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Treatment of Psoriasis with Secukinumab in Challenging Patient Scenarios: A Review of the Available Evidence.

Psoriasis (PsO) is a common, systemic, chronic, inflammatory disease characterized by key clinical symptoms, including itching, pain, and scaling. PsO is associated with a high prevalence of comorbidities, including other autoimmune diseases and malignancies. Furthermore, special populations, such as pregnant, pediatric, and elderly patients, and those with erythrodermic PsO, are challenging to treat and require tightly monitored disease and treatment management. Because certain populations have demographic or clinical characteristics that can affect the presentation of PsO and complicate trea

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… He was initially treated with methotrexate and multiple cycles of cyclosporine, acitretin, and phototherapy for 4 years, with minimal improvement and recurrent flares. … She had a 20-year history of PsO and a 2-year history of psoriatic arthritis (PsA) that was no longer effectively treated with topical corticosteroids and phototherapy. …

Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials.

BACKGROUND: Rocatinlimab is a T cell rebalancing therapy that inhibits and reduces the number of pathogenic T cells by targeting the OX40 re … ng a ≥2-point improvement from baseline) at week 24. Rescue therapy use, including topical therapy, phototherapy, and systemic therapy, was permitted from day 1; all patients who received rescue therapy were considered non-responders for all visits after the first use of rescue therapy but could generally continue study treatment unless prohibited per protocol …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… In addition, treatment should be directed against the specific type of reaction (e.g., phototherapy or acitretin for psoriasiform or lichenoid rashes; doxycycline/niacinamide, omalizumab, rituximab for bullous pemphigoid; Coleman et al., 2019 , Phillips et al., 2019a , Phillips et al., 2019b ). … Pruritus can be treated with antihistamines, but gabapentin, pregabalin, aprepitant, phototherapy, doxepin, and/or systemic corticosteroids may be required in more severe cases ( Coleman et al., 2019 , Collins et al., 2017 ). …

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics.

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell-neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to

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… Systemic options for PN treatment encompass phototherapy, immunosuppressants, gabapentinoids, antidepressants, and MOR antagonists [ 27 , 150 ]. … While phototherapy combined with topical therapy may be adequate for a minority of PN patients, the majority will likely require supplemental systemic therapy. 5.2.2. …

Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy.

Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of

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… Copper has captured the attention of many researchers among metal-based nanoparticles due to its strong redox potential and its use as an adaptable carrier for drug delivery and phototherapy. … Sheng et al. employed nanoliposomes to transport perfluorooctyl bromide and ICG for improved multimodal imaging-guided phototherapy [ 67 ]. …

A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer.

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common

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… Phototherapy can be safely combined with other therapeutic options to improve the effects of therapy [ 11 ]. … Emerging trends in combination strategies with phototherapy in advanced psoriasis management. Inflammopharmacology. 2023;31:1761–1778. doi: 10.1007/s10787-023-01257-2. 12. Xu Y., Li Z., Wu S., Guo L., Jiang X. …

Roles of circadian clocks in cancer pathogenesis and treatment.

Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in a timely manner, optimizing temporal physiology and behaviors. Dysregulation of circadian rhythms by genetic and environmental risk factors increases susceptibility to multiple diseases, particularly cancers. A growing number of studies have revealed dynamic crosstalk between circadian clocks and cancer pathways, providi

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… Other experimental human studies with a simulated night shift work model have shown that bright light induces complete and rapid adjustment of peripheral clocks, suggesting that phototherapy may be a potential nonpharmacological intervention to counteract the progressive effects of shift work or jet … Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work. Sci. Rep. 2017;7:16310. doi: 10.1038/s41598-017-16429-8. 58. Kervezee L, Cuesta M, Cermakian N, Boivin DB. …

Active versus expectant management for women in the third stage of labour.

BACKGROUND: Active management of the third stage of labour involves giving a prophylactic uterotonic, early cord clamping and controlled cor … this group, active management may make little difference to the rate of neonatal jaundice requiring phototherapy (average RR 1.31, 95% CI 0.78 to 2.18; 1 study, 1447 women).Hypertension and interference with placental transfusion might be avoided by using modifications to the active management package, for example, omitting ergot and deferring cord clamping, b …

Drugs for discoid lupus erythematosus.

BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to t … for DLE against either another drug or against placebo cream. We excluded laser treatment, surgery, phototherapy, other forms of physical therapy, and photoprotection as we did not consider them drug treatments. DATA COLLECTION AND ANALYSIS: At least two reviewers independently extracted data onto a data extraction sheet, resolving disagreements by discussion …

Уникальные диагностические и терапевтические функции порфиринов и фтальокянинов в области фотодинамической терапии, визуализации и термостимы.

Порфиринические молекулы играют уникальную тераностическую роль в лечении болезней; они используются для отображения, обнаружения и лечения различных форм заболевших тканей, в том числе в связи с возрастной маркулярной дегенерацией и рядом различных видов рака. В настоящее время основное внимание уделяется клинической съемке опухолей; целенаправленной доставке фотосенитеров и потенциалу фотоэнцедентов в мультимодальных биомедицинских наноплатформах. В настоящем Обзоре подчеркиваются роли порфириновых молекул в области съемки и пдта, а также исследования по совершенствованию их селективного пог

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… They are also used as photosensitisers in phototherapy; as fluorescent reporters in vitro and in vivo ; as non-linear optical materials; and as industrial catalysts 16 - 22 . … Phototherapy: History Porphyrins and PCs have been widely investigated for use in photodynamic therapy (pdt). …

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis.

BACKGROUND AND OBJECTIVES: Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an important member of the skin microenvironment and play an important role in the surrounding environment and in neighbouring cells, but they are also affected by the microenvironment. We studied the glucose metabolism of DMSCs in psoriasis patients and a control group to reveal the relationship among glucose metabolism, cell proliferation activity，and VEC (vascular endothelial cell)

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… Materials and Methods Subjects We chose 16 psoriasis patients (8 men and 8 women, ages 19∼55, PASI score 17.67±6.19) who visited our Hospital and had no systemic diseases or treatments with corticosteroids, immunosuppressive agents, or ultraviolet phototherapy within the 3 months before enrolment. …

Interventions for treatment of herpes labialis (cold sores on the lips).

RATIONALE: Herpes labialis (also known as cold sores or fever blisters) is a highly prevalent recurrent infection caused by the herpes simpl … cluded topical, oral, and physical therapies (e.g. nucleoside antivirals, anti-inflammatory agents, phototherapy, photodynamic therapy). Eligible comparators were placebo, no treatment, or another active intervention. We applied no restrictions related to publication language or status (published, unpublished, in press, or in progress). OUTCOMES: Our critical …

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.

BACKGROUND: Patent ductus arteriosus (PDA) is associated with significant morbidity and mortality in preterm infants. Several non-pharmacolo … gs, prophylactic surgical PDA ligation, and non-pharmacologic interventions (chest shielding during phototherapy and restriction of fluid intake); one review reported on the use of indomethacin for the management of asymptomatic PDA; nine reviews reported on interventions for the management of symptomatic PDA, and included pharmacotherapy with prostaglandin in …

Diabetes mellitus and the skin.

Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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… Scleredema diabeticorum successfully treated with ultra¬violet A1 phototherapy. J Dermatol. 2010;37:1036–1039. doi: 10.1111/j.1346-8138.2010.01014.x. 61. Alsaeedi SH, Lee P. Treatment of scleredema diabeticorum with tamoxifen. J Rheumatol. 2010;37:2636–2637. doi: 10.3899/jrheum.100561. 62. … UVA1 phototherapy for treatment of necrobiosis lipoidica. Clin Exp Dermatol. 2006;31:235–238. doi: 10.1111/j.1365-2230.2005.02059.x. 84. Nieboer C, Kalsbeek GL. Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher. …

Keyword Index for Volume 95

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… stage 1050 paxoral 794 PBSC 1326 PEA3 1404 pemetrexed 677 perceived needs 667 periostin 1396 persistent infection 1020 pharmacodynamics 450 pharmacokinetics 450, 677, 729 phase I 253, 571 phase II 450, 794, 1148 Phellinus linteus 282 phosphorylated EGFr 1525 photodynamic therapy 189 phototherapy …

Advanced multifunctional thermo- and electro-stimulative hydrogels for bone regeneration.

Bone defects caused by trauma, infection, tumors, osteoporosis, and diabetes disrupt skeletal integrity and impair regeneration. The healing process involves inflammatory hematoma formation, callus development, and remodeling, coordinated by diverse cells and signaling pathways. Conventional grafts and inorganic implants are limited by donor scarcity, immune rejection, and low bioactivity, necessitating more effective repair strategies. Recently, multifunctional smart hydrogels have emerged as a frontier in bone regeneration due to their biocompatibility, tunable structure, and ability to inte

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… Osteosarcoma and tumor-related bone defects | [ 72 ] β-TCP/SrCuSi 4 O 10 /HPMC/Sodium alginate@Gelatin/DOX | SrCuSi 4 O 10 | / | 1064 nm,1.5 W cm −2 | 5 min | ≈52 °C | SrCuSi 4 O 10 serves as a NIR-II photothermal agent releasing Sr/Cu/Si ions to promote osteogenesis and angiogenesis; DOX synergizes with phototherapy …

Neutrophilic and eosinophilic dermatoses associated with hematological malignancy.

Cutaneous manifestations of hematologic malignancy represent both a clinical challenge for the treating physician and a pathophysiological model for advancing the knowledge on individual neoplasms. Indeed, a growing body of evidence supports the concept of recurrent molecular defects associating with specific clinical features, as best exemplified by VEXAS. Herein neutrophilic and eosinophilic dermatoses of potential interest for both hematologists and dermatologists will be reviewed, including subcorneal pustular dermatosis-type IgA pemphigus, neutrophilic eccrine hidradenitis, Sweet's syndro

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… Other therapeutic options include topical and oral corticosteroids (used concurrently or as primary treatment), immunosuppressants such as mycophenolate mofetil and azathioprine, phototherapy, photochemotherapy and acitretin ( 20 ). … In the past, systemic and topical corticosteroids, dapsone, other nonspecific immunosuppressant/immunomodulating agents (e.g., doxycycline) as well as UVA1 light phototherapy have proved effective at controlling the cutaneous picture ( 92 , 93 ). …

Indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis.

BACKGROUND: Chronic plaque psoriasis is an immune-mediated, chronic, inflammatory skin disease, which can impair quality of life and social … after Dead Sea salt soak in the salt bath and UVB group and two instances of inadequate response to phototherapy and conversion to psoralen bath + UVA reported in the UVB only group (low-certainty evidence). AUTHORS' CONCLUSIONS: Salt bath with artificial ultraviolet B (UVB) light may improve psoriasis in people with chronic plaque psoriasis compared with UVB …

Interventions for chronic pruritus of unknown origin.

BACKGROUND: Pruritus is a sensation that leads to the desire to scratch; its origin is unknown in 8% to 15% of affected patients. The preval … l antidepressants, systemic antihistamines, systemic antidepressants, systemic anticonvulsants, and phototherapy. We included one study with 257 randomised (253 analysed) participants, aged 18 to 65 years; 60.6% were female. This study investigated the safety and efficacy of three different doses of oral serlopitant (5 mg, 1 mg, and 0.25 mg, once daily for six …

Evidence for the use of intravenous immunoglobulins--a review of the literature.

Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel

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… or phototherapy alone 189 patients Less use of exchange transfusion in the IVIg group: when given for prophylaxis RR = 0.21 ( p < 0.001), when given as treatment RR = 0.36 ( p < 0.006) [ 145 ] Meta-analysis of 3 RCTs IVIg and phototherapy or phototherapy alone 189 patients Overall less use of exchange … or phototherapy alone | 189 patients | Less use of exchange transfusion in the IVIg group: when given for prophylaxis RR = 0.21 ( p < 0.001), when given as treatment RR = 0.36 ( p < 0.006) [ 145 ] | Meta-analysis of 3 RCTs | IVIg and phototherapy or phototherapy alone | 189 patients | Overall less use …