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Treatment of sarcoid granulomatous interstitial nephritis with adalimumab.

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. After therapy with adalimumab, her renal function improved with a significant reduction in proteinuria. Repeat kidney biopsy showed res

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… Semin Arthritis Rheum. 2005;34(Suppl 1):7–11. doi: 10.1016/j.semarthrit.2005.01.003. …

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

Patients with multiple myeloma, an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions that severely impact quality of life and clinical outcomes. Eliglustat, a U.S. Food and Drug Administration-approved glucosylceramide synthase inhibitor, reduced osteoclast-driven bone loss in preclinical in vivo models of myeloma. In combination with zoledronic acid, a bisphosphonate that treats myeloma bone disease, eliglustat provided further protection from bone loss. Autophagic degradation of TRAF3, a key step for osteoclast differentiation, was inhibited by eliglustat as ev

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… Rheum. Dis. 2016 75 1203 1210 26113650 10.1136/annrheumdis-2015-207240 Lin, N. Y. et al. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss. Ann. Rheum. Dis. 75 , 1203–1210 (2016). 26113650 10.1136/annrheumdis-2015-207240 17. …

Paraneoplastic scleroderma: a patient with a history of breast cancer presenting with sclerodactyly and Raynaud's phenomenon.

A woman in her 70s with a past history of breast cancer in remission presented with several months of dyspnoea, skin tightness and Raynaud's phenomenon. Physical examination was significant for hypertension, hypoxaemia, sclerodactyly, diffuse crackles on auscultation and mild respiratory distress. Work-up revealed elevated serum creatinine, elevated right ventricular systolic pressure on echocardiography and nuclear bone scan findings of osseous metastatic disease. Captopril was initiated with concern for scleroderma renal crisis. The scleroderma panel was positive for RNA polymerase 11 and 15

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… References 1 Naschitz JE Rosner I Rozenbaum M et al Rheumatic syndromes: clues to occult neoplasia Semin Arthritis Rheum 1999 29 43 55 10.1016/s0049-0172(99)80037-7 10468414 2 Shah AA Casciola-Rosen L Cancer and scleroderma: a paraneoplastic disease with implications for malignancy screening Curr Opin …

A new four-area method for evaluating biochemical changes in lumbar facet joint degeneration on T2* mapping.

PURPOSE: To investigate the diagnostic efficacy of a new four-area method for evaluating biochemical changes in lumbar facet joint (LFJ) degeneration on T2* mapping. METHODS: LFJ degeneration was morphologically graded on T2-weighted imaging using the Weishaupt system. T2* value of LFJ was measured on T2* mapping using both all-inclusive and four-area methods. Inter-observer reliability for continuous and categorical variables was evaluated using intraclass correlation coefficient (ICC) and Kappa value, respectively. The correlation between continuous variables and ordered categorical variabl

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… Ann Rheum Dis. 2014;73(6):968–74. 10.1136/annrheumdis-2013-204428. [Published Online First: 26 Mar 2014]. 2. March L, Smith EU, Hoy DG, et al. Burden of disability due to musculoskeletal (MSK) disorders. Best Pract Res Clin Rheumatol. 2014;28(3):353–66. 10.1016/j.berh.2014.08.002. …

The place of cyclical therapy for the treatment of membranous nephropathy in the era of rituximab.

Primary membranous nephropathy (MN) is the most frequent cause of nephrotic syndrome in adults, due to a variety of autoantibodies, most frequently against phospholipase A2 receptor (PLA2R). In severe cases or when spontaneous remission is not achieved, immunosuppression is required. Cyclical therapy, based on glucocorticoids and cyclophosphamide on alternate months for 6 months, has proven effective to induce remission and reduce the risk of end-stage renal disease. Since the early 2000s, rituximab (RTX) has emerged as a key player in the management of MN, showing overall comparable effective

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… Arthritis Rheum 2002;46:2121–31. 10.1002/art.10461 54. Luzardo L, Ottati G, Cabrera Jet al. Substitution of oral for intravenous cyclophosphamide in membranous nephropathy. Kidney360 2020;1:943–9. 10.34067/KID.0002802020 55. Mathrani V, Alejmi A, Griffin Set al. …

Hepatitis B virus-infection related cryoglobulinemic vasculitis. Clinical manifestations and the effect of antiviral therapy: A review of the literature.

OBJECTIVE: Hepatitis B virus (HBV) infection causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Furthermore, about 20% of the patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV), polyarteritis nodosa, non-rheumatoid arthritis, glomerulonephritis and non-Hodgkin lymphoma. This review analyzed literature data on clinical manifestations of HBV-related CV and the impact of antiviral therapy with analoques nucleotide. METHODS: A PubMed search was performed to select eligible studies in the literature, up to July 2022. RESULTS: Some studies have an…

Osteoporosis: Current Concepts.

Osteoporosis is a worldwide disease characterized by reduction of bone mass and alteration of bone architecture resulting in increased bone fragility and increased fracture risk. Causes of osteoporosis include increasing age, female sex, postmenopausal status, hypogonadism or premature ovarian failure, low body mass index, ethnic background, rheumatoid arthritis, low bone mineral density (BMD), vitamin D deficiency, low calcium intake, hyperkyphosis, current smoking, alcohol abuse, immobilization, and long-term use of certain medications. The diagnosis of osteoporosis is established by measure…

Conjunctival Acute Graft-versus-Host Disease in Adult Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation: A Cohort Study.

BACKGROUND: To investigate the incidence, risk factors and survival of conjunctival acute graft-versus-host disease (aGVHD) in adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: This retrospective study included a total of 139 patients undergoing allogeneic HSCT between January 2012 and December 2014 at a tertiary referral hospital. Patients with ocular complaints after allogeneic HSCT or first donor lymphocyte infusion were evaluated by ophthalmologists. The risk factors for conjunctival aGVHD were analyzed using the Cox proportional hazards model.

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… Arthritis Rheum 1998 ; 41 ( 5 ): 761 – 7 . 10.1002/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M 9588727 29 Migita K , Eguchi K , Kawabe Y , Nakamura T , Shirabe S , Tsukada T , et al Apoptosis induction in human peripheral blood T lymphocytes by high-dose steroid therapy . …

NF-κB: master regulator of cellular responses in health and disease.

The NF-κB transcription control proteins play widespread roles in cellular behavior, regulating immune responses, inflammation, cell survival, proliferation, and development. Here, we attempt to comprehensively review these diverse functions and underlying mechanisms, leading readers to relevant references of both historic and topical importance. Because of the huge number of NF-κB control mechanisms and functions, and the vast literature that describes these, being comprehensive is a daunting task but we hope that readers will find clues to lead them to whatever understanding they may seek. A

Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics.

The extracellular matrix (ECM) is the common denominator of more than 50 chronic diseases. Some of these chronic pathologies lead to enhanced tissue formation and deposition, whereas others are associated with increased tissue degradation, and some exhibit a combination of both, leading to severe tissue alterations. To develop effective therapies for diseases affecting the lung, liver, kidney, skin, intestine, musculoskeletal system, heart, and solid tumors, we need to modulate the ECM's composition to restore its organization and function. Across diverse organ diseases, there are common denom

Diffuse alveolar hemorrhage in rheumatic diseases: Clinical features, diagnosis, and management.

Diffuse alveolar hemorrhage (DAH) is a catastrophic pulmonary manifestation of systemic autoimmune and rheumatic diseases, particularly systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV), and antiphospholipid syndrome (APS). It arises from immune-mediated injury to the pulmonary microcirculation, leading to intra-alveolar bleeding, respiratory failure, and high mortality. Despite advances in immunosuppression, DAH continues to pose major diagnostic and therapeutic challenges, with limited consensus on optimal management. We conducted an updated and comprehensive review of the…

Нейрофизиологические, радиологические и молекулярные биомаркеры условий, связанных с болью: обзор &quot; Umbrella &quot; .

Справочная информация/цели: Боль и условия, связанные с болью, считаются глобальным медико-санитарным и финансовым бременем. В целях совершенствования методов обезболивания, оценки болеутоляющей силы и диагностики боли были предложены различные биомаркеры. Поскольку их клиническая полезность еще не доказана, цель этого зонтичного обзора заключается в обобщении имеющихся данных о всех видах обезболивающих биомаркеров. Методы: Систематические обыски проводились в Пуббмеде, Скопусе и Кокрейнской библиотеке с момента их создания 2 Июнь 2025. Приемлемыми исследованиями были систематические обзоры и

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… Pain exacerbation as a major source of lost productive time in US workers with arthritis Arthritis Rheum. 2005 53 673 681 10.1002/art.21453 16208644 10. Eldabe S. Obara I. Panwar C. Caraway D. Biomarkers for Chronic Pain: Significance and Summary of Recent Advances Pain Res. … Rheum. Dis. 2015 74 703 710 10.1136/annrheumdis-2013-204494 24363360 46. Hunter D.J. Zhang W. Conaghan P.G. Hirko K. Menashe L. Li L. Reichmann W.M. Losina E. Systematic review of the concurrent and predictive validity of MRI biomarkers in OA Osteoarthr. …

Cryoglobulin Test and Cryoglobulinemia Hepatitis C-Virus Related.

Cryoglobulins are immunoglobulins that precipitate in serum at temperatures below 37°C and resolubilize upon warming. The clinical syndrome of cryoglobulinemia usually includes purpura, weakness, and arthralgia, but the underlying disease may also contribute other symptoms. Blood samples for cryoglobulin are collected, transported, clotted and spun at 37°C, before the precipitate is allowed to form when serum is stored at 4°C in a Wintrobe tube for at least seven days. The most critical and confounding factor affecting the cryoglobulin test is when the preanalytical phase is not fully complete

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… /10.1093/rheumatology/keu271 24994905 10.1093/rheumatology/keu271 35 Cacoub P Renou C Kerr G Hue S Rosenthal E Cohen P Kaplanski G Charlotte F Thibault V Ghillani P Piette JC Caillat-Zucman S Influence of HLA-DR phenotype on the risk of hepatitis C virus-associated mixed cryoglobulinemia Arthritis Rheum … Am J Kidney Dis 1996 27 476 83 https://doi.org/10.1016/S0272-6386(96)90156-0 8678056 10.1016/s0272-6386(96)90156-0 53 Andre M Mahammedi H Aumaitre O Tridon A Tissot JD Piette JC A “missed” cryoglobulin: the importance of in vitro calcium concentration Ann Rheum Dis 2000 59 490 https://doi.org/10.1136 …

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of

Bridging the Gap in Secondary Antibody Deficiencies: Current Evidence and Unmet Needs in Diagnosis and Management with Immunoglobulin Replacement.

Secondary antibody deficiency (SAD) represents a substantial yet under-recognised global healthcare burden. It is more prevalent than primary antibody deficiency, but frequently under-diagnosed and variably managed worldwide. Prompt diagnosis is often hindered by insufficient awareness among clinicians, lack of global consensus on screening/monitoring for SAD among at-risk patients, inadequate clinical immunology services and lack of standardised referral pathways/protocols. Management practices vary widely, with little international agreement, particularly regarding threshold to initiate immu

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… Li PH Lau CS Secondary antibody deficiency and immunoglobulin replacement Hong Kong Bull Rheum 2017 17 1 1 5 10.1515/hkbrd-2017-0001 Li PH, Lau CS (2017) Secondary antibody deficiency and immunoglobulin replacement. Hong Kong Bull Rheum 17(1):1–5. 10.1515/hkbrd-2017-0001 8. …

Риск инфицирования в реальном мире у многочисленных склерозов при долгосрочном лечении иммуномудулятора.

ВВЕДЕНИЕ: Существует множество методов иммуномодуляционного лечения для нескольких склерозов (MS), включая те из них, которые истощают иммунные клетки (например, лекарства против CD20), переносимые иммунные клетки (например, натализумаб, S1P модуляторы) или модулирующие иммунные поднаборы (например, фумараты). Все методы лечения, корректирующие заболевания (ДМТ), могут повысить риск инфицирования, который может ухудшиться в результате длительного применения. МЕТОДЫ: Это ретроспективное, одноцентральное, когортное исследование. Мы проанализировали медицинские записи взрослых людей с MS, которые

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… Arthritis Rheum. 48, 149–154. Bou Rjeily N, Fitzgerald KC, Mowry EM, 2024. Extended interval dosing of ocrelizumab in patients with multiple sclerosis is not associated with meaningful differences in disease activity. Mult. Scler. J. 30, 257–260. Butzkueven H, et al. , 2020. …

Anti-fracture Efficacy of Monthly Risedronate Compared with That of Weekly Risedronate in Postmenopausal Korean Women with Osteoporosis: A Nationwide Cohort Study.

BackgroundIntermittent dosing regimens for oral risedronate (once-monthly and once-weekly) were developed for patient convenience. While several studies have reported the anti-fracture efficacy of weekly dosing, few have assessed monthly dosing. The lower efficacy of monthly dosing has been previously suggested. The aim of this study was to compare the anti-fracture efficacy of monthly and weekly dosing.MethodsWe obtained information from the Korea National Health Insurance Service database from 2012 to 2017 of Korean women of ≥50 years of age who used weekly or monthly risedronate. We compare

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… Arthritis Rheum. 2001;44:1496–503. doi: 10.1002/1529-0131(200107)44:7<1496::AID-ART271>3.0.CO;2-5. 21. Austin PC. Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research. Commun Stat Simul Comput. 2009;38:1228–34. 22. …

A Future for Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Arthritis Rheum (2007) 56(7):2410–21. 10.1002/art.22656 18. Snowden JA, Saccardi R, Allez M, Ardizzone S, Arnold R, Cervera R, et al. Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. …

The Pathophysiology and Treatment of Pyoderma Gangrenosum-Current Options and New Perspectives.

Pyoderma gangrenosum (PG) is an uncommon inflammatory dermatological disorder characterized by painful ulcers that quickly spread peripherally. The pathophysiology of PG is not fully understood; however, it is most commonly considered a disease in the spectrum of neutrophilic dermatoses. The treatment of PG remains challenging due to the lack of generally accepted therapeutic guidelines. Existing therapeutic methods focus on limiting inflammation through the use of immunosuppressive and immunomodulatory therapies. Recently, several reports have indicated the successful use of biologic drugs an

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… Pyoderma gangrenosum: An update Rheum. Dis. Clin. N. Am. 2007 33 787 802 10.1016/j.rdc.2007.07.016 18037117 87. Graziano F. Macaluso F.S. Cassata N. Citrano M. Orlando A. … Rheum. Dis. 2022 25 1333 1338 10.1111/1756-185X.14425 36004431 147. Jaeger T. Andres C. Grosber M. Zirbs M. Hein R. Ring J. Traidl-Hoffmann C. Pyoderma gangrenosum and concomitant hidradenitis suppurativa--rapid response to canakinumab (anti-IL-1β) Eur. J. …

The Role of TAM Receptors in Bone.

The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis …