Результаты поиска

Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… . | Synthetic peptide analog | UCB, Inc. 37 | Bimzelx | Bimekizumab | 10/17/2023 | Interleukin-17 A/F antagonist | To treat moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy | Monoclonal antibody (mAb) | UCB, Inc. 38 | Agamree | Vamorolone | 10/26/2023 … 2023 | α-glucosidase | For the treatment of glycogen storage disease type II | Recombinant protein | Sanofi (China) Investment Co., Ltd. 44 | Sotyktu | Deucravacitinib | 10/18/2023 | TYK2 inhibitor | For adult patients with moderate to severe plaque psoriasis who are suitable for systemic therapy or phototherapy …

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study.

INTRODUCTION: The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. METHODS: We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. RESULTS: We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patie

Совпадение в полном тексте источника
… Martins et al. also studied the association of laser phototherapy (LPT) and PRP on healing outcome of BRONJ in cancer patients. … Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: A preliminary study Oral Oncology 2012 48 1 79 84 2-s2.0-84855901323 10.1016/j.oraloncology.2011.08.010 21940198 48 Longo F. Guida A. Aversa C. …

Potential role for microRNA-16 (miR-16) and microRNA-93 (miR-93) in diagnosis and prediction of disease progression in mycosis fungoides in Egyptian patients.

Mycosis Fungoides (MF) is the most common type of cutaneous T-cell lymphomas. Early stage patients are treated with topical therapies and have normal life expectancy whereas patients with advanced disease encounter frequent relapses and have a five-year survival rate that does not exceed 15%. The aim of the present study was to characterize the expression of microRNA-16 (miR-16) and microRNA-93 (miR-93) in early and advanced cases of MF in relation to the clinicopathological parameters. Ten skin biopsies of early and advanced MF were investigated for the expression of miR-16 and miR-93 using R

Совпадение в полном тексте источника
… Currently, the most effective treatments for MF/SS, such as phototherapy [ 14 ], photopheresis [ 15 ] and even systemic therapies act by enhancing apoptosis of malignant T-cells. … In CTCL, most of the currently used therapeutic modalities like phototherapy and photopheresis are directed towards enhancing apoptosis of tumor cells [ 14 , 15 ]. …

Oral Graft-Versus-Host Disease: A Pictorial Review and a Guide for Dental Practitioners.

IntroductionGraft-versus-host disease (GVHD) is a complication of haematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred. GVHD affects multiple organs, including the oral tissues.ObjectiveThis pictorial review provides a background of GVHD to dental practitioners, describes the most common oral manifestations of GVHD and highlights the main treatment modifications needed to deliver dental care to patients with GVHD.MethodsA narrative review enhanced with clinical photographs.ResultsAcute GVHD

Совпадение в полном тексте источника
… Non-pharmacological modalities include extracorporeal photopheresis and phototherapy. Ancillary therapies have an important role in symptom palliation, preventing secondary complications and maintaining quality of life. … Narrow-band UVB phototherapy for management of oral chronic graft-versus-host disease. Photodermatol Photoimmunol Photomed. 2015;31(2):75–82. doi: 10.1111/phpp.12141. 52. Bojanic I, Mravak Stipetic M, Pulanic D, et al. …

Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities.

Pruritus is the most frequently described symptom in dermatology and can significantly impair the patient's quality of life. In 10-50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial

Совпадение в полном тексте источника
… Anecdotal reports of successful treatment of cholestatic pruritus include the use of intravenous lidocaine, UVB phototherapy, and androgens [ 21 , 59 ]. 4. … Recommended strategies in PV are as follows: alkalinization of bathing water with sodium bicarbonate, topical capsaicin treatment, systemic therapy with antihistaminics and antiserotonergic drugs, or phototherapy [ 70 ]. …

[Systemic therapy of atopic dermatitis].

The optimal treatment of atopic dermatitis requires regular medical supervision. The course of this chronic skin disease is influenced by multiple triggers which are relevant for the treatment. The mainstays of topical therapy include regular use of emollients coupled with antimicrobial substances, corticosteroids and immune modulators as required. Ultraviolet radiation and immunosuppressive regimens represent further options for the treatment of severe exacerbations and may lead to long term improvement. Data from experimental studies provide insight into possible future treatment methods.

Lymphomatoid Papulosis Type B in a Patient with Crohn's Disease Treated with TNF-Alpha Inhibitors Infliximab and Adalimumab.

Dear Editor, Lymphomatoid papulosis (LP) is a chronic, recurrent, usually self-limited papulonecrotic or papulonodular skin disease, which b … inued, and oral budesonide therapy was started in combination with topical corticosteroids and PUVA phototherapy. The skin lesions resolved with hyperpigmentation, and there was no relapse during the twelve-month follow-up. Recent data suggest that LP occurs more commonly in immunocompromised patients, especially in those with solid organ or bone marrow transp …

Topical antifungals for seborrhoeic dermatitis.

BACKGROUND: Seborrhoeic dermatitis is a chronic inflammatory skin condition that is distributed worldwide. It commonly affects the scalp, face and flexures of the body. Treatment options include antifungal drugs, steroids, calcineurin inhibitors, keratolytic agents and phototherapy. OBJECTIVES: To assess the effects of antifungal agents for seborrhoeic dermatitis of the face and scalp in adolescents and adults.A secondary objective is to assess whether the same interventions are effective in the management of seborrhoeic dermatitis in patients with HIV/AIDS. SEARCH METHODS: We searched the f…

Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp.

BACKGROUND: Seborrhoeic dermatitis is a chronic inflammatory skin disorder affecting primarily the skin of the scalp, face, chest, and intertriginous areas, causing scaling and redness of the skin. Current treatment options include antifungal, anti-inflammatory, and keratolytic agents, as well as phototherapy. OBJECTIVES: To assess the effects of topical pharmacological interventions with established anti-inflammatory action for seborrhoeic dermatitis occurring in adolescents and adults. SEARCH METHODS: We searched the following databases up to September 2013: the Cochrane Skin Group Special…

Scleredema in a Patient with AIDS-Related Lipodystrophy Syndrome.

Scleredema is a form of cutaneous mucinosis caused by an increased accumulation of collagen and mucin in the dermis. It is characterized by diffused, nonpitting swelling and induration of the skin. Scleredema diabeticorum is one type of scleredema associated with diabetes mellitus. AIDS-related insulin resistance and lipodystrophy syndrome are a newly emerging entities in HIV-infected patients associated with severe metabolic disturbances and insulin resistance. The long-standing diabetes in these patients may contribute to the development of scleredema diabeticorum. Here, we report the rare o

Совпадение в полном тексте источника
… Ultraviolet A-1 phototherapy has been tried with good response [ 7 ]. In the last few years, cutaneous mucinoses have been reported with increased frequency in HIV patients. …

Induction of labour at or near term for suspected fetal macrosomia.

EDITORIAL NOTE: It has been brought to the authors' attention that there may be an error in the data (Analysis 1.9). This is currently under … perineal damage, and the plausible, but of uncertain significance, observation of increased use of phototherapy, both in the largest trial, should also be kept in mind.Findings from trials included in the review suggest that to prevent one fracture it would be necessary to induce labour in 60 women. Since induction of labour does not appear to alter the rate …

Objective determination of Fitzpatrick skin type.

The overall aim of this Ph.D. project was to clarify what the subjective Fitzpatrick skin type represents with regard to the skin's reaction to UVR. Fitzpatrick skin type is used as an expression of the constitutive UV-sensitivity. It has been used for guiding dose-levels in phototherapy and is an important risk factor for skin cancer. The subjective Fitzpatrick skin type and the measured skin type PPF (pigment protection factor, calculated based on a skin reflectance measurement, predicts the UV-dose (SED) to give 1 MED) were investigated parallelly in relation to the clinically determined do…

Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage.

OBJECTIVE: To review the clinical aspects of postpartum hemorrhage (PPH) and provide guidelines to assist clinicians in the prevention and m … e clamping. (I-A) 10. For term newborns, the possible increased risk of neonatal jaundice requiring phototherapy must be weighed against the physiological benefit of greater hemoglobin and iron levels up to 6 months of age conferred by delayed cord clamping. (I-C) 11. There is no evidence that, in an uncomplicated delivery without bleeding, interventions to ac …

Eosinophilic Dermatosis of Hematological Malignancy.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Vesicles or bullae may also present due to intraepidermal or subepidermal edema.[ 2 ] Treatment of EDHM includes topical and systemic steroids, narrow-band ultraviolet B (UVB) phototherapy, oral antihistamines, dapsone, and antibiotics. …

Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy.

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, the survival rates of some cancers have increased. Nevertheless, due to the complexity of the mechanisms underlying tumors, cancer remains a serious public health issue that threatens the health of the population globally. Manganese (Mn) is an essential trace element for the human body. Its regulatory role in tumor biology has received much attention in recent years. Developments in nanotechnology have led to the emergence

Совпадение в полном тексте источника
… These results indicate that the C-BM/I nanocomposite could be used for sensitive T1-weighted MR, NIR-II FL, and PA multimodal imaging and highly efficient cancer phototherapy. … Summary of application of manganese-based nanomaterials in tumor therapy CHEMO, chemotherapy; RT, radiation therapy; PTT, photothermal therapy; PDT, photodynamic therapy; PT, phototherapy; EMT, electromagnetic therapy; SDT, sonodynamic therapy; CDT, chemodynamic therapy; CPT, chemo-photothermal therapy …

Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation.

Innovative strategies to re-establish the immune-mediated destruction of malignant cells is paramount to the success of anti-cancer therapy. Accumulating evidence suggests that radiotherapy and select chemotherapeutic drugs and small molecule inhibitors induce immunogenic cell stress on tumors that results in improved immune recognition and targeting of the malignant cells. Through immunogenic cell death, which entails the release of antigens and danger signals, and immunogenic modulation, wherein the phenotype of stressed cells is altered to become more susceptible to immune attack, radiother

Совпадение в полном тексте источника
… Another non-ionizing radiotherapy that induces immunogenic cell stress is phototherapy [ 7 , 8 ]. Phototherapy destroys cancer cells by utilizing light to trigger photosensitizers that produce ROS (photodynamic therapy) or photothermal agents that generate heat (photothermal therapy) [ 145 , 146 ]. … When appropriate photoagents and light doses are employed, phototherapies can promote the release of TAAs and DAMPs [ 8 , 147 ]. …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

Совпадение в полном тексте источника
… UV phototherapy is recommended for generalized pruritus, especially in the elderly pruritus patients or in case of contraindications for systemic therapy. Anticonvulsants/pain modulators are recommended in neuropathic pruritus. … Gunal AI Ozalp G Yoldas TK Gunal SY Kirciman E Celiker H Gabapentin therapy for pruritus in haemodialysis patients: A randomized, placebo-controlled, double-blind trial Nephrol Dial Transplant 2004 19 3137 9 15575002 10.1093/ndt/gfh496 54 Gilchrest BA Rowe JW Brown RS Steinman TI Arndt KA Ultraviolet phototherapy …

Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, and antiangiogenic medications). Adjunctive therapies for the surgical management of MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source of various cells and growth factors that aid tissue healing and regeneration. This review evaluated the use of platelet-rich plasma (PRP), plasma-rich in growth factors (PRGF), and leukocyte- and platelet-rich fibrin (L-PRF) as adjuvant therapies for the surgic

Совпадение в полном тексте источника
… Sixteen lesions were managed with PRP application and laser phototherapy after sequestrectomy and bone surgery, with complete resolution in 15 lesions and partial response in one lesion. … Association of laser phototherapy with PRP improves healing of bisphosphonate‐related osteonecrosis of the jaws in cancer patients: a preliminary study. Oral Oncol. 2012;48(1):79‐84. 33. Mathias Duarte LFS, dos Reis HB, Tucci R, Dib LL. …

Дупилумаб улучшает зуд, но не фиброз, у пациента со склеромаксидемой: отчет о деле.

Scleromyxedema — редкая хроническая слизь, характеризующаяся широко распространенным фиброзом кожи и связанной с этим моноклонной гаммопатией. Терапевтические варианты по-прежнему ограничены. Мы представляем случай мужчины в возрасте 50 лет с биопссически подтвержденной склеромикседемой и ИгГ моноклональной гаммопатией, который сначала отреагировал на иммуноглобулин внутривенно, но позже продвинулся, несмотря на полную дозу. Из-за сильной pruritus и недавних доказательств, связанных с типом 2 Цитокины патогенеза склеромиксадемы, дупилумаба, были добавлены в текущий иммуноглобулин внутривенно.

Совпадение в полном тексте источника
… Over the following years, the patient was treated with topical corticosteroids, phototherapy, lenalidomide (discontinued early due to recurrent infections and lack of efficacy), methotrexate, and cyclosporine, with limited or no success. …

Cutaneous Graft-Versus-Host Disease Lichen Spinulosus-like: a New Form of Presentation of an Old Entity.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Skin-directed treatments such as topical corticosteroids, topical calcineurin inhibitors, and phototherapy have demonstrated efficacy in improving skin symptoms and reducing the need for systemic immunosuppression ( 15 ). …