typically affecting younger individuals, with a median age of 33. Our patient experienced atypical subacute symptoms over 3 months, the longest duration reported, and ultimately achieved a functional outcome with a modified Rankin Scale (mRS) score of 2. A comprehensive review of 152 cases available through PubMed, revealing a 58% mortality rate wit

Rapid recovery in a child with febrile ulceronecrotic Mucha-Habermann disease following intravenous immunoglobulin administration.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a lymphocyte-mediated inflammatory skin disorder, is considered a severe variant of pityriasis lichenoides et varioliformis acuta that can lead to a fatal outcome if not managed in a timely fashion. Children with FUMHD can have systemic complications involving various organs. The scarcity of reported cases and the absence of well-designed studies or randomized clinical trials to evaluate different therapeutic modalities pose a major challenge in treating this potentially life-threatening disorder. We report a five-year-old child with FUMH…

Primary Pleural Angiosarcoma Treated with Nivolumab and Ipilimumab: A Case Report.

Primary pleural angiosarcoma (PPA) is a rare and clinically fatal pleural tumor originating from vascular endothelial cells. Herein, we presented the case of a 73-year-old man who was referred to our emergency room with complaints of right chest and back pain for a few days. Chest computed tomography revealed massive pleural effusion and a large mass in the right chest cavity. Thoracoscopic examination demonstrated a large hemorrhagic tumor on the parietal pleura whose pathological analysis indicated PPA. The patient received immunotherapy combined with nivolumab and ipilimumab. A cycle of niv

A Fatal Case of Ciprofloxacin-induced Fulminant Hepatitis.

UNLABELLED: Fatal hepatotoxicity associated with ciprofloxacin is extremely rare. This is the second fully investigated case of fulminant hepatotoxicity due to ciprofloxacin in a male patient previously ciprofloxacin tolerant. The patient's medical history included stable Waldenstrom's macroglobulinaemia, inguinal hernia repair, prostate cancer (radiotherapy in 2006) and idiopathic Parkinson's disease. Extensive investigation for progressive liver failure confirmed drug-induced liver injury. LEARNING POINTS: Idiosyncratic drug-induced liver injury is rare, so a history of consumption of any p

Unusual Presentations of Birth Related Cervical Spinal Cord Injury.

Neonatal spinal cord injury is a rare complication of birth trauma by difficult delivery. The typical manifestations are often catastrophic, include decreased or absent movement, loss of reflexes, apnea or periodic breathing, and a lack of response to painful stimulation. The outcome is usually fatal or severe, with long-term sequelae of respiratory insufficiency, limb weakness, or even paralysis of the limbs. We described a male neonate with a C2 spinal cord injury who was born smoothly by vaginal delivery and was unnoticed initially due to unusual subtle symptoms. He presented with a hoarse

Острая лёгкая артериопатия в неонате с врожденным синдромом Рубелы и Патентным Дюктусом Артериос.

Известно, что у неонатов с врожденным синдромом краснухи (CRS) возникают врожденные сердечные расстройства. Патентный патрубок артериос (PDA) является одним из наиболее распространенных сердечных аномалий, связанных с CRS. Для хирургической перевязки рассматривается возможность отказа ПДД от медицинской помощи и связанной с дыхательной зависимостью. Вместе с тем управление ПДД может быть сопряжено с трудностями в случае заболеваний легких или легочных сосудистых заболеваний. Результаты работы после закрытия в неонатальных учреждениях зависят от возраста, веса, состояния питания, дооперационной

Совпадение в аннотации оригинала
Neonates with congenital rubella syndrome (CRS) are known to have associated congenital cardiac malformations. Patent ductus arteriosus (PDA … red surgical PDA closure. The neonate developed severe pulmonary arterial hypertension which led to fatal outcome. The clinical course is corroborated with histo-pathological changes observed on the autopsy of this neonate.

[Adrenal surgery : Multidisciplinarity is mandatory].

Adrenal tumours are rare and their management is challenging. Every patient presenting with adrenal mass or symptoms of hormones hypersecret … r surgical procedure before excluding pheochromocytoma or adrenocortical carcinoma which could have fatal outcome for the patient. Every adrenal mass has to be investigated and should not be made commonplace.

Pituitary apoplexy: a rare complication of leuprolide therapy in prostate cancer treatment.

Gonadotropin-releasing hormone agonists, used widely in the treatment of metastatic prostate cancer and hormone receptor-positive breast cancer, are associated with a rare but potentially fatal outcome of pituitary apoplexy (PA). An 85-year-old man presented with sudden onset of headache, left eye pain, sensitivity to light, nausea and vomiting. The symptoms started 4 hours after initiation of leuprolide therapy for treatment of recently diagnosed metastatic prostate carcinoma. Radiological imaging of the brain demonstrated a heterogeneously enlarged pituitary gland measuring 19×16×13 mm and T…

A case of fulminant subacute sclerosing panencephalitis presenting with acute myoclonic-astatic epilepsy.

The neurologic sequelae post-measles are less common than other complications measles-related and can lead to severe disability or death: pr … ks. The course of SSPE in the majority of affected children is that of a progressive worsening with fatal outcome within two years. This report described an Italian case of fulminant SSPE syndrome that led to death within few months from the initial onset.

Novel splice-site mutation in SMN1 associated with a very severe SMA-I phenotype.

Spinal muscular atrophy (SMA) is a genetic disorder characterized by degeneration of motor neurons and muscle weakness and atrophy. The majo … fected the donor splice site of exon 7 and resulted in an unusually severe SMA phenotype with rapid fatal outcome in an Italian infant.

Feeding tube replacement: not always that simple!

Although surgical gastrostomy is not a technically troublesome surgery, the procedure may be accompanied by unfavorable outcomes. Most complications occur early in the post-operative period and include feeding tube dislodgment, stomal infection, peritonitis, and pneumonia. The authors report the case of an 83-year-old man who underwent a surgical gastrostomy because of a swallowing disorder after an ischemic stroke. Nine months after the procedure, the feeding tube dislodged and a new tube was inserted with a certain delay and with some difficulty, causing a false path and consequently an intr

Food allergy in adolescence and adulthood.

In young children, food allergy is usually acquired via the gastrointestinal tract and directed toward egg and milk. Adolescent and adult pa … oms, as in contact urticaria of the oral mucosa, to systemic symptoms involving distal organs, to a fatal outcome. Plant foods, such as fruits, nuts, and vegetables, are the most prevalent allergenic foods in this age group.

Urea cycle disorders: a life-threatening yet treatable cause of metabolic encephalopathy in adults.

Urea cycle disorders are inborn errors of metabolism that, in rare cases, can present for the first time in adulthood. We report a perplexin … esentation of an uncommon disease, it is a treatable disorder and its early diagnosis can prevent a fatal outcome.

Septic shock due to community-acquired Pseudomonas aeruginosa necrotizing fasciitis: A case report and literature review.

Necrotizing fasciitis is a rare but fatal infection, characterized by the rapid progression of necrosis of the fascia, skin, soft tissue and muscle. The most common bacteria associated with necrotizing fasciitis is group A streptococcus, although other pathogens have also been implicated. In the present study, a case of community-acquired necrotizing fasciitis, complicated with septic shock and multiple organ dysfunction syndromes due to Pseudomonas aeruginosa, is presented. Despite intensive medical treatment, the condition of the patient deteriorated rapidly and the patient subsequently succ

Pompe disease with heterogeneous presentations within a family.

Pompe disease is an acid maltase deficiency being part of glycogen storage diseases that affects all age groups. In both childhood and adult forms, the classic clinical picture is that of a progressive myopathy. Respiratory muscle involvement is common, may occur early in the course of the disease, and is the most frequent cause of mortality from acid maltase deficiency. Its association with rhabdomyolysis is rare and with a fatal prognosis. We describe the cases of a family with Pompe disease with a clinical spectrum extending throughout different ages of onset, degrees of organ involvement,

[Necrotizing community-acquired Staphylococcus aureus pneumonia].

Acute necrotizing pneumonia due to Panton-Valentine secreting Staphylococcus aureus was identified as a clinical entity by Gilet et al., in 2002. This severe acute necrotizing pneumonia occurring in previously healthy children and adolescents can lead to a rapid fatal outcome even if quickly diagnosed and treated. We report the case of a healthy 10-year-old girl presenting with hemorrhagic necrotizing pneumonia and septic shock. Bacteriological cultures yielded methicillin-susceptible Staphylococcus aureus. The course of the disease was characterized by recurrent uncontrolled hemoptysia leadin…

[Disseminated histoplasmosis caused by Histoplasma capsulatum in a renal transplant patient: first case report in the Reunion Island].

The purpose of this report is to describe the first case of indigenous disseminated histoplasmosis caused by Histoplasma capsulatum in a patient on immunosuppression 22 months after renal transplantation in the Reunion Island. Involvement was predominantly pulmonary and outcome was rapidly fatal. Diagnosis based on isolation of characteristic intramacrophagic Histoplasma capsulatum yeast cells from bronchoalveolar fluid was delayed since indigenous cases of this opportunistic infection were unprecedented. In addition to demonstrating the difficulty of achieving diagnosis in places located outs

Scrub typhus in Southern India: are we doing enough?

Scrub typhus is a potentially fatal infectious disease caused by Orientia tsutsugamushi. We report on a retrospective analysis of clinical manifestations, lab investigations and outcome of patients admitted to our hospital from January 2009 to December 2009 with scrub typhus. The Weil-Felix test was the serological method used to diagnose scrub typhus. A total of 29 patients were diagnosed with scrub typhus and the majority of them presented with fever (100%), headache (51%), myalgia (51%) and gastrointestinal symptoms (44%) as predominant features. Six patients (20%) presented with altered se

Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine: case report.

Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte) has proven to be useful in clinical tri…