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[Endothelium and endogenous fibrinolysis].

Reduced activity of the endogenous fibrinolytic system contributes to intramural deposition of microthrombi in atherogenesis and to intraluminal deposition of thrombi leading to acute complications of atherosclerosis such as acute coronary syndromes. Endogenous fibrinolytic activity is predominantly regulated by the plasminogen activator inhibitor type 1 (PAI-1). Increased activity of PAI-1 leading to reduced endogenous fibrinolytic activity has been identified as an important independent risk factor for cardiovascular disease. Vascular endothelial cells form a barrier between the circulating

IgA Nephropathy: Beyond the Half-Century.

In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin-angiotensin-aldosterone system inhibitors (RAAS-Is), tonsillectomies, and glucocorticoids are currently used worldwide. There have been great strides in the past 20 years since the discoveries of the specific dysregulation of mucosal immunity, galactose-deficient IgA1 (Gd-IgA1), and Gd-IgA1 immune complexes in patients with IgAN. According to these findings, a multi-hit hypothesis was developed, and this multi-hit hypothesis

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… Age: ramipril-alone group, 34.9 ± 11.2 years; prednisone plus-ramipril group: 31.8 ± 11.3 years. Histological grade: moderate. UP > or = 1.0 g/day, and eGFR > or = 5 mL/min/1.73 m 2 | Ramipril-alone group ( n = 23): dose arrangement for BP under 120/80 mmHg with ramipril (starting with 2.5 mg/day). … The mean rate of eGFR decline was higher in the ramipril alone group than in the combination therapy group (−6.17 ± 13.3 vs. −0.56 ± 7.62 mL/min/1.73 m 2 ). Prednisone plus-ramipril treatment reduced 24-h proteinuria more than ramipril alone during the first 2 years. …

What have we learned from the current trials?

Even well-conducted randomized controlled trials can only reduce uncertainty, not eliminate it. The trials presented in this article all hav … nephropathy now belongs to ARBs. In contrast, however, the HOPE trial showed that ACE, specifically ramipril, had the greatest evidence for prevention of cardiovascular outcomes in patients with renal insufficiency, regardless of diabetic status. Cardiovascular outcomes were secondary end points in the RENAAL and IDNT trials, and with the exception of hear …

Treatment of hypertension in peripheral arterial disease.

BACKGROUND: Peripheral arterial disease (PAD) causes considerable morbidity and mortality. Hypertension is a risk factor for PAD. Treatment … tudy there was a significant reduction in the number of cardiovascular events in patients receiving ramipril (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.58 to 0.91; n = 1725). In the second trial using perindopril (n = 52) there was a marginal increase in claudication distance but no change in ABI and a reduction in maximum walking distance. A tr …

Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system-from molecular mechanisms to therapeutic applications.

Few millions of new cancer cases are diagnosed worldwide every year. Due to significant progress in understanding cancer biology and developing new therapies, the mortality rates are decreasing with many of patients that can be completely cured. However, vast majority of them require chemotherapy which comes with high medical costs in terms of adverse events, of which cardiotoxicity is one of the most serious and challenging. Anthracyclines (doxorubicin, epirubicin) are a class of cytotoxic agents used in treatment of breast cancer, sarcomas, or hematological malignancies that are associated w

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… Based on their molecular structure ACEIs can be divided into three groups: dicarboxylate-containing agents (enalapril, ramipril, perindopril, lisinopril), sulfhydryl-containing agents (captopril, zofenopril) and phosphonate-containing agents (fosinopril). … Small prospective, single-arm study evaluated protective effects of ramipril or/and bisoprolol in 35 non-Hodgkin lymphoma patients with high risk of anthracycline cardiotoxicity [ 158 ]. …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… Moreover, angiotensin-converting enzyme inhibitors and specifically ramipril have been shown to reduce the risk of myocardial infarction, stroke or vascular death by 25% in patients with PAD [ 51 ]. … Ramipril has also been associated with improvement in walking distance in stable claudicants in a single study and should be considered in all patients with symptomatic PAD who do not have any contraindications to this class of drugs [ 52 ]. …

Ангина из-за обструкционистской болезни коронарной артерии в сочетании с периферической болезнью артерии.

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… His was on aspirin 100 mg once daily, atorvastatin 20 mg once daily, ramipril 5 mg once daily, and metformin 1000 mg twice daily. His blood pressure was 145/90 mmHg and heart rate was 90 b.p.m. at admission. … The patient has treated with ramipril 5 mg, which was switched to the ramipril/hydrochlorothiazide 10/12.5 mg combination and metoprolol succinate 50 mg once daily was added to the regimen. …

Недооцененная причина гиперкальцемии: доклад о деле о синдроме Молка-Алкали.

Молоко-щелочный синдром (MAS) был впервые охарактеризован как отрицательное воздействие режима Sippy, в котором содержится большое количество бикарбоната натрия, что создает клинический сценарий, в котором гиперкальцемия, метаболический алкалоз и острая почечная недостаточность могут создать одновременные характеристики MAS. Синдром возобновился из-за широкого применения добавок кальция. A 50-year-old Белая женщина была доставлена в отделение скорой помощи ее врачом-терапевтом после случайного обнаружения гиперкальцемии во время проверки на усталость. У нее диагностировали острую почечную недо

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… Discussion Our patient was taking 3 g of calcium carbonate daily along with alfacalcidol and ramipril, which increased the risk of MAS. … Calcium carbonate, alfacalcidol, and ramipril were avoided during hospitalization as they have contributory effects on the escalation of hypercalcemia and renal dysfunction. …

Biologics and Non-Biologics Immunosuppressive Treatments for IgA Nephropathy in Both Adults and Children.

Immunoglobulin A nephropathy represents the most prevalent cause of glomerulonephritis worldwide and may lead to renal failure in a relevant number of cases in both paediatric and adult subjects. Although their pathogenesis is still largely unclear, evidence of immune abnormalities provides the background for the use of immunosuppressive drugs, such as corticosteroids, calcineurin inhibitors, and antiproliferative and alkylating agents. Unfortunately, these treatments fail to achieve a sustained remission in a significant percentage of affected patients and are burdened by significant toxiciti

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… Manno et al. [ 19 ], in an RCT including 97 biopsy-proven IgAN patients, reported that the combination of CS and ramipril versus ramipril significantly reduced proteinuria and the risk of a renal function decrease at 2 years of follow-up. … Manno et al., 2009 [ 19 ] | RCT | 8 | 97 | Prednisone 1 mg/kg/day for 2 months and then tapered by 0.2 mg/kg/day every month, plus ramipril vs. ramipril | Combination of steroids and ramipril may provide additional benefits compared with ramipril alone in preventing the progression of renal disease. …

Bortezomib Treatment for Refractory PLA2R-Positive Membranous Nephropathy.

INTRODUCTION: B-cell depletion has been shown to be an effective strategy for the majority of patients with membranous nephropathy (MN), and in PLA2R-positive MN, immunologic remission (improvement or elimination of measurable serum anti-PLA2R antibodies) precedes renal remission. Yet, cases exist of patients who do not achieve immunologic remission despite achieving peripheral B-cell depletion. This has led to the hypothesis that some patients have plasma cells that are responsible for producing anti-PLA2R antibodies. CASE PRESENTATION: A 66-year-old man with a past medical history of hypert

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… doses over 2 weeks) after having failed rituximab therapy [ 10 ], and a second of a patient with severe nephrotic syndrome due to MN who experienced a complete remission in proteinuria with bortezomib therapy (1.6 mg/m 2 on days 1, 4, 8, and 11) after having failed treatment with high dose steroids and ramipril …

Repurposing Pharmaceuticals Previously Approved by Regulatory Agencies to Medically Counter Injuries Arising Either Early or Late Following Radiation Exposure.

The increasing risks of radiological or nuclear attacks or associated accidents have served to renew interest in developing radiation medical countermeasures. The development of prospective countermeasures and the subsequent gain of Food and Drug Administration (FDA) approval are invariably time consuming and expensive processes, especially in terms of generating essential human data. Due to the limited resources for drug development and the need for expedited drug approval, drug developers have turned, in part, to the strategy of repurposing agents for which safety and clinical data are alrea

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… Captopril, lisinopril (Prinivil), enalapril (Vasotec), and ramipril (Altace) all appear to mitigate radiation-induced nephropathy in rats. Captopril has been shown to be a better mitigator than lisinopril, enalapril, or ramipril. … Administration of ramipril reduced the frequency of paralysis at higher photon doses (LINAC - linear accelerator) and also for exposures with high-LET carbon ions, suggesting that ramipril’s effect is independent of the radiation quality ( Saager et al., 2020 ). …

Cardiotoxicity after cancer treatment: a process map of the patient treatment journey.

Background/aimCardiotoxicity is a potential complication of anticancer therapy. While guidelines have been developed to assist practitioners, an effective, evidence based clinical pathway for the treatment of cardiotoxicity has not yet been developed. The aim of this study was to describe the journey of patients who developed cardiotoxicity through the healthcare system in order to establish baseline data to inform the development and implementation of a patient-centred, evidence-based clinical pathway.MethodsMixed-methods design with quantitative and qualitative components using process mappi

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… clonidine, clopidogrel, digoxin, diltiazem, enalapril, enoxaparin, eprosartan, exemestane, frusemide, ibandronate, irbesartan, itraconazole, ivabradine, letrozole, lisinopril, metoprolol, telmisartan/hydrochlorothiazide, nebivolol, olmesartan, oxycodone, pantoprazole, perindopril, prazosin, prednisolone, ramipril … clonidine, clopidogrel, digoxin, diltiazem, enalapril, enoxaparin, eprosartan, exemestane, frusemide, ibandronate, irbesartan, itraconazole, ivabradine, letrozole, lisinopril, metoprolol, telmisartan/hydrochlorothiazide, nebivolol, olmesartan, oxycodone, pantoprazole, perindopril, prazosin, prednisolone, ramipril …

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

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… Aspreva Lupus Management Study (ALMS) trials were able to reassess the predictive value of proteinuria response to induction and maintenance therapy as a surrogate for CKD progression. 95 Similar attempts were made on “failed” diabetes trials such as ONgoing Telmisartan Alone and in combination with Ramipril … Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome. Kidney Int. 2003;63:438–446. doi: 10.1046/j.1523-1755.2003.00779.x. 65. Tomas N.M., Beck L.H., Jr., Meyer-Schwesinger C. …

Kidney failure in the course of focal segmental glomerulonephritis in a patient after alloHSCT - a case study and review of the literature.

Nephrotic syndrome is a rare complication of allogeneic haematopoietic stem cell transplantation (alloHSCT). Its pathogenesis is not fully understood. Membranous nephropathy and minimal change disease are the most common causes of nephrotic syndrome. Nephrotic syndrome occurs more frequently in people with chronic graft-versus-host disease (GvHD). Glucocorticosteroids and cyclosporine are the most common treatments, but their use is associated with the risk of side effects and variable responses. We present a case of a patient after alloHSCT with advanced GvHD who developed nephrotic syndrome

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… Nephroprotection with ramipril was introduced by a haematologist, and proteinuria slightly declined. In March 2021, creatinine concentration was 1.4–1.6 mg/dL, albumin was 2.5 g/dL, and total protein was 5 g/dL. …

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities.

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies are associated with these conditions, with adverse drug reaction being the most common. Though the worldwide incidence of these conditions is recorded as low, diverse types of medication are being observed to lead to these conditions. This review compiles in

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… Angiotensin-converting enzyme inhibitors Ramipril: Ramipril resulted in SJS after being newly prescribed for a patient for hypertension. ACE inhibitors are known to interfere directly with cell cohesion causing bullous eruptions, which are similar to pemphigus vulgaris or bullous pemphigoid. … -5 16633933 68 Teo SL Santosa A Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Induced by Fexofenadine J Investig Allergol Clin Immunol 2017 27 3 191 193 https://doi.org/10.18176/jiaci.0158 PMid:28570227 10.18176/jiaci.0158 28570227 69 Oskay T Stevens–Johnson Syndrome associated with Ramipril …

Organic Nanoparticles in Progressing Cardiovascular Disease Treatment and Diagnosis.

Cardiovascular diseases (CVDs), the world's most prominent cause of mortality, continue to be challenging conditions for patients, physicians, and researchers alike. CVDs comprise a wide range of illnesses affecting the heart, blood vessels, and the blood that flows through and between them. Advances in nanomedicine, a discipline focused on improving patient outcomes through revolutionary treatments, imaging agents, and ex vivo diagnostics, have created enthusiasm for overcoming limitations in CVDs' therapeutic and diagnostic landscapes. Nanomedicine can be involved in clinical purposes for CV

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… A different study described the creation of a poly(amidoamine) (PAMAM) dendrimer-based drug delivery system that combines the delivery of hydrochlorothiazide (HCTZ) and ramipril (RAPL). The drugs HCTZ (a diuretic) and RAPL (an antihypertensive) are used to treat high blood pressure. … convertase subtilisin–kexin type 9 PEG | Polyethylene glycol PEI | Poly ethylenimine PGA | Polyglycolic acid PIGF | Placental growth factor PLA | Polylactic acid PLGA | Poly lactic-co-glycolic acid PLGA-mPEG | Poly(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol) PPS | Propylene sulfide RAPL | Ramipril …

Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti-Phospholipase A2 Receptor Autoantibody-Positive Primary Membranous Nephropathy.

IntroductionPrimary membranous nephropathy (PMN) is most often caused by autoantibodies to phospholipase A2 receptor (PLA2R). M-PLACE (NCT04145440) is an open-label, phase 1b/2a study that assessed the safety and efficacy of the fully human anti-CD38 monoclonal antibody felzartamab in high-risk anti-PLA2R+ PMN.MethodsPatients with newly diagnosed or relapsed PMN (cohort 1 [C1]; n = 18) or PMN refractory to immunosuppressive therapy (IST) (cohort 2 [C2]; n = 13) received 9 infusions of felzartamab 16 mg/kg in the 24-week treatment period, followed by a 28-week follow-up. The primary end point w

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… However, this patient’s medications before study entry were listed as furosemide, ramipril, atorvastatin, carvedilol, nifedipine, and rivaroxaban, which are not immunosuppressive therapies. e Baseline anti-PLA2R antibody titer was the last value before starting treatment. f Baseline UPCR value was defined … However, this patient’s medications before study entry were listed as furosemide, ramipril, atorvastatin, carvedilol, nifedipine, and rivaroxaban, which are not immunosuppressive therapies. e Baseline anti-PLA2R antibody titer was the last value before starting treatment. f Baseline UPCR value was defined …

Частота и факторы риска в случае вновь диагностированной гиперкалемии после выписки из больницы пациентов, не зависящих от диализа, которые лечатся ингибиторами RAS.

ВВЕДЕНИЕ: Ингибиторы системы " ренин-ангиотенсин " (РАС) все чаще предписываются в силу их позитивного воздействия на систему " конечная организация " . Иатрогенная гиперкалемия представляет собой хорошо известное опасное для жизни осложнение использования ингибитора RAS у пациентов, страдающих хроническим заболеванием почек (CKD). Мы предположили, что у пациентов, проходящих курс лечения с помощью ингибиторов RAS, часто возникает гиперкалемия после выписки из больницы, даже если во время госпитализации у них была нормальная оклемия, так как их образ жизни существенно измен

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… Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events. N Engl J Med. 2008;358: 1547–59. doi: 10.1056/NEJMoa0801317 3. Weir MR. Effects of renin-angiotensin system inhibition on end-organ protection: Can we do better? …

Cardiotoxicity of Non-Anthracycline Cancer Chemotherapy Agents.

Throughout the last decades, newly developed chemotherapeutic agents and immunotherapies that target signaling pathways have provided patients with better prognoses, improved their quality of life and increased survival rates, thus converting cancer to a stable chronic disease. However, non-anthracycline cancer chemotherapy agents and immunotherapies including human epidermal growth factor receptor 2 (HER2) inhibitors, vascular endothelial growth factor (VEGF) inhibitors, Bcr-Abl tyrosine-kinase inhibitors (TKI), proteasome inhibitors, immune checkpoint inhibitors and chimeric antigen receptor

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… Bisoprolol, ramipril, or both drugs compared with placebo were administered for one year from the initiation of chemotherapy or until the end of trastuzumab therapy in case of ERBB2-positive patients. … At 12 months, 3D-LVEF worsening was significantly lower in the bisoprolol and ramipril combination patients and a significantly lower percentage showed a 10% or greater worsening of GLS in the cardioprotection arms [ 44 ]. …

Case report: A case of proliferative glomerulonephritis with monoclonal kappa-light chain deposits treated with daratumumab combination therapy.

INTRODUCTION: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a chronic glomerular disease caused by monoclonal gammopathy. IgG (mainly IgG3) is the most commonly involved isotype of PGNMID. Here we illustrated a novel medication regimen for the rare variant of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-LC). Daratumumab has been proved effective in the treatment of plasma cell myeloma while its effect for PGNMID-LC has rarely been reported. METHODS: A daratumumab combination therapy (D-VCd regimen, specifically are daratum

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… The patient was treated with ramipril, amlodipine, and daratumumab, and showed significant improvement after the completion of the treatment course. Another case report ( 9 ), involved a patient diagnosed with PGNMID-IgG who did not respond well to steroids combined with valsartan after 1 month. …