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Поврежденное когнитивное и поведенческое функционирование в детском возрасте и экономические результаты взрослой жизни.

Метформин был назван следующим: one :: из наиболее важных медицинских агентов первой линии в управлении типом 2 Болит диабет. Поскольку метформин является главным образом антигипергликемическим агентом, он также оказывает огромное влияние на различные системы и процессы. Он действует главным образом путем активации AMPK (Adenosine Monophosphate-Activated Protein Kinase) в клетках и сокращения выхода глюкозы из печени. Кроме того, она сокращает производство современных продуктов гликации и реактивных видов кислорода в эндотелии, помимо регулирования глюкозы и липидного метаболизма в кардиомиоки

Manic and hypomanic states in cancer patients: A systematic review.

OBJECTIVES: While there have been reports on the relationship between cancer and depression, reports on the association between cancer and manic states, a reciprocal state of depression, have been relatively few. Therefore, we conducted a systematic review on the relationships between cancer and manic states, focusing on their etiology, clinical course, and impact on cancer treatments. METHODS: A systematic review was conducted using four electronic databases, following the PRISMA guidelines. The scope of the study included research on manic or hypomanic states associated with cancer in patie

Bone fragility and osteoporosis in children and young adults.

Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for timely diagnosis, management and follow-up. Early-onset osteoporosis is defined as the presence of a low BMD (Z-score of ≤ -2.0 in individuals aged < 20 years; T-score of ≤ -2.5 in those aged between 20 to 50 years) accompanied by a clinically significant fracture history, or the presence of low-ene

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… Peris P, Guañabens N, Martínez de Osaba MJ, Monegal A, Alvarez L, Pons F, Ros I, Cerdá D and Muñoz-Gómez J, (2002) Clinical characteristics and etiologic factors of premenopausal osteoporosis in a group of Spanish women Semin Arthritis Rheum 32:64-70. 10.1053/sarh.2002.33725 97. … Peris P, Monegal A, Martínez MA, Moll C, Pons F, Guañabens N. Bone mineral density evolution in young premenopausal women with idiopathic osteoporosis. Clin Rheumatol. 2007;26:958–961. doi: 10.1007/s10067-006-0405-0. 114. Lorentzon M, Mellström D, Ohlsson C. …

Effects of Obesity and Calorie Restriction on Cancer Development.

The risk of malignant tumor development is increasing in the world. Obesity is an established risk factor for various malignancies. There are many metabolic alterations associated with obesity which promote cancerogenesis. Excessive body weight leads to increased levels of estrogens, chronic inflammation and hypoxia, which can play an important role in the development of malignancies. It is proved that calorie restriction can improve the state of patients with various diseases. Decreased calorie uptake influences lipid, carbohydrate and protein metabolism, hormone levels and cell processes. Ma

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… Pons V. Riera J. Capó X. Martorell M. Sureda A. Tur J.A. Drobnic F. Pons A. Calorie restriction regime enhances physical performance of trained athletes J. Int. Soc. Sports Nutr. 2018 15 12 10.1186/s12970-018-0214-2 29556158 PMC5845356 76. Stekovic S. Hofer S.J. Tripolt N. Aon M.A. Royer P. …

Facing financial barriers to healthcare: patient-informed adaptation of a conceptual framework for adults with a history of cancer.

BackgroundCancer-related financial hardship is associated with negative clinical outcomes, which may be partially explained by cost-related delayed or forgone care in response to financial barriers. We sought to understand patient experiences facing financial barriers to medical care following a cancer diagnosis.MethodsWe conducted virtual, semi-structured interviews in Fall 2022 with 20 adults with a history of cancer who had experienced cancer-related financial hardship in the prior year. We used template analysis within a pragmatic paradigm, combining constructivist and critical realist the…

The Effect of Exercise on Pain in People with Cancer: A Systematic Review with Meta-analysis.

IntroductionCancer-related pain is common and undertreated. Exercise is known to have a pain-relieving effect in non-cancer pain.ObjectivesThis systematic review aimed to evaluate (1) the effect of exercise on cancer-related pain in all cancers, and (2) whether the effect of exercise differed according to exercise mode, degree of supervision, intervention duration and timing (during or after cancer treatment), pain types, measurement tool and cancer type.MethodsElectronic searches were undertaken in six databases to identify exercise studies evaluating pain in people with cancer, published pri

Trust and shared decision-making among individuals with multiple myeloma: A qualitative study.

BackgroundMultiple myeloma (MM) is an incurable cancer with complex treatment options. Trusting patient-clinician relationships are essentia … ated trust is driven primarily by clinician communication practices that demonstrate competence, responsiveness, listening, honesty, and empathy; and (3) trust in relation to shared decision-making describes how patients relate the feeling of trust, or lack thereof, to the process of shared decision-making.ConclusionMany factors contribute to the devel …

Challenges in the cultural adaptation of the German Myeloma Patient Outcome Scale (MyPOS): an outcome measure to support routine symptom assessment in myeloma care.

BACKGROUND: Patients with multiple myeloma report more problems with quality of life (QoL) than other haematological malignancies over the course of their incurable illness. The patient-centred Myeloma Patient Outcome Scale (MyPOS) was developed to assess and monitor symptoms and supportive care factors in routine care. Our aim was to translate and culturally adapt the outcome measure to the German context, and to explore its face and content validity. METHODS: Translation and cultural adaptation following established guidelines used an exploratory, sequential mixed method study design. Steps

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers.

Application of the CAR targeting strategy in solid tumors is challenged by the need for adequate target antigens. As a consequence of their tissue origin, embryonal cancers can aberrantly express membrane-anchored gangliosides. These are carbohydrate molecules consisting of a glycosphingolipid linked to sialic acids residues. The best-known example is the abundant expression of ganglioside GD2 on the cell surface of neuroblastomas which derive from GD2-positive neuroectoderm. Gangliosides are involved in various cellular functions, including signal transduction, cell proliferation, differentia

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… G D2 was further found to be expressed in several additional childhood tumors, including tumors of the CNS [retinoblastoma ( 41 ), diffuse intrinsic pons glioma ( 42 )] and mesenchymal malignancies of the bone (Ewing sarcoma, osteosarcoma) and soft tissues (rhabdomyosarcoma, desmoplastic small round … In preclinical studies, G D2 -specific CAR T cells were highly active against G D2 -positive diffuse intrinsic pons glioma xenografts in the CNS. …

Случай тригеминального нервного нейросаркоида, который первоначально представлял собой изолированные неврологические выводы, имитирующие тригеминальную шванному: отчет о деле и обзор литературы.

Саркоидоз — грануломатное воспалительное заболевание, в первую очередь затрагивающее легкие. Задействование центральной нервной системы является редким и происходит примерно в 5-10% Количество дел. Изолированные повреждения краниального нерва, особенно затрагивающие тригеминальный нерв, являются еще менее распространенными. Эти повреждения могут быть очень похожи на более известные опухоли, такие, как тригеминальные шванномы, менингиома и множественный склероз, что может осложнить диагностику, когда в пещере Меккеля впервые обнаружена одиночная масса.ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: Мы сообщаем о случае

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… There was an extension posteriorly along the cisternal segment of cranial nerve V3, with the lesion projecting into the prepontine cistern with the abutment of the pons. No extracranial extension along the skull base foramina was detected. …

Myohythmia: Количественное исследование синхронии и ритмичности между головой и верхним лимбом.

Мьоритмия — это расстройство осцилляционного движения <4 Гц, которое было в разной степени охарактеризовано как синхронное или асинхронное между частями тела и как вялое или ритмичное по внешнему виду, но никакого доклада о количественном анализе движения не опубликовано. МЕТОДЫ: 51-летняя женщина развила недееспособную миоритмию в голове и верхних конечностях (право) (слева) примерно через три месяца после рецидива множественных склерозов в ее мозговой стебле и мозжечке. Движение головы и двусторонних рук было зафиксировано в состоянии покоя и в позе с трехосными акселерометрами и гироскопиче

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… MRI in February 2024 revealed non-enhancing demyelinating lesions in the medulla > pons > midbrain and in the inferior, middle and superior cerebellar peduncles and deep cerebellar white matter bilaterally. …

Vincristine-Induced Seizure from Drug Interactions: A Case Report and Review of Literature.

Vincristine (VCR) as a key drug for the treatment of acute lymphoblastic leukemia (ALL) is associated with neurotoxicity. We present a young man with a history of controlled childhood seizures who was diagnosed with pre-B-cell ALL and developed generalized tonic-clonic seizures following the Cancer and Leukemia Group B (CALGB) 8811 regimen. The patient also received oral itraconazole to prevent fungal infection initiated by chemotherapy. Possible causes of seizure, including electrolyte abnormalities, hypoglycemia, central nervous system infection or inflammation, were ruled out. According to

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… This hypothesis is based on finding neuronal lesions in the cerebellum, pons, medulla and autopsy in patients with ALL who were treated with VCR. These changes are commensurate with those induced in animals by VCR [12, 20] . …

When tissue is not the only issue: Poorly differentiated lung squamous-cell carcinoma with adrenal, costochondral, and cardiac metastases - case report.

Nonmelanoma skin cancer is the most common cancer in the world, and lung cancer is the leading cause of death from cancer. Histologically, squamous cell carcinoma (SCC) is the second most prevalent type of both skin and lung cancers. We report the case of a 38-year-old female with metastatic, poorly differentiated lung SCC detected on chest X-ray after she presented to the hospital with cough and dyspnea. She had had a 7.5 cm moderately differentiated well-circumscribed posterior scalp SCC completely excised eight years earlier. CT scan showed a large right lung mass, nodular filling defect in

Optimizing Patient Education of Oncology Medications: A Patient Perspective.

The medication information needs of patients with cancer have been primarily studied using quantitative methods and little qualitative research on this topic exists. The purpose of this study was to explore patients' perspectives of optimal oncology medication education provided to patients at the Nova Scotia Health Authority (NSHA). Adult (≥ 18 years) outpatients in medical, gynecological and hematology oncology at NSHA were invited to participate in focus groups, which were audio-recorded, transcribed and analyzed thematically. Three focus groups, including 21 outpatients, were conducted. Fo

Множественный склероз, инфекция мочевого тракта и бесплодие: всеобъемлющий обзор аналитического исследования.

Множественный склероз (MS) — аутоиммунное заболевание, связанное с центральной нервной системой. ПМС широко распространены среди взрослых молодых людей и постепенно уничтожают аксоны и миелин. Лица, страдающие НР, часто сталкиваются с такими осложнениями, как дефункция мочевого тракта, инфекция мочевого тракта и сексуальная дисфункция. У молодых людей РС может вызывать сексуальную дисфункцию и бесплодие, которое ухудшается по мере развития болезни. Были рассмотрены имеющиеся данные из различных исследований (микробиологические и клинические исследования, полученные из баз данных PubMed и Scopu

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… As shown by magnetic resonance imaging in patients with relapsing-remitting multiple sclerosis, sexual dysfunction is also related to severe lesions in the pons ( 62 ). …

Utilization and quality of palliative care in patients with hematological and solid cancers: a population-based study.

BackgroundPalliative care (PC) contributes to improved end-of-life care for patients with hematologic malignancies (HM) and solid tumors (ST) by addressing physical and psychological symptoms and spiritual needs. Research on PC in HM vs. ST patients is fragmented and suggests less use.MethodsWe analyzed claims data of all deceased members of a large German health insurance provider for the year before death. First, we analyzed the frequency and the beginning of different types of PC and compared patients with HM vs. ST. Second, we analyzed the adjusted impact of PC use on several end-of-life q

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… Am J Hosp Palliat Care. 10.1177/10499091221149150 36592366 10.1177/10499091221149150 Arias-Casais N López-Fidalgo J Garralda E Pons JJ Rhee JY Lukas R de Lima L Centeno C Trends analysis of specialized palliative care services in 51 countries of the WHO European region in the last 14 years Palliat Med … 2020 34 8 1044 1056 10.1177/0269216320931341 32519584 PMC7388149 Arias-Casais N, López-Fidalgo J, Garralda E, Pons JJ, Rhee JY, Lukas R, de Lima L, Centeno C (2020) Trends analysis of specialized palliative care services in 51 countries of the WHO European region in the last 14 years. …

Cancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals.

In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onset cancer therapy-related cardiovascular toxicity (CTR-CVT); (2) Patients with long-term control of not-curable cancers in whom CTR-CVT may need to be addressed. This paper highlights the importance of the cancer care continuum, of a patient-centered approach and of a prevention-oriented policy. The

Fit theory: A cancer experience grounded theory emerging from semi-structured interviews with cancer patients and informal caregivers in Manitoba Canada during the COVID-19 pandemic.

BackgroundIt is not clear how changes to healthcare delivery related to the COVID-19 pandemic, including virtual care and social distancing restrictions, have impacted the experience of living with cancer. This study aimed to discover a theory capable of describing the cancer experience, how the pandemic impacted it, and for guiding predictions about how to improve it.MethodsBetween October 2020 and July 2021 digitally recorded semi-structured one-on-one interviews were conducted virtually with adult cancer patients and informal caregivers in Manitoba, Canada. Transcriptions and field notes fr

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm.

Acute kidney injury (AKI) is a common clinical condition among patients admitted in the hospitals. The condition is associated with both increased short-term and long-term mortality. With the development of a standardized definition for AKI and the acknowledgment of the impact of AKI on patient outcomes, there has been increased recognition of AKI. Two advances from past decades, the usage of computer decision support and the discovery of AKI biomarkers, have the ability to advance the diagnostic method to and further management of AKI. The increasingly widespread use of electronic health reco

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… Pons B. Boulet E. Boyer A. Chevrel G. Lerolle N. Carpentier D. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit N. Engl. J. Med. 2016 375 122 133 10.1056/NEJMoa1603017 27181456 181. Barbar S.D. Clere-Jehl R. Bourredjem A. Hernu R. Montini F. Bruyère R. Lebert C. … Pons B. De Prost N. Besset S. The Artificial Kidney Initiation in Kidney Injury 2 (AKIKI2): Study protocol for a randomized controlled trial Trials 2019 20 726 10.1186/s13063-019-3774-9 31843007 PMC6915917 185. Smith O.M. Wald R. Adhikari N.K. Pope K. Weir M.A. Bagshaw S.M. …

Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial.

Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia through a double-blind randomized controlled trial. Twenty-four patients were selected from a dental oncology clinic and randomly assigned to the over-the-counter or compounded mouthwash group. Each patient was instructed to rinse their oral cavity with the assigned solution three times a day for 30 days. Both p

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… López Jornet P, Hernandez L, Gomez García F, Galera Molero F, Pons-Fuster López E, Tvarijonaviciute A. A clinical study on the efficacy and tolerability of a new topical gel and toothpaste in patients with xerostomia: a randomized controlled trial. …