Результаты поиска

Regenerative rehabilitation: a novel multidisciplinary field to maximize patient outcomes.

Regenerative rehabilitation is a novel and rapidly developing multidisciplinary field that converges regenerative medicine and rehabilitation science, aiming to maximize the functions of disabled patients and their independence. While regenerative medicine provides state-of-the-art technologies that shed light on difficult-to-treated diseases, regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative medicine. However, regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each

Precision Medicine Through Network Language: Integrating Clinical Insight and Data Expertise.

Precision medicine is facing a critical transition driven by the growing complexity of biological data and the insufficient ability of current models to translate such data into clinically meaningful information. Linear, single-gene approaches are no longer adequate to explain the multifactorial nature of most modern diseases, whose phenotypes emerge from combinations of genetic, molecular, and environmental factors. Network-based precision medicine addresses this by providing a systemic framework capable of integrating heterogeneous omics data, interactomes, and clinical information to identi

Frailty as an Effect Modifier in Randomized Controlled Trials: A Systematic Review.

BackgroundThe effect of clinical interventions may vary by patients' frailty status. Understanding treatment effect heterogeneity by frailty could lead to frailty-guided treatment strategies and reduce overtreatment and undertreatment. This systematic review aimed to examine the effect modification by frailty in randomized controlled trials (RCTs) that evaluate pharmacological, non-pharmacological, and multicomponent interventions.MethodsWe searched PubMed, Web of Science, EMBASE, and ClinicalTrial.gov, from their inception to 8 December 2023. Two reviewers independently extracted trial data a

To what degree is palliative care integrated in guidelines and pathways for adult cancer patients in Europe: a systematic literature review.

BackgroundPalliative Care (PC) aims to improve the quality of life for patients with cancer and their families and its benefits have been demonstrated by several studies. The objective of this systematic review is to assess the integration of PC in the content of guidelines/pathways of adult cancer patients in Europe.MethodsWe included studies of adult patients with cancer published from 01/01/1995 and 31/12/2013 in Europe in six languages. We searched nine electronic databases, hand-searched six journals and also performed citation tracking. Studies were ranked using Emanuel's Integrated Pall

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease.

BackgroundSurgical decompression (SD), with or without posterior stabilization followed by radiotherapy, is an established treatment for patients with metastatic spinal disease with epidural spinal cord compression (ESCC). This study aims to identify risk factors for occurrence of neurological compromise resulting from local recurrence.MethodsAll patients who received surgical treatment for metastatic spinal disease at our center between 2011 and 2022 were included in this study. Cases were evaluated for tumor entity, surgical technique for decompression (decompression, hemilaminectomy, lamine

Разработка приложения " Смешанная реальность " для подготовки людей с множественным склерозом по принципу " Volitional step " ( < < Волонтеральная подготовка по ступеням > > ): Межсекторальное исследование по вопросам качества, ориентированное на пользователей.

КОЛИЧЕСТВО: Люди с множественным склерозом (МС) подвергаются высокому риску падения, причем примерно половина из них испытывает по крайней мере 1 попадают в 6 месяцев. Многонаправленная подготовка кадров продемонстрировала потенциал для предотвращения осенних осадков, однако данные о лицах, имеющих НР, остаются непоследовательными. Смешанная реальность (МРП) открывает возможности для адаптации и реабилитации на дому. Однако успешное внедрение серьезных игр на основе MR требует структурированных процессов совместного проектирования, объединяющих пациенты, клинические и технические аспекты.ЦЕЛЬ:

Complex Regional Pain Syndrome in Cancer Cases: Current Knowledge and Perspectives.

BACKGROUND: Complex regional pain syndrome (CRPS) is a disabling painful disorder caused by many different and poorly understood mechanisms. It often affects the distal limbs and usually happens as consequence of a trauma. Its severity can remarkably affect patients' quality of life. When this painful complication happens in a cancer patient, the impact may be exponential. To date, there is limited knowledge of the surrounding circumstances of CRPS cases in this population. METHODS: We present two clinical cases of patients diagnosed with cancer-related pain presenting with symptoms and signs

Choosing the Right Therapy for Patients with Relapsed/Refractory Multiple Myeloma (RRMM) in Consideration of Patient-, Disease- and Treatment-Related Factors.

Treatment of relapsed/refractory multiple myeloma (RRMM) is more complex today due to the availability of novel therapeutic options, mostly applied as combination regimens. immunotherapy options have especially increased substantially, likewise the understanding that patient-, disease- and treatment-related factors should be considered at all stages of the disease. RRMM is based on definitions of the international myeloma working group (IMWG) and includes biochemical progression, such as paraprotein increase, or symptomatic relapse with CRAB criteria (hypercalcemia, renal impairment, anemia, b

A Combined Cyto- and Histopathological Diagnostic Approach Reduces Time to Diagnosis and Time to Therapy in First Manifestation of Metastatic Spinal Disease: A Cohort Study.

Malignant spinal lesions (MSLs) are frequently the first manifestation of malignant disease. Spinal care, diagnostic evaluation, and the initiation of systemic therapy are crucial for outcomes in patients (pts) with advanced cancer. However, histopathology (HP) may be time consuming. The additional evaluation of spinal lesions using cytopathology (CP) has the potential to reduce the time to diagnosis (TTD) and time to therapy (TTT). CP and HP specimens from spinal lesions were evaluated in parallel in 61 pts (CP/HP group). Furthermore, 139 pts in whom only HP was performed were analyzed (HP gr

Cardiac amyloidosis: Innovations in diagnosis and treatment.

Cardiac amyloidosis (CA) is a progressive, underdiagnosed condition caused by the deposition of misfolded proteins in the myocardium, forming amyloid fibrils that impair cardiac structure and function. This review highlights recent advances in the diagnosis and treatment of amyloid light-chain (AL) and transthyretin (ATTR) CA, which globally account for most cases of CA. Novel diagnostic tools, including artificial intelligence-enhanced analysis and advanced imaging modalities like positron emission tomography with amyloid-specific tracers, might improve detection rates and diagnostic accuracy

Important learning points for setting up a dental-oncology service in Ireland.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Patient-specific risk factors for adverse outcomes following geriatric proximal femur fractures.

BACKGROUND: Proximal femur fractures (PFFs) occur frequently among geriatric patients due to diverse risk factors, such as a lower bone mineral density and the increased risk of falls. METHODS: In this review, we focus on recent literature of patient-specific risk factors and their impact on common complications and outcome parameters in patients with PFF. RESULTS: Patient- and treatment related factors have a significant impact on outcome and are associated with an increased risk of mortality, impairments in functional rehabilitation and complicative courses. CONCLUSION: Geriatric patients

Картирование ухода в конце жизни для пациентов с неврологическими заболеваниями на немецких хоспезах: обследование распространенности точечных заболеваний.

ОБРАЩЕНИЕ: Доступ пациентов с неврологическими заболеваниями к паллиативной помощи по-прежнему ограничен. К числу факторов, способствующих этому, относятся трудности с прогнозированием траекторий заболеваний, ограниченность ресурсов для долгосрочного ухода и трудности с выявлением фазы завершения жизни, которая зачастую усугубляется коммуникационными и когнитивными нарушениями. МЕТОДЫ: Мы провели национальное обследование точечной распространенности среди германских стационарных хоспей с использованием онлайнового вопросника. Результаты: доля ответивших 44%, с 83% - наличие у участников хоспей

Extracorporeal shock wave therapy in the supportive care and rehabilitation of cancer patients.

PURPOSE: Cancer patients sometimes show immobilizing musculoskeletal conditions which prohibit active exercise due to severe bodily pain. Therefore, before starting a rehabilitative exercise program, the pain has to be reduced to enable the patient to participate actively in the exercise program. Extracorporeal shock wave therapy (ESWT, the application of radial and/or focused shock waves with low or high energy) has been shown to be effective and efficient in the treatment of musculoskeletal disorders. However, one historical paradigm was the fact that, in the past, cancer was seen as a contr

Инструменты скрининга для раннего выявления потребностей в паллиативном уходе у пациентов с повышенными хроническими условиями: обновленный систематический обзор.

Предыстория/задачи: Более раннее начало паллиативного ухода способствует улучшению клинических результатов, включая повышение эффективности мер по борьбе с симптомами, повышение качества жизни и сокращение использования ресурсов здравоохранения для лечения передовых заболеваний. Цель этого систематического обзора заключалась в выявлении и критической оценке существующих инструментов, разработанных как в обычном порядке, так и на основе искусственного интеллекта, предназначенных для выявления пациентов, имеющих право на раннее паллиативное лечение. Методы: Six Были изучены электронные базы данн

Progress in the application of 68Ga-Pentixafor PET/CT in lung cancer: a review.

68Ga-Pentixafor PET/CT, a molecular imaging technique targeting the C-X-C chemokine receptor 4 (CXCR4), has emerged as a promising tool in the diagnosis and therapeutic evaluation of lung cancer. Lung cancer remains a leading cause of cancer-related mortality worldwide, and accurate imaging modalities are critical for early detection, staging, and treatment monitoring. Current imaging approaches face challenges in differentiating tumor subtypes and assessing tumor biology, which limits personalized treatment strategies. This review systematically summarizes the application of 68Ga-Pentixafor P

Research Hotspots and Trends in Global Cancer immunometabolism:A Bibliometric Analysis from 2000 to 2023.

BackgroundCancer poses a major global health challenge, and immunotherapy, known as the third revolution in cancer treatment, has brought new hope to patients. The emerging field of immunometabolism has further enhanced the safety and efficacy of immunotherapy. Over the past two decades, this field has rapidly evolved in oncology, leading to numerous significant findings. This review systematically examines the literature on immunometabolism in cancer, visualizing research trends and identifying future directions.MethodsA comprehensive literature search was conducted in the Web of Science, Pub

Совпадение в полном тексте источника
… As shown in Figure 6C , the orange paths indicate that journals from fields such as Molecular, Biology, and Genetics are most likely to be cited by journals focusing on Molecular, Biology, and Immunology, suggesting that the latest research includes many interdisciplinary studies. …

Development of a quality indicator set for day hospices in Germany - a multi-stage, quality-assured review of German guidelines and quality indicator sets.

BackgroundDay hospices are an emerging component of outpatient palliative care in Germany. However, a standardized quality management system utilizing defined quality indicators has not yet been implemented. This study aimed to develop a new set of quality indicators for day hospices.MethodsThrough a multi-phase, quality-assured review, we screened validated quality indicators from German-language S3 guidelines and established quality indicator sets, including the Quality Indicator System for Outpatient Care (QISA) and Outpatient Quality Indicators and Key Figures (AQUIK) based on defined crit

Текущие данные о связи языковой прочности с когнитивным снижением у пожилых людей и известными факторами риска, связанными со слабостью, саркопией и питанием: протокол аналитического обзора.

ВВЕДЕНИЕ: Факты указывают на то, что патология, лежащая в основе когнитивного упадка, ведущего к слабоумию, начинается 15-20 За годы до появления когнитивных симптомов. Таким образом, идентификация биомаркеров на этом предклиническом этапе имеет исключительно важное значение. Связанное с возрастом снижение массы и силы мышц, что является известным фактором риска для саркопсии, слабость и когнитивное упадок, также влияет на язык. В настоящем документе описывается априори протокол, подготовленный междисциплинарной группой для решения следующих вопросов, касающихся взрослых ≥50 возраст:1) Каковы

Interdisciplinary Multidimensional Assessment of Transthyretin Amyloidosis before and after Tafamidis.

BackgroundClinically, there is considerable heterogeneity in the presentation of transthyretin amyloidosis (ATTR), which ranges from primarily cardiac and primarily neurologic to mixed disease, among other manifestations. Because of this complex presentation, the diagnosis and management of patients with ATTR are often challenging and should be performed in interdisciplinary centers specialized in amyloidosis. Here, we aimed to increase awareness of ATTR detection and pathophysiology through a multidimensional multiorgan approach.Case reportWe reported on a 60-year-old man with wild-type ATTR