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Research Progress and Prospects of Flavonoids in the Treatment of Diseases by Regulating Autophagy: A Narrative Review.

Autophagy is an essential mechanism through which cells break down and reuse intracellular proteins and organelles to preserve cellular homeostasis. Under physiological conditions, autophagy primarily exerts a cytoprotective effect; however, aberrant activation or deficiency of autophagy pathways can disturb cellular balance and even trigger apoptosis, thereby contributing to the occurrence and progression of multiple diseases. Flavonoids are natural bioactive components widely distributed in plants, characterized by distinct benefits of synergistic regulation via multiple targets and pathways…

Low flavonoid intake is associated with bilateral hearing impairment in US older adults.

This study investigated the association between dietary flavonoid intake and hearing impairment in older adults aged ≥ 70 years, using cross-sectional data from the National Health and Nutrition Examination Survey 2009-2010 and 2017-2018. Flavonoid intake was estimated from two 24-h dietary recalls and categorised as low or high based on the median intake (85·4 mg/d). Hearing impairment was defined using a pure-tone average > 25 dB in one or both ears. Among the 1492 participants, 55·7 % had bilateral hearing impairment, 15·6 % had unilateral hearing impairment and 28·7 % had normal hearing. T

Phytochemical Characterization of Pouteria guianensis: Optimized Flavonoid Extraction and HPLC Method Validation.

Plant biodiversity of Brazil offers significant potential for the development of phytotherapeutics, highlighting the Pouteria spp. genus. Despite traditional use and ethnopharmacological support, Pouteria species remain underexplored in scientific literature. This study aims to explore the flavonoids class, by optimizing flavonoid extraction from Pouteria guianensis (Aubl.) leaves through response surface methodology and by developing and validating a high-performance liquid chromatography (HPLC) method. Parameters reported in the literature as important for the extraction of this genus were o…

A comprehensive review of Drynariae rhizoma: botany, traditional applications, and active flavonoid components.

OBJECTIVES: Drynaria fortunei, a species within the Drynaria genus, is a widely distributed medicinal plant with abundant resources. Its rhi … hemical investigations have identified a diverse array of compounds in Drynariae rhizoma, including flavonoids, phenolic acids, lignans, steroids, and glycosides. Among these, flavonoids represent the principal active constituents, attracting considerable research attention due to their extensive pharmacological activities. This review systematically integra …

Flavonoids from the stems of Ammopiptanthus nanus and their in vitro and in vivo anti-inflammatory activities.

Ammopiptanthus nanus (M. Pop.) Cheng f. (A. nanus) is known for its anti-rheumatoid arthritis effects in folk medicine. This study conducted an anti-inflammatory activity-guided exploration of A. nanus stem crude extract. Twenty-five flavonoids, including five isoflavonoids with novel structures, were isolated and identified. Their structures were determined by using HRESIMS, NMR, IR, UV, optical rotation data and X-ray crystallography. Among them, compound 1 features a unique dihydropyran skeleton connected to the A-ring of the isoflavone. The obtained flavonoids were screened for their anti-…

Effects of the Flavonoid Diosmin on Post Exercise Muscle Soreness - A Randomized Controlled Trial.

Delayed-onset muscle soreness (DOMS) is hypothesized to be due to reversible damage at the cellular level, affecting both recreational and professional athletes. For elite athletes, the prevalence of DOMS is more pronounced during the beginning of the sports season, when they return to the reality of exercise training after a period of inactivity, thus potentially having a negative impact on performance. Era evaluate the effects of supplementation with the flavonoid diosmin (DSM) on athletic performance and DOMS-related symptoms in the pre-season of a futsal team from the Brazilian women's lea

Neuroprotective Effect of Flavonoid Agathisflavone in the Ex Vivo Cerebellar Slice Neonatal Ischemia.

Agathisflavone is a flavonoid that exhibits anti-inflammatory and anti-oxidative properties. Here, we investigated the neuroprotective effects of agathisflavone on central nervous system (CNS) neurons and glia in the cerebellar slice ex vivo model of neonatal ischemia. Cerebellar slices from neonatal mice, in which glial fibrillary acidic protein (GFAP) and SOX10 drive expression of enhanced green fluorescent protein (EGFP), were used to identify astrocytes and oligodendrocytes, respectively. Agathisflavone (10 μM) was administered preventively for 60 min before inducing ischemia by oxygen and

Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease.

Recent discoveries have shown that enteric glial cells play an important role in different neurodegenerative disorders, such as Parkinson's disease (PD), which is characterized by motor dysfunctions caused by the progressive loss of dopaminergic neurons in the substance nigra pars compacta and non-motor symptoms including gastrointestinal dysfunction. In this study, we investigated the modulatory effects of the flavonoid rutin on the behavior and myenteric plexuses in a PD animal model and the response of enteric glia. Adult male Wistar rats were submitted to stereotaxic injection with 6-hydro

CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus.

Flavonoids are plant-produced secondary metabolites that are found ubiquitously. We have previously reported that apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus (S. aureus), one of the major human pathogens. Apigenin inhibited fluoroquinolone-resistant S. aureus with DNA gyrase harboring the quinolone-resistant S84L mutation but did not inhibit wild-type DNA gyrase. In this study, we describe five flavonoids, quercetin, luteolin, kaempferol, baicalein, and commercially available CID12261165, that show similar antimicrobial activity against fluor…

The Impact of Flavonoid-Loaded Nanoparticles in the UV Protection and Safety Profile of Topical Sunscreens.

Excessive UV radiation exposure is harmful to skin cells since sunburn is accompanied by oxidative burst, leading to a rapid increase in ski … and review articles published in the last 6 years were analyzed. Formulations containing nanosized flavonoids with improved UVA photoprotection and safer toxicological profiles, associated or not with synthetic filters, are promising sunscreens and more clinical investigation must be performed to validate these findings.

Synergistic or antagonistic antioxidant combinations - a case study exploring flavonoid-nitroxide hybrids.

Neurodegenerative diseases impose a considerable medical and public health burden on populations throughout the world. Oxidative stress, an … approach, free radical nitroxide antioxidants were hybridised with a class of natural antioxidants, flavonoids, to form a potential multitargeted antioxidant. Modification of the Baker-Venkataraman reaction achieved the flavonoid-nitroxide hybrids (6-9) in modest yields. Antioxidant evaluation of the hybrids by cyclic voltammetry showed both redox functional …

A Scoping Review on the Effects of Carotenoids and Flavonoids on Skin Damage Due to Ultraviolet Radiation.

Skin exposure to ultraviolet (UV) rays in the sun causes premature ageing and may predispose to skin cancers. UV radiation generates excessive free radical species, resulting in oxidative stress, which is responsible for cellular and DNA damage. There is growing evidence that phytonutrients such as flavonoids and carotenoids may impede oxidative stress and prevent photodamage. We conducted a systematic review of the literature to explore the effects of certain phytonutrients in preventing skin photodamage. We searched the electronic Medline (Ovid) and Pubmed databases for relevant studies publ…

Human Monocyte-Derived Dendritic Cells Are the Pharmacological Target of the Immunosuppressant Flavonoid Silibinin.

Silibinin, a natural polyphenolic flavonoid, is known to possess anti-inflammatory, anticancer, antioxidant, and immunomodulatory properties. However, the effects of Silibinin on the maturation and immunostimulatory functions of human dendritic cells (DC) remain to be elucidated. In this study, we have attempted to ascertain whether Silibinin influences the maturation, cytokine production, and antigen-presenting capacity of human monocyte-derived DC. We show that Silibinin significantly suppresses the upregulation of costimulatory and MHC molecules in LPS-stimulated mature DC and inhibits lipo

The Synthetic Flavonoid Hidrosmin Improves Endothelial Dysfunction and Atherosclerotic Lesions in Diabetic Mice.

In diabetes, chronic hyperglycemia, dyslipidemia, inflammation and oxidative stress contribute to the progression of macro/microvascular complications. Recently, benefits of the use of flavonoids in these conditions have been established. This study investigates, in two different mouse models of diabetes, the vasculoprotective effects of the synthetic flavonoid hidrosmin on endothelial dysfunction and atherogenesis. In a type 2 diabetes model of leptin-receptor-deficient (db/db) mice, orally administered hidrosmin (600 mg/kg/day) for 16 weeks markedly improved vascular function in aorta and me…

Флавоноид на мозге: Кварчен как потенциальный терапевтический агент в нарушениях центральной нервной системы.

Кверцетин является одним из наиболее распространенных, естественно встречающихся флавоноидов, структурно отнесенных к подсемейству флавонола. Это соединение, обнаруженное во многих съедобных и лекарственных растениях либо в свободной, либо в гликозидированной форме, используется в научных целях в течение многих лет, и вряд ли можно ожидать, что оно станет героем какой-то дополнительной истории. Общепризнанный в качестве противовоспалительного агента, герцетин не только ограничивает проницаемость капиллярных судов путем сдерживания гиалуронидаза, но и блокирует циклоксигеназы и липоксигеназы. К

Совпадение в аннотации оригинала
Quercetin is one of the most common, naturally occurring flavonoids, structurally classified to the flavonol subfamily. This compound, found in many edible and medicinal plants either as a free or glycosidated form, has been scientifically exploited for many years, and one could hardly expect it could be a hero of some additional story. Commonly recognized a…

Impact of citrus flavonoid supplementation on inflammation in lipopolysaccharide-induced periodontal disease in mice.

In general, the consumption of flavonoid-rich foods may influence the control/dysregulation of the magnitude and duration of inflammation an … dicating decreased oxidative damage. These results suggest that a diet supplemented with the citrus flavonoids eriocitrin or eriodictyol may aid in the prevention of periodontitis, representing a potential method to enhance local immunity and host defense.

Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review.

Neurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several …

Solvent polarity dependent ESIPT behavior for the novel flavonoid-based solvatofluorochromic chemosensors.

In this work, we explore the excited-state intramolecular proton transfer (ESIPT) mechanisms and relative solvent effects for three novel 3-hydroxylflavone derivatives (i.e., HOF, SHOF, and NSHOF) in acetonitrile, dichloromethane, and toluene solvents. Through calculations, we optimize the structures of HOF, SHOF, and NSHOF. Through the analysis of a series of structural parameters related to hydrogen bonding interactions, it could be found that the hydrogen bonds of the three derivatives are all enhanced in the S1 state, and more importantly, the excited-state hydrogen bonds of HOF are strong

Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021.

Tyrosinase is a multifunctional copper-containing oxidase enzyme that initiates melanin synthesis in humans. Excessive accumulation of melanin pigments or the overexpression of tyrosinase may result in skin-related disorders such as aging spots, wrinkles, melasma, freckles, lentigo, ephelides, nevus, browning and melanoma. Nature expresses itself through the plants as a source of phytochemicals with diverse biological properties. Among these bioactive compounds, flavonoids represent a huge natural class with different categories such as flavones, flavonols, isoflavones, flavan-3-ols, flavanone…

Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen.

Eleven compounds, including nine known flavonoid glycosides (1-4, 6-8, and 10-11), one isoflavone glycoside (5), and a glansreginic acid (9), were isolated from the 80% ethanol extract of commercial Astragali Complanati Semen (ACS). All chemical structures were determined by spectroscopic analyses, including 1D and 2D NMR. Compounds 2, 4, 5, 6, 9, and 10 were isolated and identified from the title plant for the first time. Biological evaluation revealed that all the isolates showed promising anti-NO production, and 1, 2, 3, and 8 were more potent in antioxidant activity than vitamin E. The maj