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Corona mortis: The leading pelvic vascular variant.

Corona mortis is a common vascular variant in the pelvis with significant clinical importance. While there is no standardised definition, the term generally refers to any anatomical situation where a vessel-either arterial or venous-crosses over the superior pubic ramus and is thus susceptible to injury. This anatomical course places it at high risk of injury in numerous clinical scenarios, including pelvic trauma and various surgical procedures. The aim of this article is to review the anatomy of arterial corona mortis using computed tomography angiography (CTA) and digital subtraction angiog

Why Reduced Inspiratory Pressure Could Determine Success of Non-Invasive Ventilation in Acute Hypoxic Respiratory Failure.

The magnitude of inspiratory effort relief within the first 2 hours of non-invasive ventilation for hypoxic respiratory failure was shown in … essure, multiple indicators of lung injury increased after application of non-invasive ventilation. Clinical Relevance- We show using computer simulation that reduced inspiratory pressure after application of noninvasive ventilation translates directly into large reductions in multiple well-established indicators of lung injury, providing a potential physiological e …

Prenatal disorders and congenital Zika syndrome in squirrel monkeys.

During the Zika virus (ZIKV) outbreak in Brazil (2015-2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged vire

An update on β-lactamase inhibitor discovery and development.

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously threatens our capability to treat bacterial diseases, including potentially deadly hospital-acquired infections. This growing issue certainly requires multiple adequate responses, including the improvement of both diagnosis methods and use of antibacterial agents, and obviously the development of novel antibacterial drugs, especially active against Gram-negative pathogens, which represent an urgent medical need. Considering the clinical relevance of both β-lactam antibiotics and β-lactamase-mediated resistan…

Detection of cardiovascular calcifications: Is it a useful tool for nephrologists?

Chronic kidney disease (CKD) has been used as a model and source of knowledge concerning the mechanisms, clinical relevance and accelerated progression of cardiovascular (CV) calcification, as well as its consequences in clinical practice, despite we know that it is a late secondary ossification phenomenon and only circumstantial evidence is available. In this comprehensive review, we firstly describe the types of CV calcification which affect CKD patients, and we analyse how its presence is directly associated with CV events and increased mortality in these patients. We also justify the use o…

Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications.

Poly(ethylene glycol) (PEG) is the most widely used polymer in delivering anticancer drugs clinically. PEGylation (i.e., the covalent attach … the synthetic advances in PEG prodrug conjugation methodologies with varied bioactive components of clinical relevance. In addition, this paper discusses FDA-approved PEGylated delivery systems, their intended clinical applications, and formulations under clinical trials.

[Intestinal malabsorption, celiac disease and associated lymphoma: from symptoms to diagnosis].

The clinical consequences of intestinal malabsorption are extremely variable and a dissociation between malabsorption, malabsorption syndrome and enteropathy is often noted. Enteropathy does not always results in malabsorption and in an alteration of the tests exploring the absorptive function. The following have particular relevance in clinical practice: coeliac disease, malabsorption induced by microbiologic agent (including Whipple's disease), post-surgical malabsorption and selective carbohydrate malabsorption. In particular, coeliac disease has been analyzed in its various aspects, from s

Incidence of Hypotension Associated With Two Different Vasopressin Discontinuation Strategies in the Recovery Phase of Septic Shock.

Introduction: Safe and effective vasopressor withdrawal strategies during the recovery phase of septic shock lack consensus and are not addressed in clinical practice guidelines. The purpose of this study was to compare the incidence of clinically relevant hypotension associated with different vasopressin (AVP) discontinuation strategies. Methods: This was a single-center, retrospective, cohort study, conducted at a university medical center over a three-year period. Adult patients ≥18 years with septic shock were included in the study. Patients were stratified into two groups; patients increm

From data entry to digital transformation: Allied health perspectives on standardised electronic medical records data.

BACKGROUND: Electronic medical records (EMRs) currently rely on standardised data fields to support secondary data use for clinical care, pe … n for health information management practice:Standardisation efforts must balance data quality with clinical relevance, ensuring data collection aligns with real-world workflows and supports meaningful use.

Химерический антигенный рецептор T-клеточная терапия в нейроиммунных болезнях: механистическое обоснование, клинический опыт и проблемы с переводом.

Нейроиммунные заболевания представляют собой разнородную группу расстройств, при которых клетки В, плазменные удары, плазменные клетки, автоантитела и Т клетки поразному влияют на повреждение тканей. Хотя биологика B-клеток улучшила контроль за заболеваниями, некоторые пациенты по-прежнему сталкиваются с реанимацией, рецидивом после лечения или кумулятивной неврологической инвалидностью. Химерическая антигенная рецепторная T-клетка (CAR-T-клетка) является средством достижения более глубокого и потенциально устойчивого истощения определенных патогенных иммунных клеток. Этот описательный обзор в

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… Complement-, CD19-, and interleukin-6 receptor-targeted therapies have substantially improved relapse prevention in AQP4-IgG-positive NMOSD, although recurrent attacks, treatment intolerance, and the need for continued maintenance therapy remain clinically relevant in some patients ( 91 ). … Within NMOSD, the clinical relevance of these platforms depends on whether residual disease can be linked to a defined pathogenic immune-cell compartment. …

From bedside observations to clinical decision support system (CDSS) rules: using real-world adverse drug events (ADEs) data to identify high-risk iatrogenic situations.

INTRODUCTION: Adverse drug events (ADEs) constitute a major clinical and economic burden in Europe. While hospital pharmacy activities improve prescription safety, pharmacists cannot review all orders in time and must prioritize high-risk patients. Rule-based clinical decision support systems (CDSS) offer an additional preventive strategy but often generate excessive, low-relevance alerts. OBJECTIVE: To develop rules for detecting iatrogenic risk in accordance with methodological standards reported in the literature, using ADEs identified in a prospective cohort of adult patients admitted to

Mapping the global evidence base of bundibugyo ebolavirus disease: a systematic scoping review of research gaps and preparedness priorities.

BACKGROUND: Bundibugyo ebolavirus (BDBV) is a rare filovirus species with an estimated case fatality rate (CFR) ranging from 25% to 51%. The 2026 BDBV outbreak in the Democratic Republic of the Congo (DRC) was declared a Public Health Emergency of International Concern (PHEIC), highlighting the critical necessity of assessing global research preparedness for this pathogen. OBJECTIVES: To systematically map the global scientific evidence base on BDBV, characterize temporal and thematic publication trends, identify critical knowledge gaps, and formulate actionable priorities for public health r

CD49f Expression in CD4+ T Cells and CD4 + FoxP3+ Tregs Reveals Immune Dysregulation and Potential Diagnostic Value in Systemic Lupus Erythematosus.

This study aimed to characterise the expression and functional heterogeneity of CD49f across CD4+ T cell subsets in human peripheral blood, and to investigate alterations in regulatory T cells (Tregs) and CD4+ T cells in patients with systemic lupus erythematosus (SLE), together with their clinical relevance. A total of 43 newly diagnosed, treatment-naïve SLE patients and 21 age- and sex-matched healthy controls were enrolled. Peripheral blood mononuclear cells were analysed by flow cytometry to assess CD49f expression in CD4 + FoxP3+ Tregs and non-Treg CD4+ T cells. Phenotypic and function-re…

Unveiling prognostic biomarkers and immunotherapeutic insights in prostate cancer through multi-omics and machine learning.

BACKGROUND: As a predominant form of cancer affecting male populations, prostate cancer (PCa) demonstrates notably high incidence rates globally. The significant heterogeneity in tumor microenvironment (TME) composition (including epithelial and diverse cell populations) hinders clear interpretation of gene and biomarker roles in disease advancement and immune response modulation. Through combined analysis of bulk and single-cell RNA sequencing data, this investigation evaluates prostate cancer-related genes' clinical relevance and prognostic potential. METHODS: We applied approaches like Fin…

Construction of a prognostic risk model for uveal melanoma based on immune-related long noncoding RNA.

Uveal melanoma (UM) is a common health challenge worldwide as a prevalent intraocular malignancy because of its high mortality rate. However … endence of our risk model compared to the tumor mutation burden score. Finally, we demonstrated the clinical relevance of our model by examining its sensitivity to different drugs. The risk score based on our risk model was significantly independent of other clinical parameters in either univariate (hazard ratio = 109.852 [15.738-766.749], P value < .001) or multiva …

Mandibular second molar impaction: introducing a novel and validated 3D classification system.

BACKGROUND: Mandibular second molar (M2M) impaction is a clinically significant manifestation of eruption disturbance in dental development. … e assessment of differences in diagnosis and decision-making protocol using 2D or 3D records, where clinical relevance ranged from 0 to 4. The secondary outcome variable was the validation analysis of the proposed 3D classification system to determine the concordance among the clinicians. Descriptive statistics and multivariable inferential analysis based on Akaike …

Development and Validation of a Supplementary Grading Scale for Outcomes of Brainstem Cavernous Malformations.

BACKGROUND: Surgical risk assessment is intriguing for clinical decision-making of brainstem cavernous malformation (BSCM) treatment. While the BSCM grading scale, encompassing size, developmental venous anomaly, crossing axial midpoint, age, and timing of intervention, is increasingly utilized, the clinical relevance of neurological fluctuation and recurrent hemorrhage has not been incorporated. This study aimed to propose a supplementary grading scale with enhanced predictive efficacy. METHODS: Using a retrospective nationwide registry of consecutive patients with BSCMs undergoing surgery i…

Simulation-based learning in palliative care in postgraduate nursing education: a scoping review.

BACKGROUND: Nurses require advanced competence in palliative care, but they face wide variations in education and a shortage in opportunities for clinical placement. Simulation-based learning (SBL) can enable students to develop clinical skills, critical thinking and confidence. No scoping reviews to date have mapped the use of SBL in palliative care within postgraduate nursing education. METHODS: The aim of this scoping review was to systematically map published studies on the use of SBL in palliative care in postgraduate nursing education. A scoping review was conducted using Arksey and O'M

Minimal Clinically Important Difference for PROMIS Physical Function in Patients With Distal Radius Fractures.

PURPOSE: This study was conducted to determine the minimal clinically important difference (MCID) of the Patient-Reported Outcomes Informati … nitudes of change on PROMIS Physical Function when patients present with better reported function. CLINICAL RELEVANCE: The MCID estimations are needed to determine the clinical relevance of changes in PROMIS scores and to more accurately calculate sample sizes needed for research incorporating PROMIS.

Risk factors associated with newly psychiatric disorder in spinal cord injury: A retrospective cohort study.

AIM AND OBJECTIVES: To predict the risk factors related to newly diagnosed psychiatric disorders resulting from spinal cord injuries (SCIs). … ment of SCI, and that this risk was more predominant in females with SCI. Our results are of direct clinical relevance as they are meant to assist clinical assessment, counselling, guidance of symptomatic monitoring and early clinical intervention.