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Pigmentation effects of blue light irradiation on skin and how to protect against them.

BACKGROUND: Visible light, in particular blue light, has been identified as an additional contributor to cutaneous photoageing. However, cli … e blue light (4 × 60 J cm-2 , 450 nm) irradiation protocol on the volunteers' inner forearms. Using hyperspectral imaging, we assessed chromophore status. In addition, we took chromameter measurements and photographs to assess visible hyperpigmentation. RESULTS: We measured significant changes in chromophore status (P < 0.001 vs baseline), that is of melanin, haemoglo …

Formulating the Li sites of Li-CoOx composites for achieving high-efficiency oxidation removal of formaldehyde over the Ag/Li-CoOx catalyst under ambient conditions.

Oxide supported noble metals are extensively investigated for ambient formaldehyde oxidation, and the Ag-CoOx complex is one promising combi … ratures, respectively. The specific Li+ positions and componential interaction were demonstrated by Hyperspectral imaging (HSI), XRD, SEM, TEM, HAADF mapping, UV-vis DRS and XPS. Moreover, the effect of reactive oxygen exposure on catalytic oxidation of formaldehyde (330-350 mg/m3) was disclosed through CO-TPR and O2-TPD. Compared with the LCO-S and LCO-L, L-CO exhibit …

Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid.

PURPOSE: Hypoxia of the retina and optic nerve head (ONH) is believed to be pivotal in the development of ocular vascular disorders, includi … ized cynomolgus monkey. Measurements were taken using, respectively, an applanation tonometer and a hyperspectral imaging system before and 7, 14, 21, 31 and 41 days after the intravitreal injection of NCX 434 (5.8 mg/eye) or TA equimolar doses (4.0 mg/eye). RESULTS: NCX 434 inhibited (3)H-dexamethasone-specific binding (IC(50)=34±5 nM) on human glucocorticoid recepto …

Effectiveness and cost-effectiveness of ozone treatment in patients with paraesthesia (numbness, tingling) secondary to chemotherapy-induced peripheral neuropathy: randomized, triple-blind clinical trial (OzoParQT).

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, disabling side effect of taxanes and platinum drugs, often compromising quality of life and treatment continuity. Existing therapies are few and largely ineffective. Given this unmet need, our prior experience suggests ozone therapy may offer clinical benefit as an adjuvant treatment. METHODS: OzoParQT is a Phase II–III randomized, triple-blind trial including 42 adults (≥ 18 years) with any cancer and Grade ≥ 2 CIPN (numbness and/or tingling) lasting ≥ 3 months. Eligible patients must be off neurotoxic chemotherapy f

Machine learning analysis of multispectral imaging and clinical risk factors to predict amputation wound healing.

OBJECTIVE: Prediction of amputation wound healing is challenging due to the multifactorial nature of critical limb ischemia and lack of objective assessment tools. Up to one-third of amputations require revision to a more proximal level within 1 year. We tested a novel wound imaging system to predict amputation wound healing at initial evaluation. METHODS: Patients planned to undergo amputation due to critical limb ischemia were prospectively enrolled. Clinicians evaluated the patients in traditional fashion, and all clinical decisions for amputation level were determined by the clinician's j

Bioactive adrenomedullin dynamics and microcirculatory changes in a porcine model of hemorrhagic shock.

BACKGROUND: Hemorrhagic shock is a leading cause of preventable trauma death, marked by impaired oxygen delivery and endothelial dysfunction … ch). Macrocirculation was assessed via vital signs and pulse contour analysis; microcirculation via hyperspectral imaging (tissue oxygenation, hemoglobin, water index). RESULTS: Fluid resuscitation improved macrohemodynamics and microcirculatory oxygenation versus control and noradrenaline, which failed to sustain perfusion and impaired microcirculatory oxygenation. B …

EARLY AND CONCOMITANT ADMINISTRATION OF NOREPINEPHRINE AND ILOMEDIN IMPROVES MICROCIRCULATORY PERFUSION WITHOUT IMPAIRING MACROCIRCULATION IN AN INTESTINAL ISCHEMIA-REPERFUSION INJURY SWINE MODEL: A RANDOMIZED EXPERIMENTAL TRIAL.

Background: Intestinal ischemia-reperfusion injury is associated with both macrocirculatory and microcirculatory failure. Association of a v … tory (Sublingual with SideStream Dark Field system and intestinal hemoglobin oxygen saturation with hyperspectral imaging) measurements and biological analysis (biomarkers of endothelial dysfunction) were performed. Results: There were no significant differences in the MAP ( P = 0.499) and the CI ( P = 0.659) between the three groups. Perfused vessel density in subling …

Protocol for assessment of pain biomarkers in orthopaedic patients undergoing total knee arthroplasty in a tertiary care hospital and neuroimmunopharmacology laboratory in South Australia: a cross-sectional matched-subject observational study.

INTRODUCTION: Knee osteoarthritis is a leading cause of pain and disability and frequently results in total knee arthroplasty (TKA). Decisio … stimulated ex vivo with toll-like receptor 2 and 4 agonists to quantify IL-1β release. In parallel, hyperspectral imaging will characterise unstimulated immune cell phenotypes. Multivariable statistical and machine-learning approaches will relate biomarker profiles to pain and psychological PROMs. ETHICS AND DISSEMINATION: The study has been approved by the Southern A …

Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells.

BACKGROUND: Airborne exposure to nanomaterials from unintended occupational or environmental exposures or as a consequence of product use ma … T3, ST3GAL4, ST6GAL1, IL-10), localized sialic acid receptors, and assessed mitochondrial function. Hyperspectral imaging analysis was performed to map the SWCNTs and virus particles in fixed SAEC preparations. We additionally performed characterization analysis to monitor SWCNT aggregate size and structure under biological conditions using dynamic light scattering (DL …

Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimer's dementias.

Familial British dementia (FBD) and familial Danish dementia (FDD) are autosomal dominant forms of dementia caused by mutations in the integral membrane protein 2B (ITM2B, also known as BRI2) gene. Secretase processing of mutant BRI2 leads to secretion and deposition of BRI2-derived amyloidogenic peptides, ABri and ADan that resemble APP/β-amyloid (Aβ) pathology, which is characteristic of Alzheimer's disease (AD). Amyloid pathology in FBD/FDD manifests itself predominantly in the microvasculature by ABri/ADan containing cerebral amyloid angiopathy (CAA). While ABri and ADan peptide sequences

Task-Specific Multimodal Imaging and Spectroscopy for Post-Mortem Interval Assessment in Human Skeletal Remains: An Exploratory Decision-Support Framework.

Background/Objectives: Estimating the post-mortem interval (PMI) of human skeletal remains remains challenging because bone undergoes struct … five PMI classes ranging from 0-2 weeks to >100 years and examined using micro-computed tomography, hyperspectral imaging, handheld and microscopic Raman spectroscopy, and NIR-ONE spectroscopy. Repeated acquisitions were aggregated at the physical-sample level. Four targeted diagnostic contrasts were defined for the present reanalysis: archaeological class 5 versus cla …

AI-Driven Food Fraud Detection Systems: A Critical Systematic Review of the Detection-Prevention Gap.

The economic impact of food fraud is difficult to quantify precisely, because fraud is structurally designed to evade detection; available e … , frequently in data-fusion combinations), followed by gas-chromatography-based systems (16/83) and hyperspectral imaging (13/83). Classical machine learning predominated (57/83 studies coded as classical ML, with a further 11 hybrid ML/DL designs and 12 deep-learning-only designs). A direct statistical comparison found no significant difference in reported accuracy be …

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

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… Comparative research was performed between quantitative fluorescence angiography and hyperspectral imaging for intestinal ischemia evaluation, as proposed by Barberio [ 70 ]. Splitting arcade branches generated ischemia bowel in hyperspectral imaging and fluorescence-based AR. … Fluorescence angiography was less accurate than hyperspectral imaging. Hyperspectral imaging-based augmented reality may measure intestinal ischemia intraoperatively without contrast. Poor arterial blood flow and venous congestion generate anastomotic issues that must be addressed together. …

Глубинные пространственные омики MLADI-MS, управляемые квантовой каскадной лазерной микроскопией среднего инфракрасного изображения.

В пространственной &quot;omics &quot; высокоуверенные молекулярные идентификации необходимы для исследования сложной биологии и для пространственной биомаркировки. Однако нынешняя масс-спектрометрическая съемка (MSI) на основе пространственной "омики" должна скомпрометировать скорость получения данных и глубину биохимического профилирования. Здесь мы введём быструю, без этикеток квантовую каскадную лазерную микроскопию среднего инфракрасного изображения (QCL-MIR), чтобы направить MSI в высокоинтересные области тканей, такие маленькие, как гломерули почки, культурные многоклеточные сфероидные я

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… QCL-MIR imaging in sweep scan mode for tissue segmentation and definition of regions-of-interest (ROI) MIR hyperspectral imaging data of tissue specimens was recorded in sweep scan mode within a spectral range of 950–1800 cm −1 , covered by four QCL modules, with a spectral sampling interval of 4  …

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

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… Intraoperative visualization of cerebral oxygenation using hyperspectral image data: A two-dimensional mapping method. Int. J. Comput. Assist Radiol. Surg. 2014;9:1059–1072. doi: 10.1007/s11548-014-0989-9. 93. … Hyperspectral imaging for in vivo monitoring of cold atmospheric plasma effects on microcirculation in treatment of head and neck cancer and wound healing. Clin. Plasma Med. 2017;7-8:52–57. doi: 10.1016/j.cpme.2017.09.002. 98. …

Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart.

Lung cancer and cardiovascular disease pose persistent threats to human health, despite advancements in targeted therapy, percutaneous coronary intervention, and drug treatments. Challenges such as side effects, drug resistance, hospitalization rates, and mortality remain high. These diseases are closely linked, sharing common risk factors and intricately influencing each other. This study aims to investigate the interplay between lung disease and cardiovascular disease by examining changes in cardiac metabolites and protein expression using spatial metabolomics and 4D-DIA quantitative proteom

Относительная эффективность аморфного силика, Малатиона и пиримифоза метила для контроля над ситофилом оризойе и триболием кастанеум и их долгосрочное воздействие на консервированный пшеницу в лабораторных условиях.

Относительная эффективность аморфной силикатной пыли, малатиона и пиримифоса метила была оценена по отношению к С. Оризае и Т. кастанему в пшенице, хранящейся в лабораторных условиях. На эффективность инсектицидов влияют такие физические свойства, как размер частиц, площадь поверхности, плотность навалом и способность к адсорбции масла/воды. Самая высокая токсичность, в частности Ваккер HDK H20 (ЛК50) 19.4 мг/100 g на 12% Влажность). Осадок силика, сипернат 22, хотя и менее мощным (LC50 = 46.6 мг/100 g) демонстрировала последовательную эффективность при различных уровнях влажности, делая ее по

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… Effect of synthetic amorphous silica powder on the cuticle of Tribolium castaneum and Sitophilus oryzae using hyperspectral imaging technique. Pest Manag. Sci. 2020;76:314–323. doi: 10.1002/ps.5517. …

Spatiotemperal Dynamics of Osteoarthritis: Преобразование значений от стенда до Бедсайда.

Остеоартрит (OA) представляет собой многогранное дегенеративное совместное расстройство, вызванное различными факторами риска, такими, как возраст, механический стресс, воспаление и метаболическое воздействие. Эти элементы способствуют его разнообразным фенотипам и эндотипам, что подчеркивает имманентную сложность болезни. Участие нескольких тканей и их взаимодействие еще больше осложняет расследование ОА. Нынешние ограничения в области технологий пространственного фенотификации в сочетании со сложной сетью многофакторных взаимодействий препятствуют обнаружению надежных ранних диагностических

Применение методов извлечения дискриминирующих и глубоких элементов для полного анализа слайдов: обследование.

Цифровые патологические технологии, включая целые слайды, значительно улучшили современные клинические методы, облегчая хранение, просмотр, обработку и совместное цифровое сканирование стеклянных слайдов. Исследователи предложили различные решения в области искусственного интеллекта (АИ) для применения в цифровой патологии, такие, как автоматизированный анализ изображений, для извлечения диагностической информации из WSI в целях повышения производительности, точности и воспроизводимости патологии. Методы экстракции особей играют решающую роль в преобразовании первичных данных об образе в значи

Preliminary Planning for Mars Sample Return (MSR) Curation Activities in a Sample Receiving Facility (SRF).

The Mars Sample Return Planning Group 2 (MSPG2) was tasked with identifying the steps that encompass all the curation activities that would happen within the MSR Sample Receiving Facility (SRF) and any anticipated curation-related requirements. An area of specific interest is the necessary analytical instrumentation. The SRF would be a Biosafety Level-4 facility where the returned MSR flight hardware would be opened, the sample tubes accessed, and the martian sample material extracted from the tubes. Characterization of the essential attributes of each sample would be required to provide enoug