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Bridging the evidence gap: three-year BCG maintenance therapy shows enhanced protection over one-year regimen in Chinese NMIBC.

BACKGROUND AND OBJECTIVE: The current recommendation of BCG therapy in China is a 1-year regimen, based on local strain variations and the absence of evidence for a 3-year instillation protocol. Our aim was to compare the protective efficacy of the 3-year BCG regimen versus a 1-year regimen in Chinese NMIBC patients. METHODS: We collected 140 patients followed by BCG monotherapy at our center from 2017 to 2024. All patients had ≥ 1 year of follow-up. Participants were allocated based on clinical practice into a standard three-year instillation group (n = 72) and a modified one-year group (n =

Specific Depressive Symptoms and Primary Tumor Location as Potential Predictors of Smoking Maintenance After Head and Neck Cancer Treatment.

BACKGROUND: Despite the known benefits of smoking cessation for head and neck cancer (HNC) patients, a significant proportion continue to us … chological symptom of sadness measured by the BDI (β = 5.279, P = 0.023) were predictive of smoking maintenance 12 months after the end of cancer treatment. Feeling like a failure before cancer treatment was the only predictor variable for smoking maintenance immediately after and 12 months after the end of treatment (β = 13.455, p < 0.001; β = 4.537, P = 0.0 …

CRISPR-Cas9 CD33-deleted allogeneic hematopoietic cell transplantation with gemtuzumab ozogamicin maintenance in AML: a phase 1/2 trial.

Patients with high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are likely to relapse despite allogenic hematopoietic cell transplantation (HCT). Post-HCT preventative maintenance can be limited by toxicity toward the normal donor cells. Tremtelectogene empogeditemcel (trem-cel) is a CRISPR-Cas9 gene-edited allogeneic HCT product lacking CD33, designed to shield the donor graft from cytotoxicity of subsequent CD33-targeted therapies such as gemtuzumab ozogamicin (GO). In this multicenter, phase 1/2a, open-label study, adult patients with AML/MDS with high relapse risk r…

A physics-informed multi-modal transformer framework for predictive maintenance and remaining useful life estimation of electrical submersible pumps.

Electrical Submersible Pumps (ESPs) are widely used in oil and gas production but are highly vulnerable to mechanical, electrical, hydraulic, and thermal degradation under harsh downhole conditions. Unexpected ESP failures can result in severe production losses, costly interventions, and reduced operational reliability, highlighting the importance of predictive maintenance and Remaining Useful Life (RUL) estimation. Existing prognostic approaches often rely on single-modality data and lack physical consistency in degradation modeling. This study proposes HF-ESPNet, a physics-informed multi-mod…

Durvalumab plus HAIC-FOLFOX followed by maintenance durvalumab for hepatocellular carcinoma with major portal invasion: phase 2 DurHope study.

Hepatocellular carcinoma (HCC) patients with Vp4 portal vein tumor thrombus (PVTT) have a poor prognosis and are underrepresented in global clinical trials. We conducted a single-arm phase 2 study (DurHope) enrolling 30 patients with Vp3/4 PVTT receiving durvalumab plus hepatic arterial infusion therapy (HAIC) of FOLFOX regimen (fluorouracil, leucovorin, and oxaliplatin) as first-line treatment. Primary endpoint was 1-year overall survival (OS) rate, and secondary endpoints included progression-free survival, objective response rate per Response Evaluation Criteria in Solid Tumors version 1.1,

Survival outcomes of dogs with multicentric lymphoma treated with sequential half-body radiotherapy and L-CHOP without maintenance chemotherapy.

BACKGROUND: L-CHOP (L-asparaginase, cyclophosphamide, doxorubicin, vincristine, prednisone) is the standard therapy for lymphoma in dogs, but relapse and limited long-term survival are common. Given the radiosensitivity of lymphoma, sequential half-body radiotherapy (HBRT) has been investigated to improve outcomes. HYPOTHESIS/OBJECTIVES: Evaluate progression-free survival (PFS), overall survival (OS), and adverse events in dogs treated with a no-maintenance L-CHOP protocol combined with low-dose-rate (LDR, 6 Gy; 8-14 cGy/min) HBRT compared to L-CHOP alone. ANIMALS: Client-owned dogs with int…

Comparative cardiovascular outcomes of renin-angiotensin system inhibitors in patients receiving maintenance hemodialysis: a large real-world cohort study.

BACKGROUND: The comparative cardiovascular effectiveness of different renin-angiotensin system (RAS) inhibitors in patients receiving maintenance hemodialysis remains uncertain, and current guideline recommendations largely assume therapeutic equivalence between angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). METHODS: Using the TriNetX multi-institutional database, we identified adults with ESKD who newly initiated ARB or ACEI therapy from 2006 to 2025. An active-comparator new-user design and 1:1 propensity score matching were applied. The primary out…

IGBP1 protects WEHI-231 cells from BCR-mediated apoptosis through the maintenance of PP6 activity and Bcl-xL stability.

The elimination of self-reactive clones through B cell receptor (BCR)-induced apoptosis is a fundamental mechanism for establishing self-tolerance in immature B cells. We previously reported that protein phosphatase 6 (PP6) suppresses BCR-induced apoptosis in the immature B cell line WEHI-231 by maintaining the expression of the anti-apoptotic protein, Bcl-xL. Immunoglobulin-binding protein 1 (IGBP1) interacts with the catalytic subunit of PP6 (PP6c) to regulate its phosphatase activity. In this study, we investigated the role of IGBP1 in BCR-mediated apoptosis. We found that IGBP1 overexpress

Case Report: Tocilizumab as time-limited induction therapy enabling steroid withdrawal and conventional maintenance in refractory cutaneous polyarteritis nodosa.

BACKGROUND: Cutaneous polyarteritis nodosa (CPAN) is a chronic, relapsing vasculitis frequently associated with glucocorticoid dependence an … b (TCZ) was implemented to achieve rapid disease control and enable steroid withdrawal, followed by maintenance with mycophenolate mofetil (MMF). RESULTS: TCZ led to rapid clinical remission after two infusions, allowing progressive steroid tapering and discontinuation. After six doses, TCZ was stopped and MMF was introduced as maintenance therapy. The patie …

Реальная эффективность обслуживания бортезомиба после введения VMP в санитарную миелому: целевое экспериментальное исследование эмуляции.

Bortezomib-melphalan-prednisone (VMP) — установленный вводный режим для сноса трансплантации, недавно диагностированный несколькими миеломами (NDMM), однако оптимальные стратегии после введения остаются неясными. В ходе этого исследования была проведена оценка эффективности обслуживания бортезомибной системы с использованием пробной эмуляции мишеней. Мы сравнили предполагаемую группу поддержки.KMMWP-174 ) с внешней контрольной когортой из многоцентрового реестра. Число пациентов, прошедших курс лечения 9 Циклы VMP, полученные ≥ частичная реакция и без движения 60 днями. Индексом была дата нача

Совпадение в аннотации оригинала
Bortezomib-melphalan-prednisone (VMP) is an established induction regimen for transplant-ineligible newly diagnosed multiple myeloma (NDMM), yet optimal post-induction strategies remain unclear. This study evaluated the effectiveness of bortezomib maintenance following VMP using target trial emulation. We compared a prospective maintenance cohort (KMMWP-174 …

Morpho-functional uterine and placental dynamics during establishment and maintenance of canine pregnancy, from early trophoblast invasion to parturition.

The placenta is an important, endocrinologically active organ that forms the interface between the maternal and fetal compartments. Evolutionarily, the canine placenta lies between the less invasive and more invasive placental types, positioning the dog as a physiologically relevant system for integrating molecular, endocrine, and structural aspects of placental biology. This narrative review updates key mechanisms underlying canine pregnancy, emphasizing progesterone receptor-mediated signaling, maternally-derived decidual cells, and their interactions with trophoblast within the recently pro

First-line camrelizumab plus chemotherapy followed by camrelizumab-apatinib maintenance for ES-SCLC: a single-arm phase II study.

BACKGROUND: Immune-antiangiogenic combinations have shown promising signals of activity in ES-SCLC, but the optimal timing of anti-angiogenic therapy and biomarkers associated with benefit remain undefined. This study evaluated the efficacy and safety of combining apatinib with camrelizumab during maintenance and explored immune-molecular biomarkers of benefit. METHODS: In this single-arm phase II trial, apatinib plus camrelizumab as maintenance therapy following induction therapy with camrelizumab plus platinum-etoposide chemotherapy was administered to treatment-naïve ES-SCLC patients (ACES…

Preventing relapse in ulcerative colitis remission maintenance: machine learning prediction and reinforcement-learning herbal prescription optimization with external validation.

INTRODUCTION: Maintaining remission in ulcerative colitis (UC) with traditional Chinese herbal medicine is challenging because fixed-intensity prescriptions may not accommodate changes in inflammatory burden. This study aimed to predict 52-week relapse and develop a data-driven policy for sequential adjustment of herbal treatment intensity. METHODS: We analysed a development cohort of 1,181 patients receiving herbal maintenance therapy and an independent external validation cohort of 96 patients. Twenty-one baseline clinical, biomarker, herbal-dose and behavioral variables, expanded to 31 fea…

Low-Dose Chidamide Maintenance Therapy After Hematopoietic Stem Cell Transplantation for T-Cell Acute Lymphoblastic Leukemia: A Case Series.

Post-transplant relapse remains a major challenge in T-ALL, with limited effective salvage options. We report on eight T-ALL patients who received low-dose chidamide (5 mg once weekly) as maintenance therapy after allogeneic HSCT. With a median follow-up of 22.7 months, the estimated 2-year OS and EFS are both 87.5%. Seven patients (87.5%) remain in continuous complete remission with sustained MRD negativity. Grade 3-4 neutropenia occurred in 57.1% of evaluable patients but was clinically manageable. This case series demonstrates that a low-dose chidamide maintenance regimen is feasible, well …

Microchromosome maintenance protein 2 is essential in immune infiltration-correlated prognosis of multiple myeloma patients by regulating cell cycle.

PURPOSE: Multiple myeloma (MM) is a common hematological malignancy, while the prognostic value of tumor-infiltrating immune cells in MM remains elusive. This study aimed to construct an immune-related prognostic model and identify potential therapeutic targets for MM. METHODS: RNA-seq and clinical data of 751 newly diagnosed MM patients were analyzed. LASSO regression was applied to establish an immune pathway-based prognostic model for patient risk stratification. WGCNA was used to screen hub genes, and in vitro and in vivo experiments validated gene functions and therapeutic effects. RESU

Periodontal maintenance therapy: A comparative study of frequent scaling versus standard check-up regimes in preventing periodontal disease recurrence.

The optimal frequency of periodontal maintenance visits remains uncertain despite their critical role in preventing recurrence of periodontal disease after active therapy. Therefore, it is of interest to compare the effectiveness of 1-month scaling intervals with standard 3-month maintenance visits in 100 patients with treated chronic periodontitis. Clinical parameters including PI, GI, PPD, CAL and BOP were assessed at baseline, 3, 6 and 12 months and recurrence was defined by increased probing depth and clinical attachment loss. Both groups improved over time but the 1-month maintenance grou…

Maintenance rucaparib after first-line platinum-based chemotherapy in HER2-negative advanced oesophagogastric adenocarcinoma: results from the PLATFORM study.

BACKGROUND: PLATFORM is a prospective, open-label, multicentre, adaptive phase II trial assessing maintenance therapy in patients with advanced HER2-negative oesophagogastric adenocarcinoma after platinum-based first-line chemotherapy. PATIENT AND METHODS: After 18 weeks of platinum-based chemotherapy, patients with response or stable disease were randomised to surveillance (4 weekly visits) or rucaparib 600 mg tablet twice daily every 28 days. The primary endpoint was progression-free survival (PFS) (prespecified P value of 0.025). Secondary endpoints were safety and overall survival (OS). E…

Postendoscopic Submucosal Dissection Bleeding Risk of Periprocedural Aspirin Maintenance Therapy in Clopidogrel Users as Single or Dual Antiplatelet Agents.

BACKGROUND/AIMS: Aspirin maintenance is recommended during endoscopic submucosal dissection (ESD) in patients with antiplatelet therapy (APT) who are at high-thromboembolic risk. We evaluated the post-ESD bleeding risk during aspirin maintenance therapy and the timing of clopidogrel resumption. METHODS: Patients who underwent ESD for early gastric cancer or adenoma between 2011 and 2020 were included. Patients receiving APT who were at low thromboembolic risk stopped APT 7 days before ESD and resumed it 1 month after ESD (interrupted group). Patients receiving APT who were at high thromboembo…