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Follow-up of patients with mycosis fungoides after interferon α2b treatment failure.

IntroductionTreatment of T cell cutaneous lymphoma( CTCL) is a controversial subject and the effectiveness of treatment is still low.AimReport of single center experience of management CTCL after progression after first line treatment.Material and methodsWe present 41 patients with CTCL, 29 received interferon α2b in first line, and 12 of them received second line therapy.ResultsOverall response rate for second line therapy was 60%.ConclusionsResults of the follow-up of patients with mycosis fungoides after interferon α2b treatment failure with the literature review and discussion.

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… Treatment of mycosis fungoides (MF) consisted primarily of psoralen phototherapy (PUVA)-therapy [ 2 , 3 ], total skin electron beam radiation therapy for stages I–III [ 4 – 6 ] and extracorporeal photopheresis when Sezary's syndrome (SS) developed [ 7 , 8 ]. … Phototherapy of mycosis fungoides. Photodermatol Photoimmunol Photomed. 2011;27:68–74. doi: 10.1111/j.1600-0781.2011.00559.x. 3. Pothiawala SZ, Baldwin BT, Cherpelis BS, et al. The role of maintenance phototherapy in cutaneous T-cell lymphoma. J Drugs Dermatol. 2010;9:800–3. 4. …

[What's new in dermato-oncology?].

One of the major advance concerning skin carcinoma is the development of targeted therapy: anti-patch/sonic/hedgehog for basal cell carcinoma (BCC) and anti-EGFR for squamous cell carcinoma (SCC). These therapies are indicated for advanced non surgically removable tumors. Their anti-tumoral efficacy has been shown, their effect seems to be suspensive which raises the question of their tolerability for long term use. Laboratory work have shown that BCC and SCC stem cells locate in different cell compartments and follow distinct molecular events which explains their distinct behaviour. The role

8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.

To elucidate the molecular action of 8-methoxypsoralen plus UVA (PUVA), a standard dermatological therapy, we used K5.hTGF-beta1 transgenic mice exhibiting a skin phenotype and cytokine abnormalities with strong similarities to human psoriasis. We observed that impaired function of CD4+CD25+ regulatory T cells (Tregs) and increased cytokine levels of the IL-23/Th17 pathway were responsible for the psoriatic phenotype in this mouse model. Treatment of K5.hTGF-beta1 transgenic mice with PUVA suppressed the IL-23/Th17 pathway, Th1 milieu, as well as transcription factors STAT3 and orphan nuclear

Long-term Follow-up of a Case of Lymphomatoid Papulosis with a Benign Course.

Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsi … CA IgG, and IgM, which could be associated with the exacerbation of LP. Topical corticosteroids and phototherapy were administered when needed in this 14-year period, and methotrexate in a lower dose was prescribed during the extensive generalized eruptions. All of the applied therapeutic modalities led to a partial response. LP is a self-limiting disease for …

[Schnitzler syndrome--report on a fourteen-year course of the disease and an overview of information on the disease].

Schnitzler syndrome is a rare disease characterised by chronic urticaria and the presence of monoclonal IgM immunoglobulin, and by other sym … e effects of interferon alpha prevailed after two years and the therapy was discontinued. Similarly phototherapy using the PUVA method resulted in partial regression of urticarious symptoms. Subsequently tested cyclosporine A (5 mg/kg/day) brought no benefit. Thalidomide (100 mg in the evening) administered on a continuous basis relieved pruritus and improved …

Ультрафиолетовое излучение и нейродегенерация: молекулярные механизмы, лежащие в основе двойного нейрозащитного и нейротоксичного воздействия.

Ультрафиолетовое излучение имеет сложную, зачастую противоречивую связь с риском/прогрессом нейродегенерации, охватывающую клинически диагностированные заболевания [Заболевания Паркинсона (PD), болезни Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS)] или промежуточные фенотипы (уменьшенный нейрогенесис, потеря гиппокампального объема). Цель этого обзора заключается в выявлении двойного воздействия УФ-излучения путем сбора и обобщения экспериментальных (доклинических и переводческих) данных, а также эпидемиологических данных. Нынешняя литература демонстрируе

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… Phototherapy was provided via UV-NB radiation to half the participants, and by the end of 12 months, 100% participants in the non-phototherapy group and 70% participants in the phototherapy group had converted to MS ( Hart, 2018 ). … group and 70% participants in the phototherapy group progressed from CIS to MS | Hart, 2018 ; Kannan et al., 2025 Beyond this, UV radiation is known to be the primary contributor to melanoma, or skin cancer. …

Наркотики и вакцины: систематический обзор литературы.

Калановые лимфомы Т-клеток (КХЛ) представляют собой тип неходгкинской лимфомы, которая обычно связана с кожей. Она имеет различные подтипы, включая микоз-фангоиды (MF), синдром Сезари (SS), первичную анапластическую большую лимфому (PC-ALCL), лимфоматоидный папулос (LyP) и подкожную панникулитную лимфому, аналогичную Т-клеток (SPTCL). Имеется несколько сообщений о случаях, рецидивах или прогрессе в работе ЦТИКС путем использования конкретных лекарственных средств. Мы стремимся определить характерные особенности ТХМЛ, связанные с наркотиками и вакцинами. Систематический поиск проводился с испол

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… However, three cases (17%) were treated with MTX, and three other cases (17%) received phototherapy (two of which were treated with steroids and MTX). … Chemoradiotherapy showed mixed outcomes [ 22 , 47 , 73 ], while phototherapy proved effective, particularly in the early stages [ 67 , 69 ]. …

How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT.

Melanoma is the most aggressive type of skin cancer, the incidence and mortality of which are increasing worldwide. Its extensive degree of heterogeneity has limited its response to existing therapies. For many years the therapeutic strategies were limited to surgery, radiotherapy, and chemotherapy. Fortunately, advances in knowledge have allowed the development of new therapeutic strategies. Despite the undoubted progress, alternative therapies are still under research. In this context, nanotechnology is also positioned as a strong and promising tool to develop nanosystems that act as drug ca

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… Although phototherapies have experienced an increased interest in recent years [ 59 ], the use of light as a therapeutic strategy has already started thousands of years ago [ 60 ]. … Nanoparticle Systems for Cancer Phototherapy: An Overview. Nanomaterials. 2021;11:3132. doi: 10.3390/nano11113132. 60. Grzybowski A., Sak J., Pawlikowski J. A brief report on the history of phototherapy. Clin. Dermatol. 2016;34:532–537. doi: 10.1016/j.clindermatol.2016.05.002. 61. …

Inflammatory Manifestations, Therapeutic Interventions, and Cancer Risk in Psoriasis: Current Epidemiological and Mechanistic Evidence.

Psoriasis is a chronic, autoimmune skin disease driven by persistent inflammation and immune dysfunction that severely impairs quality of life and is associated with serious comorbidities, including psoriatic arthritis, cardiovascular diseases (CVDs), and depression. Emerging epidemiological evidence suggests an association between psoriasis and an increased risk of certain malignancies, such as breast cancer (BC) and non-Hodgkin's lymphoma (NHL), although the strength and consistency of these associations vary across study designs, and the underlying thrombo-inflammatory mechanisms remain inc

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… Phototherapy Phototherapy utilizing ultraviolet (UV) radiation is an established treatment option for moderate-to-severe psoriasis. UV radiation downregulates cutaneous dendritic cell activity and suppresses the activation of pathogenic effector T cells, thereby reducing local inflammation. … Finally, targeted local phototherapy, such as the 308 nm excimer laser or light therapy, utilizes monochromatic ultraviolet wavelengths to treat recalcitrant, localized psoriatic plaques. …

Biological Therapies or Apremilast in the Treatment of Psoriasis in Patients with a History of Hematologic Malignancy: Results from a Retrospective Study in 21 Patients.

BackgroundFew studies addressing the safety and efficacy of biological therapy (BT) or apremilast (APR) in patients with psoriasis with a history of hematologic malignancy (HM) exist.AimTo describe the tolerance and efficacy of BT and APR in moderate-to-severe psoriasis in patients with a history of in-remission or evolving HM.MethodologyA retrospective, multicenter chart review of the tolerance and efficacy of BT or APR in patients with moderate-to-severe psoriasis and a clinical history of in-remission or evolving HM.ResultsTwenty-one patients with severe psoriasis and a history of HM were i

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… Eighteen (18) patients had past first-line psoriasis treatments including phototherapy, acitretin, methotrexate and cyclosporine prior to BT or APR. … This patient had previously received treatment with multiple sessions of phototherapy, prior to the onset of BT. Two (2) patients had a stroke after taking etanercept for 9 months and more than 10 years after treatment had started; treatment was maintained ( Table 2 ). …

Преобразование фотоэнергетики в наноматериалах для точной терапостики.

Быстро развивающаяся область тераностистики направлена на интеграцию терапевтических и диагностических функций в единую платформу для точной медицины, позволяющую одновременно лечить и контролировать болезни. Наноматериалы, основанные на преобразовании фотоэнергии, стали разносторонней платформой, использующей уникальные свойства света для активации тераностистики с высокой пространственной и временной точностью. В настоящем обзоре содержится всеобъемлющий обзор последних изменений в области преобразования фотоэнергетики с использованием наноматериалов с уделением особого внимания их применени

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… Recent advancements in CDs engineering highlight their advantages, such as simpler synthesis, better chelation stability, and superior multimodal imaging capabilities, making them valuable complements to GQDs in bioimaging and phototherapy. [ 28 , 68 , 69 ] Nanoparticles with quantum confinement effects …

Non-pharmacological interventions feasible in the nursing scope of practice for pain relief in palliative care patients: a systematic review.

BackgroundPalliative care patients desire more symptom management interventions that are complementary to their medical treatment. Within the multi-professional team, nurses could help support pain management with non-pharmacological interventions feasible for their practice and adaptable to palliative care patients' needs.ObjectivesThe objective was to identify non-pharmacological interventions feasible in the nursing scope of practice affecting pain in palliative care patients.DesignA systematic review.Data sources and methodsA defined search strategy was used in PubMed, CINAHL, PsycINFO, an

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… ’/exp OR ‘phototherapy’:ab,ti OR (‘light’:ab,ti AND ‘therapy’:ab,ti) OR ‘hypnosis’/exp OR ‘hypnosis’:ab,ti OR ‘musculoskeletal manipulation’/exp OR ‘musculoskeletal manipulation’:ab,ti OR (‘musculoskeletal’:ab,ti AND ‘manipulation’:ab,ti) OR ‘reflexology’:ab,ti OR ‘relaxation training’/exp OR ‘relaxation … Determinant (#2) | exp Aromatherapy/ OR exp Cognitive behavior therapy/ OR exp Biofeedback/ OR exp Phototherapy/ OR exp Hypnosis/ OR exp Autogenic Training/ OR exp Progressive Relaxation Therapy/ OR exp Guided Imagery/ OR exp Imagery/ OR exp Meditation/ OR exp Yoga/ OR exp Music Therapy/ OR exp Massage …

How should very low birthweight babies best be managed in Papua New Guinea?

Short-term outcome in very low birthweight babies has never been closely examined in Papua New Guinea. A cohort of neonates born over a year at Port Moresby General Hospital was followed from birth to death or discharge. Intrauterine growth retardation was an important contributor to low birthweight. Simple, inexpensive care resulted in respectable survival figures. Improving antenatal surveillance will have much more impact in reducing mortality in this group in the future than trying to emulate sophisticated and costly western neonatal care.

Induction of labour at or near term for suspected fetal macrosomia.

BACKGROUND: Women with a suspected large-for-dates fetus or a fetus with suspected macrosomia (birthweight greater than 4000 g) are at risk … n birthweight, and fewer birth fractures and shoulder dystocia. The observation of increased use of phototherapy in the largest trial, should also be kept in mind. Findings from trials included in the review suggest that to prevent one fracture it would be necessary to induce labour in 60 women. Since induction of labour does not appear to alter the rate of ca …

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation.

Heat-shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the … minimise off-target effects and overcome the blood-brain barrier. Emerging strategies such as chemophototherapy, immunotherapy and photothermal therapy leverage HSP70's interactions within the tumour microenvironment, enabling synergistic treatment modalities. The review also highlights translational challenges, including heterogeneity of GBM, regulatory hurd …

Ассоциация < < Между воздействием Солнца и риском возврата > > в педиатрии-посете с множественным склерозом.

ОБСТАНОВКА И ЗАДАЧИ: Облучение с низким Солнцем и ультрафиолетовым излучением (УВР) связано с повышенным риском развития педиатрического многоразового склероза (МС); однако их влияние на курс болезни не является достаточно наглядным. В первую очередь мы изучили, существует ли связь между временем, проведенным на солнце в раннем детстве, и риском рецидива в педиатрии MS. Во-вторых, мы изучали последствия воздействия солнца в последние периоды с точки зрения риска рецидива. МЕТОДЫ: Мы провели многоцентральное когортное исследование участников с педиатрической системой MS, нанятых в 18 детских кл

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… The only randomized controlled trial of narrowband ultraviolet B (UVB) radiation to date, for patients with CIS, did not reach its recruitment target but found that 100% of those in the “no phototherapy” arm and 70% of those in the “phototherapy” arm converted to MS within 12 months, although this did … not reach statistical significance. 28 Further investigation into the potential for UVB phototherapy to slow MS progression is warranted. …

Secukinumab in the Treatment of Plaque Psoriasis in Patients with Malignancy.

Although available data are conflicting, psoriasis seems to be associated with an increased baseline risk of malignancy. In addition, some antipsoriatic systemic treatments have been associated with risk of malignancy. There is not enough data on the association of interleukin (IL)-17 and IL-23 inhibitors with malignancy rate, but there have been no cases reported so far. Secukinumab is a recombinant human monoclonal immunoglobulin G1/κ antibody that selectively targets IL-17A; it was demonstrated to be effective and safe for the treatment of moderate to severe psoriasis that may be appropriat

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… In previous years, psoriasis had been treated with topical agents, UVB phototherapy, and cyclosporin. Phototherapy failed to improve the skin lesions. …

Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.

Epigenetic regulation of gene transcription by small molecule inhibitors of histone deacetylases (HDAC) is a novel cancer therapy. Vorinostat (Zolinza()) is the first FDA approved HDAC-inhibitor for treatment of patients with cutaneous T cell lymphoma (CTCL) who have progressive, persistent or recurrent disease on or following two systemic therapies. Vorinostat was active against solid tumors and hematologic malignancies as intravenous and oral preparations in Phase I development. In two Phase II trials, vorinostat was safe and effective at an oral dose of 400 mg/day with an overall response r

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… For thicker or hypertrophic lesions, the topical retinoid gels or creams may be effective, can reduce the time of clearing with phototherapy, but may cause irritation, especially in intertriginous areas. … HDAC inhibitors may prove even more effective when they are combined with other agents such as retinoids, ie, bexarotene, phototherapy and extracorporeal photophoresis with not-overlapping toxicities ( Table 9 ). …

Biological Therapy for Psoriasis in Cancer Patients: An 8-Year Retrospective Real-Life Study.

Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evidence on the safety of the use of biologic treatments in cancer patients with psoriasis, and the use of this therapeutic class in patients with a pre-existing or concomitan

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… Eleven patients (60%) had previously undergone non-biologic systemic treatments (such as cyclosporine, methotrexate and acitretin) and/or phototherapy prior to commencing biologic therapy. Table 1 Characteristics of cancer patients treated with biologics for psoriasis in our clinic. … Malignancy concerns with psoriasis treatments using phototherapy, methotrexate, cyclosporin, and biologics: Facts and controversies. Clin. Dermatol. 2010;28:88–92. doi: 10.1016/j.clindermatol.2009.03.003. 50. Kirby B., Owen C.M., Blewitt R.W., Yates V.M. …

The IL-17 family in diseases: from bench to bedside.

The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, ho

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… in adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet or UV light). | Psoriasis | 761105 06/16/2022 | IL-23 | Treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy, active … Secukinumab is recommended for patients eligible for systemic therapy and/or phototherapy. …