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Information exchange or discussion? A qualitative study on cross-sectoral collaboration between social security service and healthcare service for patients with chronic fatigue.

BACKGROUND: Chronic fatigue, with or without an identified underlying cause, can severely restrict social participation, education, employment, and daily activities, often leading to long-term disability. In parallel with the health challenges, many affected individuals also seek support from social security services. While cross-sectoral collaboration between healthcare and social security service in managing chronic conditions is increasingly studied, little is known about such collaboration for patients with chronic fatigue. The aim of this study was therefore to investigate the experiences…

The Fried Phenotype Is More Closely Associated With Dementia in Older Adults Than the FRAIL (Fatigue, Resistance, Ambulation, Illness, and Loss of Weight) Index.

INTRODUCTION: There is a close relationship between dementia and frailty in older adults. The aim of our study was to compare the relationship between the Fried and FRAIL (fatigue, resistance, ambulation, illness, and loss of weight) frailty scales and the frequency of dementia in elderly individuals. METHODS: A cross-sectional study was conducted on 558 patients who presented to the geriatric outpatient clinic between 2022 and 2024. The Fried and FRAIL frailty scales were used to assess frailty. On both scales, the groups were divided into three subgroups: frail, prefrail, and robust. The gr…

Brain-Derived Neurotrophic Factor (BDNF) as a Marker of Physical Exercise or Activity Effectiveness in Fatigue, Pain, Depression, and Sleep Disturbances: A Scoping Review.

Background/Objectives: Brain-derived neurotrophic factor (BDNF) has been investigated as a potential mechanistic marker or therapeutic target to manage symptoms such as fatigue, pain, depression, and sleep disturbances. However, the variability in BDNF response to exercise or physical activity (exercise/PA) and its clinical relevance in symptom management remains unclear. This scoping review assesses existing studies exploring the relationships between exercise/PA, symptoms, and BDNF levels, specifically focusing on fatigue, pain, depression, and sleep disturbances in adults. Methods: Relevant…

Strength Training Improves Running Economy Durability and Fatigued High-Intensity Performance in Well-Trained Male Runners: A Randomized Control Trial.

INTRODUCTION: Strength training improves running economy (RE) in a nonfatigued state and performance after prolonged exercise at moderate intensity. However, it is unknown if strength training improves RE durability at marathon race intensity, or high-intensity performance akin to the final stages of a competitive race. This study quantified the effect of a supplementary 10-wk strength training program on RE throughout 90 min of running in the heavy-intensity domain, and subsequent fatigued performance in runners. METHODS: Twenty-eight well-trained male runners (maximal oxygen uptake (V̇O 2ma…

The impact of fatigue and different environmental conditions on heart rate responses and shooting accuracy during laser run event in elite modern pentathletes.

BACKGROUND: The final event in modern pentathlon, the laser run, determines the final ranking, and it is not known whether the athletes' heart rates (HRs) and success rates during the shooting in the laser run are affected by environmental conditions. Although heart rate (HR) affects shooting performance, exercise-induced muscle fatigue accompanying increased HR can affect shooting speed and accuracy. The aims of this research were (a) to compare the HRs of pentathletes before and after fatigue, (b) to compare the shooting performance of pentathletes in the field vs. laboratory environment, an…

Influence of coffeeberry extract on soccer specific skill performance during simulated soccer match-play and following fatiguing exercise in academy players.

OBJECTIVES: To investigate the effects of acute coffeeberry extract ingestion on soccer-specific technical skill performance, sprint performance, high-intensity running capacity, and subjective perceptions of fatigue, energy, and alertness during a soccer match simulation in academy soccer players. DESIGN: Double-blind, randomised, placebo-controlled, crossover trial. METHODS: Twenty trained male soccer players completed two experimental trials (coffeeberry extract [300 mg] and placebo [flavour and colour matched] beverages), separated by 7-14 days. Each trial, conducted 1 h after ingestion …

Effects of acute sleep deprivation and extreme fatigue on cognitive performance and cardiac autonomic function during an expedition adventure race: a case report.

Four ultra-endurance athletes (3M/1F) navigated ~800 km via trekking, biking, and paddling using topographical maps and compass, sleeping ~6 h each. Mood, cognitive performance, and heart rate variability were measured at baseline (PRE), post-race (POST), and 18-h post-race (POST18). Decreased anxiety (ΔMdn = 6.5, p = 0.047) along with increased fatigue (ΔMdn = 13.5, p = 0.02) and confusion (ΔMdn = 5.5, p = 0.02) at POST, and improved reaction time (ΔMdn = 0.12 ms, p = 0.04) at POST18 were observed. Findings suggest that extreme exertion and acute sleep-deprivation can elevate psychological st…

Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS-CoV-2 infection.

Following an acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a substantial percentage of patients report the persistence of debilitating symptoms, often grouped in a syndrome termed 'long COVID'. We sought to identify potential pathophysiological mechanisms responsible for the persistence, in some long COVID patients, of symptoms related to fatigue/exercise intolerance (excessive or early fatigue, excessive or early dyspnoea, muscle weakness, and myalgias) more than 2 years after the original infection. Twelve patients who reported persistent symptoms (Long C…

Impact of Physical Exercise Programs on Fatigue and Functional Capacity in People With Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review.

OBJECTIVE: To evaluate the effect of physical activity programs on fatigue and functional capacity, in addition to other variables related to patient's health in people suffering Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) through a systematic review. DATA SOURCES: Four databases (PubMed, Web of Science, Scopus, and EBSCO) were searched according to Preferred Reporting Items for Systematic review and Meta-Analyses guidelines. The search was conducted from the inception until March 1, 2025. STUDY SELECTION: Inclusion criteria focused on s…

The Impact of Tilburg Frailty on Poststroke Fatigue in First-Ever Stroke Patients: A Cross-Sectional Study With Unified Measurement Tools and Improved Statistics.

BACKGROUND: Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. OBJECTIVE: To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI) while controlling for modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), anxiety, depression, and other confounding factors. METHODS: A single-center cross-sectional study was conducted with 320 first-ever stroke patients. F…

ActiLup: is it feasible? High-intensity interval training in systemic lupus erythematosus patients with fatigue: protocol for a prospective, monocentric proof-of-concept study.

The symptoms of active systemic lupus erythematosus (SLE) potentially lead to inactivity, muscle loss and social isolation. In addition to medical treatment, the current EULAR recommendations describe the relevance of physical activity, exercise and training as a non-pharmacological management option in patients with SLE. A positive interaction between fatigue and the basic health-promoting effects of exercise is well established. Still unclear is what kind of training, setting, and intensity show optimal objective and subjective outcomes. The study will include 40 adult SLE patients with mode…

Effects of vegetarian and vegan diets on disease activity, pain, fatigue, and physical function in patients with rheumatoid arthritis: A systematic review and meta-analysis.

BACKGROUND: This systematic review and meta-analysis aim to assess the effects of vegan and vegetarian diets on disease activity, pain, fatigue, and physical function in people with rheumatoid arthritis. METHODS: We conducted searches on the MEDLINE, EMBASE, CINAHL, and Central electronic databases up to December 2024. Randomized controlled trials that investigated vegan or vegetarian dietary interventions (including lacto-ovo-vegetarian, vegan, or whole-food plant-based diets) in people with rheumatoid arthritis were included, and independent of outcomes measured. RESULTS: Of 1408 screened …

Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19: A TSPO PET Study.

A significant number of patients report persistent fatigue and difficulty concentrating after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a condition known as post-coronavirus disease 2019 (post-COVID) syndrome. The underlying mechanisms for these complaints remain poorly understood. Dysregulated immune and neurologic systems may play a role in the pathophysiology of post-COVID syndrome. A target providing direct information on immune activation is the 18-kDa translocator protein (TSPO), which is upregulated in activated microglia. The PET tracer N,N-diethyl-2-…

Воздействие онлайновой программы поддержки пациентов под руководством медсестер на усталость, сон и качество жизни у пациентов с множественным склерозом: квазиэкспериментальное исследование.

Множественный склероз (MS) становится все более распространенным. Физические расстройства и проблемы со сном, особенно усталость, ухудшают качество жизни этих пациентов. One Одним из наиболее успешных и долгосрочных стратегий борьбы с симптомами является обучение пациентов. Цель этого исследования заключалась в оценке воздействия онлайновой программы поддержки под руководством медсестер на усталость, сон и качество жизни пациентов с множественным склерозом (PwMS). МЕТОДЫ: Это квазиэкспериментальное исследование было проведено в амбулаторной клинике MS одной из университетских больниц в Стамбул

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is becoming more prevalent. Physical impairments and sleep issues, particularly fatigue, diminish these patients' quality of life. One of the most successful and long-lasting strategies for managing symptoms is patient education. The aim of this study was to evaluate effect of a nurse-led online support program on fatigue,…

Качественное сопоставление восприятия врачами усталости как симптома в неврологических условиях: наблюдения из центра третичной медицинской помощи в Саудовской Аравии.

ВВЕДЕНИЕ: Усталость как симптом серьезно сказывается на людях с неврологическими заболеваниями, однако ее понимание и управление остаются ограниченными, особенно в уникальном контексте здравоохранения Саудовской Аравии. Несмотря на то, что он широко изучался в инсульте, его проявления в неврологических условиях и представления медицинских работников не были тщательно изучены в этой конкретной обстановке. Учитывая глубокое воздействие усталости на результаты лечения пациентов, понимание отношения медицинских работников имеет решающее значение для определения адресных мер и существенного улучшен

Совпадение в аннотации оригинала
INTRODUCTION: Fatigue as a symptom severely affects individuals with neurological diseases, but its understanding and management remain limited, especially in the unique healthcare context of Saudi Arabia. While it has been extensively studied in stroke, its manifestations in neurological conditions and the perceptions of health professionals have not been t…

Effects of the powerball® system on muscle strength, coordination, fatigue, functionality and quality of life in people with multiple sclerosis. A randomized clinical trial.

INTRODUCTION: Although clinical and functional impairments in the lower limbs have been extensively studied in patients with MS, the upper limb (UL) are also frequently affected. Clinical impairment of the UL in patients with MS is very common with muscle strength and hand dexterity as critical factors in maintaining functional activities that are the basis for independence and quality of life in people with MS. OBJECTIVE: To investigate the effects of a training protocol using the Powerball® system in combination with conventional physiotherapy on muscle strength, coordination, fatigue, func…

Effects of acceptance and commitment therapy on fatigue interference in patients with advanced lung cancer and caregiving burden: protocol for a pilot randomised controlled trial.

INTRODUCTION: Cancer-related fatigue is common in patients with advanced lung cancer. It not only interferes with patients' health-related quality of life, but also increases the caregiving burden of their caregivers. Acceptance and commitment therapy is emerging as a novel way to advocate accepting negative experiences and taking effective actions based on their own values to help patients commit meaningful actions in the course of cancer diseases. This trial aims to test the feasibility, acceptability and preliminary effects of acceptance and commitment therapy for fatigue interference in pa…

Association of fatigue with disease activity and clinical manifestations in patients with Crohn's disease and ulcerative colitis: an observational cross-sectional study in the United States.

BACKGROUND: Fatigue imposes a socioeconomic burden on patients with Crohn's disease (CD) and ulcerative colitis (UC). We assessed the prevalence of fatigue among patients with CD or UC and identified disease activity measures associated with fatigue. METHODS: Data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD) were analyzed separately for CD and UC. Fatigue was defined based on a subjective and dichotomic questionnaire. Patients indicated if they experienced fatigue within the last week. The overall prevalence of fatigue was analyzed using de…

The Effects of Lower Leg Compression Garments on Lower Extremity Sports Injuries, Subjective Fatigue and Biomechanical Variables: A Systematic Review with Meta-analysis.

The objective of this study was to systematically review the literature on the effect of CGs versus non-CGs (such as regular socks) or versus placebo garments on 1) the incidence of lower extremity sports injuries and 2) subjective ratings of fatigue and biomechanical variables in athletes at participating in any sport that required any level of running performance, given that fatigue-related biomechanical alterations may increase the risk of sports injuries. This study was a systematic review with meta-analyses. PubMed, Embase, CINAHL, Cochrane, PEDro, and Scopus were searched for eligible st…

Investigation of the effect of residual waviness formed by rail profile milling of reshaped surface on wheel-rail contact stresses and low cyclic fatigue.

The rail profile milling process allows considerable thickness to be removed in a single pass. However, the residual waviness formation law … e element analysis model of wheel-rail contact was employed to analyze the contact stresses and low fatigue cycles at a wheel load of 11.5 tons with no residual waviness on the rail profile surface and with three types of residual waviness, respectively. The results show that the residual waviness changes the wheel-rail contact position and the morphology …