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Distress and symptom burden in patients with monoclonal gammopathy of undetermined significance and smoldering myeloma.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Эпилептические изъятия как однократное представление радиологически изолированного синдрома: доклад по делу и обзор литературы.

Множественный склероз (MS) является наиболее распространенным долгосрочным воспалительным состоянием, влияющим на центральную нервную систему у взрослых. Вместе с тем изъятия редко описываются как первое представление MS или как единственное проявление радиологически изолированного синдрома (РИС) или клинически изолированного синдрома (СНГ). Диагностика MS, как правило, требует клинических данных о неврологических недостатках и вспомогательных радиологических данных; однако РИС характеризуется случайными результатами магнитно-резонансной съемки (MRI), которые указывают на наличие MS в отсутств

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… MRI: magnetic resonance imaging Figure 5 Postictal dorsal spine magnetic resonance (sagittal section, T2 imaging) Slight T2 hyperintensity within the spinal cord at the level of the T5-T6 disc, extending over less than one vertebral body (white arrow) Figure 6 Postictal brain MRI centered on the pons …

Risk Prediction and New Prophylaxis Strategies for Thromboembolism in Cancer.

Venous thromboembolism (VTE) is a compelling challenge across all phases of cancer care as it may result in treatment delays, impaired quality of life (QoL), and increased mortality [...].

Understanding DMG: current treatment options and prospective solutions using nanoparticles.

Diffuse Midline Gliomas (DMGs), which include the subset formerly known as Diffuse Intrinsic Pontine Glioma (DIPG), are associated with an extremely poor prognosis and a five-year survival rate below 2-3%. The devastating prognosis stems from an inherently invasive nature, a deep, anatomically restricted location, rapid cellular drug efflux mediated by transporters such as P-glycoprotein (ABCB1) and breast cancer resistance protein (BCRP/ABCG2), and an immunologically "cold" microenvironment. Coupled with limited Blood-Brain Barrier (BBB) permeability, these biological factors render conventio

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… DMG is a broad diagnostic category for high-grade gliomas located in midline structures such as the thalamus, brainstem (pons), and spinal cord, representing 10–20% of all pediatric central nervous system (CNS) tumors. … Diffuse Intrinsic Pontine Glioma (DIPG) is the term referred specifically to the subset of DMG located in the pons, typically estimated to account for 10–15% of pediatric CNS tumors. …

Person-centred care in oncological home services: a scoping review of patients' and caregivers' experience and needs.

BackgroundCancer became a chronic disease that could be managed at home. Homecare supported person-centred care, which was guided by the Picker Principles defining key elements for care delivery. The study aimed to explore and appraise the dimensions underlying cancer patients' and caregivers' experience and expectations with Home Cancer Care, adopting a person-centerd care framework.MethodsWe carried out a scoping review of the literature using three databases, PubMed, Scopus, and WoS for a total of 703 articles. PRISMA guidelines were followed. 57 articles were included in the review. The ex

Identifying the informational needs and sources of support of Adolescent and Young Adult (AYA) cancer survivors to inform the development of a digital platform.

PurposeThis study aimed to examine the (age-specific) informational needs and support sources used by Adolescent and Young Adult (AYA) cancer survivors throughout their cancer trajectory and socio-demographic and clinical factors associated with most common AYA-related informational needs.MethodsA cross-sectional questionnaire study was conducted among AYA cancer survivors (mean, 10.3 years after diagnosis, SD = 5.6). Informational needs and sources of support were examined via open questions and analyzed via a thematic inductive approach. Responses on informational needs were categorized acco…

Defining neuroblastoma: From origin to precision medicine.

Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development that contribute to NB. We discuss current treatment regimens, present and future directions for the identification of novel therapeutic metabolic targets, differentiation

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… Judit Liaño-Pons, Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum B7, Karolinska Institutet, Stockholm SE-17165, Sweden. … Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M.. Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death Differ. 2022;29(7):1304–1317. 104. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH.. …

The Role of Response-Shift in Studies Assessing Quality of Life Outcomes Among Cancer Patients: A Systematic Review.

Objective: Response-shift has been cited as an important measurement consideration when assessing patient reported quality of life (QoL) outcomes over time among patients with severe chronic conditions. Here we report the results of a systematic review of response shift in studies assessing QoL among cancer patients. Methods: A systematic review using MEDLINE, EMBASE, and PsychINFO along with a manual search of the cited references of the articles selected, was conducted. A quality review was performed using STROBE criteria and reported according to PRISMA guidelines. Results: A systematic rev…

Moments of deep connection between clinicians and patients in oncology: a mixed-methods study of sacred moments.

PurposeSacred moments are periods of deep connection between clinicians and patients, associated with increased clinician career fulfillment and stronger therapeutic alliances in radiation oncology and internal medicine. Our study is the first to investigate sacred moments in medical oncology.MethodsWe conducted semi-structured qualitative interviews with clinicians and patients at an NCI-designated Comprehensive Cancer Center. Interviews were recorded, transcribed, and analyzed using inductive coding. Participants completed a closed-ended (Likert-style) questionnaire that assessed demographic

Prevalence and determinants of sleep problems in cancer survivors compared to a normative population: a PROFILES registry study.

PURPOSE: To (1) identify the prevalence of sleep problems in cancer survivors across cancer types and survivorship durations compared to a normative population and (2) determine demographic, clinical, lifestyle, and psychosocial determinants. METHOD: Cancer survivors diagnosed between 2008 and 2015 (N = 6736) and an age- and sex-matched normative cohort (n = 415) completed the single sleep item of the EORTC QLQ-C30: Have you had trouble sleeping? Participants who responded with "quite a bit"/ "very much" were categorized as poor sleepers. A hierarchical multinomial logistic regression was use

Impact of nurse-led supportive care intensity on quality of life and symptom burden in patients undergoing palliative chemotherapy: A prospective cohort study

Nurse-led supportive care is integral to palliative oncology, yet the intensity of nursing contact is rarely quantified, and its clinical relevance remains incompletely defined. We prospectively examined the association between supportive care intensity (SCI) and patient-reported outcomes and survival in patients receiving palliative chemotherapy. This prospective observational cohort study enrolled adults with advanced solid tumors undergoing palliative chemotherapy. All participants received routine physician-led oncology care and standard chemotherapy nursing, while additional supportive se

A Rapid Systematic Review on the Experiences of Cancer Survivors Residing in Rural Areas during the COVID-19 Pandemic.

The COVID-19 pandemic has caused considerable disruption to cancer care and may have exacerbated existing challenges already faced by cancer survivors from rural areas. This has created a need for a rapid evidence synthesis to inform the development of tailored interventions that address the specific needs of rural cancer survivors who continue to be affected by the pandemic. The review was conducted following guidance from the Cochrane Rapid Review Methods Group. Database searches were performed via the EBSCOHost interface (includes MEDLINE, CINAHL, PsycINFO) on 25 May 2022 and supplemented w

Informal caregivers' quality of life and management strategies following the transformation of their cancer caregiving role: A qualitative systematic review.

ObjectivesGlobally, informal caregivers caring for cancer patients meet challenges within their caregiving role, which significantly influence their quality of life. This qualitative systematic review aimed to analyze how cancer caregiving influence the quality of life of informal caregivers and the management strategies of informal caregivers for their role as cancer caregivers.MethodsFollowing the enhancing transparency in reporting the synthesis of qualitative research (ENTREQ) statement, Wanfang database, the China National Knowledge Infrastructure (CNKI), CINAHL, MEDLINE, PubMed, Cochrane

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

Aceruloplasminemia Презентация с выдающимися психиатрическими симптомами и нейродегенерацией: доклад по делу.

Aceruloplasminemia (ACP) часто имеет системные, психические и неврологические особенности. В этом случае сахарный диабет был диагностирован за несколько лет до психических симптомов, за которыми последовало неврологическое расстройство, что значительно задержало диагностику. Этот случай подчеркивает важность учета причин метаболизма и нейродегенеративного характера в нетипичных психиатрических представлениях и расширяет генетический спектр с помощью новой генной мутации CP.

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… MRI brain FLAIR sequence showing a white matter hyperintensity along the corticospinal pathway extending to the pons (red arrow) and a hypointense signal in the dentate nuclei (yellow arrows) (top right). …

Patients with precursor disease exhibit similar psychological distress and mental HRQOL as patients with active myeloma.

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Development of a Patient-Centered Preference Tool for Patients With Hematologic Malignancies: Protocol for a Mixed Methods Study.

BackgroundThe approval of novel therapies for patients diagnosed with hematologic malignancies have improved survival outcomes but increased the challenge of aligning chemotherapy choices with patient preferences. We previously developed paper versions of a discrete choice experiment (DCE) and a best-worst scaling (BWS) instrument to quantify the treatment outcome preferences of patients with hematologic malignancies to inform shared decision making.ObjectiveWe aim to develop an electronic health care tool (EHT) to guide clinical decision making that uses either a BWS or DCE instrument to capt

Patient Engagement in Oncology Practice: A Qualitative Study on Patients' and Nurses' Perspectives.

Patient engagement has gained increasing attention in cancer care as it is widely acknowledged as an essential element of high-quality care. There are limited data on how oncology nurses might apply techniques that encourage patient engagement. Therefore, this study aims to understand which nursing strategies can favour patient engagement in oncological care from patients' and nurses' perspectives. We conducted a qualitative study involving oncology patients and oncology nurses. Patients were interviewed, while nurses were involved in focus groups (FGs). Both interviews and FGs were analysed b

A qualitative study on patients' and their support persons' preferences for receiving one longer consultation or two shorter consultations when being informed about allogeneic hematopoietic stem cell transplantation.

BackgroundAllogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment option for many patients … mework analysis.ResultsTwenty patients and 13 support persons were recruited (consent rate: 96%, response rate: 91%). Most patients (60%) and support persons (62%) preferred two shorter consultations over one longer consultation. This helped them digest and recall the information provided, remember questions they had, involve significant others and sea …

Which cancer survivors are at risk for a physically inactive and sedentary lifestyle? Results from pooled accelerometer data of 1447 cancer survivors.

BackgroundPhysical activity has beneficial effects on the health of cancer survivors. We aimed to investigate accelerometer-assessed physical activity and sedentary time in cancer survivors, and describe activity profiles. Additionally, we identify demographic and clinical correlates of physical activity, sedentary time and activity profiles.MethodsAccelerometer, questionnaire and clinical data from eight studies conducted in four countries (n = 1447) were pooled. We calculated sedentary time and time spent in physical activity at various intensities using Freedson cut-points. We used latent p