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Nanoparticle-Based Drug Delivery Systems for Periodontitis: Antibacterial, Immunomodulatory, and Regenerative Strategies.

Periodontitis is a chronic inflammatory disease associated with obesity, type 2 diabetes, and cardiovascular disease, and has become a serious public health issue. Antibacterial treatment and mechanical debridement are the main treatment strategies for periodontitis. However, side effects and bacterial resistance might lead to treatment failure. Nanotechnology systems have new opportunities for the management of periodontitis. With benefits including superior targeting and fewer side effects, drug delivery systems constructed with nanoparticles (NPs) may provide local, delayed, and regulated d…

Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells.

Small interfering RNAs (siRNAs) are powerful tools to target cellular protein expression, making them promising candidates for therapeutic applications. siRNA-based approaches to target detrimental mechanisms in airway diseases such as asthma and chronic obstructive pulmonary disease are highly appealing. However, such delivery systems must be nontoxic, protect siRNAs from degradation, and enable intracellular uptake that accesses cytosolic RNA machinery. The present study examines the mechanisms by which guanidinium-functionalized poly(oxanorbornene)imide polymer (PONI-Guan) nanoparticles can…

Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances.

Cardiomyopathy comprises heterogeneous diseases characterized by structural or functional myocardial abnormalities and caused by conditions such as hypertension and coronary atherosclerotic heart disease. Current management relies mainly on pharmacotherapy and lifestyle interventions, but these approaches are limited by poor bioavailability and adverse effects. Nanoparticles (NPs) can deliver therapeutic drugs to cardiac muscle tissue through passive or active targeting, protecting the drugs they carry from premature degradation. They also show good biocompatibility and minimize damage to heal…

Evaluation of the effects of ivermectin and Moringa oleifera nanoparticles on muscular trichinellosis in a murine model.

The parasitic nematode Trichinella spiralis (T. spiralis) offers a rich experimental model in the study of muscle inflammation and regeneration. The larval stage of the parasite is a particularly challenging drug target due to its encystation inside the sophisticated nurse cell complex. Non-conventional pharmacological approaches such as herbal remedies and nanoformulations have garnered special research attention in the management of T. spiralis-induced myositis. The current study investigated the effects of Moringa oleifera nanoparticles (MON) and Ivermectin nanoparticles (IVN) on T. spirali…

Recent Progress on Selenium Nanoparticles: Synthesis and Neuroprotective Effects for the Treatment of Alzheimer's Disease.

Alzheimer's disease (AD) is the most prevalent cause of dementia, affecting over 50 million individuals worldwide, with projections suggesting a tripling of cases by 2050. Current Food and Drug Administration (FDA)-approved treatments, including cholinesterase inhibitors, N-Methyl-D-aspartic acid (NMDA) receptor antagonists, and monoclonal antibodies, provide only modest symptomatic relief or partial disease modification. Their limitations include poor blood-brain barrier penetration, systemic side effects, and reduced efficacy in advanced stages. This has caused the exploration of novel nanot

Nanoparticle-Like Scavenger Mediated by NIR/pH Stimulation for MRSA-Associated Infections.

Methicillin-resistant Staphylococcus aureus (MRSA) infections represent a severe global clinical threat due to its multi-antibiotic resistance, abundant virulence factors, and complex pathogenic mechanisms. In the present study, hollow copper sulfide (CuS) nanoparticles (NPs) with a strong photothermal effect were employed as carriers for the loading of the NO-releasing bioactive molecule S-nitrosoglycine (GSNO). These NPs were also camouflaged with mouse red blood cell membranes (RBCMs) via extrusion to fabricate CuS-GSNO@RBCM NPs designed to effectively eliminate MRSA and its biofilms. Under…

An electrochemical biosensor to detect exosomes based on their assembly with silver nanoparticles and multifunctional peptides.

Exosomes have been valuable biomarkers for disease diagnosis, however their low abundance still presents challenge for clinical application. In this paper, we report an electrochemical biosensor that enables sensitive and specific detection of exosomes without the requirement of pretreatment steps and signal amplification. In this study, the designed multifunctional peptides are firstly conjugate with silver nanoparticles (AgNPs) through sulfhydryl groups to form Pep-AgNPs, and subsequently combine with exosomes via the targeting sequence. Under acidic conditions, protonation of the peptide te…

Precision Targeting of Human M2 Macrophages by Magnetic Nanoparticles Functionalized with an in-House Antibody.

INTRODUCTION: Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, particularly due to resistance induc … macrophages (M1M) or monocytes. Here, we investigated the conjugation of this antibody on magnetic nanoparticles (MNPs) as a potential nanoplatform for specific M2 TAM targeting. METHODS: Magnetic iron oxide multicore nanoflowers (NF) were functionalized with a fluorophore allowing their detection and the mAb6-25 for M2 TAM targeting. The M2M targeting by MNP …

Целевые стратегии лечения рака цвета кожи: изучение использования аптемеров и золотых нанопчастей.

Рак цвета кожи (КЗК) является второй ведущей причиной смертности от рака и является причиной ~10% из всех случаев рака. По оценкам, во всем мире случаи, связанные с КПР 1.9 million и 930,000 смертями в 2022. Несмотря на расширение доступа к обследованиям и лечению в рамках КПР, ожидается, что показатели смертности резко возрастут в районах с низким уровнем ресурсов, что подчеркивает настоятельную необходимость принятия новаторских мер по лечению в рамках КПР. Текущая химиотерапия создает проблемы, такие, как плохая биодоступность, резистентность к многочисленным лекарствам и негативные побочны

Совпадение в аннотации оригинала
Colorectal cancer (CRC) is the second leading cause of cancer-associated mortality and accounts for ~10% of all cancer cases. Global CRC cas … about targeted CRC treatment. Hence, this review highlights the promising role of aptamer- and gold nanoparticles (AuNPs)-based systems for targeted CRC treatment. This strategy leverages the unique properties of aptamers and AuNPs as drug carriers, targeting and therapeutic agents. Overall, aptamers in combination with AuNPs are projected to improve the delive …

Crossing the blood-brain barrier: nanoparticle-based strategies for neurodegenerative disease therapy.

Neurodegenerative conditions, including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Huntington's disease, represent a criti … of neurodegenerative diseases. The nanocarriers reviewed in this work encompass a diverse array of nanoparticles, including polymeric nanoparticles (e.g. micelles and dendrimers), inorganic nanoparticles (e.g. superparamagentic iron oxide nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, selenium and cerium oxide nanoparticles), lipid nanopar …

Nanoparticle-Mediated CXCL12-CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma.

Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches. This study investigates the efficacy of self-assembled M2pep-Cs NPs/Plerixafor nanoparticles in suppressing GC by targeting the CXCL12-CXCR4 signaling pathway and reprogramming tumor-associated macrophages (TAMs) to enhance anti-tumor immunity. The nanoparticles' physicochemical properties and biocompatibility are assessed using transmission electron microscopy, dynamic light scattering, and biological assays. A GC mouse model is established, followed by histological and immunohistochemical …

A Liposome-Based Nanoparticle Vaccine Induces Effective Immunity Against EBV Infection.

Background: Epstein-Barr virus (EBV) infects approximately 95% of the global population, causing numerous malignancy-related cases annually and some autoimmune diseases. EBV-encoded gp350, gH, gL, gp42 and gB glycoproteins are identified as antigen candidates for their key role in viral entry, and nanoparticle vaccines displaying them were developed for the advantage of inducing cross-reactive B cell responses. Methods: To develop liposomes displaying nanoparticle vaccine, we synthesized liposomes to present the well-identified EBV-encoded gp350D123 glycoprotein on their surface to imitate the

Ionizable guanidine-based lipid nanoparticle for targeted mRNA delivery and cancer immunotherapy.

The development of lipid nanoparticle (LNP) systems has largely advanced RNA therapeutics, particularly mRNA-based cancer immunotherapy. Conventional amine-LNPs, designed for hepatic RNA delivery, face challenges in targeting lymphoid organs effectively and maximize antigen presentation. In this study, we present the development of pH-responsive ionizable guanidine-LNPs (G-LNPs). Our cholesterol-free G-LNP system enables efficient delivery of mRNA to the spleen following intravenous administration. Notably, while both amine-LNPs and G-LNPs can deliver mRNA to the spleen, G-LNPs exhibit a uniqu

A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease.

Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson's disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and β-synuclein (β-syn) peptides with a near infrared-responsive linker. ATB NPs b

Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting.

Effective delivery of drug and gene cargos to hematopoietic stem and progenitor cells (HSPCs) is a major challenge. Current therapeutic strategies in genetic disorders or hematological malignancies are hindered by high costs, low accessibility, and high off-target toxicities. Layer-by-layer nanoparticles (LbL NPs) are modular systems with tunable surface properties to enable highly specific targeting. In this work, we developed LbL NPs that target HSPCs via antibody functionalization with reduced off-target uptake by circulating myeloid cells. NPs layered with poly(acrylic acid), a bioinert po…

Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.

Melanoma, a highly aggressive and therapy-resistant cutaneous malignancy, presents formidable clinical challenges owing to its propensity for early metastasis and frequent postoperative recurrence. Here, a nanofiber-based drug delivery system (5F/STFM/R-ES) is developed that synergistically induces ferroptosis and potentiates immunotherapy to inhibit melanoma growth and reduce the risk of metastasis and recurrence. To this end, mesoporous silica nanoparticles encapsulating resiquimod (R848) are surface-coated with Fe/Mn-based metal-polyphenol networks (TFM) to form STFM/R. Subsequently, STFM/R…

Effect of Ag film roughness in a dielectric nanoparticle-on-mirror dark-field microscope.

A dielectric nanoparticle-on-mirror system can enhance the scattering signal and modulate the scattering direction of a low-index sample placed on the mirror, so that more of the signal sample can be collected by the objective lens. We find that the surface roughness of the Ag film increases as the deposition rate increases, and the scattering intensity of the sample increases and then decreases as the root-mean-square (RMS) roughness (deposition rate) increases. Under dark-field illumination, the scattering intensity of an individual polystyrene (PS) nanoparticle placed on a 50 nm thick Ag-fi

In Vitro Assessment of Gold Nanoparticles Synthesized by Gamma Irradiation for Antimicrobial and Anticancer Effects.

The emergence of multidrug-resistant microbes presents a serious public health threat that requires new antimicrobial methods. A potential solution to combat resistance involves using metal nanoparticles that possess improved biological characteristics. The researchers have synthesized gold nanoparticles (Au-NPs) using gamma irradiation of Polyacrylamide (PAM) at 5, 10, and 15 kGy doses and through Au/chitosan nanocomposite production methods. They have also assessed the antimicrobial and anticancer functions of the produced nanomaterials by testing them on various microorganisms and cancer ce…

Assessment of carbon nanoparticle suspension in sentinel lymph nodes biopsy for acral melanoma.

BACKGROUND: Acral melanoma is characterized by high propensity of lymph node metastasis. Accurate diagnosis and staging are important for patient management. OBJECTIVE: This study aimed to evaluate the efficacy of carbon nanoparticle suspension (CNS) as a tracer in SLNB for AM and to compare its performance with methylene blue (MB) and 99mTc. And it aimed To improve the technology of accurate diagnosis and treatment in melanoma. METHODS & MATERIALS: A retrospective analysis was conducted on 71 patients who underwent surgery between January 2022 and August 2024 at our hospital. Patients were di

Study of the biomolecular corona of surface-modified polystyrene and silica nanoparticles: application to cancer.

Nanotechnology offers promising tools for disease diagnosis through the unique biomolecular corona (BC) that surrounds nanoparticles (NPs) when exposed to biological fluids, creating personalized profiles. In this study, we investigated the capability of BC of polystyrene and silica NPs with diverse surface functionalization in distinguishing eight types of cancer (breast, ovarian, kidney, lung, colon, bladder, uterus, and thyroid) using a straightforward method based on one-dimensional gel electrophoresis. A total of six NPs, silica and polystyrene NPs with various functional groups (plain, N…