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The Long Arm of Adverse Childhood Friendships Among Middle-Aged and Older Cancer Survivors: Associations With Social Isolation and Frailty in Later Life.

BACKGROUND: Middle-aged and older cancer survivors experience frailty related to both age and cancer. While studies have explored the associations between risk factors and frailty in this population, there is still a gap in understanding the long-term associations and mechanisms linking adverse childhood experiences (ACEs) to frailty in later life. OBJECTIVE: This study examines the long-term association between a social connectedness-oriented dimension of ACEs-adverse childhood friendships-and frailty in later life among cancer survivors. Additionally, this study seeks to elucidate the media

IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.

The clonal glioma driver mutation IDH1R132H gives rise to a major histocompatibility class II-restricted neoepitope. A multicenter, first-in-human phase 1 trial met its prespecified primary endpoints by demonstrating safety and immunogenicity of an IDH1-R132H peptide vaccine (IDH1-vac) integrated into standard of care in 33 participants with newly diagnosed grade III and IV (World Health Organization classification 2007) IDH1-R132H+ astrocytomas (NOA16). Here we report on the clinical and immunological long-term follow-up of this trial as secondary and translational endpoints. The 8-year progr

Resource-strengthening training for adolescents with problematic gaming (Res@t-A): Results from an exploratory single-arm pre-post-follow-up intervention study.

BACKGROUND AND AIMS: Gaming is a popular leisure activity among adolescents. Yet, they are especially vulnerable to develop problematic gaming (PG). Those affected are often additionally impaired by deficits in attention, mood, emotion regulation, sleep quality, and social skills. Thus, effective treatment offers should address main PG symptomology and associated problems alike. However, clinical studies on multi-faceted treatments of adolescents are scarce. Therefore, the aim of this study was to preliminarily test feasibility and efficacy of the newly developed, fully manualized CBT-based pr

Efficacy of calcineurin inhibitors in interstitial lung disease of patients with antisynthetase syndrome: a systematic literature review and single-arm prevalence meta-analysis.

Ferritin is one of the most requested blood tests in both primary and inpatient care, and high values occur frequently. One of the greatest challenges in the investigation of hyperferritinemia is to determine if there is a presence of iron overload. Patient history (chronic liver disease, excessive alcohol consumption, hereditary factors), clinical features (metabolic syndrome, acute or chronic inflammation, infection, malignancy) and biochemical tests (ferritin, transferrin saturation, hemoglobin, liver enzymes, CRP/SR, phosphatidyl ethanol, lipid profile, glucose) facilitate the determinatio

Fundamental evaluation of a novel upright shield to protect medical personnel from scattered radiation during endoscopic retrograde cholangiopancreatography using a C-arm system.

Medical personnel performing endoscopic retrograde cholangiopancreatography (ERCP) are at a high risk of developing radiation-induced injuries, such as cataracts, due to scattered radiation, making the use of appropriate radiation protection equipment essential. We developed two types of upright shields attached to a C-arm system (under-couch tube position): one for the operator and the other for the anesthesiologist. The purpose of this study was to evaluate the protective effect of these upright shields. We conducted a phantom study in typical ERCP settings and compared the scattered radiati…

Feasibility, safety and preliminary effectiveness of an epilepsy treatment smartphone application in rural primary care: A two-arm prospective observational study from India.

BACKGROUND: The epilepsy treatment gap remains a major public health challenge in low- and middle-income countries, including India, where up to 90% of people with epilepsy in rural settings receive no treatment. Smartphone applications capable of guiding non-specialist doctors through diagnosis and individualized treatment have been proposed as a scalable solution. We evaluated the feasibility, safety, and preliminary effectiveness of a novel decision-support application -the Epilepsy Treatment Aid (ETA) in rural primary care settings in Chhattisgarh, India. METHODS: We conducted a two-arm p…

Association of tranexamic acid use and autologous predonation with blood loss and transfusion outcomes after periacetabular osteotomy: An arm-based multilevel meta analysis.

PURPOSE: To evaluate the association between tranexamic acid (TXA) use, autologous predonation and perioperative blood management outcomes after periacetabular osteotomy (PAO) using an arm-based multilevel meta-analytic framework. METHODS: A systematic search of PubMed, Embase, Epistemonikos and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed up to 30 March 2026. Prospective and retrospective primary clinical studies reporting perioperative blood management outcomes after PAO were included. Comparisons between TXA and non-TXA arms, as well as predonation and no-pred…

Mechanizing the Laparoscope Operator in Sleeve Gastrectomy: A Single-Surgeon Before-and-After Study of a Pneumatic Endoscope-Holding Device (Lock-Arm®).

BACKGROUND: Japan faces a critical shortage of gastrointestinal surgeons. In the Japanese standard of care for laparoscopic surgery, three p … paroscope operator (Reverse Trendelenburg position, legs apart); the M group (n = 69) used the Lock-Arm® pneumatic passive endoscope holder (Reverse Trendelenburg position, legs together). Primary outcomes were OR occupancy time and operative time. Secondary outcomes included blood loss, intraoperative body temperature at three time points, Clavien-Di …

CARE-ing for concussions: Development of the Calgary Adapted aRm Ergometer (CARE) exertion test: A physiological alternative to the Calgary Concussion Cycle Test.

Aerobic exercise testing helps facilitate recovery post-concussion. Current protocols (Calgary Concussion Cycling Test: CCCT) are inaccessible for athletes with lower-body impairments (i.e. Para athletes). This study compared physiological parameters for a novel arm crank test, the Calgary Adapted aRm Ergometer (CARE) test, with the CCCT. Twenty non-disabled adults (10F:10M, aged 18-51) completed CCCT and CARE to volitional fatigue. Middle cerebral artery velocity (MCAv), heart rate (HR), mean arterial pressure (MAP) and end-tidal carbon dioxide ( P ETC O 2 ${{P}_{{\mathrm{ETC}}{{{\mathrm{O…

Direct warming and rehydration method in frozen embryo transfer: study protocol for a pragmatic, multi-center, double-blinded, two-arm randomized controlled trial.

BACKGROUND: Embryo cryopreservation through vitrification is widely used to store surplus embryos for future transfer. Traditional multi-step warming methods are both time-consuming and costly. This study evaluates the clinical outcomes and the effectiveness of a novel direct warming method for frozen embryo transfer (FET) in comparison to the conventional multi-step method. METHODS: This is a pragmatic, two-arm, double-blinded randomized controlled trial (RCT) comparing the new direct warming method with the conventional multi-step method. Participants undergoing FET will be randomly assigne…

Short commentaries on data published by Yono et al. on avoiding breast cancer-related arm lymphedema with the lymphatic microsurgical preventive healing approach.

Lymphatic microsurgical preventive healing approach (LyMPHA) is being adopted to prevent arm lymphedema after axillary lymph node dissection (ALND), but open questions remain over selection bias, non-standardized endpoints and variable surgical protocols before robust evidence is available.

Robotic-arm assisted total hip arthroplasty using a short metaphyseal filling collared femoral implant through a direct anterior approach: minimum two-year outcomes.

INTRODUCTION: Short, collared, metaphyseal-filling femoral stems preserve proximal bone and achieve stable fixation while reducing stress shielding compared to diaphyseal-engaging stems. Early six-month data for one such stem demonstrated improved patient-reported outcomes with no implant-related complications. This study extends follow-up of the same cohort to a minimum of two years to evaluate (a) functional outcomes, (b) implant-related complications, and (c) survivorship. MATERIALS AND METHODS: The prospective cohort of 120 patients underwent robotic-arm assisted total hip arthroplasty (T…

Плитидепсин в сочетании с дексаметазоном (испытание ADMYRE) против внешнего контрольного рычага помалидомида плюс дексаметасона у пациентов с повторной/отходной миеломой.

Plitidepsin (P) — морской антираковый комплекс, изолированный от аплидиевых албиканов. P плюс дексаметасон с низкой дозой (LD-DXM) оценивался в сравнении с LD-DXM в одиночку у пациентов с повторной/редактированной множественной миеломой (r/r MM) в ходе случайного этапа III испытания ADMYRE. В отсутствие случайного исследования P + LD-DXM vs. POM + LD-DXM, прямое сопоставление между P + LD-DXM (данные ADMYRE) и помалидомидом (POM) + LD-DXM в качестве внешнего контрольного механизма (ECA), было проведено с использованием индивидуальных данных, полученных в ходе нескольких современных испытаний P

Совпадение в аннотации оригинала
Plitidepsin (P) is a marine-derived anticancer compound isolated from the tunicate Aplidium albicans. P plus low-dose dexamethasone (LD-DXM) … comparison between P + LD-DXM (ADMYRE data) and pomalidomide (POM) + LD-DXM as an External Control Arm (ECA) was conducted using individual patient-level data from several contemporary POM + LD-DXM trials with a similar design. A first analysis (ECA1) showed that P + LD-DXM was non-inferior to POM + LD-DXM in terms of median overall survival (OS): 11 …

Outcomes of Internal, External, and Hybrid Fixation in Hindfoot Charcot Neuroarthropathy: A Descriptive Systematic Review and Single-Arm Meta-analysis of Observational Studies.

BACKGROUND: Charcot neuroarthropathy (CN) of the hindfoot often requires internal fixation (IF), external fixation (EF), or hybrid constructs. This descriptive systematic review and single-arm meta-analysis summarizes outcomes of these strategies, focusing on amputation, fusion, ambulation, and complications. METHODS: Following PRISMA guidelines, 30 studies with 957 patients undergoing hindfoot or ankle reconstruction were included. A single-arm meta-analysis assessed amputation and fusion rates; qualitative analysis examined ambulation, infection, ulceration, hardware failure, and revision. …

Clinical improvement but substantial arthroplasty risk following fresh osteochondral allograft transplantation of the femoral head: A systematic review and single-arm meta-analysis.

PURPOSE: To systematically review the literature and perform a single-arm meta-analysis to evaluate clinical outcomes, failure rates and survivorship following fresh osteochondral allograft transplantation of the femoral head. METHODS: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Ovid MEDLINE and Scopus. Clinical studies reporting outcomes of fresh osteochondral allograft transplantation of the femoral head with a minimum follow-up of 12 months were included. A single-arm random-effects meta-an…

Effect of spinning babies® on labor progression and cesarean delivery rates: protocol for an open-label, two-arm, parallel randomized controlled trial.

BACKGROUND: Cesarean section rates remain high worldwide, especially in Brazil, where they far exceed international recommendations. Arrest … pared with standard intrapartum care. METHODS: This is an open-label, single-center, parallel, two-arm randomized controlled trial conducted in a large public university maternity hospital in Southern Brazil. Nulliparous women aged 18 years or older, at term, with singleton pregnancies, cephalic fetal presentation, and fetuses located in the midpelvi …

Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal enuresis: a prospective single-arm cohort study from Gaza (2023-2025).

BACKGROUND: Primary monosymptomatic nocturnal enuresis (PMNE) is a common pediatric condition characterized by involuntary nighttime urination with high spontaneous remission rates. OBJECTIVE: To describe observed changes in PMNE frequency following folic acid supplementation combined with behavioral therapy. METHODS: A prospective single-arm cohort study was conducted in Gaza (2023-2025). Children aged 5-15 years with PMNE received folic acid (5 mg/day for 3 months) and standardized behavioral therapy. Data were collected using parental bladder diaries. The study is reported in accordance w…

Comparison of breath hold and abdominal compression for liver SABR on C-arm Linac and MR Linac: A single institution retrospective planning study.

BACKGROUND: Respiratory motion is a challenge for accurate stereotactic ablative radiotherapy (SABR) to the liver. This study compares the dosimetric impact of abdominal compression (AC), breath hold (BH) and free-breathing (FB) strategies for liver SABR on conventional C-arm linear accelerators (Linacs) and magnetic resonance Linacs (MR Linacs). METHODS: Five patients undergoing liver SABR were imaged using T2-weighted turbo-spin echo and cine-MRI with FB and AC, and mDixon with BH. The gross tumour volume (GTV) was expanded based on quantified motion to generate the internal target volume (…

Semaglutide as adjunct treatment for obesity in adolescents receiving antipsychotic medication (the GOAL trial): protocol for a single-arm, open-label feasibility study.

INTRODUCTION: Adolescents treated with antipsychotic medication are at increased risk of obesity and metabolic complications, yet evidence-b … e-up of a subsequent randomised controlled trial. METHODS AND ANALYSIS: The GOAL trial is a single-arm, open-label feasibility study conducted at Copenhagen University Hospital, Bispebjerg, Denmark, in collaboration with the Child and Adolescent Mental Health Center. A total of 34 adolescents aged 12-18 years with obesity, defined as body mass index …