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[Neuritis of the optic nerve after vaccinations against hepatitis A, hepatitis B and yellow fever].

BACKGROUND: Vaccinations are preventive measures against serious infections. In relation to the number of vaccinations per year, the incidence of severe complications is extremely low. PATIENT: Two weeks after vaccinations against hepatitis A, hepatitis B and yellow fever in preparation for a trip to Africa a 21-year-old woman experienced an acute and irreversible loss of vision to 0,05 and nasal visual field defect in the left eye. Whereas vision acuity did not recover the scotoma disappeared within 6 weeks. Cerebrospinal fluid showed a lymphocytic pleocytosis. Oligoglonale bands were absent

[The relationship between mosquito vectors and aquatic birds in the potential transmission of 2 arboviruses].

The authors studied for two years the role of the chicks of aquatic birds in the arboviral cycles in coastal lagoons in central Panama in order to determine the relation between Culex (Melanoconion) ocossa and Mansonia (Mansonia) dyari mosquitoes in the transmission and dissemination of the viruses of Saint Louis Encephalitis (SLE) and Venezuelan Equine Encephalitis (VEE). Mosquitoes were captured every fifteen days on two consecutive nights to isolate the virus, using light traps (CDC) and baited traps. The attempts to isolate the virus were made using Vero cell cultures and the determination

[Presence of antibodies against Venezuelan equine encephalitis virus subtype VI in patients with acute febrile illness].

In Argentina, there is no record of human cases produced by Dengue virus (Flavivirus), but Paraguay and Brasil (neighbouring countries) have notified human outbreaks of Dengue Haemorrhagic Fever. In this report, we inform the serological results of a limited human outbreak of a Dengue-like acute illness that occurred in General Belgrano Island, Formosa, Argentina in April 1989. This island is 35 km far from Clorinda city of Paraguay river, with a human population of 150 inhabitants. The weather of this area is humid with abundant rainfall, favouring mosquitoes proliferation. Two samples of ser

Experimental inoculation of three arboviruses in black-bellied whistling ducks (Dendrocygna autumnalis).

Wild-caught, immature black-bellied whistling ducks (Dendrocygna autumnalis) were inoculated with eastern equine encephalitis (EEE), St. Louis encephalitis (SLE), or western equine encephalitis (WEE) virus. Susceptibility, duration and titer of viremia, and antibody response to these arboviruses were determined. Birds from all inoculated groups became viremic. Higher virus titers occurred in the EEE group but overall mean titers were not significantly different among experimental groups. All birds inoculated with EEE and SLE viruses developed antibodies, and six of seven ducks receiving WEE vi

Viral encephalitis.

Nonherpetic encephalitis outside the newborn period is usually a self-limited disease. The majority of patients will recover without significant sequelae, and require only supportive therapy during the acute illness. Though the underlying viral etiology frequently will escape detection, identification of the infecting agent has considerable prognostic value which can complement clinical measures of severity of disease. The most important initial task of the clinician faced with a case of presumptive viral encephalitis is to eliminate the possibility of a treatable illness. Once this has been d

Experimental lead encephalopathy in the suckling rat: concentration of lead in cellular fractions enriched in brain capillaries.

Five-day old rats subjected to short-term (2-day) lead exposure by gastric gavage of aqueous lead acetate at the highest non-lethal dosage (1mgPb/g body weight/day) developed a hemorrhagic encephalopathy. Capillaries and microvessels isolated from brains of these rats showed abnormal morphology consisting of an increased number of irregularly dispersed endothelial nuclei and swollen, vacuolated endothelial cells. Lead was concentrated in isolated brain capillary-microvessel fractions, as demonstrated by both atomic absorption and 210Pb tracer methods. When lead exposure was continued for 20 da

Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness lacking objective diagnostic biomarkers and clear pathophysiological understanding. Patients exhibit immune dysregulation and chronic inflammation reminiscent of aging phenotypes, yet the role of myeloid cell senescence in this disease remains unexplored. METHODS: A stepwise integrative transcriptomic and computational strategy was employed. Differentially expressed genes were identified from the bulk transcriptomic dataset GSE14577. Weighted gene co-expression network analysis was performed to identi…

Effects and mechanism of CYBB on the progression of multiple sclerosis: Evidence from bioinformatic analysis and experimental validation.

BACKGROUND: Neutrophil extracellular traps (NETs) are involved in the pathological progression of multiple sclerosis (MS), yet the intrinsic … interaction networks were performed on these candidate biomarker genes. An experimental autoimmune encephalomyelitis (EAE) mouse model was established and intervened with cytochrome b-245 beta chain (CYBB) overexpression. Neurological scores, inflammatory factors (tumor necrosis factor-α [TNF-α], interleukin-1β [IL-1β], interleukin-18 [IL-18], and monocyte chemoat …

Beyond Wilson Disease: a comprehensive review of the Non-Wilsonian Causes and differentiating imaging features of the "Face of the Giant Panda" sign.

The "Face of the Giant Panda" sign is a characteristic magnetic resonance imaging (MRI) appearance classically associated with Wilson diseas … nidazole neurotoxicity, Japanese and West Nile encephalitis, neurocysticercosis, acute disseminated encephalomyelitis, Wernicke encephalopathy, maple syrup urine disease, primary CNS lymphoma, Creutzfeldt-Jakob disease, and select vascular and space-occupying lesions. Recognition of accompanying imaging findings-diffusion restriction, enhancement, hemorrhage, calci …

FreeSurfer-based amygdala subfield volumetry in long COVID and ME/CFS: clinical and immunological correlations.

BACKGROUND: Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share debilitating symptoms and have been associated with limbic-system dysfunction. We investigated amygdala subfield volumes to identify disease-specific neuroanatomical features and their clinical and immunological correlates. METHODS: We prospectively examined 27 patients with long COVID, 38 patients with ME/CFS, and 47 healthy controls (HCs). Amygdala subfields were segmented using high-resolution 3-T MRI and FreeSurfer software. Group comparisons were performed using analysis of covariance, and partia…

Prevalence of Bodily Distress Syndrome and Prediction of Patient Outcomes: Cohort Study of 3762 Individuals With Persistent Pain.

BACKGROUND: Persistent physical symptoms are common and often result in disability and high healthcare use. To capture how such symptoms co-occur, Bodily Distress Syndrome (BDS, also called Functional Somatic Disorders) was developed as an empirically derived construct, in contrast to consensus-based syndromes such as fibromyalgia and chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). BDS is distinct from ICD-11 Bodily Distress Disorder and reflects the multisystem symptom pattern described in the Functional Somatic Disorder framework. However, its prevalence, symptom structure and p…

The invisible emergencies: metabolic and neuro-critical disorders often missed in the pediatric ED - a narrative review.

BACKGROUND: Delayed recognition of metabolic and neuro-critical disorders in children presenting to emergency departments (EDs) contributes … missed include nonconvulsive status epilepticus (NCSE), autoimmune encephalitis, acute disseminated encephalomyelitis (ADEM), and early signs of elevated intracranial pressure (ICP) from infection, trauma, or hydrocephalus. Key contributors to delayed diagnosis are the absence of focal deficits, low clinical suspicion for rare disorders, and the underutilization of …

Неврологические последствия гипергликемии: сообщение о редком представлении о синдроме осмотической демиелинации.

Синдром осмотического обезвоживания (ОРД) представляет собой редкое, но потенциально опасное для жизни неврологическое расстройство. Она характеризуется невоспалительным обезвоживанием, которое, как правило, вызвано внезапными сменами сыворотки. Однако появляющиеся данные свидетельствуют о том, что резкие осмотические изменения, вызванные сильной гипергликемией, даже при отсутствии натриевого дисбаланса, могут также приводить к образованию ОРВ. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: А 57-year-old мужского пола с плохо управляемым типом 2 Больной диабет и хроническое употребление алкоголя сопровождаются период

Совпадение в аннотации оригинала
BACKGROUND: : Osmotic demyelination syndrome (ODS) is a rare but potentially life-threatening neurological disorder. It is characterized by … erved. DIFFERENTIAL DIAGNOSIS: : Radiological differentials considered included acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), ischemic infarction, vasculitis, and brainstem glioma. However, the symmetric pontine involvement without enhancement or mass effect, along with the clinical context of hyperosmolar hyperglycemia, favored a diagnosis …