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Real-world efficacy of BDP/FF/G fixed triple inhalation powder (NEXThaler) therapy in the treatment of moderate to severe COPD patients (RESPONSE study).

PURPOSE: Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, placing a significant burden on healthcare systems and patients' quality of life. The cornerstone of treatment includes fixed triple combinations of inhaled corticosteroids (ICS), long-acting β2-agonists (LABA), and long-acting muscarinic antagonists (LAMA) shown to improve lung function, reduce exacerbations, and enhance symptom control in patients with moderate to severe disease. However, there is still a lack of clinical evidence for the real-life effectiveness of fixed triple

Связанные с мукосом инвариантные Т клетки в автоматическом иммунитете, заболеваниях, вызванных иммунной медициной, и заболеваниях дыхательных путей.

Инвариантные клетки, связанные с мукосалом Т (MAIT) — это новый класс врожденных Т клеток, выражающий полуинвариантный рецептор Т-клеток (TCR) и способный распознавать небольшие молекулы, представленные на неполиморфическом белоке MHC 1. Их врожденный фенотип фемориального эффекта, позволяющий секретить провоспалительные цитокины, и их относительное изобилие в человеке означает значительный потенциал для содействия аутоиммунным процессам. Однако, поскольку до недавнего времени клетки MAIT были неизвестны, а конкретные иммунологические инструменты отсутствовали, мало что известно об их роли в б

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… Abbreviations: BDP , beclomethasone dipropionate; r s, Spearman's correlation coefficient. … It is remarkable that a systemic deficiency in peripheral blood MAIT cells can be induced even by the small doses of corticosteroid that are absorbed systemically after administration of low‐dose ICS, 70 such as the patients with moderate asthma in our study who received a median 400 μg beclomethasone …

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.

We identify an autosomal mutation in the CSF3R gene in a family with a chronic neutrophilia. This T617N mutation energetically favors dimerization of the granulocyte colony-stimulating factor (G-CSF) receptor transmembrane domain, and thus, strongly promotes constitutive activation of the receptor and hypersensitivity to G-CSF for proliferation and differentiation, which ultimately leads to chronic neutrophilia. Mutant hematopoietic stem cells yield a myeloproliferative-like disorder in xenotransplantation and syngenic mouse bone marrow engraftment assays. The survey of 12 affected individuals

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.

BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and co … d more women than men, with mean age ranging from 38 to 45, and mean baseline steroid dose (inhaled beclomethasone (BDP) equivalent) from 636 to 888 μg. Mean baseline forced expiratory volume in one second (FEV1) percentage predicted was between 70% and 73% in three of the trials, and 96% in another. All studies were funded by AstraZeneca and were generally free …

Cutaneous Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Cohort Study of Clinical Spectrum and Treatment Patterns.

Cutaneous graft-versus-host disease (GVHD) is a common complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT). Despite established guidelines, discrepancies persist between clinical trial evidence and real-world practice, particularly for newer agents such as ruxolitinib. To characterize the phenotypic spectrum of cutaneous GVHD, evaluate real-world treatment strategies-with a specific focus on systemic and topical ruxolitinib-and assess adherence to national and international guidelines, we conducted a retrospective observational study of patients undergoing allo-HSCT

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… Betamethasone was employed in roughly 50% of the patients with aGVHD, followed by mometasone, beclomethasone, deoxymethasone, and clobetasol, each of which were employed in 13% of patients. …

Topical and oral steroids for otitis media with effusion (OME) in children.

BACKGROUND: Otitis media with effusion (OME) is an accumulation of fluid in the middle ear cavity, common amongst young children. The fluid … used prednisolone for 7 to 14 days. Studies of topical (nasal) steroids used various preparations (beclomethasone, fluticasone and mometasone) for between two weeks and three months. All studies had at least some concerns regarding risk of bias. Here we report our primary outcomes and main secondary outcome, at the longest reported follow-up. Oral steroids comp …

Respiratory and Thoracic Medicine

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… 62.5 mg/cat, PO, every 12 hours, 14 days Interferon-alpha | 10 U PO, every 24 hours (chronic); 10,000 U SC, every 24 hours, 21 days (acute) Lysine | 500 mg/cat, PO, every 12 hours NSAIDs | Meloxicam | 0.025-0.1 mg/kg, PO, every 2 to 3 days Piroxicam | 0.3 mg/kg, PO, every 2 days Glucocorticoids | Beclomethasone … Beclomethasone or fluticasone can be administered by metered dose inhaler (MDI) with an inhalation chamber at 1 to 2 puffs once to twice daily. Resistant cases may respond to administration of cyclosporine at up to 7.5 mg/kg, orally, daily or every other day, but controlled data are lacking. …

Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease.

UNLABELLED: Severe intestinal graft-vs-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT) causes mucosal ulceration and induces innate and adaptive immune responses that amplify and perpetuate GVHD and the associated barrier dysfunction. Pharmacological agents to target mucosal barrier dysfunction in GVHD are needed. We hypothesized that induction of Wnt signaling by lithium, an inhibitor of glycogen synthase kinase (GSK3), would potentiate intestinal crypt proliferation and mucosal repair and that inhibition of GSK3 in inflammatory cells would attenuate the deregula

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… Most patients also received oral beclomethasone dipropionate in corn oil with or without oral enteric-coated budesonide. Other immunosuppressive agents were added at the discretion of the patient care team if patients had an unsatisfactory response or rapid progression of severe symptoms. …

Glucocorticoids-based prodrug design: Current strategies and research progress.

Attributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin, and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis, arthritis, ulcerative colitis, asthma, keratitis, macular edema, and leukemia. However, long-term use often causes undesirable side effects, including metabolic disorders-induced Cushing's syndrome (buffalo back, full moon face, hyperglycemia, etc.), osteoporosis, aggravated infection, psychosis, glaucoma, and cataract. These notorious side e

GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation.

We present the largest prospective real-world experience in 159 patients who received the triple combination of tacrolimus/sirolimus/mycophenolate mofetil after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) from matched-related (MRD), matched-unrelated (MUD) or mismatched-unrelated donors (MMURD). Despite the high-risk and elderly population, non-relapse mortality (NRM) at day +100 and 1 year was 5.1% and 8.6%. Grades 2-4 and 3-4 acute Graft-versus-host disease (GvHD) at day +180 was 30.3% and 13%, respectively. Chronic GvHD at 1 and 3 years w

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… The CuIn of aGvHD 2-4 at day +100 and +180 was 29.15% (95% CI: 22.1–36.6) and 30.77% (95% CI: 23.5–38.3), including 40% of cases with upper gastrointestinal tract involvement, which resolved with topical treatment with beclomethasone (Table 2 , Fig. 1a ). …

Essential Medicinal Chemistry of Essential Medicines.

Since 1977, the World Health Organization publishes a list of essential medicines, i.e., those that satisfy the priority health care needs of the population and are selected with regard to disease prevalence and public health relevance, evidence of clinical efficacy, and safety, as well as comparative costs and cost-effectiveness. The Essential Medicines List (EML) is an invaluable tool for all countries to select those medicines that have an excellent risk/benefit ratio and that are reputed to be of pivotal importance to health. In the present perspective, we describe the chemical composition

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… that there was an incomplete correspondence between the index and the main text of the list when drugs presented a modified International Nonproprietary Name (INNM, that is a two-word name in which the first word indicates the active principle and the second word indicates the esterification, 15 e.g., beclomethasone …

Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?

Multiple organ dysfunction syndrome (MODS) occurs in response to major insults such as sepsis, severe haemorrhage, trauma, major surgery and pancreatitis. The mortality rate is high despite intensive supportive care. The pathophysiological mechanism underlying MODS are not entirely clear, although several have been proposed. Overwhelming inflammation, immunoparesis, occult oxygen debt and other mechanisms have been investigated, and - despite many unanswered questions - therapies targeting these mechanisms have been developed. Unfortunately, only a few interventions, usually those targeting mu

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… Nomura S Kanazawa H Hirata K Iwao H Yoshikawa J Relationship between vascular endothelial growth factor and angio-poietin-2 in asthmatics before and after inhaled beclomethasone therapy J Asthma 2005 42 141 146 15871447 176. …

Saliva как матрица для терапевтического мониторинга наркотиков и биомаркеров заболеваний у детей и подростков.

Saliva — более доступная, менее напряженная и менее дорогостоящая биологическая матрица, чем кровь, и она может применяться в терапевтическом мониторинге лекарственных средств (ПТМ). Концентрации слюны отражают фармацевтический активный ненавязанный препарат. В этом обзоре содержится последняя информация о слюне в качестве матрицы для лечебного контроля за наркотиками и определения биомаркеров у младенцев, детей и подростков. К октябрю 2024 года по базе данных PubMed были проведены обыски литературы, 64 исследования были включены в TDM, стероиды, добавки, биомаркеры заболеваний, стоматология,

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… The genomic DNA extracted from saliva was used in a study, which hypothesized that associations between asthma outcomes and CYP3A5 polymorphisms may result from the altered metabolism of beclomethasone dipropionate. …

History of hematopoietic cell transplantation: challenges and progress.

After more than 60 years of research in allogeneic hematopoietic cell transplantation (HCT), this therapy has advanced from one that was declared dead in the 1960s to a standard treatment of otherwise fatal malignant and non-malignant blood diseases. To date, close to 1.5 million hematopoietic cell transplants have been performed in more than 1,500 transplantation centers worldwide. This review will highlight the enormous efforts by numerous investigators throughout the world who have brought the experimental field of HCT to clinical reality, examine ongoing challenges, and provide insights fo

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… A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. Blood. 2007;109(10):4557-4563. 97. Mielcarek M, Storer BE, Boeckh M, et al. …

Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations.

In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare community has raced to find effective therapeutic agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, dexamethasone is the first and an important therapeutic to significantly reduce the risk of death in COVID-19 patients with severe disease. Due to powerful anti-inflammatory and immunosuppressive effects, dexamethasone could attenuate SARS-CoV-2-induced uncontrolled cytokine storm, severe acute respiratory distress syndrome and lung injury. Nevertheless, dexamethasone tre

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… Posterior subcapsular cataract (PSC) has been reported in a few adults and children treated with beclomethasone dipropionate or dexamethasone aerosol, but the risk seems to be much lower than when taking these corticosteroids systemically [ 115 ]. …

Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity.

Acute radiation dermatitis (ARD) is a common adverse effect experienced by patients undergoing radiation therapy. Effective assessment tools to accurately measure and manage ARD's impact on patients' quality of life and treatment outcomes is needed. The aim of this study was to evaluate the diverse tools and outcome measures used in the assessment of ARD. A systematic review of MEDLINE®, Embase, and Cochrane was conducted for records 1946-March 2024. A total of 423 studies, including 227 randomized controlled trials (RCTs), were included in the analysis. The review identified 58 distinct tools

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… infants after cardiac surgery, 410 pulmonary infiltrates in the non-HIV-infected immunocompromised patient: etiologies, diagnostic strategies, and outcomes, 260 Balloon dilatation using flexible bronchoscopy for the management of benign and malignant airway stenoses, 354 Barber and asbestosis, 1594 Beclomethasone …

Abstracts for NAPCON 2025

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… Table 1 AIR combinations used by different practitioners AIR combination ( n =402) | Pulmonologist (%) | Physician (%) | Paediatrician (%) | Total (%) Beclomethasone + Levosalbutamol | 12.8 | 15.1 | 17.1 | 14.1 Budesonide + Formoterol | 44.6 | 38.2 | 56.1 | 43.0 Beclomethasone + Formoterol | 12.6 | 15.1 …

Emergency Care

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Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

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