Результаты поиска

Clinical Profile and Severity Correlation of Acute Leptospirosis in Northern India, 2019-2023: A Tertiary Care Center-based study.

BACKGROUND: Leptospirosis is a globally important zoonotic disease with substantial morbidity and mortality, yet it remains underreported in … work (62.6%) were predominantly affected. Common presentations were fever (100%), headache (70.7%), myalgia (62%), and calf pain (50%), followed by jaundice (39.7%), and reduced urine output (33.3%).. The mortality rate was 20.1%. Severity correlated significantly with nausea/vomiting, abdominal pain, cough, and complications, including diffuse alveolar h …

Comparing myocardial perfusion scan findings in patients with and without Covid-19.

BACKGROUND: Covid-19 is a pandemic viral disease that directly or indirectly affects multiple organ systems, including the cardiovascular sy … ally abnormal MPI who have gone undetected. In addition, Covid-19 patients with pleural chest pain, myalgia or dyspnea may have been misdiagnosed as having chest pain secondary to heart disease.

Undifferentiated autoinflammatory disease in adults: a prospective study in 61 patients.

BACKGROUNDS: Undifferentiated or undefined systemic autoinflammatory disease (uSAID) encompasses a group of rare, heterogeneous diseases cha … thout pulmonary manifestations, patients with pulmonary involvement exhibited higher frequencies of myalgia, skin lesions, cardiac involvement, gastrointestinal involvement, urinary involvement, lymphadenopathy, headache, and intellectual impairments. Twenty-four patients exhibited monogenic SAID-like phenotypes, 12 had polygenic SAID-like phenotypes, and …

Defining Breast Implant Illness: A Systematic Review and Meta-analysis of Patient-reported Symptoms.

BACKGROUND: Although no definitive scientific link has been established, public concern surrounding breast implant illness (BII) is increasi … included in this study, accounting for 10,519 patients. Fatigue or malaise (RR = 3.15 [2.89-3.43]), myalgia or weakness (RR = 2.96 [2.76-3.18]), and cognitive dysfunction (RR = 2.87 [2.64-3.12]) were most strongly associated with the presence of breast implants. Implants that were ruptured (RR = 1.12 [1.04-1.21], P = 0.003) or filled with silicone (RR = 2 …

"Goofballing": An Emerging Threat With Clinical Challenges.

BACKGROUND: The coinjection of methamphetamine and opioids, known as "goofballing," is an emerging practice among people who inject drugs. T … nous heroin use. During methadone substitution therapy, the patient developed hyperthermia, diffuse myalgia, and mild somnolence. Physical investigation revealed no evidence of infection. Toxicological analyses were conducted on blood and urine samples using targeted and nontargeted screening methods. RESULTS: Toxicological analyses revealed the presence …

Case Report: Serum sickness induced by dupilumab-clinical insights and Olinkproteomic analysis.

Dupilumab is a humanized monoclonal antibody that targets interleukin-4 (IL-4) and IL-13 pathways, commonly used in the treatment of various … e patient with serum sickness exhibited a range of symptoms, including fever, rash, arthralgia, and myalgia, as well as thrombotic events, transient microscopic hematuria, and abnormal signals in the spleen and kidneys. A proteomic analysis of 92 inflammatory factors in the patient's serum was performed using Olink technology, revealing significant elevat …

Adverse Event Profile Differences Between Metyrapone and Osilodrostat: A Pharmacovigilance Study of the FDA Adverse Event Reporting System.

Metyrapone and osilodrostat are both steroidogenic inhibitors targeting the 11β-hydroxylase, yet their safety profile has not been comprehen … , involving 26 and 27 SOC categories. Unexpected AEs such as asthenia, decrease of blood potassium, myalgia, increase of blood pressure, abdominal distension, increase of blood testosterone, nephrolithiasis, and hunger were associated with osilodrostat. while metyrapone was linked with respiratory failure, deep vein thrombosis, interstitial lung disease, …

Another traveler's tale: African tick-bite fever.

BACKGROUND: In the present report, we discuss the clinical and species-specific diagnosis of African tick-bite fever. CASE SUMMARY: A 58-year-old man was admitted to the hospital for fever, headache, and myalgia. The clinical examination yielded only two small purpuric lesions with a dark center on the thigh and the abdomen. The patient reported that he had just returned from a 10-day trip to the eastern region of South Africa, and that he had hiked through the bush in Eswatini 7 days before the onset of fever. The white blood cell count showed lymphopenia, and the C reactive protein and alan…

Distribution and Clinical Profile of Human Parainfluenza Viruses in Hospitalized Patients With Acute Febrile Illness.

INTRODUCTION: Human parainfluenza viruses (HPIVs) are significant causes of respiratory infections, particularly in children, yet their epid … espiratory symptoms, along with gastrointestinal issues and systemic manifestations such as chills, myalgia, and weakness, are commonly reported. CONCLUSION: HPIVs contribute to respiratory illness across diverse demographics. HPIV-3 is the predominant serotype, with distinct seasonal and age-related patterns. Improved surveillance and diagnostics could …

Sociodemographic characteristics, clinical manifestations, and concurrent outcomes of Oropouche fever and dengue in Espírito Santo, Brazil.

OBJECTIVE: To compare sociodemographic and clinical characteristics and the outcome severity between confirmed cases of Oropouche fever and … nts of rural and peri-urban areas (52.1%). Fever (84.5% vs. 78.7%), headache (83.9% vs. 72.1%), and myalgia (76.5% vs. 67.5%) were the most common symptoms in both groups, with significantly higher proportions among Oropouche fever cases. Dengue cases showed higher odds of progressing to severe disease (OR 15.35; 95% CI 10.60-22.23) and death (OR 2.09; 95 …

A Case of Fasciitis Following SARS-CoV-2 mRNA Vaccination: Case Review and Literature Overview.

Vaccines play a crucial role in preventing various infectious diseases, and their safety has been well established, with adverse effects gen … ronavirus 2 (SARS-CoV-2). A 29-year-old Japanese woman presented with bilateral lower leg swelling, myalgia, ankle arthralgia, and transient painful erythema 15 days after vaccination. The erythema was diagnosed as erythema nodosum by skin biopsy and resolved spontaneously. Physical examination revealed swelling and tenderness of the gastrocnemius muscle, …

A rare case report of neuro-brucellosis with concurrence of depression, visual impairment, bilateral sensorineural hearing loss, and paraplegia.

Neurobrucellosis is a rare manifestation of brucella infection, which would be life-threatening and result in multiple disabilities. Brucellosis commonly manifests with fever, arthralgia, and myalgia. Moreover, most patients with Neurobrucellosis present with significant lesions in the brain, spinal cord, or vertebral column; some cases show no lesions in their magnetic resonance imaging (MRI). The present case is a 32-year-old rural man with suspicious contact with animals at his work who was presented with ataxia, paraplegia, and urine-fecal incontinence without typical symptoms of brucellos…

When vision loss signals vasculitis: central retinal artery occlusion leading to microscopic polyangiitis diagnosis-a case report.

Central retinal artery occlusion (CRAO) is an ophthalmic emergency characterized by sudden vision loss; it is rarely associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Herein, we report a case of a man in his 80s who, experiencing persistent fever, weight loss, and myalgia, received corticosteroid therapy at a local hospital for a presumptive diagnosis of polymyalgia rheumatica. While on this treatment, he suddenly developed vision loss in the left eye; visual acuity was limited to light perception, and fundus examination revealed a cherry-red spot in the macula,…

Efficacy and Safety of Tofacitinib for Acute Severe Ulcerative Colitis: A Systematic Review and Meta-Analysis.

BACKGROUND: Acute severe ulcerative colitis (ASUC) is associated with a high risk of colectomy. About 30% of patients do not respond to ster … dverse events were Clostridioides difficile infection, nausea, cardiovascular events, arthralgia or myalgia, herpes zoster infection, venous thromboembolism, and pneumonia. There was no significant difference in 90-day colectomy rate between tofacitinib and control (OR: 0.52; 95% CI: 0.25 - 1.08; P = 0.08). CONCLUSION: Tofacitinib demonstrated high clini …

The Return of Chikungunya in Bangladesh in 2024: Implications for Future Outbreaks.

After a major outbreak in Bangladesh in 2017, chikungunya nearly vanished from its territory until its resurgence in late 2024. However, its … chikungunya virus infections (72.7%) had moderate to high viral loads, with symptoms of joint pain, myalgia, and headaches. This resurgence of chikungunya in late 2024 highlights the potential for a major outbreak in 2025, necessitating proactive measures to mitigate public health impact and ensure a robust response to this re-emerging threat.

Severe dengue, aneurysmal sub-arachnoid hemorrhage, and hemophagocytic lymphohistiocytosis: a rare case combination.

Dengue, a vector-borne acute febrile illness caused by members of the Flavivirus genus, has dramatically increased its occurrence worldwide. Neurological complications of dengue range from 2.63 to 40%, and subarachnoid hemorrhage is a rare, but significant manifestation. Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory syndrome, sometimes secondary to infections such as dengue. This report presents a rare case of severe dengue with subarachnoid hemorrhage and hemophagocytic lymphohistiocytosis. A 19-year-old male presented with a 7-day history of fever and myalgia, fo…

Молекулярное исследование в Q Fever: обнаружение на основе ПКР ожогов Коксиеллы из ретроспективного исследования клинических образов в больнице третьей инстанции Северной Индии.

Q лихорадка, вызванная Coxiella signetii, является недостаточно диагностированной зоонотической болезнью, имеющей значительные последствия для здоровья населения. Серологические тесты остаются диагностическим краеугольным камнем, но зачастую не дают результатов при ранней инфекции. В этом исследовании изучается полезность цепной реакции полимеразы (ПХР), ориентированной на ген IS1111 для молекулярного обнаружения C. sergetii в клинических образцах человека в условиях ограниченных ресурсов. МЕТОДЫ: Было проведено ретроспективное исследование на основе ПЦР на 243 архивных клинических образцах, с

Совпадение в аннотации оригинала
BACKGROUND: Q fever, caused by Coxiella burnetii, is an underdiagnosed zoonotic disease with significant public health implications. Serolog … se showed coinfection with spotted fever group rickettsia. Clinical features included fever (100%), myalgia (75%), and rash (25%). Phylogenetic analysis revealed that the isolates clustered with the Z3055 reference strain, indicating a close genetic relationship to known zoonotic strains. CONCLUSION: PCR targeting IS1111 is a valuable diagnostic tool for …

Case Report: Chronic Q fever mimicking malignancy and tuberculosis in a hemodialysis patient: multidisciplinary diagnosis guided by metagenomic next-generation sequencing.

BACKGROUND: Q fever, caused by Coxiella burnetii, is a rare zoonosis whose clinical presentation is highly heterogeneous. Chronic Q fever can present with atypical systemic masses, creating significant diagnostic challenges as it lacks distinctive imaging features, often leading to misdiagnosis. CASE PRESENTATION: We report a case of a 50-year-old woman on maintenance hemodialysis who presented with a one-month history of generalized myalgia and abdominal discomfort. Initial PET-CT imaging revealed multiple hypermetabolic abdominal lesions (SUV∼max∼ 7.1), mimicking metastatic malignancy. Hist…

Clinical features and outcomes of dengue and scrub typhus in hospitalized adults in the Maldives.

BACKGROUND: Dengue and scrub typhus are common causes of acute undifferentiated febrile illness in the Maldives. METHODS: This retrospectiv … serving as a useful diagnostic clue. In contrast, dengue patients more often presented with chills, myalgia, arthralgia, bleeding, and thrombocytopenia. There were no fatalities in this cohort. CONCLUSIONS: In acute undifferentiated febrile illness in the Maldives, certain clinical indicators, including eschar for scrub typhus and bleeding with severe th …

Dengue Fever-Induced Complete Heart Block (Cardiac Dengue) Requiring Permanent Pacemaker Implantation in a 53-Year-Old Man: A Case Report.

Dengue fever is an endemic mosquito-borne viral infection in many tropical and subtropical regions. While its common manifestations include high-grade fever, rash, and myalgia, cardiac complications, particularly complete heart block, are rare but potentially life-threatening, underscoring the importance of vigilance. A 53-year-old man with type 2 diabetes mellitus and hypertension presented with dizziness, weakness, and a five-day history of high-grade fever with chills. He lived in a dengue-endemic area and denied any recent travel. Physical examination revealed bradyarrhythmia (38-49 beats …