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Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris.

Dermatologic diseases are the fourth most frequent nonfatal common illness, yet they have a psychological, economical, and professional burden that is comparable to or larger than other chronic conditions. From a survey in China of 6 provinces, the overall prevalence of psoriasis with squamous cell carcinoma was 0.47%. According to the current investigation, the outburst of skin disease was not associated with gender, but mainly with the climate of the environment; that is, dry cold weather will more likely to induce psoriasis. Approximately 3% of people around the world have psoriasis, which

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… Topicals, phototherapy, traditional systemic immunomodulators, or biologic therapy may be utilized to block the inflammatory response, depending on the severity of the psoriasis. … Systematic treatment photochemotherapy or phototherapy are suggested in situations of moderate-to-severe psoriasis, and biologic therapy is used as a last resort when earlier therapies have failed or are contraindicated. 5. …

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges.

To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in several pathological conditions such as cancer, autoimmune, and infectious diseases. In contrast to the conventional liposomes, this photoresponsive element greatly improves therapeutic efficacy and reduces the adverse effects of gene/drug therapy during treatment. Recently, cancer immunotherpay has been one of the hot topics in the field of oncology due to the great success a

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… It has been evidenced that a liposome-based combination of phototherapy and immunotherapy can increase the therapeutic index of these modalities by improving the stability and biocompatibility of the cargo as well as minimizing the adverse effects. 24 , 25 In the same context, various studies have suggested … Challenges and Opportunities of Translational Phototherapy Although various photoresponsive liposomes are considered the mainstay of phototherapy, poor light penetration limits the applicability to cutaneous conditions. 59 However, different solutions to this problem have been suggested, such as the …

Increased Risk of Renal Malignancy in Patients with Moderate to Severe Atopic Dermatitis.

BackgroundEvidence for an association between atopic dermatitis (AD) and cancer is still insufficient. In particular, the association between the risk of renal malignancy and the severity of AD has not been thoroughly investigated.ObjectiveTo investigate the risk of renal malignancy and determine the association between AD severity and cancer risk using data from the Korean National Health Insurance Service (KNHIS) database.MethodsWe performed a population-based cohort study using the National Health Claims database from the NHIS in Korea.ResultsWe found a statistically significant association

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… Patients with AD who received at least one systemic treatment (cyclosporin, methotrexate, retinoids, azathioprine, phototherapy, or biologic agents) were considered to have moderate to severe AD. Patients with AD who did not receive any systemic treatment were deemed to have mild AD. 2.4. … Management and treatment with phototherapy and systemic agents. J. Am. Acad. Dermatol. 2014;71:327–349. doi: 10.1016/j.jaad.2014.03.030. 17. Cheol Seong S., Kim Y.-Y., Khang Y.-H., Heon Park J., Kang H.-J., Lee H., Do C.-H., Song J.-S., Hyon Bang J., Ha S., et al. …

Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis.

Cancer stem cells (CSCs) are essential for the growth of malignancies because they encourage resistance to cancer therapy and make metastasis and relapse easier. To effectively tackle the obstacles presented by CSCs, novel therapeutic approaches are required. Photodynamic therapy (PDT) is a promising treatment option for cancer cells, which uses light-sensitive medications that are activated by light wavelengths. This review investigates the use of PDT to overcome malignancies driven by CSCs that have innate resistance mechanisms. PDT works by causing tumor cells to accumulate photosensitizers

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… Nano-phototherapy: Favorable prospects for cancer treatment Wiley Interdiscip Rev. Nanomed. Nanobiotechnol. 2024 16 e1930 10.1002/wnan.1930 37752098 3. Merlin J.P.J. Dellaire G. Murphy K. Rupasinghe H.P.V. … Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential Bioact. Mater. 2023 23 471 507 10.1016/j.bioactmat.2022.11.013 36514388 PMC9727595 36. Ghorbani J. Rahban D. Aghamiri S. Teymouri A. Bahador A. …

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

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… Clinical evidence shows easy, effective, biocompatible nano-theranostic cancer phototherapy. 3. Results ICG is a fluorescent dye, as described by Morales-Conde [ 15 ] in the 2022 guidelines for using fluorescence dyes in general surgery. … A near infrared-modulated thermosensitive hydrogel for stabilization of indocyanine green and combinatorial anticancer phototherapy. Biomater. Sci. 2019;7:1705–1715. doi: 10.1039/C8BM01541D. 10. Ren L., Nie J., Wei J., Li Y., Yin J., Yang X., Chen G. …

Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.

Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.

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… Phototherapy and photochemotherapy. Semin Dermatol. 1990;9(1):84–90. 84. Querfeld C, Rosen ST, Kuzel TM, et al. Long-term follow-up of patients with early-stage cutaneous T-cell lymphoma who achieved complete remission with psoralen plus UV-A monotherapy. … Interferon alfa-2a combined with phototherapy in the treatment of cutaneous T-cell lymphoma. J Natl Cancer Inst. 1990;82(3):203–207. doi: 10.1093/jnci/82.3.203. 117. Rupoli S, Goteri G, Pulini S, et al. …

Secukinumab in Patients with Psoriasis and a Personal History of Malignancy: A Multicenter Real-Life Observational Study.

INTRODUCTION: There is limited evidence to guide clinicians on the treatment of psoriasis with biologics in patients with a history of malignancy who are often excluded from clinical trials investigating biologics. The aim of this work is to report a multicenter real-life experience of secukinumab treatment in patients with psoriasis and a personal history of cancer. METHODS: This retrospective observational study included adult patients with moderate-to-severe plaque psoriasis treated with secukinumab for at least 24 weeks and a previous diagnosis of cancer at 15 Italian referral centers. Th

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… In a patient with a current cancer diagnosis or if cancer was diagnosed within the previous 5 years, the EuroGuiDerm guidelines provide a strong recommendation for topical treatment, narrowband UVB phototherapy, and/or acitretin and a weak recommendation for methotrexate, apremilast, and biologic agents … The most frequent previous treatment was methotrexate, reported by 80.9% (34/42) of patients, followed by acitretin and phototherapy 50% (21/42), adalimumab 47.6% (20/42), cyclosporine 45.2 (19/42), apremilast 30.9 (13/42), etanercept and infliximab 26.2% (11/42), certolizumab 4.7% (2/42), golimumab …

Theranostics - a sure cure for cancer after 100 years?

Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade. From the early concept of targeted d

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… Chemotherapy has been combined with other therapeutic methods, such as phototherapy 126 , 128 , 129 , 132 , 136 , 137 , 160 and chemodynamic therapy (CDT) 131 , 133 , 134 . … Since phototherapy has been discussed in the previous section, CDT will be exemplified to demonstrate the power of combination therapies with synergistic effects. …

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.

Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation of macrophage-, dendritic cell-, or monocyte-differentiated cells in various tissues and organs. The discovery of recurrent genetic alterations in many of these histiocytoses has led to their recognition as clonal neoplastic diseases. Moreover, the identification of the same somatic mutation in histiocytic lesions and peripheral blood and/or bone marrow cells from histiocytosis patients has provided evidence for systemic histiocytic neoplasms to originate from haematopoietic stem/progenitor cells (HSPCs). H

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… Due to stable, asymptomatic CMML but increasing pruritic ICH skin lesions (Figure 2G ), topical corticosteroids and UV‐B phototherapy for the ICH and an active monitoring strategy for the CMML were initiated. … Santos‐Briz A, Medina‐Miguelañez M, Moyano‐Bueno D, et al Indeterminate dendritic cell tumor as cutaneous involvement of chronic myelomonocytic leukemia successfully treated with phototherapy. Am J Dermatopathol 2020; 42: 876–880. 49. …

Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression.

Long-term, curative treatment of cutaneous T-cell lymphomas (CTCL) remains a major challenge. Therapy resistance is often based on apoptosis deficiency, and may depend on antiapoptotic Bcl-2 proteins, such as Bcl-2, Bcl-xL, Bcl-w and Mcl-1. For their targeting, several antagonists have been generated, which mimic the Bcl-2 homology domain 3 (BH3 mimetics). As dysregulation and overexpression of Mcl-1 has been reported in CTCL, the use of Mcl-1 inhibitors appears as an attractive strategy. Here, we investigated the effects of the selective Mcl-1 inhibitor S63845 in a series of four CTCL cell li

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… As for CTCL, several therapeutic approaches have been related to apoptosis induction, as phototherapy, photopheresis, the retinoid bexarotene and the histone deacetylase inhibitor vorinostat [ 7 , 8 , 9 , 10 ]. Apoptosis can be induced through extrinsic and intrinsic pathways. … Phototherapy for cutaneous T-cell lymphoma. Dermatol. Ther. 2003;16:303–310. doi: 10.1111/j.1396-0296.2003.01642.x. 8. Zhang C., Hazarika P., Ni X., Weidner D.A., Duvic M. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: Relevance to mechanism of therapeutic action. Clin. …

Advances and Prospects of Prolamine Corn Protein Zein as Promising Multifunctional Drug Delivery System for Cancer Treatment.

Zein is a type of prolamine protein that is derived from corn, and it has been recognized by the US FDA as one of the safest biological materials available. Zein possesses valuable characteristics that have made it a popular choice for the preparation of drug carriers, which can be administered through various routes to improve the therapeutic effect of antitumor drugs. Additionally, zein contains free hydroxyl and amino groups that offer numerous modification sites, enabling it to be hybridized with other materials to create functionalized drug delivery systems. However, despite its potential

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… These nanoparticles can be engineered to be pH-sensitive or GSH-sensitive, or to target highly expressed receptors on the tumor surface. 11–13 Nanoparticles can combine phototherapy, chemotherapy, and immunotherapy to further inhibit drug resistance and tumor cell migration. 14 Overall, nanoparticle … Photosensitizer Phototherapy is a treatment for tumors that includes reactive oxygen species (ROS)-mediated photodynamic therapy (PDT) and fever-mediated photothermal therapy (PTT). …

Time to Next Treatment as a Meaningful Endpoint for Trials of Primary Cutaneous Lymphoma.

Time to next treatment (TTNT) is an emerging endpoint in clinical studies of primary cutaneous T-cell lymphomas (CTCL), with utility as a surrogate marker for the "duration of clinical benefit". TTNT provides a highly clinically meaningful endpoint that uniquely reflects not only the duration of treatment efficacy on disease and symptom control, but also incorporates the patient experience by accounting for patient compliance and tolerance to the studied therapy(s). Given the distinct challenges of pin-pointing the exact date of progression in patients with multi-compartmental CTCL, TTNT overc

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… In 2015, DOCB was explored as a new endpoint in a pooled analysis of three prospective trials of low-dose TSE, using the definition of “time from initial response until the initiation of any total skin equivalent treatment (topical treatment to >50% of body surface, phototherapy, second TSE), systemic … DOCB = duration of clinical benefit; nbUVB/PUVA = narrowband UVB phototherapy and psoralen-UVA photochemotherapy; TSE = total skin electron therapy. …

Interventions for treating painful nipples among breastfeeding women.

BACKGROUND: Leading health authorities all recommend exclusive breastfeeding to six months' postpartum. While most women initiate breastfeed … e.g. lanolin); dressings (e.g. hydrogel dressings); nipple protection devices (e.g. breast shells), phototherapy, and expressed breast milk. Nipple pain in women who are feeding with expressed breast milk (i.e. women of infants in neonatal units) is associated with other methods of removing milk from the mother's breast such as manual expression and various ty …

Успешное лечение гуселкумаба у пациента с коморбидом псориазом и амиотропическим латеральным склерозом: тематическое исследование и обзор литературы.

Псориаз имеет генетические последствия и может быть вызван такими факторами, как инфекция, стресс и образ жизни. Хроническая доска psoriasis, наиболее распространенная форма, включает в себя ключевые роли для IL-17 и IL-23 в его патогенезе. Амиотропический боковой склероз (ALS) — нейродегенеративное расстройство, характеризующееся дегенерацией моторных нейронов, что приводит к слабости мышц и атрофии. В настоящее время нет лекарства от БАС, а лечение является симптоматическим и направлено на повышение качества жизни. Сочетание псориаза и БАС является относительно редким. Хотя биологические аге

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… Previous treatments, including phototherapy, acitretin, methotrexate, and various topical agents, had failed to achieve remission. The patient also had a 10-year clinical history of ALS, with a definitive diagnosis made by a neurology team three years ago. …

Is photobiomodulation an effective preventive strategy for oral mucositis in patients with hematologic diseases undergoing chemotherapy?: A systematic review of randomized controlled trials.

Purpose to conduct a systematic review to assess whether photobiomodulation is effective in preventing oral mucositis in patients with hematologic diseases undergoing chemotherapy. Methods: A systematic search was conducted in the Embase, Medline/PubMed, Cochrane, Scopus, Web of Science and LILACS databases. The strategy included selected randomized clinical trials that evaluated the prevention of oral mucositis, directly comparing the use of photobiomodulation for chemotherapy-induced oral mucositis in patients with hematologic diseases with alternative non-laser therapies. The risk of bias i

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… Lacerda-Santos JT, Fernandes Neto JA, Catão HCV (2019) Phototherapy in the treatment of oral mucositis: a literature review. Arq Odontol 55:e11 38. Gondim FM, Gomes IP, Firmino F (2010) Prevention and treatment of oral mucositis. Rev Enferm 18:67–74 39. … Simões A, Eduardo F, Luiz A et al (2009) Laser phototherapy as topical prophylaxis against head and neck cancer radiotherapy induced oral mucositis: comparison between low and high/low power lasers. Lasers Surg Med 41(4):264–270 41. …

Promising Highly Targeted Therapies for Cholangiocarcinoma: A Review and Future Perspectives.

To overcome the poor prognosis of cholangiocarcinoma (CCA), highly targeted therapies, such as antibody-drug conjugates (ADCs), photodynamic therapy (PDT) with/without systemic chemotherapy, and experimental photoimmunotherapy (PIT), have been developed. Three preclinical trials have investigated the use of ADCs targeting specific antigens, namely HER2, MUC1, and glypican-1 (GPC1), for CCA. Trastuzumab emtansine demonstrated higher antiproliferative activity in CCA cells expressing higher levels of HER2. Similarly, "staphylococcal enterotoxin A-MUC1 antibody" and "anti-GPC1 antibody-monomethyl

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… Currently, there are six primary modalities of anticancer treatment for CCA: (1) surgical therapy; (2) chemotherapy; (3) radiotherapy, including brachytherapy and proton radiotherapy; (4) immunotherapy, including immune checkpoint inhibitor and chimeric antigen receptor (CAR) T-cell therapy, (5) phototherapy … Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer. Int. J. Cancer. 2023;152:1425–1437. doi: 10.1002/ijc.34362. 101. Nishimura T., Mitsunaga M., Sawada R., Saruta M., Kobayashi H., Matsumoto N., Kanke T., Yanai H., Nakamura K. …

Effects of Carbon Nanomaterials and Aloe vera on Melanomas-Where Are We? Recent Updates.

Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as Aloe vera, have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new p

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… Accordingly, aloe-emodin, when combined with phototherapies or photodynamic therapies, induces apoptosis in mucinoma cells, gastric cancer cells, and breast cancer cells [ 79 , 80 ]. … An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers. Chem. Commun. 2013;49:4459–4461. doi: 10.1039/c3cc40714d. 16. Skubitz K.M. Phase II Trial of Pegylated-liposomal Doxorubicin (DoxilTM) In Sarcoma*. …

Scleredema of Buschke: 2 cases with a remarkable response to treatment of the underlying paraprotein.

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… Grudeva-Popova and Dobrev proposed noninvasive skin elasticity measurements as another useful method for evaluating treatment response. 1 Management of type 2 scleredema of Buschke is difficult; narrowband UV-B phototherapy and intravenous immunoglobulin can yield some benefit. …

Множественность в псориазисе вульгарис: ретроспективный анализ.

Частота комбинаций у пациентов с псориазом была сопоставлена с частотой, характерной для населения в целом, во многих исследованиях. Кроме того, в ряде исследований были изучены факторы риска, влияющие на количество коморбидов у пациентов с псориазом. Однако в нескольких исследованиях были изучены группы пациентов с псориазом в зависимости от их соперничества. В этом исследовании мы стремились изучить многосопоставимость псориазиса вульгариса с точки зрения факторов риска и кластеров. МЕТОДЫ: Все диагнозы 452 Пациенты с псориазным вульгарисом были извлечены из электронных медицинских записей т

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… Impact of comorbidities of patients with psoriasis on phototherapy responses. Int J Mol Sci . 2022;23(17):9508. doi: 10.3390/ijms23179508 13. Zhang Y, Guo Y, Zhang K, et al. Comorbidities among adult patients with psoriasis in Tianjin: a cross-sectional analysis of the health database study. …

Screening for gestational diabetes mellitus based on different risk profiles and settings for improving maternal and infant health.

BACKGROUND: Gestational diabetes mellitus (GDM) is a form of diabetes that occurs in pregnancy. Although GDM usually resolves following birt … neonatal complications: composite outcome, including: hypoglycaemia, respiratory distress, need for phototherapy, birth trauma, shoulder dystocia, five minute Apgar less than seven at one or five minutes, prematurity (RR 0.99, 95% CI 0.57 to 1.71; participants = 690; low-quality evidence), or neonatal hypoglycaemia (RR 1.10, 95% CI 0.28 to 4.38; participants = …