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REALITEC: Мультистрановое ретроспективное исследование теклистамаба у пациентов с повторной/редактированной множественной миеломой вне рамок клинических испытаний.

Teclistamab является первым утвержденным антиклеточным антигенным антигеном (BCMA) для пациентов с трехклассным обнаженным рецидивом/хребтом множественной миеломы (RRMM). MajesTEC-1 Клинические испытания. В этой связи мы в первую очередь сообщаем результаты исследования REALITEC, ретроспективного наблюдения за пациентами, получившими теклистамаб вне рамок клинических испытаний в Европе и Израиле. Исследование включало в себя 113 пациенты из 23 на участках eight в странах, имеющих большинство88.5%) доступ к лекарственным препаратам через программы предварительного утверждения. Средний возраст ж

Совпадение в аннотации оригинала
Teclistamab is the first approved anti-B-cell maturation antigen (BCMA) bispecific antibody for patients with triple-class exposed relapsed/ … e observational study of patients who received teclistamab outside of clinical trials in Europe and Israel. The study included 113 patients from 23 sites in eight countries, with most (88.5%) accessing the medication through pre-approval access programs. The median age was 66 years, and patients had a median of 6 prior lines of therapy. Notably, 78.8% we …

Factors associated with rates of long-acting injectable antipsychotic use for schizophrenia: A subgroup analysis of the multinational ADVANCE study.

INTRODUCTION: Long-acting injectable antipsychotics (LAIs) are underused despite known benefits. This subgroup analysis from the Attitudes DriVing regional differences in LAI ANtipsychotic utilization for schizophrenia among healthcare professionals (HCPs), patients, and CaregivErs (ADVANCE) study aimed to understand factors influencing high versus low use of LAIs by HCPs. METHODS: HCPs in ADVANCE included psychiatrists and psychiatric non-physicians from Australia, Canada, China, Germany, Israel, South Korea, Spain, and the United States who reported treating patients with schizophrenia. HCP…

How Physicians Manage Colchicine-Resistant Familial Mediterranean Fever: Insights From a Multinational Survey in High-Prevalence Countries.

OBJECTIVE: This study aimed to investigate real-world clinical practices regarding biologic therapy in colchicine-resistant familial Mediterranean fever (FMF), focusing on treatment initiation, tapering, discontinuation strategies, and related challenges. METHODS: A 29-item English-language survey was distributed to pediatric and adult rheumatologists via email. The target population consisted of rheumatologists from Türkiye, Israel, and Italy (countries with a high prevalence of FMF) as well as Germany, where migrants of eastern Mediterranean origin live. The survey addressed preferences for…

Prognostic Implications of Elevated Left Ventricular Ejection Fraction in Patients with Sepsis.

The role of left ventricular systolic function as a prognostic marker for sepsis patients remains an area of ongoing research and debate. The present investigation exhibited the comprehensive evaluation of the relationship between different levels of left ventricular ejection fraction (LVEF) and mortality outcomes in sepsis-diagnosed patients. A retrospective, single-center longitudinal cohort investigation was conducted involving the intensive care unit (ICU) admitted adults' patients at Beth Israel Deaconess Medical Center who underwent transthoracic echocardiography (TTE) during their hospi…

Managing healthcare for female BRCA carriers in the population screening era: developing a harmonized national policy for surveillance and risk-reduction.

BACKGROUND: The implementation of Israeli National screening for BRCA1/BRCA2 pathogenic variants (PVs) in 2020 has led to a significant increase in the number of unaffected female carriers who are referred to high-risk surveillance clinics (HRSCs). Lack of standardization in protocols for risk reduction and surveillance between HRSCs results in confusion and gaps in care. We aimed to identify discrepancies in existing practices and lead to policy development of a national policy for surveillance, management and risk reducing strategies in BRCA-PV carriers. METHODS: A comparative analysis of ri…

Reversible Mitochondrial Iron Toxicity in Wolfram Syndrome Type 2 Monogenic Diabetes.

CONTEXT: Wolfram syndrome type 2 (WS2) is a rare monogenic diabetes syndrome caused by CISD2 mutations. Its cellular pathophysiology remains poorly understood, and no targeted therapies exist. OBJECTIVE: To characterize the clinical phenotype and cellular pathophysiology of the largest WS2 cohort to date, and to evaluate a novel, mechanistically targeted pharmacological intervention. DESIGN: Observational cohort study paired with ex vivo functional cellular assays and a proof-of-concept pilot clinical intervention. SETTING: Multicenter academic and clinical institutions in Israel and the Pa…

Diagnostic yield and cost of three-level H&E sectioning in prostate biopsies.

AIM: The traditional three-level H&E sectioning protocol for prostate biopsies was developed for ultrasound-guided systematic sampling and predates lesion-targeted biopsy approaches. Multiparametrical MRI (mpMRI) has improved detection of clinically significant prostate carcinoma but has also increased biopsy volume, workload, costs and digital pathology requirements, including whole-slide imaging and artificial intelligence (AI) integration. METHODS AND RESULTS: A retrospective institutional cost-yield analysis was performed on prostate biopsy cases at Beth Israel Deaconess Medical Center (2…

Profile of a pediatric hypertensive cohort in a tertiary referral center.

BACKGROUND: The overall prevalence of hypertension (HTN) among Israeli Jewish adolescents was reported to be 0.4% in males and 0.074% in females. The demographic characteristics of the Northern Israeli population are unique, with a nearly equal distribution of Arab and Jewish ethnicity. We describe the demographic and clinical characteristics of pediatric hypertensive patients in northern Israel. METHODS: Data were retrospectively collected from the electronic medical records (EMRs) of pediatric patients aged 0-18 diagnosed with HTN at Rambam Health Care Campus between 2010-2020. Demographic …

Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

BACKGROUND: The use of biological response modifying drugs (BRMDs) in women of reproductive age is increasing, with reassuring safety data during pregnancy. However, their long-term impact on infant immunity remains unclear, and recommendations regarding live-attenuated vaccines in exposed infants are inconsistent. We aimed to evaluate the association between antenatal BRMD exposure and infant infection risk during the first year of life, and to compare vaccination rates between exposed and unexposed infants. METHODS: This nationwide cohort study included all live births in Israel between Jan…

Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder.

CONTEXT: Maternal thyroid hormones are essential for fetal neurodevelopment. Gestational thyroid imbalance has been associated with atypical neurodevelopment, including increased risk of autism spectrum disorder (ASD). OBJECTIVE: To examine the association between maternal thyroid dysfunction and ASD risk in offspring. DESIGN: Retrospective cohort study with follow-up through January 2021. SETTING: Single tertiary hospital in southern Israel (Soroka University Medical Center); linked to Clalit Health Services electronic records. PATIENTS OR OTHER PARTICIPANTS: A total of 51 296 singleton b…

Nontuberculous Mycobacteria in Primary Ciliary Dyskinesia: A National Multicenter Cohort Study.

INTRODUCTION: The prevalence and clinical significance of nontuberculous mycobacteria (NTM) in individuals with primary ciliary dyskinesia (PCD) remain unclear, with most data extrapolated from cystic fibrosis. This first national multicenter cohort study evaluating NTM in PCD patients aimed to determine the prevalence, species distribution, and clinical impact of NTM isolation. METHODS: A retrospective, longitudinal study was conducted across four tertiary centers in Israel (2010-2024). Patients with confirmed PCD were evaluated for demographic, clinical, microbiological, and longitudinal lu…

PET/CT as a Diagnostic Tool in Pediatric Fever of Unknown Origin: A Multicenter Study.

BACKGROUND: Fever of unknown origin (FUO) in pediatric patients remains a persistent diagnostic challenge, despite advances in imaging and l … FUO who underwent fluorodeoxyglucose PET/CT imaging between 2010 and 2022, at 3 medical centers in Israel. Clinical presentations, laboratory findings, and final diagnoses were compared between cases where PET/CT contributed to diagnosis or did not. RESULTS: A total of 112 patients were included. PET/CT contributed to diagnosis in 51 (45.5%) cases. Amo …

Factors associated with methicillin resistance in Staphylococcus aureus: a case-case-control analysis of AMR surveillance data.

OBJECTIVE: This study examined clinical, demographic, and geographic factors associated with methicillin-resistant and methicillin-susceptib … ), and Taiwan (OR = 1.57), while MSSA odds were higher in India, Kuwait, Brazil, Chile, Taiwan, and Israel. Compared with infants aged 0-2, children aged 3-12 and adolescents aged 13-18 years had higher odds of both MRSA and MSSA isolation. Relative to general surgery units, both MRSA and MSSA were more frequently isolated from the emergency and general …

Post Pacing Interval Following Failed Anti-Tachycardia Pacing Predicts Epicardial Ventricular Tachycardia Circuits in Patients With Non-Ischemic Cardiomyopathy.

BACKGROUND: Anti-tachycardia pacing (ATP) that entrains but fails to terminate ventricular tachycardia (VT) provides an opportunity to use post-pacing interval minus tachycardia cycle length (PPI - TCL) as a diagnostic tool. We evaluated whether PPI - TCL from failed ATP could predict the presence of epicardial re-entrant VT circuits in patients with ischemic cardiomyopathies (ICM) vs. non-ischemic cardiomyopathies (NICM). METHODS: A retrospective analysis was conducted of 51 patients who underwent VT ablation at Beth Israel Deaconess Medical Center from January 2020 to March 2025 and had fai…

Childhood sexual abuse and recovery trajectories among Jewish women survivors: A longitudinal comparison of trauma characteristics and clinical outcomes across the religious spectrum.

BACKGROUND: Despite comparable Childhood sexual abuse (CSA) rates in Orthodox and ultra-Orthodox Jewish communities relative to the general … and ultra-Orthodox) receiving phase-oriented psychotherapy at specialized public trauma centers in Israel. METHODS: Participants self-reported at treatment initiation and after 12 months on levels of religiosity (childhood and adulthood), childhood maltreatment (CM), posttraumatic stress disorder (PTSD) symptoms, dissociation, borderline personality (B …

Resilience and Quality of Life: The Role of Positive Affect on Healthcare Professionals in High-Stress Environments.

BACKGROUND: Healthcare professionals (HCPs) operate within environments of chronic occupational stress; a burden significantly amplified in Israel by the compounded pressures of the COVID-19 pandemic and active warfare. While resilience and positive affect (PA) are established protective factors, the nature of their interactive role in sustaining quality of life (QoL) during prolonged, extreme crises remains under-explored. AIM: This study examines resilience, positive affect (PA), and quality of life (QoL) among healthcare professionals (HCPs), investigating whether PA moderates the relation…

Point-of-Care White Blood Cell Differential Testing in Pediatric Inpatients (2 Months-17 Years): How Does HemoScreen Perform?

BACKGROUND: Point-of-care (POC) hematology testing is of growing interest in pediatric practice. We previously evaluated an image-based POC hematology analyzer (HemoScreen, PixCell Medical, Yokneam Illit, Israel) for total white blood cell (WBC), red blood cell, and platelet counts and associated indices in pediatric inpatients. Given the diagnostic importance of WBC differentials, this study aimed to extend the evaluation to five-part differential counts. METHODS: We prospectively analyzed 141 venous K2-EDTA samples from pediatric inpatients aged 2 months-17 years. Complete blood counts were…

Prognostic value of PANOMEN-3 classification for hypopituitarism in surgically and nonoperatively managed pituitary adenomas.

BACKGROUND: The prognostic value of Pituitary Adenoma Nomenclature 3 (PANOMEN-3) for incident or persistent hypopituitarism remains uncertain. This study aimed to assess whether baseline PANOMEN-3 grade and its components predict secondary adrenal insufficiency or secondary hypothyroidism in surgically and nonoperatively managed patients. METHODS: We conducted a retrospective cohort study of adults with newly diagnosed pituitary adenoma at Rambam Health Care Campus, a tertiary referral center in Haifa, Israel, between 2010 and 2023. Follow-up was censored on August 31, 2025. Patients were str…

Comprehensive molecular characterization of Theileria equi: Detection, genetic diversity, and risk factors assessment.

Equine piroplasmosis, caused by Theileria equi, has been widely studied globally, but genetic diversity research in India remains limited. A … ing geographic clustering. Brazil had the most haplotypes (n = 13), followed by Sri Lanka (n = 11), Israel (n = 9), South Africa and China (n = 6 each), Switzerland (n = 4), and India (n = 3). The star-like network indicates rapid population expansion and the emergence of new haplotypes. Low overall nucleotide diversity (π = 0.172 ± 0.007) but high haplo …

A qualitative, test-replicate approach to understanding trauma in late adolescence and early emerging adulthood.

OBJECTIVE: To evaluate how racially diverse, late-adolescent/early emerging adult college students in the American Southeast would describe … xposure to school/mass shootings (22.4% in Study 1) and other international traumatic events (e.g., Israel-Hamas/Gaza war; 16.3% in Study 2). Students often reported learning about national/international traumatic events via social media. Direct and indirect trauma, especially death or illness/injury of a loved one, were also relevant. CONCLUSION: Multi …