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Tumor angiogenesis as a target for dietary cancer prevention.

Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain,

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… All parts of the pomegranate contain high levels of ellagitannins, of which the primary type is punicalagin. … Effects of pomegranate extract (POMx)—derived from the skin and seeds of the pomegranate fruit—have been shown on endothelial cells (HUVECs) and human prostate cancer cells (LNCaP line) in vitro [ 261 ]. …

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis.

Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonu

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… Pomegranate In folk medicine, pomegranate has long been used to treat inflammatory processes in OA [ 69 , 70 ]. The high content of polyphenols and tannins endows pomegranate with significant antioxidant activity [ 65 , 71 ]. … Pomegranate anthocyanins and polyphenols have an anti-inflammatory effect. It is known [ 12 , 28 ] that high doses of pomegranate juice injected into mice with OA reduced joint damage and promoted proteoglycan preservation. …

Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

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… Several studies have examined the effect of interventions with pomegranate products in prostate cancer patients, showing that pomegranate juice administration (8 oz per day for up to 33 months) is well tolerated. … The peel and fruit of pomegranates and walnuts are rich in ellagitannins, being punicalagin ( Figure 7 ) the most abundant ellagitannin in pomegranate [ 240 ]. …

< < Холистическое управление множественной миеломой > > : доклад по делу < < Терапия Сидды > > как дополнение к режиму Бортезомиба-Леналидомида-Дексаметасона (БЛД).

Множественная миелома (ММ) — сложная гематология, характеризующаяся клональным распространением плазменных клеток в костном мозге. Это вторая по распространенности гематологическая халатность, которая проявляется у пожилых пациентов. Инкорпорирование дополнительной медицины в обычные методы лечения рака все чаще наблюдается среди пациентов, что обусловлено такими факторами, как управление симптомами, целостное благосостояние и культурная увязка. В настоящем докладе представлена информация о комплексном управлении деятельностью 65-year-old Пациент мужского пола диагностировал ММ, который получа

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… Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Kim ND, Mehta R, Yu W, et al. Breast Cancer Res Treat. 2002;71:203–217. doi: 10.1023/a:1014405730585. 13. … Pomegranate for prevention and treatment of cancer: an update. Sharma P, McClees SF, Afaq F. Molecules. 2017;22 doi: 10.3390/molecules22010177. …

Punicalagin Targets FDX1 to Induce Cuproptosis for the Treatment of Gastric Cancer.

Gastric cancer represents the fifth most common malignancy globally and the third leading cause of cancer-related deaths. Due to its insidious early symptoms and frequent metastasis at diagnosis, the survival rate remains dismal. There is thus an urgent clinical need for novel therapeutic agents. Innovative strategies combining traditional chemotherapy with interventions that induce novel cell death pathways represent a promising translational direction for improving patient outcomes. Punicalagin (PUN), a natural polyphenol derived from pomegranate, exhibits potent antioxidant and broad-spectr…

The Power of Phytochemicals Combination in Cancer Chemoprevention.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit c

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… Ellagic acid, pomegranate and prostate cancer — a mini review. Journal of Pharmacy and Pharmacology. 2008;60:139–44. doi: 10.1211/jpp.60.2.0001. 131. Wang N, Wang Q, Tang H, Zhang F, Zheng Y, Wang S. et al. … Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9. Cancer biology & therapy. 2017;18:990–9. doi: 10.1080/15384047.2017.1394542. 133. Lernoux M, Schnekenburger M, Dicato M, Diederich M. …

Dietary Polyphenols and Their Biological Significance

Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis, anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascular protection, improvement of the endothelial function, as well as inhibition of angiogenesis and cell proliferation activity. Most of these biological actions have bee

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… Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease Neurobiol. Dis 2006 24 506 515 17010630 10.1016/j.nbd.2006.08.006 7 Hollman P.C. van Trijp J.M. Buysman M.N. van der Gaag M.S. Mengelers M.J. de Vries J.H. Katan M.B. … Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice Clin. Chim. Acta 2004 348 63 68 15369737 10.1016/j.cccn.2004.04.029 29 Rangkadilok N. Sitthimonchai S. Worasuttayangkurn L. Mahidol C. Ruchirawat M. …

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to po

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… Pomegranate juice has also been muted to exert some antileukemic effects; this was reported in a 44-year-old Caucasian man who was diagnosed with a T cell lymphoblastic lymphoma but had spontaneous remission without any chemotherapy treatment. … The patient admitted to regularly drinking pomegranate juice, during the period after diagnosis. However, there was a tumor recurrence. Pomegranate juice extracts could be speculated to have caused the initial spontaneous remission ( 211 ). …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… According to these results, in an experimental assay it was observed that pomegranate juice and resveratrol, orally administered to mice mothers, provide significant protection to their newborn pups against the brain damage caused by hypoxic-ischemic insult. … Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatric Research. 2005;57(6):858–864. doi: 10.1203/01.PDR.0000157722.07810.15. 86. West T., Atzeva M., Holtzman D. M. …

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

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… Abbreviations Apple pectin (AP), Fiber pectin (FP), High methoxy pectins (HP), Low methoxy pectins (LP), Low-molecular-weight CP (LCP), Modified pectin (MP), Modified citrus pectin (Pect-MCP), Protein galectin 3 (Gal-3), Pomegranate fruit extract (PFE), Pectin extract (GW), PectaSol-C Modified Citrus … Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice Carcinogenesis 2007 28 163 173 10.1093/carcin/bgl145 16920736 74. Nangia-Makker P. Hogan V. Honjo Y. Baccarini S. Tait L. Bresalier R. Raz A. …

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma.

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabolites depended on the expression levels of certain non-coding RNAs, in particular, of small microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The development of tumor resistance towards antimetabolites was regulated by non-coding RNAs. An overview of the interplay between gemcitabine/pemetrexed antimetabolites and non-coding RNAs in mesothelioma is provided. Further to th

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… MiR-148a was upregulated by caffeic acid, miR-15b by mangiferin (from mango) and miR-34a by pomegranate extract rich in polyphenolic components [ [142] , [143] , [144] ]. … Antiproliferative effects of polyphenols from pomegranate rind ( Punica granatum L .) on EJ bladder cancer cells via regulation of p53/miR-34a axis Phytother Res. 29 2015 415 422 25572695 10.1002/ptr.5267 145 Henwood J.M. Brogden R.N. Etoposide. …

New Treatment Strategies Making an Impact in Multiple Myeloma.

Even though multiple myeloma remains incurable, mean overall survival has improved dramatically as newer game-changing therapies enter the scene. At the same time, treatment decisions and the management of toxicities related to newer drug regimens are becoming more complex.

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… "Ensure that antidiarrheals are at home, and avoid vitamin C and grapefruit, star fruit, and pomegranates," she advised. Other toxicities include fatigue, nausea and vomiting, peripheral edema, low appetite, fever, myelosuppression, and electrolyte abnormalities. …

Карвацоль Ойл как нейропоохранный агент: обзор дизайна исследований и последних достижений.

Нейродегенеративные заболевания в основном воспринимаются как болезни стареющего населения, однако сегодня в день эти заболевания представляют угрозу для населения всех возрастных групп, несмотря на значительное улучшение качества жизни. Согласно сообщениям, почти все основные масла (ЭО) обладают определенными нейрозащитными способностями и на протяжении столетий использовались в качестве добавок к хорошему психическому здоровью. Этот обзор свидетельствует о терапевтическом потенциале одного такого монотерпенового фенола, карвакрула (CV), который может быть использован в качестве основного тер

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… anti-AChE activity of CV was proposed to be dependent on the concentration and the target tissues. 3 | In vivo | [ 43 ] | Solution | 73 mg/kg | 2 | Male Wistar albino rats | IP | Biochemical analysis | CV protected the sciatic nerve tissues against methotrexate (MTX)-induced oxidative stress better than pomegranate … Neuroprotective Effects of Carvacrol and Pomegranate against Methotrexate-Induced Toxicity in Rats. Eur. Rev. Med. Pharmacol. Sci. 2013;17:2988–2993. 44. Wang P., Luo Q., Qiao H., Ding H., Cao Y., Yu J., Liu R., Zhang Q., Zhu H., Qu L. …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Pomegranate seed oil has ability to inhibit TPA induced skin cancer in the mice [ 84 ]. Antioxidant activity of EOs has been reported to be helpful in the scavenging of free radicals generated in the diseased state, leading to the cancer prevention. … 0034284901 10967450 10.1016/s0378-8741(00)00194-x 83 Gali-Muhtasib HU Affara NI Chemopreventive effects of sage oil on skin papillomas in mice Phytomedicine 2000 7 2 129 136 2-s2.0-0034069142 10839216 10.1016/S0944-7113(00)80085-9 84 Hora JJ Maydew ER Lansky EP Dwivedi C Chemopreventive effects of pomegranate …

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.

The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a

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… Resveratrol inhibits angiogenesis through HIF‐1α‐dependent inhibition of VEGF. [ 147 ] Ellagitannin is the main component of the high content of polyphenols in pomegranate (Punica granatum L.) known as “nature's power fruit”, which has potent antioxidant and anti‐inflammatory properties. [ 55 ] Pomegranate … Angiogenesis is inhibited by HIF‐1α‐dependent inhibition of VEGF135. [ 147 ] Pomegranate | Ellagitannin | Ellagitannin has powerful anti‐inflammatory and antioxidant functions and has an inhibitory effect on breast cancer and prostate cancer. [ 55 ] | Inhibit the growth of MCF‐7 breast cancer cells by …

Берберин защищает от поведенческого дефицита, дисфункции памяти и каллозаального обезвоживания в мышах C57BL/6.

ЦЕЛИ: Множественный склероз (MS) — неврологическое расстройство, характеризующееся постепенным обезвоживанием и нейроинфламмацией. Берберин, производный растительным изоквинолоидным алкалоидом, обнаруженным в берберских породах, обладает заметными антивоспалительными и антиоксидантами. Цель этого исследования состояла в том, чтобы оценить защитный эффект берберина от интоксикации чайников в мышах C57BL/6. МАТЕРИАЛЫ И МЕТОДЫ: C57BL/6 Мыши получали пищевые продукты, содержащие чашечник (0,2% по весу) в течение пяти недель и проходили одновременно курс лечения берберина (5 или 10 мг/кг). Была про

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… Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats. Avicenna J Phytomed. 2026;16:192–203. doi: 10.22038/ajp.2025.26495. 36. Omotoso GO, Ukwubile II, Arietarhire L, Sulaimon F, Gbadamosi IT. …

Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview.

Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and

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… Several herbal extracts and components could hinder SARS-CoV-2 replication in vitro and relieve COVID-19 symptoms in vivo in experimental and clinical settings such as Echinacea purpurea extract, Cuphea Ignea extract, Pomegranate Peel extract and juice (Punica Granatum), Clove ( Syzygium aromaticum L …

Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment.

BackgroundRibonucleotide reductase (RR) is a key enzyme in tumor proliferation, especially its subunit-RRM2. Although there are multiple therapeutics for tumors, they all have certain limitations. Given their advantages, traditional Chinese medicine (TCM) monomers have become an important source of anti-tumor drugs. Therefore, screening and analysis of TCM monomers with RRM2 inhibition can provide a reference for further anti-tumor drug development.AimTo screen and analyze potential anti-tumor TCM monomers with a good binding capacity to RRM2.MethodsThe Gene Expression Profiling Interactive An

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… Pomegranate for Prevention and Treatment of Cancer: An Update. Molecules. 2017;22 doi: 10.3390/molecules22010177. 3. Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681–706. doi: 10.1146/annurev.biochem.75.103004.142443. 4. …

Терапевтическая ориентация на нейроинфламацию, вызванную ожирением, и нейродегенерацию.

Ожирение является одним из основных из изменяемых факторов риска, ведущих к нейроинфламмации и нейродегенерации. Чрезмерное содержание жира в ожирении способствует постепенному проникновению иммунных клеток в жировые ткани, что приводит к высвобождению провоспалительных факторов, таких, как цитокины и адипокины. Эти подстрекательские посредники циркулируют по кровотоку, пропагандируя воспаление как на периферии, так и в центральной нервной системе. Гут дисбиоз, который приводит к утечке кишечного барьера, усугубляет воспаление и играет важную роль в увязке ожирения с патогенезом нейроинфламмац

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… The administration of pomegranate seed oil, juice, fruit and leaves also reduced oxidative stress within rats that were fed a high fructose diet and led to lowered ACHE activity ( 161 ). …

Stage-specific treatment of colorectal cancer: A microRNA-nanocomposite approach.

Colorectal cancer (CRC) is among the leading causes of cancer mortality. The lifetime risk of developing CRC is about 5% in adult males and females. CRC is usually diagnosed at an advanced stage, and at this point therapy has a limited impact on cure rates and long-term survival. Novel and/or improved CRC therapeutic options are needed. The involvement of microRNAs (miRNAs) in cancer development has been reported, and their regulation in many oncogenic pathways suggests their potent tumor suppressor action. Although miRNAs provide a promising therapeutic approach for cancer, challenges such as

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… in colorectal cancer patients | CRC | Biological: analysis of circulating exosomes, size, and number NCT04294953 | Unknown/II | Efficacy of perioperative duloxetine as a part of multimodal analgesia in laparoscopic colorectal cancer surgery | CRC | Drug: duloxetine NCT01916239 | Completed/I, II, | Pomegranate … extract supplementation in colorectal cancer patients | CRC | Dietary supplement: standard pomegranate extract formulation NCT03362684 | Completed | PETACC-8 miR-31–3p and miR-31–5p ancillary study | CRC | Drug: Cetuximab, FOLFOX NCT02876133 | Unknown | Narrow band imaging versus white light for colonoscopy …