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Polysaccharide-based beads and water purification: A review.

Polysaccharide-based beads have attracted considerable interest as efficient materials for remediation of water contamination because of their excellent adsorption capability and eco-friendly properties. This review analyzes recent progress in developing biopolymeric magnetic hydrogels deduced from polysaccharides like cellulose, starch, alginate, chitosan, lignin, pectin, guar gum, carrageenan, and agar. It emphasizes their use in eliminating heavy metals, dyes, oil, and antibiotics from polluted water. Adsorbents derived from those materials improve adsorption capacity/efficiency and streaml…

Biological Macromolecule-Based Dressings for Combat Wounds: From Collagen to Growth Factors-A Review.

Wound care in military and combat environments poses distinct challenges that set it apart from conventional medical practice in civilian se … o beyond basic wound coverage by incorporating biologically active macromolecules such as collagen, chitosan, thrombin, alginate, therapeutic peptides, and growth factors. These compounds contribute to properties including moisture balance control, exudate absorption, microbial entrapment, and protection against secondary infection. This review highlights …

Potential health benefits of insect bioactive metabolites and consumer attitudes towards edible insects.

Particular attention has been paid to the nutritional potential of edible insects as well as the health benefits associated with their bioac … tatin, narciclasin, ungeremin, cantharidin, cordycepin, roseoflavin, lecithin, reblastatin, chitin, chitosan and desmosterol deemed to have biological activities, such as tumor suppression, anticancer, antihypertensive, anti-inflammatory, antioxidant, immunomodulator, neuroprotective, glycemic and lipid regulation, blood pressure reduction, regulation of i …

Programmable hierarchical hydrogel dressing for sequential release of growth factor and DNase to accelerate diabetic wound healing.

Dysregulation of growth factor expression causes impaired healing of diabetic foot ulcer (DFU). Platelet-derived growth factor (PDGF)-contai … enhanced healing of DFU. The hydrogel is constructed by crosslinking of anti-bacterial quaternized chitosan and hypochlorite-degradable nanogel via a copper-free click reaction, in which PDGF-BB is loaded in the hydrogel matrix while DNase I is encapsulated in the inner nanogel. Programmable release of combinatorial therapeutics is implemented by the hydr …

Tannic Acid-Based Injectable Hydrogel Promotes the Recovery of Traumatic Brain Injury by Anti-Ferroptosis.

Traumatic brain injury (TBI) can trigger a series of complex physiological responses, with iron overload and neuronal ferroptosis playing particularly pivotal roles. These processes exacerbate secondary brain injury and significantly deteriorate neurological function. To address this challenge, this study developed an innovative local drug delivery strategy: an injectable, post-traumatic microenvironment-responsive hydrogel. The hydrogel, composed of tannic acid (TA) and quaternized chitosan (QCS), is designed to alleviate neurological deficits secondary brain injury following TBI through its …

Advances in coagulation peptides: Exploring diverse functions from hemostasis to disease treatment.

Coagulation dysfunction and bleeding control remain major challenges in trauma, surgery, and interventional therapy. Millions of patients die from excessive blood loss every year. Traditional hemostatic materials such as gelatin sponge, chitosan, and zeolite have limitations such as a single mechanism of action and poor biological stability. At the same time, clotting peptides have attracted much attention due to their low molecular weight, high biological activity, and precisely designed molecular structure. This paper systematically reviews the latest progress of coagulation peptides as a ne…

An injectable hydrogel for hemostasis and tumor suppression in intraoperative breast cancer.

In the period between surgery and systemic therapy for breast cancer, residual tumor cells may proliferate, leading to tumor recurrence. Additionally, intraoperative wound bleeding may cause surgical failure or the spread of tumor cells. This study introduces an innovative injectable hydrogel composed of oxidized hyaluronic acid (OHA) loaded 5-fluorouracil (5-FU) and N-carboxyethyl chitosan (CEC), designed for intraoperative hemostasis and tumor suppression in intraoperative breast cancer. The CEC/OHA injectable hydrogel was synthesized through a Schiff base reaction between the aldehyde group…

Emerging roles of arginine metabolism in skeletal health and disease.

Arginine, as a semi-essential amino acid, plays a pivotal role in bone metabolism and orthopedic diseases. Beyond its function in protein sy … grated into various biomaterial systems, including Poly (lactic-co-glycolic acid) (PLGA) scaffolds, chitosan hydrogels, hydroxyapatite composites, and RGD-functionalized polymers, significantly enhancing osteogenic, angiogenic, and immunomodulatory capabilities. Despite ongoing research advancements, challenges persist in understanding the environment-depe …

Application of Antimicrobial Peptides (AMPs) in Treatment of Osteomyelitis in Human and Veterinary Orthopedics.

Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to t … erapeutic approaches, including free AMPs, their conjugation with biomaterials such as collagen and chitosan to enhance delivery and stability, and the development of AMP-based nanoparticles. Furthermore, we analyze preclinical and clinical findings, highlighting the efficacy and safety of AMPs in combating osteomyelitis in both human and animal patients. …

Betulinic Acid Self-Assembled Nanodelivery System Attenuates Osteoarthritis by Dually Modulating Macrophage Polarization and Macrophage-Chondrocyte Crosstalk via Disruption of the GSK3β/NF-κB/CCL20 Axis.

Osteoarthritis (OA) is a degenerative joint disease characterized by M1 macrophage-driven synovitis, worsening progression. In this study, it is found that betulinic acid (BA), a natural compound, inhibits M1 macrophage characteristics while promoting conversion to the M2 phenotype. However, BA suffers from poor solubility and a short half-life in vivo, restricting therapeutic use. Here, a thermosensitive hydrogel is developed using hydroxypropyl chitosan, loaded with poly(betulinic acid) nanoparticles (PBA NPs) and a folic acid (FA) targeting moiety, yielding FA-modified PBA NPs-loaded hydrog…

Delivery Routes of Topical Eyedrops Reaching the Posterior Segment of the Eye-Recent Advances.

Current topical eyedrop treatments for posterior segment diseases face significant challenges, including rapid tear clearance and ocular bar … ll-penetrating peptides and PepT-1-targeting ligands mainly utilize the conjunctival route; whereas chitosan nanoparticles, polymeric micelles, and supramolecular peptide-based eyedrops can access the posterior segment via both routes. By systematically clarifying the pathways and mechanisms by which eyedrops formulations traverse ocular barriers, this rev …

Near-infrared light-responsive on-demand puerarin-releasing injectable hydrogel for promoting healing of infected wounds.

Wound infection is a serious clinical challenge, often accompanied by persistent inflammatory response and the threat of increased bacterial resistance, there is an urgent requirement to develop a wound dressing with potent antimicrobial as well as immunomodulatory effects. In this study, we developed a multifunctional wound dressing to promote healing of infected wounds by doping puerarin-loaded mesoporous polydopamine nanoparticles into a carboxymethyl chitosan/sodium alginate oxide-based hydrogel. The hydrogel has good injectability, adhesion, and self-healing capabilities, and can be well …

Evaluation of the efficacy of microencapsulatedscaffold against Edwardsiellatardain oral vaccinated Nile tilapia (Oreochromis niloticus).

Edwardsiellatarda, a re-emerging pathogen, significantly impacts the productivity of marine and freshwater aquaculture by causing edwardsiellosis. Vaccination is a promising strategy to address this challenge. This study explores an innovative oral vaccination approach using a biomaterial-based scaffold encapsulated with an α-Ketoglutarate (AKG) adjuvant to combat E. tarda in Nile tilapia (Oreochromis niloticus). The scaffold was prepared through ion-gelation using chitosan and alginate, and its structural properties were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and s…

Антиоксидант естественно окуривает плейотропические биоактивные соединения, как полимерные нанотерапии против аутоиммунных заболеваний.

Аутоиммунные заболевания вызваны хроническим воспалением и окислительным стрессом, что требует новаторских терапевтических подходов. Полимерные нанотерапевтические соединения, содержащие антиоксидантные биоактивные соединения, являются перспективной стратегией для иммунной модуляции и расширения доставки наркотиков. В рамках этого обзора изучаются возможности применения полимерных нанокарьеров для улучшения растворимости, биодоступности и адресной поставки антиоксидантных соединений при аутоиммунном лечении. Был проведен всеобъемлющий анализ последних достижений в области полимерных наноформул

Совпадение в аннотации оригинала
Autoimmune diseases are driven by chronic inflammation and oxidative stress, thus requiring innovative therapeutic approaches. Polymeric nan … ymeric nanoformulations, including poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), chitosan, and hyaluronic acid, was conducted. The therapeutic efficacy of various antioxidant-loaded nanoparticles has been assessed in both preclinical and clinical studies. Phenolic antioxidants, such as resveratrol, curcumin, quercetin, and epigallocatech …

Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression.

Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonst … M-SeNPs) encapsulated within a colon-targeted hydrogel delivery system containing alginate (SA) and chitosan (CS). This biocompatible nanosystem was efficiently taken up by IECs and led to increased expression of Se-dependent glutathione peroxidases (GPXs), thereby modulating IECs' immune response. Using a mouse model of DSS-induced colitis, (CS/SA)-embedd …

Biomaterials for Corneal Regeneration.

Corneal blindness is a significant reason for visual impairment globally. Researchers have been investigating several methods for corneal regeneration in order to cure these patients. Biomaterials are favored due to their biocompatibility and capacity to promote cell adhesion. A variety of natural and synthetic biomaterials, along with decellularized cornea, have been employed in corneal wound healing. Commonly utilized natural biomaterials encompass proteins such as collagen, gelatin, and silk fibroin (SF), as well as polysaccharides including alginate, chitosan (CS), hyaluronic acid (HA), an…

Modified magnetic Nano-Biocomposite as friendly environmental catalyst for rapid degradation of organic dyes and selective aerobic oxidation of cyclohexene through advance oxidation process.

To eliminate contaminated organic matter from water and wastewater, a stable, recyclable, and environmentally friendly nano-biocomposite was designed. The magnetic Fe3O4 nanoparticles were functionalized by SiO2/N-2-(aminoethyl)-3-aminopropyl/glutaraldehyde/chitosan/Cobalt to fabricate nano-biocomposite (FS-(Am/g/Cs)@CoNPs). The morphological/structural identification of nano-biocomposite was carried out by ICP-OES, DR-UV, XRD, FE-SEM, TEM, HR-TEM, BET, EDX, FT-IR, TGA, and VSM techniques. The catalytic performance of this heterogeneous catalyst was studied in the degradation of organic dyes i…

Development of gallic acid loaded composite nanovesicles for the topical treatment of acne: optimization, characterization, and clinical investigation.

Gallic acid (GA) proved to produce desired effects topically in the treatment of acne, through its antibacterial, anti-inflammatory and antioxidant characteristics. In the current work, nanovesicular systems; aspasomes loaded with GA were prepared, and evaluated on in-vitro and ex-vivo levels. Formulations were coated with chitosan due to its mucoadhesive properties. Results indicated that the size of the formulations ranged between 273.20 and 855.00 nm, with positively charged zeta potential ranging between 30.60 and 34.40 mV, EE% ranging between 57.651% and 95.20% and good stability after 3-…

Extreme Toughening of Conductive Hydrogels Through Synergistic Effects of Mineralization, Salting-Out, and Ion Coordination Induced by Multivalent Anions.

Developing conductive hydrogels with both high strength and fracture toughness for diverse applications remains a significant challenge. In this work, an efficient toughening strategy is presented that exploits the multiple enhancement effects of anions through a synergistic combination of mineralization, salting-out, and ion coordination. The approach centers on a hydrogel system comprising two polymers and a cation that is highly responsive to anions. Specifically, polyvinyl alcohol (PVA) and chitosan quaternary ammonium (HACC) are used, as PVA benefits from salting-out effects and HACC unde…

Nanofiber Hydrogel Drug Delivery System for Prevention of Postsurgical Intestinal Adhesion.

Intestinal adhesion is one of the complications that occurs more frequently after abdominal surgery. Postsurgical intestinal adhesion (PIA) can lead to a series of health problems, including abdominal pain, intestinal obstruction, and female infertility. Currently, hydrogels and nanofibrous films as barriers are often used for preventing PIA formation; however, these kinds of materials have their intrinsic disadvantages. Herein, we developed a dual-structure drug delivery patch consisting of poly lactic-co-glycolic acid (PLGA) nanofibers and a chitosan hydrogel (NHP). PLGA nanofibers loaded wi…