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C3 nephritic factor in an individual with recurrent viral infection and lipodystrophy.

A patient with nephritic factor in the serum following an attack of disseminated herpes is described. In the majority of cases, the factor is associated with mesangio-capillary glomerulonephritis, with or without partial lipodystrophy. It has, however, been described in cases of partial lipodystrophy alone, in one patient with recurrent pyogenic infections, and in one healthy individual. It has not previously been described in an individual with disseminated viral infection.

An epidemic of syphilis among homosexuals and bisexuals.

22 cases of syphilis were diagnosed in the last part of 1982 in the Department of Dermatology and Venereology. Out of them 21 were male cases and 16 were homo- or bisexuals. Most cases were in the secondary stage and Herxheimer reaction only developed in these. Serological titers to both lipoidal and treponemal antigens were extremely high. All bisexual males were positive in herpes and CMV complement fixation test. Two of the homosexuals appeared with iridocyclitis and motile treponemes were isolated from the anterior chamber in one case.

The management of postherpetic neuralgia with chlorprothixene.

Sixteen patients with established postherpetic pain were treated with chlorprothixene. Several other pain problems were simultaneously treated. Chlorprothixene was found to produce a favorable pain response in most patients with postherpetic pain while failing to be of value in other clinical pain problems. Chlorprothixene may be a satisfactory drug for the control of spinal or ophthalmic postherpetic pain.

CTC1 mutation causing cerebro-retinal microangiopathy with calcifications and cysts type 1, masquerading as TORCH Infection.

An early adolescent male from a consanguineous family presented with progressive neurological deterioration, including developmental delay, seizures, left hemiparesis and cognitive decline from early childhood. He subsequently developed gastrointestinal bleeding, chronic liver disease with oesophageal varices, severe anaemia and thrombocytopenia. Initial investigations suggested TORCH (Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes simplex) infection due to intracranial calcifications and multisystem involvement. However, detailed neuroimaging revealed extensive periventricular calcifi…

Bilateral Vocal Cord Paralysis Following Influenza A: Case Report.

Bilateral vocal cord paralysis (BVCP) is a rare but potentially life-threatening condition. Viral infections such as COVID-19, herpes simplex virus, Epstein-Barr virus, and cytomegalovirus have been widely reported; however, influenza A is a rarely reported cause. We describe a 57-year-old male who developed BVCP following an influenza A infection. Comprehensive investigations, including neuroimaging and nerve conduction studies, ruled out structural, neoplastic, demyelinating, medication-related, and autoimmune causes. A transient CMV viremia was identified but deemed a secondary phenomenon d…

Neuroimaging features of incontinentia pigmenti: prompting genetic confirmation.

A term female neonate presented with vesicular skin lesions along Blaschko's lines and refractory seizures in the first week of life. Brain … iopathy-driven central nervous system lesions, guiding genetic diagnosis and distinguishing IP from herpes simplex virus encephalitis, human parechovirus encephalitis and congenital varicella syndrome. Early neuroimaging is essential for timely diagnosis and management.

In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence.

Postoperative tumor recurrence represents a major challenge for patients. Oncolytic virus (OV) therapy has attracted increasing attention in … nt in situ treatment with adv@Nap gel to inhibit postoperative tumor recurrence. Notably, oncolytic herpes simplex virus or vaccinia virus loaded in Nap gel can also control postoperative tumor recurrence. Thus, hydrogel-loaded OVs that induce extended immune activation represent a paradigm for sustained antitumor immunotherapy, and in situ sustained immune acti …

COVID-19 infection and vaccines: potential triggers of Herpesviridae reactivation.

Since the onset of the COVID-19 outbreak, numerous articles have highlighted a possible link between COVID-19 vaccination or infection and Herpesviridae co-infection or reactivation. The authors conducted an exhaustive literature review on this topic, the results of which are presented individually for each member of the Herpesviridae family: Herpes Simplex Virus (HSV) types-1 (HSV-1) and 2 (HSV-2); Varicella-Zoster Virus (VZV); Epstein-Barr Virus (EBV); Cytomegalovirus (CMV); HHV-6; HHV-7; and HHV-8. These human herpesviruses can serve as prognostic markers for the COVID-19 infection and may …

HPV co-infections with other pathogens in cancer development: A comprehensive review.

High-risk human papillomaviruses (HR-HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co-infecting agents that influence infection dynamics and disease progression. Bacterial co-infections (e.g., C…

[Anti-NMDA Receptor Encephalitis].

Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease caused by autoantibodies against the extracellular conformational epitope of the NR1 subunit of the NMDAR (GluN1 antibodies). A series of autoantibodies directed against neuronal surface (NS) or synaptic proteins play an important role in the pathophysiological mechanisms of post-herpes simplex encephalitis (post-HSE), overlapping autoimmune encephalitis and demyelinating syndrome, epileptic seizures, psychosis, involuntary movements (orofacial and limb dyskinesias, catatonia, dystonia, chorea, myoclonus, psychogenic nonepileptic…

Central nervous system involvement of anaplasmosis.

A 64-year-old woman presented with 24 hours of lethargy, confusion, headache, nausea and vomiting. Examination revealed expressive aphasia, … 2% lymphocytes, 1460 red blood cells, normal glucose and protein and negative cryptococcal antigen, herpes simplex PCR and Lyme PCR. Serum Lyme IgG/IgM antibodies and PCR, Erlichia chaffeensis serum IgG/IgM antibodies and PCR and anaplasma serum IgG/IgM antibodies were negative. Anaplasmosis serum PCR was positive. The tick was identified as Ixodes scapularis Th …

Oral ulceration and blistering in patients with COVID-19.

Design Case series.Introduction The most common signs and symptoms of SARS-CoV-2 infection include headache, sore throat, hyposmia, hypogeus … rted in the tongue. The first two patients had lesions affecting keratinised tissue consistent with herpes simplex lesions but with no history of herpetic infection. The third patient had lesions compatible with erythema multiforme.Conclusions The authors suggest a link between COVID-19 and oral ulceration and blistering, but acknowledge these signs may often go …

Увязка антимикробного потенциала природных продуктов, полученных из акватических организмов, и микробов, связанных с болезнью Альцгеймера - обзор.

Приводимый ниже обзор ориентирован на микробы, связанные с болезнью Альцгеймера (АБ), и антимикробное воздействие соединений и экстрактов, полученных из водных организмов, на конкретные бактерии, грибы и вирусы, которые ранее были обнаружены у пациентов, страдающих АД. Основная группа микробов, связанных с АД, включает бактерии: хламидиозная пневмония, геликобактотер пилори, порфиромоны ингивалис, нуклеатум Фусобактерия, нуклеатум Превотелла, межмедиа Actimonices naeslundii, спирошетическая группа; грибы: Candida sp., Cryptoccus sp., Saccharomyces sp., Malassezia sp., Botritis sp., и вирусы: г

Совпадение в аннотации оригинала
The following review is oriented towards microbes linked to Alzheimer's disease (AD) and antimicrobial effect of compounds and extracts deri … fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve …

Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency.

A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insuff … of real-time polymerase chain reaction assay. Serologic examination (IgM) for rubella, toxoplasma, herpes simplex type 2, and human immunodeficiency virus (anti-HIV) was negative. During the further evaluation for systemic immune dysfunction, decreased immunoglobulin and lymphocyte levels that confirm the diagnosis of severe combined immunodeficiency have been …

Virus and Immune-Mediated Encephalitides: Epidemiology, Diagnosis, Treatment, and Prevention.

Virus encephalitis remains a major cause of acute neurological dysfunction and permanent disability among children worldwide. Although some disorders, such as measles encephalomyelitis, subacute sclerosing panencephalitis, and varicella-zoster virus-associated neurological conditions, have largely disappeared in resource-rich regions because of widespread immunization programs, other disorders, such as herpes simplex virus encephalitis, West Nile virus-associated neuroinvasive disease, and nonpolio enterovirus-induced disorders of the nervous system, cannot be prevented. Moreover, emerging vir…

Pattern of Acute Retinal Necrosis in a Referral Center in Tunisia, North Africa.

PURPOSE: To describe the pattern of acute retinal necrosis (ARN) syndrome in a referral center in Tunisia. METHODS: Retrospective review of the charts of 12 patients (12 eyes). RESULTS: Necrotizing retinitis involved >50% of the retina in 33.3% of eyes. Polymerase chain reaction on aqueous humor sample identified herpes simplex virus-1 in 4 eyes (33.3%) and varicella zoster virus in 3 eyes (25%), and was negative in 5 eyes (41.7%). All patients received intravenous acyclovir, followed by oral antivirals. Follow-up ranged from 6 to 16 months. Retinal detachment (RD) occurred in 3 eyes (25%), …