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Epidemiology of patients treated for multiple myeloma using a new algorithm in the French national health insurance database (SNDS): Results from the MYLORD study.

BACKGROUND: Management of multiple myeloma (MM) has evolved in the last decade, impacting epidemiology and creating the need for a revised algorithm for patient identification in the French National Health Insurance database (SNDS). The objective of the MYLORD study was to provide up-to-date epidemiological indicators for MM using the SNDS. METHODS: Adults treated for MM between 2014 and 2020 were identified using hospital stays (ICD-10 code C90*) and/or Long-Term Disease status for MM (ICD-10 C90*) and treatment dispensation (MM specific treatments), or lenalidomide or thalidomide with 2 con

Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies.

The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from Cannabis sativa, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacological uses due to its anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. The molecular mechanisms involved in CBD's biological effects are not limited to its interaction with classical cannabinoid receptors, exerting anti-inflammatory or pain-relief effects. Several pieces of evidence demonstrate

Are you "tilting at windmills" or undertaking a valid clinical trial?

In this review, several aspects surrounding the choice of a therapeutic intervention and the conduct of clinical trials are discussed. Some of the background for why human studies have evolved to their current state is also included. Specifically, the following questions have been addressed: 1) What criteria should be used to determine whether a scientific discovery or invention is worthy of translation to human application? 2) What recent scientific advance warrants a deeper understanding of clinical trials by everyone? 3) What are the different types and phases of a clinical trial? 4) What c

Community-based adaptation of early adolescent skills for emotions for urban adolescents and caregivers in New York City.

An increasing number of studies have sought to explore the applicability of scalable mental health interventions to bridge the adolescent mental health treatment gap. This study aimed to adapt the World Health Organization's mental health intervention Early Adolescent Skills for Emotion (EASE) for urban communities in New York City (NYC). Following the mental health Cultural Adaptation and Contextualization for Implementation framework and in collaboration with three Brooklyn community-based organizations and the NYC Mayor's Office of Community Mental Health, the intervention was intensively w

Forgoing life-sustaining treatment - a comparative analysis of regulations in Japan, Korea, Taiwan, and England.

BackgroundRegulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England.Main textFindings from a literature review are first presented to describe the development of th

Знания, отношение и практика у пациентов с множественной миеломой: перекрестное исследование с использованием моделей структурного уравнения в одной третичной больнице в Вэньчжоу, Китай.

ВВЕДЕНИЕ: Это исследование было направлено на оценку знаний, отношения и практики пациентов с множественной миеломой (ММ) в отношении этого заболевания. МЕТОДЫ: Это перекрестное исследование проводилось среди пациентов с MM в Руанской народной больнице в провинции Чжэцзян, Китай, в период с августа по ноябрь. 2024. Данные собирались с использованием структурированного вопросника, предназначенного для сбора демографической информации и оценки КПД участников. РЕЗУЛЬТАТЫ: Всего 442 Были проанализированы действительные вопросники. Среди респондентов 226 (В тыс.51.1%) были мужчинами, и 298 (В тыс.6

Socioeconomic Burden of Cancer in Korea from 2011 to 2015.

PurposeThough the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to sex and age.Materials and methodsA prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients. Patients who received treatment for cancer from 2011 to 2015 were the study subjects. The total socioeconomic burden of their

A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy.

PurposeChemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy.MethodsRandomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over th

Adaptation of Coping Together - a self-directed coping skills intervention for patients and caregivers in an outpatient hematopoietic stem cell transplantation setting: a study protocol.

BackgroundDespite numerous reports of significant distress and burden for hematopoietic stem cell transplantation (HSCT) patients and caregivers (CGs), HSCT-specific coping interventions remain rare. The few in use lack specificity and are often not easily accessible or cost-effective. Whereas the development of new interventions is resource-intensive, theory-informed adaptation of existing evidence-based interventions is promising. To date, no HSCT-specific intervention has relied on a formal adaptation approach.MethodsUsing the Center for Disease Control and Prevention's Map of Adaptation, t

Developing high-concentration monoclonal antibody formulations for subcutaneous administration to improve patient treatment.

The transition of immunotherapy administration from intravenous infusion to subcutaneous (SC) administration of monoclonal antibody formulations for oncology patients has garnered significant interest. SC administration offers multiple benefits, including potential for at-home administration, enhanced patient compliance, reduced hospital congestion, lowered health care costs, and improved sustainability by reducing drug wastage and minimizing environmental impact. However, for many biologics, the shift to SC administration requires the development of high-concentration monoclonal antibody prod

Оказание помощи лицам, страдающим множественным склерозом, в Италии: восходящий подход проекта < < Континхом > > .

ЦЕЛЬ: В Италии, вокруг 137,000 Люди живут с множественным склерозом, сталкиваясь с организационными сложностями из-за того, что нынешняя модель уделяет ограниченное внимание уходу в непосредственной близости. Этот проект направлен на определение модели близости в соответствии с последними изменениями в итальянской системе здравоохранения, которая включает в себя: 150 Заинтересованные стороны в области здравоохранения, которые могут оказать 14,000 Пациенты. МЕТОДЫ: Был проведен анализ с целью картирования многоразового склерозового пути, после чего были проведены собеседования для выявления фак

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… Additionally, the inclusion of several specialists among the care pathway such as neuropsychologists, specialist in neurological rehabilitation (speech, occupational therapist), neuro-radiologists, psychologists and social workers contribute to comprehensive care delivery [ 34 ]. …

A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017.

BackgroundHematologic malignancies (HMs) are a heterogeneous group of cancers that comprise diverse subgroups of neoplasms. So far, despite the major epidemiologic concerns about the quality of care, limited data are available for patients with HMs. Thus, we created a novel measure-Quality of Care Index (QCI)-to appraise the quality of care in different populations.MethodsThe Global Burden of Disease data from 1990 to 2017 applied in our study. We performed a principal component analysis on several secondary indices from the major primary indices, including incidence, prevalence, mortality, ye

Разнообразие по признаку пола 90-Day Послеоперационные осложнения у пациентов с анемической атропластикой.

Первичная анемия представляет собой фактор риска для неблагоприятных последствий после полной артропопластики (THA), что в непропорционально большой степени сказывается на женщинах и способствует заболеваемости. Хотя как анемия, так и пол независимо связаны с постоперационными осложнениями, лишь в немногих исследованиях анализировались результаты у анемических пациентов, стратифицированных по признаку пола. По сравнению с этим исследованием 90-day Коэффициент осложнений послеоперационного периода между анемическими пациентами мужского пола и анемическими пациентами женского пола, проходящими п

Тенденции заболеваемости астмой, аптечным дерматитом и множественным склерозом до, во время и после COVID-19 Пандемия в базе данных о претензиях США.

Имеются лишь ограниченные данные о том, каким образом сокращение использования ресурсов здравоохранения в период COVID-19 Пандемия повлияла на выявление подстрекательских и иммунологических заболеваний. Мы стремились описать наблюдаемые показатели заболеваемости (ИР) астмой, атомным дерматитом (АД) и множественным склерозом (МС) до, во время и после пандемии. Лица пожилого возраста ≥6 Годы были определены в базе данных Optum, в которой не были указаны данные по клинформатике. 2018 в адрес 2022 для изготовления 20 сезонные когорты. Была проведена оценка ИП астмы, AD и MS с разбивкой по возрасту

What is the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on outcomes in people living with chronic hepatitis B (CHB)? An umbrella review protocol.

IntroductionAn estimated 254 million people are living with chronic hepatitis B virus (CHB) and 1.6 billion with metabolic dysfunction-associated steatotic liver disease (MASLD) worldwide. CHB remains a major global health challenge, despite a robust vaccine and suppressive antiviral treatment, and MASLD prevalence is increasing in line with a rise in cardiometabolic risk factors, such as obesity and type 2 diabetes. Thus, understanding the impact of concurrent CHB and MASLD on liver health is important to inform clinical practice and population surveillance. Current literature, including over

A smartphone app to improve the safety of patients undergoing treatment with oral antineoplastic agents: 4 years of experience in a university hospital.

ObjectiveThis study aims to analyze the impact of the eOncosalud app on the management and follow-up of adverse effects (AE) in patients receiving oral antineoplastic agents.Material and methodsWe performed an observational, prospective study of cancer outpatients treated with oral antineoplastic agents (OAA), monitored by the eOncosalud app between August 2017 and October 2021. Safety variables were collected from eOncosalud: the number of AE; severity of the AE according to CTCAE, version 4.03; timelapse from app installation to first recorded AE; automatic recommendations issued; and the pa

Воздействие физических упражнений на мышечную силу и характеристики ревматических заболеваний и саркопсии: Протокол исследования по вопросам ухода за мышечными мышцами (C4M).

ЦЕЛЬ: слабость мышечных мышц характерна для ревматоидного артрита (RA), остеоартрита (OA) и саркопсии (SARC). Упражнения на выносливость могут улучшить митохондриальную функцию и окислительную способность, в то время как считается, что упражнения на прочность стимулируют синтез белка миофибрилла. Цель этого исследования заключается в сопоставлении последствий упражнений на прочность и выносливость и в изучении связи между мышечными характеристиками и результатами упражнений у пациентов с RA, OA и SARC. Мы предполагаем, что реакция на выносливость и сильные упражнения у пациентов с мышечной сла

Using Continuous Passive Assessment Technology to Describe Health and Behavior Patterns Preceding and Following a Cancer Diagnosis in Older Adults: Proof-of-Concept Case Series Study.

BackgroundDescribing changes in health and behavior that precede and follow a sentinel health event, such as a cancer diagnosis, is challenging because of the lack of longitudinal, objective measurements that are collected frequently enough to capture varying trajectories of change leading up to and following the event. A continuous passive assessment system that continuously monitors older adults' physical activity, weight, medication-taking behavior, pain, health events, and mood could enable the identification of more specific health and behavior patterns leading up to a cancer diagnosis an

Cardiotoxicity after cancer treatment: a process map of the patient treatment journey.

Background/aimCardiotoxicity is a potential complication of anticancer therapy. While guidelines have been developed to assist practitioners, an effective, evidence based clinical pathway for the treatment of cardiotoxicity has not yet been developed. The aim of this study was to describe the journey of patients who developed cardiotoxicity through the healthcare system in order to establish baseline data to inform the development and implementation of a patient-centred, evidence-based clinical pathway.MethodsMixed-methods design with quantitative and qualitative components using process mappi

Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9).

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus that spread worldwide from 2019 causing the Coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 infection is characterised by an initial viral phase followed in some patients by a severe inflammatory phase. Importantly, immunocompromised patients may have a prolonged viral phase, shedding infectious viral particles for months, and absent or dysfunctional inflammatory phase. Among haematological patients, COVID-19 has been associated with high mortality rate in acute leukaemia, high risk-myelodysplastic syndromes,