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Local expression of IL-4 and IL-5 in perennial allergic rhinitis and their modulation by topical corticosteroid therapy.

Perennial allergic rhinitis (PAR) is an increasing problem for which new and exciting therapies are being developed. A T(H)2-polarized cytokine pattern is thought to predominate regulating local IgE synthesis and cell recruitment in PAR and the development of intranasal steroids has resulted in several agents with quick actions, localized effects and great efficacy in its management. The aim of work was to determine the differences in the local expression of IL-4 and IL-5 in patients with PAR compared to non-atopic healthy controls and investigate the relationship between the expression of the

Conjunctivitis in Adults with Atopic Dermatitis Treated with Dupilumab: An Observational Study of Clinical Characteristics, Symptomatology, and Treatment.

INTRODUCTION: Conjunctivitis is more prevalent in patients with atopic dermatitis (AD) than the general population, and is the most common a … ence of tear volume insufficiency. One patient in group 1 (3%) and two in group 2 (18%) had eyelash mites. Three patients (9%) in group 1 and one in group 2 (9%) had Staphylococcus aureus-positive conjunctival swabs. Most patients (88%) received multiple ophthalmic treatments for the qualifying conjunctivitis event. Investigators assessed topical cortic …

First Report on Molecular Identification of Moniezia expansa in Sheep from Mannavanur, Palani Hills, Tamil Nadu, India.

PURPOSE: Tape worm infection is common among sheep at SRRC, Mannavanur, Palani hills, Tamil Nadu, India. The aim of the present study is to … gene of M. expansa from Sheep of Indian peninsula. An investigation on the involvement of oribatid mites as the vector in the transmission of M. expansa among sheep at SRRC, Mannavanur needs to be carried out.

Sri Lanka: report on its children's environmental health.

Sri Lanka is an island country located in the Indian Ocean, characterized by tropical weather, with an estimated population of 21.4 million … mercury, mosquito coils and biological pollutants also prevail. Biological pollutants, such as dust mites, droppings and urine from pets, insects and rodents, pollen from indoor plants and outdoor air, and fungi, including moulds in poorly maintained buildings, can trigger asthma or cause allergic reactions and infections among children inhabiting these …

Effect of indoor air quality on the development of rhinitis in an urban population in Poland.

Background: Indoor air significantly impacts the incidence of rhinitis among residents of urban agglomerations. Objective: To assess the imp … ndition of the building, the use of heating devices, stoves, and also mold allergens and house-dust mites contributed to a higher incidence of rhinitis, mainly among adults, ages 20‐44 years; (2) gas-storage tanks and solid fuels contribute to rhinitis in the group of children ages 6‐7 years and children ages 13‐14 years.

Comparison of Efficacy and Safety of Two Tea Tree Oil-Based Formulations in Patients with Chronic Blepharitis: A Double-Blinded Randomized Clinical Trial.

INTRODUCTION: It was aimed to evaluate the efficacy of two tea tree oil (TTO)-based cleansing gels in chronic blepharitis patients. METHODS: Group-1 (basic gel containing 3%(w/w)-TTO) included 50 eyes of 25 patients and group-2 (advanced gel containing 3%(w/w)-TTO plus essential oils and vitamins) included 48 eyes of 24 patients. Ocular Surface Disease Index (OSDI), tear breakup time (TBUT), ocular surface staining pattern, Schirmer's test, impression cytology, Demodex presence and TNF-α, IL-6, IL-1β levels were evaluated at the first visit and 1 month after treatment. RESULTS: In both group

Erratum.

In the article "House Dust Mite Sublingual Immunotherapy for Allergic Rhinoconjunctivitis: Comprehensive Review and Meta-Analytical Evidence … th hyperresponsiveness to HDMsBożek 2023 [31]Prospective, observational studyPoland60SLIT (Staloral mites) or SCIT (Purethal mites) for HDM.120Patients (>60 y) with perennial AR. Monosensitized to HDMAIT (SLIT and SCIT) may be beneficial for treating seniors with HDM-allergic rhinitis. Sustained decrease in clinical symptoms relative to placebo after 7 …

A Case Report of Sebaceous Filaments.

This report details a case of a 16-year-old African American girl who presented with a two-year history of white spicules on her face without associated symptoms, including pruritus or pain. On physical examination, there were many 1-2 mm discreet white to yellow filamentous spicules on the mid and lower face. Histopathology scrapings showed cornified cells and calcification consistent with sebaceous filaments. Sebaceous filaments are a rare condition that presents as white-to-yellow spicules distributed in highly sebaceous areas on the face. It is caused by sebum accumulation and cornified ke

Совпадение в полном тексте источника
… Pityriasis folliculorum results from infestation of the Demodex folliculorum mite and presents similarly to sebaceous filaments with plugged sebaceous hair follicles. … Skin scraping demonstrates Demodex folliculorum mites [ 9 ]. Treatment includes topical metronidazole, topical ivermectin, permethrin, and benzoyl benzoate [ 8 ]. …

Allergen specificity and endothelial transmigration of T cells in allergic contact dermatitis and atopic dermatitis are associated with the cutaneous lymphocyte antigen.

Recent investigations have indicated a role for antigen-specific T lymphocytes in the local skin immunity. The cutaneous lymphocyte antigen (CLA) is supposed to represent a skin-homing receptor for T cells. Inhibition experiments with specific monoclonal antibody demonstrate that CLA participates in selective transendothelial migration of memory/effector T cells in vitro by interaction with E-selectin on endothelial cell layers after activation with proinflammatory cytokines. In addition, the receptor-ligand pairs VLA-4/VCAM-1 and LFA-1/ICAM-1 are involved in this process. Moreover, only CLA+,

Blomia tropicalis allergen 5 (Blo t 5) T-cell epitopes and their ability to suppress the allergic immune response.

Blomia tropicalis is the major asthma allergen in the tropics comparable to Dermatophagoides pteronyssinus. However, little is known about the B. tropicalis epitopes recognized by T cells. Our aim was to identify the T-cell epitopes in the major B. tropicalis allergen, Blo t 5, and investigate the potential of the corresponding peptides to inhibit the allergic inflammatory lung response. C57BL/6 mice were immunized with plasmid DNA encoding Blo t 5 and T-cell epitopes identified using the interferon-γ ELISPOT assay with 15-mer overlapping peptides. C57BL/6 mice were sensitized with bone-marrow

Frequency of allergic diseases following measles.

OBJECTIVE: Viral and bacterial infections in childhood decrease the likelihood of allergic diseases in later life. The frequency of allergic diseases in patients with a history of measles has been reported to be low but some studies still suggest that measles can increase the frequency of allergic diseases. The aim of this study was to investigate the frequency of allergic diseases following measles in childhood. METHODS: Fifty-two children hospitalized in our clinic with measles were compared with 51 children without measles. Allergic diseases were investigated in both groups by using the In

A Prospective, Interventional, Randomized, Double-Blinded, Placebo-Controlled, Monocentric Clinical Study to Evaluate the Efficacy and Safety of Alkalihalobacillus clausii 088AE in Resolution of Acute Allergic Rhinitis Symptoms.

BACKGROUND: Allergic rhinitis (AR) is a common inflammatory disease of the upper respiratory tract mainly triggered by allergens such as dust mites, pollen, spores, and viral or bacterial infections. AR is primarily associated with symptoms such as nasal itching, sneezing, rhinorrhea, nasal congestion, and watery, itchy, or red eyes. AR significantly affects an individual's quality of life. Probiotics have been proven effective in the clinical management of AR through immunomodulation. However, studies on the use of Alkalihalobacillus clausii to alleviate the symptoms of AR have rarely been re…

Distribution and Risk Factors of Scrub Typhus in South Korea, From 2013 to 2019: Bayesian Spatiotemporal Analysis.

BACKGROUND: Scrub typhus (ST), also known as tsutsugamushi disease, is a common febrile vector-borne illness in South Korea, transmitted by trombiculid mites infected with Orientia tsutsugamushi, with rodents serving as the main hosts. Although vector-borne diseases like ST require both a One Health approach and a spatiotemporal perspective to fully understand their complex dynamics, previous studies have often lacked integrated analyses that simultaneously address disease dynamics, vectors, and environmental shifts. OBJECTIVE: We aimed to explore spatiotemporal trends, high-risk areas, and r…

Respiratory infection in asthma.

Ever since the first decades of the 20th century, some authors have given respiratory infection triggered by bacteria an etiologic role in b … ed a study with 40 children, aged 2-14 years, where we observed that children with sensitization to mites and a positive culture had higher levels of histamine release than did children with negative culture and controls, the differences being significant. We also found, like other authors, that the joint presence of Staphylococcus aureus and Derrmatoph …

[Analysis of the prevalence characteristics and trends of allergen-specific IgE levels in a children's hospital in Wuhan City from 2019 to 2024].

Objective: To investigate the changes in the positive rate of specific immunoglobulin E (sIgE) for inhalant and ingestive allergens in child … positive rate of allergens in male children was higher than that in female children for house dust mites, house dust, Alternaria alternata, peanuts, soybeans, milk, crabs, shrimp, eggs, codfish, and wheat flour, with statistically significant differences (P<0.05). There were statistically significant differences in the positive rate of inhalant and ing …

Chronic Humidity and Nasal Mucosal Dysfunction in Tropical Climates: Implications for Sinonasal Health in Sub-Saharan Africa and the Developing World - A Systematic Review.

The nasal mucosa is the primary defense mechanism of the upper respiratory tract. Its functionality relies heavily on the intricate balance … upted osmotic gradients, and increased susceptibility to perennial aeroallergens such as house dust mites and fungal spores. High ambient humidity in tropical climates is associated with altered nasal mucosal function, including impaired MCC and changes in mucus rheology. These findings highlight the need for climate-specific approaches to the managemen …

Cyanogenesis in Arthropods: From Chemical Warfare to Nuptial Gifts.

Chemical defences are key components in insect⁻plant interactions, as insects continuously learn to overcome plant defence systems by, e.g., … or cyanogenic glucosides. In arthropods, cyanogenic glucosides are found in millipedes, centipedes, mites, beetles and bugs, and particularly within butterflies and moths. Cyanogenic glucosides may be even more widespread since many arthropod taxa have not yet been analysed for the presence of this class of natural products. In many instances, arthropod …

[Examination of acute phase proteins concentrations in children with allergic rhinitis].

INTRODUCTION: Allergic rhinitis is an inflammatory disorder of upper respiratory tract (about 15 per cent of the population in industrialize … indoor irritants such as feathers, mold spores, animal dander (hair and skin shed by pets) or dust mites. It is often aggravated by a food allergy, the most common being an allergy to milk. Acute phase proteins (APP) belong to the most ancient part of the unspecific immunity and contribute markedly to the keeping of homeostasis. As much as 30 various p …