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Синдром Гильен Барре: главная причина острого легкого паралича в деле Хазары.

Острый легкий паралич (АФП) может быть вызван рядом условий. Одной из общих предотвратимых причин является полиомиелит, о котором по-прежнему сообщается в Пакистане, еще одной общей причиной острого ледникового паралича является синдром Гильен Барре (ГБС), известный также как острая воспламенительная демиелинация. Важно признать, что ГПС в детстве, поскольку родители считают, что любой острый легкий паралич обусловлен полиомиелитом. Цель настоящего исследования состояла в том, чтобы выяснить частотность различных причин острого легкого паралича в отделении Хазара.МЕТОДЫ: Этот анализ представля

Совпадение в аннотации оригинала
BACKGROUND: Acute flaccid paralysis (AFP) can be caused by a number of conditions. A common preventable cause is poliomyelitis which is still being reported in Pakistan, Guillain Barre Syndrome (GBS), also known as Acute Inflammatory Demyelinating Polyneuropathy, is another common cause of acute flaccid paralysis. It is important to recognize GBS in childhoo…

Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus.

Lafora disease (LD) is the most common teenage-onset progressive myoclonus epilepsy. It is caused by recessive mutations in the EPM2A or EPM2B genes. The authors describe a family with three affected members with no mutations in either gene. Linkage and haplotype analyses exclude both loci from causative involvement in this family. Therefore, a third LD locus is predicted. Its identification will be a crucial element in the understanding of the biochemical pathway underlying the generation of Lafora bodies and LD.

Распределение детородного веса пакистанских младенцев.

ЦЕЛЬ: Определение распределения веса новорожденных и его связи с конкретными социально-демографическими и медицинскими факторами. МЕТОДЫ: Все дети, родившиеся после 24 недель беременности в период с ноября 1994 года по июнь 1996 года, были включены независимо от того, являются ли они живыми или еще рожденными. Младенцы, имеющие весы при рождении 2,5-4 кг, были названы как обычно взвешенные младенцы, менее 2,5 кг - как низкий вес при рождении и более 4 кг - как макросомики. Собранные данные включают социально-демографические и медицинские переменные. Вес новорожденных измерялся без одежды до бл

Comparison of case fatality in south Asian and white patients after acute myocardial infarction: observational study.

OBJECTIVE: To compare mortality in south Asian (Indian, Pakistani, and Bangladeshi) and white patients in the six months after hospital admission for acute myocardial infarction. DESIGN: Observational study. SETTING: District general hospital in east London. PATIENTS: 149 south Asian and 313 white patients aged < 65 years admitted to the coronary care unit with acute myocardial infarction from 1 December 1988 to 31 December 1992. MAIN OUTCOME MEASURE: All cause mortality in the first six months after myocardial infarction. RESULTS: The admission rate in the south Asians was estimated to b…

[Hookworm disease. A differential diagnosis in iron deficiency anemia].

Hookworms are among the most widespread of human parasites and occur all over the tropics and subtropics. They are bloodsucking roundworms that inhabit the duodenum and jejunum. Usually the infection is mild (hookworm carrier state), but sometimes the infection is heavy and results in anaemia and/or hypoproteinemia (hookworm disease). Hookworms are occasionally imported to Norway by immigrants. This paper describes two cases of severe and life-threatening hookworm disease treated in our hospital. The first patient was a Pakistani woman born in 1929 who on admission was hypovolemic with severe …

Interactions between infections, malnutrition and iron nutritional status in Pakistani infants. A longitudinal study.

The interactions between infections, malnutrition and poor iron nutritional status in infants at weaning ages are poorly defined. Therefore, four groups of infants from an area with a high incidence of malnutrition (Lahore, Pakistan) were enrolled in a prospective, randomized nutritional intervention study. Between 122 and 365 days of age, the infants from one community received either a milk cereal without iron fortification (n = 29), a milk cereal fortified with ferrous fumarate (7.5 mg/100 g; n = 30), or a milk cereal fortified with ferric-pyrophosphate (7.5 mg/100 g; n = 27). Forty-four in…

The spectrum of beta-thalassaemia mutations on the Indian subcontinent: the basis for prenatal diagnosis.

The beta-thalassaemia mutations in 702 unrelated carriers originating from seven different regions of the Indian subcontinent have been characterized using allele specific priming of the polymerase chain reaction (PCR). It was possible to identify the mutations in 688 (98%) of the individuals studied. Eleven different mutations were identified, of which five common ones accounted for 93.6%; namely the ones at IVS-1 position 5 (G-C), codons 8/9 (+G), IVS-1 position 1 (G-T), codons 41/42 (-CTTT) and the 619 bp deletion at the 3' end of the gene. The mutations at IVS-2 position 1 (G-A) and codon

Oral submucous fibrosis: two cases of malignant transformation in Asian immigrants to the United Kingdom.

Three cases of oral submucous fibrosis are reported, two of which were associated with oral carcinoma. The disease is described and aspects of its clinical presentation, aetiology and treatment are discussed. It is argued that the condition is not as rare amongst Asian immigrants as the small number of reported cases might suggest and that early detection and follow up are important because of the risk of neoplasia.

Outcome of Pregnancy-Related Acute Kidney Injury and Resulting Maternal Renal Morbidity in a South Asian Population: A Single-Center Study.

Objective  The study aimed to determine the outcome of pregnancy-related acute kidney injury (PR-AKI) and resulting maternal renal morbidity … ade. Materials and methods This was a retrospective study conducted in the Nephrology Department of Pakistan Kidney and Liver Institute and Research Centre (PKLI & RC), Lahore, Pakistan. A total of 42 female patients aged 18-45 years presented to the outpatient or acute medical unit of PKLI & RC between April 2018 and April 2025 with PR-AKI. Their clinical …

Crimean-Congo Hemorrhagic Fever Case Series: a Chronology of Biochemical and Hematological Parameters.

Introduction Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne zoonotic disease. Sporadic outbreaks of CCHF occur in endemic regions, including Pakistan. The clinical spectrum of the illness varies from asymptomatic seroconversion to severe disease which may end in death. The treatment is supportive, including blood and blood products. There is multi-organ involvement in CCHF including acute hepatitis, thrombocytopenia, coagulopathy, acute kidney injury (AKI), and encephalopathy. Hematological and biochemical parameters may identify patients at substantial risk of worse outcome…

Feto-Maternal Outcomes and Treatment Compliance in Metformin Versus Insulin-Treated Gestational Diabetic and Non-Diabetic Patients at the Rehman Medical Institute, Peshawar.

Introduction Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during preg … s mellitus type 2. GDM had a prevalence of 11.8% in the year 2018 in all trimesters of pregnancy in Pakistan. This study was thus conducted to determine the feto-maternal outcomes of non-GDM and GDM patients on insulin, metformin, and combined treatment respectively admitted to gynecology ward Rehman Medical Institute (RMI) Khyber Pakhtunkhwa, Pakistan in …

Depression and the Use of Selective Serotonin Reuptake Inhibitors in Patients with Acute Intracerebral Hemorrhage.

Introduction Depression is a common psychiatric complication associated with stroke. However, while most studies focus on post-stroke depression (PSD) subsequent to ischemic strokes, fewer studies have specifically explored depressive symptoms and the use of selective serotonin reuptake inhibitors (SSRIs) in patients with acute intracerebral hemorrhage (ICH). The aim of our study was to identify the incidence and factors associated with depression in ICH patients and the use of SSRIs as therapy by physicians at a tertiary care hospital in Karachi, Pakistan. Materials and methods A retrospectiv…

Viability of reducing plastic waste disposal by utilization in hot mix asphalt: a multicriteria analysis with cost considerations.

Plastic waste is a non-biodegradable material which is extensively used in many applications, creating a critical environmental challenge of its disposal. Therefore, its utilization in large quantities as a recycled product in road infrastructure will mitigate ill effects occurring because of its dumping. The aim of this study was to analyze the impacts of adding recycled plastic waste aggregate (RPWA) in hot mix asphalt (HMA) mixes using a wide range of variables by employing the Marshall mix design procedure in the context of Pakistan. A data-driven framework is employed with a novel multiva…

Maternal and fetal outcomes in pregnant women with liver disease.

OBJECTIVE: To determine the maternal and fetal outcomes among pregnant females with liver disease. METHODOLOGY: This prospective observational study was performed at the department of obstetrics & gynecology, Nishtar Hospital Multan, Pakistan, during August 2024 to July 2025. Pregnant females aged 20-40 years with gestational age ≥ 28 weeks, regardless of their parity or gravidity status, with liver disease, and planned to undergo delivery were analyzed. Demographic, clinical and laboratory parameters were documented. Clinical presentation, causes of liver disease, and details about the treat…

Association of the ABCB1 gene polymorphism C3435T (rs1045642) with acute myeloid leukemia: A genetic study.

INTRODUCTION: The ATP Binding Cassette Subfamily B1 (ABCB1) gene is responsible for encoding the permeability glycoprotein (P-gp), a crucial … orphism C3435T (rs1045642) in acute myeloid leukemia patients at tertiary care hospitals in Lahore, Pakistan. METHODS: A cross-sectional comparative study was conducted to investigate the association between ABCB1 gene polymorphism (C3435T) and acute myeloid leukemia. A total of 100 samples (50 cases and 50 healthy controls) were genotyped using restricti …

Cognitive biases, risk perception, and investment decision-making under information asymmetry: A moderated mediation study.

Investment decisions in emerging markets are often made under conditions of incomplete, uncertain, and difficult to verify information. This study explored the relationship between anchoring bias, framing bias, and investment decision-making through risk perception and whether the association between risk perception and investment decision-making varied across levels of information asymmetry. A cross-sectional survey study of individual investors on the Pakistan Stock Exchange, with a sample of 620, was conducted, and a second-stage moderated mediation model was tested. The reliability, conver…