Результаты поиска

Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment.

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammation and demyelination of CNS neurons. Up to now, there are many therapeutic strategies for MS but they are only being able to reduce progression of diseases and have not got any effect on repair and remyelination. Stem cell therapy is an appropriate method for regeneration but has limitations and problems. So recently, researches were used of exosomes that facilitate intercellular communication and transfer cell-to-cell biological information. MicroRNAs (miRNAs) are a class of short n…

Subgroup analyses and patterns of multiple sclerosis health service utilisation: A cluster analysis.

BackgroundPrevious investigations of multiple sclerosis (MS)-related healthcare have focused on utilisation of specific individual health services (e.g. hospital care, office-based neurologists) by people with MS (PwMS). Meanwhile, little is known about possible patterns of utilisation across health services and their potential differences across patient characteristics.ObjectiveTo comprehensively analyse and identify patterns of MS-related health service utilisation and detect patient characteristics explaining such patterns.MethodsIn 2021, we invited all PwMS insured by the largest insurance…

Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports.

Nicolau syndrome is a rare, iatrogenic skin reaction after parental drug administration, characterized by severe pain at an injection site, followed by hemorrhage, ulceration, and often necrosis. We present a case of a patient on glatiramer acetate for many years (initially Copaxone then Glatopa) who developed Nicolau syndrome, the second reported case after generic glatiramer acetate. All reported cases of Nicolau syndrome after glatiramer acetate are reviewed. The case highlights the importance of prompt recognition of this skin reaction by neurologists and raises awareness of the risks of s

Glatiramer acetate in situ forming gel, a new approach for multiple sclerosis treatment.

BACKGROUND: Glatiramer acetate (GA), a commonly used treatment for multiple sclerosis (MS), requires long-term frequent injections to ensure its effectiveness. This often leads to adverse effects, patient noncompliance, and economic inefficiency. OBJECTIVES: In this study, poloxamer, as a thermosensitive polymer modified by chitosan (CS) and hyaluronic acid (HA), was employed to prepare an in situ forming prolonged release formulation of GA to overcome the problems derived from frequent repeated injections and to enhance the patient compliance. METHODS: The sol-gel formulation was produced t…

Exploring subtypes of multiple sclerosis through unsupervised machine learning of automated fiber quantification.

PURPOSE: This study aimed to subtype multiple sclerosis (MS) patients using unsupervised machine learning on white matter (WM) fiber tracts and investigate the implications for cognitive function and disability outcomes. MATERIALS AND METHODS: We utilized the automated fiber quantification (AFQ) method to extract 18 WM fiber tracts from the imaging data of 103 MS patients in total. Unsupervised machine learning techniques were applied to conduct cluster analysis and identify distinct subtypes. Clinical and diffusion tensor imaging (DTI) metrics were compared among the subtypes, and survival a…

Serum teriflunomide concentrations in routine multiple sclerosis therapy: A cross-sectional pilot study.

BACKGROUND: Teriflunomide is administered orally to treat relapsing-remitting multiple sclerosis. In this prospective pilot study, the free and total serum concentrations of teriflunomide obtained during routine health care were measured and their relationship with disease activity was evaluated. METHODS: Eighty-nine patients were included in this study. Blood samples were collected from April 2021 to February 2022, and free and total teriflunomide serum concentrations were measured. Patient assessment involved monitoring of blood counts and potential adverse effects of teriflunomide. RESULT…

Microstructural alterations of cerebellar peduncles in multiple sclerosis: a diffusion tensor imaging study.

BACKGROUND AND PURPOSE: Ataxia, tremors, dysarthria, and sometimes impaired cognition are the signs of cerebellum involvement in multiple sclerosis (MS). These symptoms affect up to 80% of patients and are usually hard to treat. To find the underlying involvement of the cerebellum in MS, we assessed the microstructural alterations with DTI in the cerebellar peduncles of the affected subjects. MATERIALS AND METHODS: We included 58 relapsing-remitting MS patients and 27 healthy controls. Patients were divided into 18 patients of relapsing-remitting MS with cerebellar impairment (RRMSc) and 40 w…

Fatigue insights from walking tests in spinal cord injury and multiple sclerosis individuals.

In the last decade, fatigue in clinical populations has been re-conceptualized, including dimensions such as perceived fatigue (trait and state fatigue) and fatigability. The aim of this study was to evaluate different expressions of fatigue in Spinal Cord Injury (SCI) and Multiple Sclerosis (MS) participants compared to able-bodied controls, during activities of daily living, especially during gait. A total of 67 participants were included in this study (23 with SCI, 23 with MS, and 21 able-bodied controls). All participants performed two functional tests (6-Minute Walk Test and 10-Meter Walk…

Comparison of ocular changes in multiple sclerosis and neuromyelitis optica spectrum disorder patients.

PURPOSE: To explore ocular changes in patients with MS and NMOSD via SD-OCT and PVEP analysis. METHODS: From August 2020 to July 2021, 82 patients (164 eyes) diagnosed with MS, 59 patients (118 eyes) diagnosed with NMOSD and 50 healthy controls (100 eyes) were retrospectively selected. SD-OCT and PVEP were performed to compare retinal nerve fibre layer (RNFL) thickness around the optic disc, ganglion cell inner plexiform layer (GCIPL) thickness in the macula and P100 latency and amplitude between the disease groups and the control group. RESULTS: In the NMOSD and MS groups, the thickness of

Subcortical plaques and inflammation reflect cortical and meningeal pathologies in progressive multiple sclerosis.

It remains elusive whether lesions and inflammation in the sub/juxtacortical white matter reflect cortical and/or meningeal pathologies. Elu … ters in a false discovery rate-corrected analysis. We compared 12 patients with primary progressive multiple sclerosis (PPMS) and 15 with secondary progressive MS to 22 controls. Fifteen patients and 11 controls contributed with hemispheric sections. Sections were stained with haematoxylin-eosin, for myelin and for microglia/macrophages. B cells and T cells were con …

Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions.

BACKGROUND AND OBJECTIVES: Myelin and iron play essential roles in remyelination processes of multiple sclerosis (MS) lesions. χ-separation, a novel biophysical model applied to multiecho T2*-data and T2-data, estimates the contribution of myelin and iron to the obtained susceptibility signal. We used this method to investigate myelin and iron levels in lesion and nonlesion brain areas in patients with MS and healthy individuals. METHODS: This prospective MS cohort study included patients with MS fulfilling the McDonald Criteria 2017 and healthy individuals, aged 18 years or older, with no ot…

Clinical outcomes after use of checkpoint inhibitor immunotherapies in people with multiple sclerosis.

BACKGROUND: Immune checkpoint inhibitors (ICIs) represent a novel class of agents approved for the treatment of several cancers and progressive multifocal leukoencephalopathy (PML). However, due to the risk of autoimmune side effects, their use in people with autoimmune diseases such as multiple sclerosis (MS) has been limited. OBJECTIVE: To characterize outcomes in a cohort of adults with MS who received ICIs. METHODS: A single-center retrospective review of medical record data was performed for people with MS treated with ICIs. RESULTS: Seven people with MS were identified, with a mean (S…

Anti-JCV antibody index seroconversion in Turkish multiple sclerosis patients treated with natalizumab.

BACKGROUND: The anti-JCV antibody index is widely used to monitor multiple sclerosis (MS) patients receiving natalizumab, as seroconversion is linked to an increased risk of progressive multifocal leukoencephalopathy. This study aimed to evaluate the prevalence and risk factors of anti-JCV antibody seroconversion in patients treated with natalizumab. METHODS: We included MS patients exposed to natalizumab treatment for at least one year, with a negative anti-JCV antibody index at baseline, and a minimum of two anti-JCV antibody assessments more than six months apart. We employed Kaplan-Meier …

Протокол количественного многопараметрового картирования, стандартизированный для клинических исследований в области множественного склероза.

Количественная магнитная резонансная съемка (qMRI) включает картирование микроструктуры в стандартизированных единицах, чувствительных к гистологическим свойствам, и дополняет обычную МРТ, которая основана на противоположных взвешенных изображениях, когда сила не имеет биофизического значения. Хотя такие свойства тканей, как миелин, железо или вода, являются желательными в контексте болезни, изменения qMRI могут, как правило, отражать смешанное влияние старения или доклинического дегенерации. Мы использовали протокол быстрого многопараметрного картографирования (МПМ) для клинической рутины на

Совпадение в аннотации оригинала
Quantitative magnetic resonance imaging (qMRI) involves mapping microstructure in standardized units sensitive to histological properties an … report reference MPM values from a healthy population with age and gender distributions typical of multiple sclerosis in whole brain white matter (WM), T2-weighted WM hyperintensities, cortical grey matter and deep grey matter regions and present post-processing optimizations including integration of lesions and normalization of PD maps against cerebrospinal fluid …

Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort.

BACKGROUND: While glucagon-like peptide-1 agonist medications (GLP-1s) are on the rise, their safety and efficacy have not been studied in people with MS (PwMS). OBJECTIVE: To investigate any adverse effects of GLP-1 medications in the MS population as well as their effectiveness for weight loss and vitamin D augmentation. METHODS: We retrospectively identified PwMS who utilized a GLP-1 medication from 2006 to 2024. Wilcoxon signed rank tests for paired samples were used to compare pre- and post-GLP-1 body mass index (BMI), expanded disability status scale (EDSS), timed 25-foot walk (25FTW),

Симптомы перед диагностикой множественного склероза у молодых людей 18 Годы.

ВАЖНОСТЬ: Растущий объем литературы свидетельствует о наличии продрома с неспецифическими признаками и симптомами до возникновения множественного склероза (МС). ЦЕЛЬ: систематическая оценка заболеваний и симптомов, диагностированных 5 За несколько лет до того, как первая MS- или центральная нервная система (CNS) демиелинизировала диагностический код, связанный с заболеваниями у педиатрических пациентов, по сравнению с контролем без MS и контроля с другим иммунопосредованным расстройством, а именно несовершеннолетним идиопатическим артритом (JIA).УЧАСТНИКИ: Это исследование, основанное на анали

Совпадение в аннотации оригинала
IMPORTANCE: A growing body of literature suggests the presence of a prodromal period with nonspecific signs and symptoms before onset of multiple sclerosis (MS). OBJECTIVE: To systematically assess diseases and symptoms diagnosed in the 5 years before a first MS- or central nervous system (CNS) demyelinating disease-related diagnostic code in pediatric pati…

Микроглийские и иммунные клетки взаимодействуют в множественных когнитивных расстройствах склероза: посмертное исследование.

Множественный склероз (MS), нервно-воспалительное заболевание центральной нервной системы, является одной из наиболее распространенных причин нетрадиционной инвалидности среди молодых людей. Поврежденное сознание возникает в качестве вредного симптома, затрагивающего более 50% пациентов и оказывающего существенное воздействие на социальное, экономическое и индивидуальное благополучие. Несмотря на отсутствие терапевтических стратегий, прилагались многочисленные усилия для понимания механизмов, лежащих в основе когнитивных расстройств у пациентов с НР. В этой связи мы стремились выяснить, усугуб

Совпадение в аннотации оригинала
Multiple Sclerosis (MS), a neuroinflammatory disease of the central nervous system, is one of the commonest causes of non-traumatic disability among young adults. Impaired cognition arises as an impactful symptom affecting more than 50% of the patients and with substantial impact on social, economic, and individual wellbeing. Despite the lack of therapeutic …

Риск инфицирования в реальном мире у многочисленных склерозов при долгосрочном лечении иммуномудулятора.

ВВЕДЕНИЕ: Существует множество методов иммуномодуляционного лечения для нескольких склерозов (MS), включая те из них, которые истощают иммунные клетки (например, лекарства против CD20), переносимые иммунные клетки (например, натализумаб, S1P модуляторы) или модулирующие иммунные поднаборы (например, фумараты). Все методы лечения, корректирующие заболевания (ДМТ), могут повысить риск инфицирования, который может ухудшиться в результате длительного применения. МЕТОДЫ: Это ретроспективное, одноцентральное, когортное исследование. Мы проанализировали медицинские записи взрослых людей с MS, которые

Совпадение в аннотации оригинала
INTRODUCTION: Numerous immunomodulatory treatments exist for multiple sclerosis (MS), including those that deplete immune cells (e.g. anti-CD20 medications), relocate immune cells (e.g. natalizumab, S1P modulators), or modulate immune subsets (e.g. fumarates). All disease-modifying treatments (DMTs) can increase infection risk which could worsen with prolong…

Self-reported longitudinal COVID-19 vaccination reactogenicity profiles in persons with multiple sclerosis.

BACKGROUND: Preventing severe COVID-19 associated outcomes continues to be a priority for persons with multiple sclerosis (PwMS). We previously reported in an interim analysis that short-term reactions to the first and second SARS-CoV-2 vaccines experienced by PwMS were mostly self-limiting and similar to reactions experienced by the general population. OBJECTIVES: First, to report short-term reactogenicity experienced by PwMS in relation to the first through fourth SARS-CoV-2 vaccines. Second, to report on short-term reactogenicity in PwMS for different sequences of the first three vaccines.…