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Urobiome and Inflammation: A Systematic Review on Microbial Imbalances and Diagnostic Tools for Urinary Disorders.

OBJECTIVE: To synthesize current knowledge on urobiome alterations, innovative diagnostic advancements, and emerging therapeutic strategies … matory conditions. Therapeutic interventions targeting urobiome dysbiosis, particularly probiotics (Lactobacillus rhamnosus, L. reuteri, L. crispatus), showed promising efficacy in reducing recurrence and inflammation in clinical trials. CONCLUSION: Urobiome dysbiosis plays a critical role in inflammatory urinary tract disorders. Innovative diagnostic methods …

Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism.

BACKGROUND: Osteoporosis is a chronic disease of bone metabolism with high incidence rates. Recently, exosome therapy has emerged as a promi … hanged diversity and composition of gut microbiota in osteoporotic mice, with a notable increase in Lactobacillus and a decrease in Dubosiella and Faecalibaculum. LC-MS analysis indicated that Auto-exo treatment reduced the elevated levels of bilirubin in osteoporotic mice. Cell experiments uncovered that bilirubin remarkably inhibited osteoblast differentiatio …

Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.

Improving the intestinal microenvironment and regulating the intestinal flora are highly important in the treatment of osteoporosis. Although previous studies have shown that oral probiotics can prevent or reverse bone loss, their survival rate and therapeutic effect are greatly reduced when they pass through the gastrointestinal chemical microenvironment, which limits their clinical application. Therefore, improving their survival rate and therapeutic effect is crucial. To address this issue, we formed a metal‒phenolic network (L@Q-Ca) on the surface of Lactobacillus rhamnosus (LR) by combini…

Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation, synovial hyperplasia, and progres … lla copri and a decreased presence of beneficial microbes such as Bifidobacterium, Bacteroides, and Lactobacillus. RA patients exhibit altered metabolite profiles, with reduced levels of short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, which are linked to immune regulation and intestinal barrier function. Specific metabolites, such as …

Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota.

Zearalenone (ZEA), produced by Fusarium, is a fungal toxin commonly found in maize, wheat, and other cereals. ZEA has the ability to bind to … relationship with lipid metabolism genes, it was found that ZEA decreased the relative abundance of Lactobacillus and increased the relative abundance of Ileococcus, E. faecalis, and Ricardia. These changes were significantly correlated with the expression of Pparg and Srebf1, etc. ZEA may contribute to the abnormality of lipid metabolism by influencing the int …

Quercetin as a Novel Antidepressant: Mechanistic Insights into Its Neuroprotective and Anti-inflammatory Effects.

Depression is a globally recognized leading cause of mental health disability and mortality worldwide, severely affecting individuals' daily … metabolomics results of hippocampal brain regions, quercetin was found to increase the abundance of Lactobacillus and modulate the levels of inosine, Creatinine, and Lithocholic acid metabolites in the hippocampus. To sum up, in the present study, we revealed the molecular mechanism of quercetin alleviating depression-like behavior in CUS mice by inhibiting CUS …

Gut microbiota diversity and composition in patients with atherosclerosis analyzed using full-length 16S rRNA gene sequencing.

BACKGROUND: Gut microbiota have been linked to atherosclerosis (AS). This study aimed to investigate the differences in gut microbiota betwe … icutes being the most abundant phylum in both groups. However, several bacterial species, including Lactobacillus fermentum, Escherichia coli, Dialister succinatiphilus, and Fusobacterium varium, were more abundant in the ASP group. Except for Escherichia coli, the other three bacterial species are associated with lipid metabolism. The ASP group exhibited small …

Pentatrichomonas hominis Infection Induces Chronic Intestinal Inflammation in Immunocompetent Mice.

Pentatrichomonas hominis (P. hominis) has traditionally been regarded as a commensal or opportunistic inhabitant of the intestine. However, … lfovibrio, while reducing the abundance of beneficial bacteria, such as Akkermansia, Roseburia, and Lactobacillus. Collectively, these results provide compelling evidence that P. hominis acts as a zoonotic pathogen capable of inducing chronic intestinal inflammation. Therefore, the clinical significance of P. hominis infection warrants attention.

Administration route and trial repetition shape the effects of a commercial synbiotic on broiler production performance, cecal microbiota and pathogen colonization.

Campylobacter and Salmonella are leading causes of foodborne bacterial enteritis, with poultry meat being an important source. This longitud … ntributing to the colonization resistance against C. jejuni were identified, belonging to the genus Lactobacillus and an unclassified representative of Bacteroidota. Administration of the synbiotic significantly influenced cecal microbiota, with outcomes depending on the administration route but, importantly, varying significantly between food business operator …

Потенциальная эффективность пробиотики в деле сокращения множественных склерозовых прогрессий в доклинических и клинических исследованиях: всемирный систематический обзор и метаанализ.

Множественный склероз (MS) — иммунопосредованное заболевание, характеризующееся воспалением нервных клеток и обезвоживанием. Эффективность пробиотики в деле уменьшения подстрекательства к ущербу в НР. Таким образом, цель этого систематического обзора и метаанализа заключалась в потенциальной эффективности пробиотиков в деле сокращения прогрессии множественных склерозов в предклинических и клинических исследованиях. МЕТОДЫ: базы данных PubMed, Scopus, Cochrane и Google Scientific были найдены с использованием нескольких соответствующих ключевых слов, и в период с января 2004 года по 16 августа

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVE: Multiple Sclerosis (MS) is an immune-mediated disease characterized by nerve cell inflammation and demyelination. … utoimmune encephalomyelitis (EAE) animal model, probiotics such as Bifidobacterium, Prevotella, and Lactobacillus can decrease the T helper 1 (Th1)/Th17 ratio while inducing interferon gamma (IFN-γ) and interleukin (IL)-17 levels. In all cases, probiotics can modulate immune cells and cytokines and consequently decrease EAE signs and symptoms. In all human stud …

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro Model of Intestinal Epithelial Barrier Dysfunction.

The gut microbiota is a very important factor in the state of health of an individual, its alteration implies a situation of "dysbiosis," which can be connected to functional gastrointestinal disorders and pathological conditions, such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), Ulcerative Colitis (UC) and Crohn's Disease (CD), and Colorectal Cancer (CRC). In this work, we studied the effect of a food supplement called ENTERO-AD containing a mix of probiotics (Lactobacillus acidophilus LA1, L. reuteri LR92, Bifidobacterium breve Bbr8), Matricaria Chamomilla, and B grou…

Antibacterial periodontal ligament stem cells enhance periodontal regeneration and regulate the oral microbiome.

BACKGROUND: The transplantation of periodontal ligament stem cells (PDLSCs) has been shown to enhance periodontal regeneration in animal mod … crease in diversity, and increase the abundance of non-pathogenic bacterial Bifidobacterium sp. and Lactobacillus sp., making the oral microbiome similar to that of the PRE group. In vitro, PDLSCs inhibit the growth of Staphylococcus aureus, Escherichia coli, and Fusobacterium nucleatum. The main mechanism of action is postulated to involve production of the ca …

Dietary starch structure modulates nitrogen metabolism in laying hens via modifying glucose release rate.

The objective of this study was to investigate the effects of starch structure (Amylopectin/Amylose, AP/AM) in a low-protein diet on product … ly, moderate-AM diets enriched with short-chain fatty acid-producing bacteria in the cecum, such as Lactobacillus, Rikenellaceae_RC9_gut_group, and Christensenellaceae_R-7_group, which are associated with the promoting nitrogen utilization. These findings may offer useful information on optimizing starch structure for the design of food products and relevant th …

Mulberry polyphenols restored both small and large intestinal microflora in db/db mice, potentially alleviating type 2 diabetes.

Polyphenols in mulberry fruit have potential anti-diabetic effects by targeting the gut microbiota. This study investigated how mulberry polyphenols (MPs) influence the microbiota of the small and large intestines and their effects on type 2 diabetes symptoms. The results showed lower microbiota densities in the small intestine. MP treatments improved microbiota richness and diversity in both intestines, similar to metformin. In particular, at a 400 mg kg-1 dose, mulberry polyphenols decreased Firmicutes, Lactobacillus, and Bacilli, while increasing Bacteroidetes, leading to elevated propionat…

Biological properties of a novel solution based on silver nanoclusters for arresting dentin caries.

OBJECTIVES: To test the biological properties of a novel non-restorative treatment method for arresting dentin caries based on silver nanocl … m bactericidal concentration (MBC) and colony forming (CFU) of Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus). 38% Silver Diammine Fluoride (SDF) was used for the control groups. RESULTS: Chemical and structural identity of the clusters did not change within 9 months; Cell viability of 92%-89% was found after 24-48 h respective …

The construction of a double-layer colon-targeted delivery system based on zein-shellac complex and gelatin-isomaltooligosaccharide Maillard product: In vitro and in vivo evaluation.

In this study, we developed a double-layer colon-targeted microcapsule. It used the Maillard product of gelatin-isomaltooligosaccharide (GI180) and zein-shellac complex (ZS) as bio-based materials, plant extracts (MPL) and Lactobacillus plantarum JJBYG12 (JJBYG12) were co-encapsulated, endowing them with strong resistance to harsh environments and precise intestinal adhesion and targeting ability. The research results indicated that ZS11 exhibits hydrogen bonding and electrostatic interactions. The encapsulation efficiencies of ZS11 for JJBYG12 and for polysaccharides, polyphenols, and flavono…

Multifaceted Effects of Subchronic Exposure to Chlorfenapyr in Mice: Implications from Serum Metabolomics, Hepatic Oxidative Stress, and Intestinal Homeostasis.

As chlorfenapyr is a commonly used insecticide in agriculture, the health risks of subchronic exposure to chlorfenapyr remained unclear. Thi … ling, Th cell differentiation, and bile acid metabolism. Microbiomic analysis showed an increase in Lactobacillus, a decrease in Muribaculaceae, and diminished anti-inflammatory microbes, which further propelled the inflammatory response and leaded to intestinal inflammation. These findings revealed the molecular mechanisms underlying chlorfenapyr-induced hepat …

Potential role of gut microbiota in major depressive disorder: A review.

Interactions between the gut microbiota and host immunity are sophisticated, dynamic, and host-dependent. Scientists have recently conducted … ression. Psychotropics, including Bifidobacterium longum NCC3001, Clostridium butyricum CBM588, and Lactobacillus acidophilus, have mental health benefits, and can have a positive effect on the host-brain relationship, and have antidepressant effects. This article reviews current studies on the association between gut microbiota dysbiosis and depression. Compre …

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection.

BACKGROUND: Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human pap … bacterial genera that respond to HPV infection in several detection sites, such as Corynebacterium, Lactobacillus, Campylobacter, and Cutibacterium have been detected in multiple sites, reflecting their potential significance in cross body sites HPV infection responses. There was a solid microbial interaction network between the cervix, vagina, and urethra. The …

A novel Bacillus aerolatus CX253 attenuates inflammation induced by Streptococcus pneumoniae in childhood and pregnant rats by regulating gut microbiome.

Streptococcus pneumoniae (Spn) is the predominant pathogen responsible for community-acquired pneumonia (CAP) in children under five years o … sequencing results showed that CX253 administration alone significantly increased the abundance of Lactobacillus, Limosilactobacillus, and Prevotella in the gut of childhood and pregnant rats. Furthermore, the CX253 increased propionate in the gut of childhood rats and increased propionate and butyrate in the gut of pregnant rats to inhibit pulmonary inflammat …