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Infections and Their Outcomes in Cancer Patients With and Without Neutropenia: A Single-Center Experience.

Background Patients with cancer are at a high risk of developing infections due to immunosuppression resulting from cancer treatment. Infections may occur both during neutropenic and non-neutropenic episodes and negatively impact outcomes both in terms of hospital stay and mortality. In this study, we aimed to determine the infection types, microbiological picture of infections, their outcomes, and associated factors in cancer patients during neutropenic and non-neutropenic episodes. Methods This is a retrospective cross-sectional study conducted at the Department of Medical Oncology, Geetanja

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… . | 0 | 1 | 1 Klebsiella pneumoniae | 0 | 7 | 7 Pseudomonas aeruginosa | 0 | 2 | 2 Bronchial aspirate | Candida albicans | 0 | 1 | 1 Escherichia coli | 0 | 1 | 1 Pus | Staphylococcus aureus | 0 | 1 | 1 Citrobacter freundii | 0 | 1 | 1 Escherichia coli | 0 | 4 | 4 Enterobacter cloacae | 0 | 1 | 1 K.pneumoniae …

Evaluating the Use of Meropenem in Hematologic Patients with Febrile Neutropenia: A Retrospective Observational Single-Cohort Study.

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IgA-producing lymphoplasmacytic lymphoma carrying the chromosomal abnormality t(8;14).

IgA-producing lymphoplasmacytic lymphoma (LPL) is rare and IgH/c-myc translocation is rare in LPL. This is the first report of a case of IgA-producing LPL carrying t(8;14). An 86-year-old woman presented inguinal and intra-abdominal lymph node swelling, and lytic bone lesions in the lumbar vertebrae. A diagnosis of IgA-producing LPL was immunohistochemically made by inguinal lymph node biopsy. The serum IgA level was 1,180 mg/dL, which was revealed to be composed of IgA-λ monoclonal protein. Bone marrow chromosomal analysis demonstrated a complex abnormal karyotype, including t(8;14)(q24;q32),

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… Many WBC and bacteria were noted in the urinary sediment, and multidrug-resistant Citrobacter freundii was detected at more than 10 9 /mL in urine bacterial culture. …

Gram-Negative Taxa and Antimicrobial Susceptibility after Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.

Fecal microbiota transplantation (FMT) has promising applications in reducing multidrug-resistant organism (MDRO) colonization and antibiotic resistance (AR) gene abundance. However, data on clinical microbiology results after FMT are limited. We examined the changes in antimicrobial susceptibility profiles in patients with Gram-negative infections in the year before and the year after treatment with FMT for recurrent Clostridioides difficile infection (RCDI). We also examined whether a history of FMT changed health care provider behavior with respect to culture ordering and antibiotic prescri

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… An analysis of a nosocomial outbreak of carbapenem-resistant Enterobacteriaceae (CRE) found evidence supporting plasmid transfer among Klebsiella pneumoniae , Enterobacter cloacae , and Citrobacter freundii , presumably in hospital sinks, using single-molecule sequencing ( 24 ). …

Multidrug-Resistant Bacteria in Immunocompromised Patients.

The increasing incidence of antibiotic resistance in bacteria is a major problem in terms of therapeutic options, especially in immunocompromised patients, such as patients from intensive care units (ICUs), HIV-positive patients, patients with malignancies or transplant patients. Commensal bacteria, especially anaerobes, serve to maintain microbial stability by preventing overpopulation with pathogenic bacteria. In immunocompromised patients, microbiota imbalance caused by antibiotic therapy and decreased host immunity favors intestinal overpopulation with pathogenic species, leading to increa

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… The most frequently isolated species were E. coli (57%) and K. pneumoniae (16%), followed by Citrobacter freundii (7%), Enterobacter cloacae (6%) and Klebsiella aerogenes (5%). …

Intestinal Microbes and Hematological Malignancies.

Hematological malignancies are diverse, with high malignancy characteristics, poor prognoses, and high mortality rates. The development of hematological malignancies is driven by genetic factors, tumor microenvironment factors, or metabolic factors; however, even when considering all of these factors, one still cannot fully estimate the risk of hematological malignancies. Several recent studies have demonstrated an intimate connection between intestinal microbes and the progression of hematological malignancies, and gut microbes play a primary role in the initiation and progression of hematolo

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… The intestinal microbes of MM patients had higher α-diversity at the genus level and species level, Anaerostipes hadrus , Clostridium saccharobutylicum , and Clostridium butyrate were significantly enriched in healthy donors, and Citrobacter freundii , Klebsiella variicola , Klebsiella pneumoniae , and … freundii , Enterobacter cloacae , Klebsiella aerogenes , Klebsiella variicola , Klebsiella pneumoniae , Streptococcus salivarius , Streptococcus oralis , Streptococcus gordonii , Streptococcus mitis , and Streptococcus pneumoniae compared with healthy donors, while the healthy donors were significantly …

Bloodstream Infections in Hematologic Malignancy Patients With Fever and Neutropenia: Are Empirical Antibiotic Therapies in the United States Still Effective?

BackgroundRising antimicrobial resistance rates may impact the efficacy of empirical antibiotic treatment for febrile neutropenia in high-risk cancer patients. Lacking contemporary data about the epidemiology, antibiotic resistance patterns, and clinical outcomes from bloodstream infections (BSIs) in US cancer patients, it is unclear if current guidelines remain relevant.MethodsIn a cross-sectional study, 14 US cancer centers prospectively identified BSIs in high-risk febrile neutropenic (FN) patients, including those receiving chemotherapy for hematologic malignancies or hematopoietic stem ce

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… Bacterial Isolates Causing Bacteremia a Two Citrobacter freundii, 2 Serratia marcescens, 1 Pantoea agglomerans . b Three Achromobacter sp., 1 Acetobacter , 1 Capnocytophaga , 1 Moraxella catarrhalis , 1 Burkholderia cepacia . …

Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… Fig. 2 Cumulative incidence of CLABSI. autoSCT: autologous stem cell transplantation (n = 164), AA: aplastic anaemia (n = 10) Table 2 Cultured pathogens in CLABSI *In 14 episodes, blood cultures showed 2 different pathogens ** Chrysobacterium indologenes, Citrobacter freundii, Enterococcus casselflavius …

Сепсис, вызванный Clostridium Perfringens у женщины пожилого возраста, больной раком груди: доклад по делу.

ЦЕЛЬ: Сообщить о редком случае заболевания раком груди, у которого септический шок и множественные повреждения органов. В нем анализируются клинические характеристики, патогенные факторы и прогноз, связанные с смешанной инфекцией, вызванной Clostridium perfringens и Escherichia coli, в целях обеспечения основы для раннего выявления и вмешательства аналогичных клинических случаев. МЕТОДЫ: Был проведен ретроспективный анализ клинических данных 75-year-old Женщина, больная раком груди, которая также страдала гипертонией и диабетом. Были резюмированы клинические проявления, результаты этиологическ

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… Clinical and microbiological features of intratumor abscess with bloodstream infection caused by Plesiomonas shigelloides, Citrobacter freundii, Streptococcus mitis/oralis, Clostridium perfringens , and Candida albicans in a patient with cholangiocarcinoma: a case report . …

Risk Factors for Serious Hypotension Induced by Intravenous Acetaminophen in Patients With Hematologic Malignancy.

PURPOSE: Owing to their rapid antipyretic effects and predictable pharmacokinetic properties, acetaminophen (AAP) are commonly administered intravenously to severely ill patients. However, the potential development of hypotension as a consequence of intravenous AAP administration has not been thoroughly addressed. In this study, we aimed to identify the risk factors associated with the occurrence of serious hypotension following intravenous AAP administration during fever in patients with hematologic malignancies. METHODS: This retrospective study included hospitalized patients in the hemato-

Plesiomonas shigelloides Bacteremia: A Scoping Review of Epidemiology, Clinical Characteristics, Outcomes, and Implications of Antimicrobial Stewardship.

Plesiomonas shigelloides, an aquatic Gram-negative bacillus often associated with self-limiting gastroenteritis, has been reported worldwide. However, to date, no reviews have specifically investigated P. shigelloides bacteremia, which is rare and potentially fatal. This scoping review aimed to examine the existing literature to identify the epidemiology, clinical characteristics, antimicrobial susceptibility, and outcomes of P. shigelloides bacteremia. A PRISMA-ScR-guided search of PubMed, Scopus, Web of Science, and Embase identified 22 published cases, all reported as single-patient case re

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… Clinical and Microbiological Features of Intratumor Abscess with Bloodstream Infection Caused by Plesiomonas shigelloides , Citrobacter freundii , Streptococcus mitis / oralis , Clostridium perfringens , and Candida albicans in a Patient with Cholangiocarcinoma: A Case Report J. Infect. …

Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.

Sulopenem (formerly known as CP-70,429, and CP-65,207 when a component of a racemic mixture with its R isomer) is an intravenous and oral pe … lung infection animal models. Studied pathogens included Acinetobacter calcoaceticus, B. fragilis, Citrobacter freundii, Enterobacter cloacae, E. coli, K. pneumoniae, Proteus vulgaris, and Serratia marcescens. These studies reported that overall, sulopenem was non-inferior to carbapenems but appeared to be superior to cephalosporins. A phase III clinical trial (SURE- …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

Роль питания и кишечного микробиома в развитии множественной миеломы и ее болезней-прекурсоров.

Множественная миелома (ММ) — вторая по распространенности гематологическая гелингология, характеризующаяся нерегулируемым моноклонным распространением в костном мозге. Моноклональная гаммопатия неопределённого значения (MMUS) и мрачная миелома (SMM) являются предмалярными условиями, которые могут развиваться до MM. Определение факторов этиологического риска для ММ и его болезней-прекурсоров имеет решающее значение для профилактики. Ожирение, питание, уровень витамина D и изменение кишечного микробиота были определены в качестве факторов образа жизни, влияющих на риск MM и MGUS. При возникновен

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… Eleven opportunistic pathogens ( Raoultella ornithinolytica, Citrobacter freundii, Enterobacter cloacae, Klebsiella aerogenes, Klebsiella variicola, Klebsiella pneumoniae, Streptococcus salivarius, Streptococcus oralis, Streptococcus gordonii, Streptococcus mitis, and Streptococcus pneumoniae ) were …

Gut Microbiota Dysbiosis and Dietary Interventions in Non-Hodgkin B-Cell Lymphomas: Implications for Treatment Response.

Non-Hodgkin B-cell lymphomas are a heterogeneous group of lymphoid malignancies with variable biological behavior, clinical presentation and treatment response. While chemoimmunotherapy remains the cornerstone of their management, growing evidence implicates the gut microbiota as a critical modulator of both lymphomagenesis and therapeutic efficacy. Gut microbiota dysbiosis, characterized by reduced microbial diversity and pathogenic taxonomic shifts, has been observed also in newly diagnosed patients and not just after therapy. This microbial imbalance contributes to mucosal barrier disruptio

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… Notably, this dysbiotic state frequently involves an overrepresentation of Enterobacteriaceae, including species such as Escherichia coli and Citrobacter freundii , and Enterococcaceae such as Enterococcus faecium , whereas healthy individuals demonstrate a higher abundance of beneficial taxa such as …

Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital.

The addition of Biofire® FilmArray® Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (3

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… . | 1 | 0 | 2 | Gram-negative bacteria (n = 93) | 28/41 (68.3%) | 32/37 (86.5%) | 33/45 (73.3%) | 0.158 E. coli | 8 | 10 | 10 | Klebsiella pneumoniae | 6 | 5 | 10 | Pseudomonas aeruginosa | 7 | 7 | 5 | Acinetobacter baumannii | 2 | 1 | 1 | Citrobacter freundii | 1 | 0 | 0 | Enterobacter cloacae …

Abstracts cont.

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Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma.

The gut microbiota, a complex microbial ecosystem closely connected to the liver via the portal vein, has emerged as a critical regulator of liver health and disease. Numerous studies have underscored its role in the onset and progression of liver disorders, including alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This review provides a comprehensive overview of current insights into the influence of the gut microbiota on HCC progre

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… In contrast, in responders, Citrobacter freundii , Azospirillum sp., and Enterococcus durans were prevalent ( 95 ). Furthermore, Ponziani et al. conducted a prospective study on 11 patients with HCC who were treated with tremelimumab and/or durvalumab. …

Clostridium butyricum alleviates multiple myeloma by remodeling the bone marrow microenvironment and inhibiting PI3K/AKT pathway through the gut‒bone axis.

Emerging evidence reveals a strong connection between the gut microbiota and cancer. However, the exact role of gut microbiota dysbiosis in multiple myeloma (MM) is poorly understood, and the therapeutic potential of microbiota-targeted interventions represents a promising strategy that demands urgent mechanistic and translational investigation. First, we conducted a comprehensive microbiome-metabolite analysis between MM patients and healthy individuals. The result revealed a marked compositional difference characterized by reduced abundances of butyrate-producing bacteria and diminished buty

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… Zhou et al. reported that the enrichment of nitrogen-cycling bacteria accelerates MM progression through elevated circulating urea nitrogen. 11 Similarly, Citrobacter freundii exacerbates drug resistance by increasing serum ammonium levels, suggesting that the microbiota as a potential therapeutic target …

The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies.

Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and preclinical experimental evidence has shown that the efficacy of immunotherapy in tumor treatment varies markedly among individuals. The commensal microbiome mainly colonizes the intestinal lumen in humans, is affected by a variety of factors and exhibits individual variation. Moreover, the gut is considered the largest immune organ of the body due to its influence on the immune system. In t

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… .; Trchuris trichiura | [ 94 ] Advanced HCC | 8 | ICB: αPD-1 mAb (nivolumab) | Citrobacter freundii ; Azospirillum sp.; Enterococcus durans ; Akkermansia ; | | [ 95 ] Melanoma | 77 | ICB: αCTLA-4 mAb and αPD-1 mAb combined | | Bacteroides intestinalis | [ 96 ] NSCLC | 88 | ICB: αPD-1 mAb | | Helicobacter …