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White Matter Microstructural Correlates of Auditory Brainstem Responses in Patients With Charcot-Marie-Tooth Disease.

INTRODUCTION: Some patients with Charcot-Marie-Tooth disease (CMT) exhibit prolonged auditory brainstem response (ABR) latencies or abnormal … ients with CMT and 14 healthy controls. DTI data were acquired using a 3.0T MRI scanner. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The latencies and interpeak latencies of the auditory pathway were measured using ABR. DTI metrics were compared between the two groups, and the relati …

White Matter Integrity in General Paresis: An Exploratory Tract-Based Spatial Statistical Analysis.

PURPOSE: The white matter integrity and fine structure changes were rarely reported in General Paresis (GP). We discussed white matter (WM) integrity in GP patients which was analyzed by Diffusion Tensor Imaging (DTI) Tract-Based Spatial Statistical Analysis (TBSS). PATIENTS AND METHODS: This was a prospective cross-sectional study. We recruited 18 GP patients and 24 age-sex-matched healthy controls (HC). DTI for WM of whole-brain was analyzed by TBSS and got of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), local diffusion homogeneity (…

Chitinase-1 in cerebrospinal fluid and white matter injury in patients with progressive multiple sclerosis.

OBJECTIVE: In patients with progressive multiple sclerosis (PMS), previous studies reported increased cerebrospinal fluid (CSF) concentratio … (p < 0.001) and decreased magnetization transfer ratio (p = 0.001) of lesions, decreased fractional anisotropy (p < 0.001) and increased mean diffusivity of normal-appearing white matter (p = 0.044) and lesions (p = 0.005) in patients with PPMS. Substudy [4] showed that natalizumab treatment reduced CSF CHIT1 concentrations (p = 0.005) in PMS. CONCLUSION: C …

Combining low-frequency magnetic stimulation with motor imagery to improve lower limb recovery and motor pathway integrity in cerebral infarction: a randomized, double-blind, and controlled study.

BACKGROUND: Lower limb dysfunction is common after stroke. While physical rehabilitation is the most widely used treatment, its effectivenes … o Time Test (TUGT). Magnetic resonance diffusion tensor imaging (DTI) was used to assess fractional anisotropy (FA) and the bilateral FA ratios (rFA) in the corona radiata, cerebral peduncles, posterior limb of the internal capsule, and infarction foci. RESULTS: The combined treatment increased lower limb motor function (FMA-LE), walking ability (FAC levels …

Cerebellar microstructural abnormalities in patients with somatic symptom disorders.

BACKGROUND: Somatic Symptom Disorder (SSD) is a condition often linked to excessive health anxiety and somatic symptoms. In recent years, st … tter microstructure. These changes were characterized by increased free water-eliminated fractional anisotropy and neurite density index, as well as decreased free water-eliminated mean diffusivity and radial diffusivity. Furthermore, the cerebellum displayed varying microstructural changes across 26 gray matter subregions. These changes included reduced mea …

Modulation of Brainstem-Cortical Pathways by Injection Laryngoplasty in Unilateral Vocal Fold Paralysis: A Longitudinal Diffusion MRI Case Study.

OBJECTIVE: This study investigates the potential role of injection laryngoplasty with hyaluronic acid in supporting spontaneous reinnervatio … n the corticobulbar and medial lemniscal tracts. RESULTS: A marked increase in weighted fractional anisotropy (wFA) was observed in left and right anterior motor tracts of interest (TOIs) between the first and second sessions, shortly after the hyaluronic acid injection. These values remained stable thereafter. In contrast, the posterior sensory tracts show …

White matter microstructure of language pathways in non-verbal autism: insights from diffusion tensor imaging and myelin water imaging.

INTRODUCTION: Absence of language development is a condition encountered across a large range of neurodevelopmental disorders, including a significant proportion of children with autism spectrum disorder. The neurobiological underpinnings of non-verbal ASD (nvASD) remain poorly understood. METHODS: This study employed multimodal MRI to investigate white matter (WM) microstructural abnormalities in nvASD, focusing on language-related pathways. We analyzed diffusion tensor imaging (DTI) metrics-fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD)-alongside myelin water…

Improved Strength Prediction Combining MRI Biomarkers of Muscle Quantity and Quality.

Muscle strength declines with aging at a faster rate compared with muscle mass, suggesting that not only muscle quantity but also muscle quality and architecture are age-dependent. This study tested the hypothesis that quantitative MRI (qMRI)-derived biomarkers of muscle quality (fractional anisotropy [FA], radial diffusivity [RD], axial diffusivity [AD], fat fraction [FF], and T2 relaxation time) and architecture (fascicle length) could improve the prediction of skeletal muscle strength over muscle mass alone. We recruited 24 adults (12 female, age range 30-79 years). Muscle mass was estimate…

Associations between negative symptoms and thermal pain perception in bipolar I disorder.

BACKGROUND: There is emerging evidence that negative symptoms are a source of functional impairment for individuals with bipolar I disorder … ssing fibers was used to analyze Diffusion Tensor Imaging (DTI) data (N = 20). Here, the fractional anisotropy (FA) of the superior longitudinal fasciculus I (SLF-I), a white matter pathway integrating sensorimotor (Brodmann areas 5 and 7), parietal, and frontal cortices was associated with negative symptom severity (CAINS Total: ρ = -0.55, pUNC = 0.019, pFD …

Decoupling of Neurochemical and White Matter Microstructural Integrity in Posterior Cingulate Cortex Predicts Early Alzheimer's Disease Progression.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by early metabolic and structural brain changes. These al … sights into neuronal health and metabolic status, while WM integrity was evaluated using fractional anisotropy (FA) and mean diffusivity (MD) metrics. In the PCC, AD-MCI patients exhibited a significant reduction in tNAA/tCr (1.22 ± 0.09 vs. HC 1.32 ± 0.07, p < 0.001) and NAA/mI (1.22 ± 0.12 vs. HC 1.44 ± 0.12, p < 0.001), along with an increase in mI/Cr (1. …

Palladium(II) and platinum(II) complexes of disubstituted imidazo[1,5-a]pyridine and imidazolylpyridine: coordination chemistry, versatile catalysis, and biophysical study.

Pincer-type mono- and poly-nuclear Pd(II) and Pt(II) complexes bearing imidazo[1,5-a]pyridine and imidazolylpyridine moieties were synthesiz … inity toward BSA, as confirmed by emission, synchronous fluorescence, and steady-state fluorescence anisotropy measurements. Moreover, the pharmacokinetic properties of two bioactive compounds (3s and 3t) obtained from the Suzuki coupling reaction were calculated, and to evaluate their activity as leukotriene A4 hydrolase (LTA4H) inhibitor, these molecules w …

Assessing Cu3BiS3 for Thin-Film Photovoltaics: A Systematic DFT Study Comparing LCAO and PAW Across Multiple Functionals.

Cu3BiS3 (CBS) has emerged as a promising earth-abundant absorber for thin-film photovoltaics, offering a sustainable alternative to conventi … h minimal changes after relaxation. The calculated hole and electron effective masses reveal strong anisotropy along the X, Y, and Z crystallographic directions. Additionally, CBS exhibits an intrinsic p-type nature, as the Fermi level consistently lies closer to the valence band maximum across all methods and functionals. However, the PAW method generally p …

Mapping the Olfactory Brain: A Systematic Review of Structural and Functional Magnetic Resonance Imaging Changes Following COVID-19 Smell Loss.

BACKGROUND: Olfactory dysfunction (OD)-including anosmia and hyposmia-is a common and often persistent outcome of viral infections. This sys … gnitive and emotional effects. Diffusion tensor imaging (DTI) findings-such as decreased fractional anisotropy (FA) and increased mean diffusivity (MD)-highlight white matter microstructural compromise in individuals with long-term OD. CONCLUSIONS: COVID-19's SARS-CoV-2 olfactory dysfunction is associated with a range of cerebral alterations that evolve wit …

Solid-Phase Synthesis Approaches and U-Rich RNA-Binding Activity of Homotrimer Nucleopeptide Containing Adenine Linked to L-azidohomoalanine Side Chain via 1,4-Linked-1,2,3-Triazole.

Nucleopeptides (NPs) are unnatural hybrid polymers designed by coupling nucleobases to the side chains of amino acid residues within peptide … 265 nm during the complexation. 5'-(FAM(6))-labeled TAR UUU and hASLLys3 were used for fluorescence anisotropy binding studies. Fluorescence data revealed that HalTzlAAA bound TAR's UUU bulge with a moderate affinity (Kd ≈ 38 µM), whereas the ASLLys3 UUUU-containing loop sequence was recognized with 2.5 times lower affinity (with Kd ≈ 75 µM). Both the standa …

[Multi-modal magnetic resonance imaging assessment and mechanism exploration of preterm white matter injury in neonatal rats].

OBJECTIVES: To evaluate preterm white matter injury (PWMI) in neonatal rats using multimodal magnetic resonance imaging (MRI) combined with … than that in the sham operation group (P<0.001). At 28 days post-modeling, the relative fractional anisotropy values, the number of EdU+Olig2+ cells, and the fluorescence intensity of myelin basic protein and neurofilament protein 200 in the white matter region of the PWMI group were all lower than those in the sham operation group (P<0.001). CONCLUSIONS: …

Healing Kinetics of Sinus Lift Augmentation Using Biphasic Calcium Phosphate Granules: A Case Series in Humans.

Sinus augmentation provides a well-established model for investigating the three-dimensional morphometry and macromolecular dynamics of bone … ificantly reduced trabecular spacing (Tb.Sp: 187 ± 70 µm vs. 325 ± 96 µm; p = 0.0155) and degree of anisotropy (DA: 0.37 ± 0.05 vs. 0.73 ± 0.03; p < 0.0001). By 12 months, the mineralized volume fraction in the regenerated area (53 ± 5%) was statistically comparable to basal bone (44 ± 3%; p > 0.05), while Tb.Sp (211 ± 20 µm) and DA (0.23 ± 0.09) remained si …

Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.

BACKGROUND: Obstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and the causal associations betw … ing higher levels in the left occipital lobe and left posterior central gyrus. Decreased fractional anisotropy (FA) but increased apparent diffusion coefficient (ADC) was shown in the bilateral superior longitudinal fasciculus. According to the results of Affiliation file 2: table s6, it is the ADC value of right superior longitudinal fasciculus was shown a …

Характеристика взаимосвязи между гиперперменными повреждениями FLAIR и парамагнитными повреждениями обода при множественном склерозе.

Повреждения парамагнитных ободов (ПЗК), выявленные с использованием последовательности, чувствительных к воздействию, устанавливаются прогностическими визуализирующими маркерами для множественных склерозов (МС). Однако во многих клинических центрах последовательности, чувствительные к чувствительности, еще не выполняются на регулярной основе. Цель состоит в том, чтобы изучить снимок, наблюдаемый на обычных последовательности инверсионного восстановления Т2 с жидкостью (FLAIR), которые называются "суперпримами ФЛЕЙР", и изучить их связь с PRL. В рамках этого исследования было проведено 61 повто

Совпадение в аннотации оригинала
Paramagnetic rim lesions (PRLs), identified using susceptibility-sensitive sequences, are established prognostic imaging markers for multipl … were compared, based on diffusion kurtosis imaging (DKI) parameters, including kurtosis fractional anisotropy (KFA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK). The correlations between lesion load and clinical scale scores and brain volume were further investigated. 1109 WM lesions were analyzed, including 338 PRLs and 300 FLAIR hype …

Probabilistic coverage of the frontal aslant tract in young adults: Insights into individual variability, lateralization, and language functions.

The frontal aslant tract (FAT) is a crucial neural pathway of language and speech, but little is known about its connectivity and segmentati … reading recognition (p = .016) and picture vocabulary (p = .0026) tests. In comparison, fractional anisotropy of the right FAT exhibited marginal significance in its correlation (p = .056) with Picture Vocabulary Test. Our findings, combined with the connectivity patterns of the FAT, allowed us to segment its structure into anterior and posterior segments. …

MR study on white matter injury in patients with acute diquat poisoning.

OBJECTIVE: To explore the microstructural damage of white matter in acute diquat (DQ) poisoning patients using diffusion kurtosis imaging (D … ngitudinal fasciculus had a mean difference of 0.18 (95 % CI: 0.12-0.24) and P = 0.0024. Fractional Anisotropy of Kurtosis (FAK) in the right corticospinal tract showed a mean difference of 0.19 (95 % CI: 0.13-0.25) and P = 0.0000318. Axial Kurtosis (AK) positively correlated with blood drug levels (r = 0.52, P < 0.05). Seven patients developed subcortical l …