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Effect of Lactiplantibacillus plantarum LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler.

INTRODUCTION: The purpose of this study was to investigate the effects of dietary supplementation of Lactiplantibacillus plantarum LPJZ-658 on body weight and serum indexes of Luhua broiler, and to explore the relevant mechanism of probiotic function of LPJZ-658 based on intestinal microbiota and serum metabolomics. METHODS: One hundred one-day-old Luhua broiler were randomly divided into the control group (CON) and LPJZ-658 treatment group (LPJZ-658). The CON group was fed a basal diet, and the LPJZ-658 group was fed the basal diet supplemented with 2 × 109 cfu/kg of LPJZ-658. The study last…

[Effect and mechanism of Liujunzi Pills on gut microbiota of rats with spleen Qi deficiency syndrome].

This article aims to explore the effect and mechanism of Liujunzi Pills on the intestinal microbiota of rats with spleen Qi deficiency syndrome. The raw Rhei Radix et Rhizoma water extract(1 g·mL~(-1)) was used to prepare spleen Qi deficiency rat models. A total of 44 SD male rats were randomly divided into a control group, a model group, Liujunzi Pills groups at high(3.24 g·kg~(-1)), medium(1.62 g·kg~(-1)), low(0.81 g·kg~(-1)) doses, and Shenling Baizhu San(2.50 g·kg~(-1)) group. The drug effect was evaluated by observing the following aspects: spleen index, fecal water content, body weight, …

Systemic lupus erythematosus and atherosclerosis: immune pathways and the uncharted territory of gut microbiota and metabolism.

Patients with Systemic Lupus Erythematosus (SLE) are significantly more susceptible to atherosclerosis, which may elevate their mortality ri … s to ascertain the efficacy and security of these therapies. The direct interactions among SLE, gut microbiota, metabolism, and atherosclerosis is underexplored, presenting innovation opportunities. Research into specific gut microbial strains and metabolites' effects on immune responses and atherosclerosis progression in SLE patients is needed. Such researc …

The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion.

BACKGROUND: Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification and screening of maternal risk factors are increasingly important to explore the potential etiologies and improve prevention and treatment strategies for ESA. This study investigates the changes in uterine microbiota and the decidual immune response in ESA patients without embryo abnormalities. METHODS: ESA patients without embryo abnormality and artificial a…

The neovaginal microbiota, symptoms, and local immune correlates in transfeminine individuals with penile inversion vaginoplasty.

Transfeminine people (assigned male at birth) often undergo penile inversion vaginoplasty to create vulva, a clitoris and a vaginal canal (referred to as a neovagina). After vaginoplasty, transfeminine people frequently experience gynecological concerns, but their etiology is unknown due to a lack of knowledge of the neovaginal microenvironment. We characterized neovaginal microbiota and cytokines in 47 transfeminine participants. Participants self-reported sexual behaviors and symptoms, enabling correlation with bacterial (16S rRNA) and immune profiles. Four distinct clusters of co-occurring …

Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota.

AIMS: In observational studies, the causal relationship between urticaria and the risk of psychiatric disorders (anxiety and depression) remains inconclusive. Furthermore, there is growing evidence that gut microbiota (GM) contributes to the pathogenesis of urticaria. This study aimed to assess the causal relationships between the genetically predicted urticaria subtypes and psychiatric disorders and further examined the role of GM in influencing the risk of these urticaria subtypes. METHODS: We conducted a meta-analysis of observational studies identified from four databases to evaluate the …

Fecal microbiota transplantation as salvage therapy for disseminated strongyloidiasis in an immunosuppressed patient: a case report.

BACKGROUND: Disseminated strongyloidiasis carries high mortality in immunosuppressed populations. We report a case of refractory Strongyloides stercoralis-induced severe diarrhea and sepsis successfully treated with fecal microbiota transplantation (FMT). CASE PRESENTATION: A 68-year-old male with nephrotic syndrome on long-term glucocorticoids developed hyperinfection syndrome manifesting as septic shock, multiorgan dysfunction, and intractable diarrhea (>30 episodes/day). Conventional therapies including antiparasitics (albendazole), antibiotics, and probiotics failed. FMT achieved rapid sy…

Comparative analysis of the clinical characteristic and lung microbiota in adult and elderly patients with pulmonary tuberculosis.

The proportion of elderly people infected with tuberculosis (TB) is increasing, and misdiagnosis and missed diagnosis are common. This study … ≥ 60, n = 77). Differences and associations in clinical characteristics, imaging findings, and lung microbiota were analyzed. Compared to adult patients, elderly patients had a higher prevalence of hypertension (31.17% vs. 9.09%, P = 0.0012), fever (20.78% vs. 4.55%, P = 0.0044) and chest tightness (24.68% vs. 10.61%, P = 0.0297), but a lower prevalence of c …

Assessing changes to the fecal microbiota in dogs undergoing elective orthopedic surgery: A preliminary investigation.

BACKGROUND: Studies assessing the impact of surgery on the canine gut microbiota are limited. This study assessed the fecal microbiota before and up to 3 months after elective orthopedic surgery. METHODS: Fourteen client-owned dogs >1 year of age undergoing elective orthopedic surgery were recruited. Dogs received perioperative antibiotics only (perioperative cefazolin, n = 7) or were discharged with oral cephalexin following surgery for 5-7 days (n = 7) in conjunction with perioperative antibiotics. Fecal samples were collected at baseline and at recheck 1 (13-50 days post-operatively) and r…

Comprehensive analysis of vaginal microbiota in Chinese women with genital tuberculosis: implications for diagnosis and treatment.

BACKGROUND: Tuberculosis remains an infectious disease of global concern, with potential impacts on respiratory and intestinal microbiota owing to prolonged broad-spectrum antibiotic therapy. Despite its potential to cause infertility, the vaginal microbiota of women with genital tuberculosis remains poorly understood. We comprehensively analyzed the vaginal microbiota in Chinese women with genital tuberculosis. RESULTS: We recruited women with pelvic (n = 28), endometrial (n = 16), and pulmonary (n = 12) tuberculosis as the research group, and healthy women (n = 11) as the control group. Vag…

Effects of astaxanthin on growth performance, intestinal integrity, and microbiota in Salmonella Enteritidis-infected chickens.

This study investigated the effects of astaxanthin (AST) supplementation in drinking water on the growth performance, intestinal barrier function, and cecal microbiota of broilers challenged with Salmonella Enteritidis. During the 20-day experiment, two hundred and forty 1-day-old male Arbor Acres birds were randomly assigned into a 2 × 2 factorial design with four groups: a non-challenged control (CON), an S. Enteritidis-challenged group (SA), a group receiving AST treatment (AST), and an S. Enteritidis-challenged group receiving AST treatment (SA+AST). Each treatment comprised six replicate …

Effects of a bacillus-based biological modulator on Salmonella Heidelberg contamination and cecal microbiota in chickens.

Broiler litter can serve as a favorable environment for the survival and propagation of pathogens, such as Salmonella, creating negative imp … digestive tract of challenged birds, as well as its influence on the composition of the intestinal microbiota. The results showed a strong influence of the BM in reducing the frequency of positivity and the average pathogen count, both in the litter and in the birds' cecal content. Moreover, it was possible to identify significant differences in the taxonom …

Investigation of Intestinal Microbiota and Short-Chain Fatty Acids in Colorectal Cancer and Detection of Biomarkers.

Colorectal cancer (CRC) is one of the most common cancers worldwide and a significant global health issue. The human gut microbiota, a complex ecosystem hosting numerous microorganisms such as bacteria, viruses, fungi, and protozoa, plays a crucial role. Increasing evidence indicates that gut microbiota is involved in CRC pathogenesis. In this study, the gut microbiota profiles, short-chain fatty acids, zonulin, and lipopolysaccharide-binding protein levels of newly diagnosed CRC patients were analyzed along with healthy controls to elucidate the relationship between CRC and the gut microbiota…

The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.

The gut microbiota and bile acid metabolism are intricately linked, playing a crucial role in immune regulation, metabolic processes, and overall health. The gut microbiome, consisting of diverse bacterial genera such as Bacteroides, Clostridium, Lactobacillus, Bifidobacterium, and Eubacterium, facilitates the conversion of primary bile acids into secondary bile acids through enzymatic modifications. Bile acids, synthesized in the liver and modified by gut microbiota, act as signaling molecules that regulate immune responses via bile acid receptors, including the farnesoid X receptor (FXR), G …

Гут Микробиота в вирусной модели множественного склероза: Modulation and Pitfalls путем перорального антибиотического лечения.

Вирусные инфекции ассоциируются с множественным склерозом (МС), иммунизированным заболеванием в центральной нервной системе (КНС). Так как вирус мюрин-энцефаломиелита (TMEV) может вызвать MS-подобные демиелинации, инфекция TMEV является наиболее широко используемой вирусной моделью для MS. Хотя точная патофизиология неизвестна, изменённые бактериальные популяции были связаны с различными иммунными генами в CNS. Мы стремились определить роль кишечного микробиота в инфекции ТМЕВ путем применения антибиотического коктейля в питьевой воде до (прогилактического управления) или после (терапевтическо

Совпадение в аннотации оригинала
Viral infections have been associated with multiple sclerosis (MS), an immune-mediated disease in the central nervous system (CNS). Since Th … associated with distinct immune gene expressions in the CNS. We aimed to determine the role of gut microbiota in TMEV infection by administering an antibiotic cocktail in drinking water before (prophylactic administration) or after (therapeutic administration) TMEV infection. The antibiotic administration reduced total eubacteria, including the phyla Bacill …

Взаимосвязь между повышением уровней липополисакарида, полученного из микробиота, и патофизиологией нейродегенеративных заболеваний.

Липополисакхарид (LPS) - мощный провоспалительный эндотоксин, полученный из внешней мембраны гра-отрицательных бактерий, - был определен как важнейшая связь между системным воспалением, связанным с ожирением, и возникновением нейродегенеративных заболеваний. Изменения в кишечной микробиоте, связанные с ожирением, нарушают целостность кишечного барьера, что ведет к повышению проницаемости и уровня циркуляции КТИ, явления, известного как метаболическая эндотоксима. Увеличенное присутствие ЛПС стимулирует устойчивое низкосортное воспаление и окислительный стресс, оба из которых являются важнейшим

Совпадение в аннотации оригинала
Lipopolysaccharide (LPS), a potent pro-inflammatory endotoxin derived from the outer membrane of Gram-negative bacteria, has been identified as a crucial link between obesity-related systemic inflammation and the onset of neurodegenerative diseases. Modifications in gut microbiota associated with obesity disrupt the integrity of the intestinal barrier, resul…

Влияние перорального и кожного микробиота на риск и остроту множественных склерозов: менделийский анализ случайности.

Недавно проведенные исследования по вопросу о воздействии кишечного микробиота на множественный склероз (MS) были обширными; однако роль микробного состава в других интерфейсах тела, таких, как рот и кожа, получила гораздо меньше внимания. В качестве первого шага на пути к устранению этого пробела мы использовали менделианскую рендемизацию (MR) — аналитический подход с использованием генетических вариантов в качестве предпочтений воздействия на окружающую среду для оценки причинно-следственной связи между фактором риска и результатом. Здесь мы провели двухвыборный анализ MR для оценки связи ме

Совпадение в аннотации оригинала
Recent research on the impact of gut microbiota on multiple sclerosis (MS) has been extensive; however, the role of microbial composition in other body interfaces, such as the mouth and the skin, has received much less attention. In a first step towards addressing this gap, we used Mendelian Randomization (MR), an analytical approach using genetic variants a…

The influence of placenta microbiota of normal term pregnant women on immune regulation during pregnancy.

BACKGROUND: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy. METHODS: Twenty-six healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-…

Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota.

Weaning is undoubtedly one of the most crucial stages in the growth and development of all mammalian animals, including donkey foals. Weaning is a dynamic and coordinated process of the body, which is closely associated with the health, nutrition, and metabolism of the host. Many studies have shown that the intestinal microbiota and serum metabolites of mammals exhibit different changes during lactation, weaning, and postweaning. However, the alterations in serum metabolites in donkey foals before and postweaning and the correlation between serum metabolites and intestinal microbiota are large…

Simulated gastrointestinal digestion of two different sources of biodegradable microplastics and the influence on gut microbiota.

Biodegradable plastics, were considered environmentally friendly, may produce more microplastic particles (MPs) within the same period and exert more pronounced adverse effects on human health than traditional non-biodegradable plastics. Thus, this study investigated the changes of two kinds of biodegradable MPs from different sources in the digestive tract by using simulated digestion and fermentation models in vitro, with particle size, scanning electron microscopy (SEM) and gel permeation chromatography (GPC) analysis, and their implications on the gut microbiota were detected by full-lengt…