Результаты поиска

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Nurses Group - Poster Sessions (NP001 - NP054).

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment.

Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complica

Совпадение в полном тексте источника
… Nanotechnology-Based Therapy for Treatment of Cancer In conventional therapy, surgery, chemotherapy, radiotherapy, immunotherapy, phototherapy, and hormonal therapy are only a few of the therapeutic options for cancer as demonstrated in Figure 2 C. … Despite advancements in chemotherapy, radiation therapy, immunotherapy, phototherapy and hormonal therapy, the main concern with these treatments is their negative side effects, which destroy healthy cells of the body along with damaged cells, which makes them a poor choice [ 17 ]. …

Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges.

Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providing the targeted therapeutics delivery, advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system (called cancer theranostics). This paper discusses the progress in the pre-clinical and clinical development of therapeutics, diagnostics, and theranostics canc

A Systematic Review of Laser Photobiomodulation Dosimetry and Treatment Protocols in the Management of Medications-Related Osteonecrosis of the Jaws: A Rationalised Consensus for Future Randomised Controlled Clinical Trials.

Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating adverse effect of bisphosphates, antiresorptive therapy or antiangiogenic agents that can potentially increase oxidative stress, leading to progressive osteonecrosis of the jaws. Despite the large number of published systematic reviews, there is a lack of potential MRONJ treatment protocols utilising photobiomodulation (PBM) as a single or adjunct therapy for preventive or therapeutic oncology or non-oncology cohort. Hence, this systematic review aimed to evaluate PBM laser efficacy and its dosimetry as a monotherapy or comb

Совпадение в полном тексте источника
… The following terms were searched in combination: “Photobiomodulation therapy” OR “phototherapy” OR “LLLT” OR “low-level laser therapy” OR “photochemotherapy” AND “surgical debridement” OR “photodynamic therapy” OR “medical therapy” OR “bone morphogenic protein therapy” OR “recombinant human bone morphogenetic …

Ataxia-Telangiectasia and Associated Bronchiectasis: Case Report and Literature Review.

Ataxia-telangiectasia is a rare, autosomal recessive primary immunodeficiency caused by mutations in the ATM gene on chromosome 11, which encodes a serine-threonine kinase essential for the recognition and repair of DNA double-strand breaks. The disease is characterized by progressive neurological impairment, immunological dysfunction, and an increased susceptibility to recurrent infections and malignancies. Pulmonary involvement represents a major source of morbidity and frequently arises from chronic infections, aspiration, and impaired airway clearance, ultimately leading to the development

Совпадение в полном тексте источника
… The newborn had physiologic jaundice requiring phototherapy. Postnatal adaptation was favorable. Vaccination was carried out following the national schedule. …

Skin Hypopigmentation in Hematology Disorders.

Hypopigmentation disorders pose significant diagnostic challenges in dermatology, sometimes reflecting underlying hematological conditions. This review explores the clinical presentations related to hypopigmentation in hematological disorders, focusing on vitiligo, morphea, and syndromic albinism. Vitiligo, an autoimmune disorder targeting melanocytes, involves interactions between genetic polymorphisms and immune responses, particularly regarding CD8+ T cells and IFN-γ. Drug-induced vitiligo, notably by immune checkpoint inhibitors and small-molecule targeted anticancer therapies, underscores

The Schnitzler syndrome.

The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of

Совпадение в полном тексте источника
… Colchicine, dapsone | Transient improvement Thalidomide | Anecdotic reports of efficiency TNF-blocking agents | Ineffective Immunoabsorption | Only a single report Intravenous immunoglobulins | Ineffective Rituximab | Ineffective Anti-histamines | Usually ineffective, even on the skin rash Phototherapy …

Cutaneous Skin Toxicities of Oncological Targeted Therapies: Comprehensive Overview of Mechanisms, Management, and Research Gaps-A Narrative Review.

Targeted therapies in oncology have become a mainstay in therapy of numerous types of cancers. They work by targeting and utilizing (activating, inhibiting, or modulating) molecular pathways that are crucial in pathogenesis of certain cancers and can be divided into numerous classes according to their mechanism. However, since the antigens and molecules they target can take part in homeostasis of the skin and the integument, cutaneous toxicities are a common occurrence. The frequency of certain cutaneous adverse events (CAEs) depends on the causal drug and varies even between drugs of the same

Совпадение в полном тексте источника
… twice a day) Oral antihistamines Uphold topical treatment Consider oral CS (0.5–1 mg/kg prednisone for 4–6 weeks) Consider adding oral retinoids (20–30 mg/day) according to the clinical presentation Continue oral CS at a 1 mg/kg dose Consider other treatment modalities and steroid-sparing agents: UVB phototherapy … a day) Oral antihistamines | Uphold topical treatment Consider oral CS (0.5–1 mg/kg prednisone for 4–6 weeks) Consider adding oral retinoids (20–30 mg/day) according to the clinical presentation | Continue oral CS at a 1 mg/kg dose Consider other treatment modalities and steroid-sparing agents: UVB phototherapy …

Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy.

Aggregation-induced emission (AIE) materials, due to their unique ability to significantly enhance optical emission in aggregated states, have demonstrated vast potential in immunology, particularly in early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights for early diagnosis. Additionally, they can act as cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal therapy, or activation of immune cells. This review highlights the applications of

Совпадение в полном тексте источника
… These thoughtfully designed strategies have achieved remarkable improvements in the field of synergistic tumor phototherapy, fully demonstrating their enormous potential for clinical translation and application. … The method highlights the synergistic effects of phototherapy and immunotherapy, offering a transformative and promising strategy for advanced cancer treatment and clinical applications. 13 Schematic representations illustrating the fabrication process of AIE@R837 nanoparticles and the mechanism underlying …

Chemo-RaST with bortezomib inhibits multiple myeloma relapse.

Rationale: Multiple myeloma (MM) is a hematological malignancy with a high relapse rate that ultimately leads to patient mortality. Current therapies often fail to achieve sustained remission due to adaptation of clonally heterogeneous tumor populations. We hypothesized that Chemo-RaST, a therapeutic strategy combining bortezomib with ⁸⁹Zr-daratumumab-mediated radionuclide dynamic therapy (RaST), would synergize photophysical generation of cytotoxic reactive oxygen species (ROS) with mitochondrial ROS induction to block clonal adaptation and prevent MM relapse. Methods: We evaluated chemo-RaST

Совпадение в полном тексте источника
… Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers. Nat Nanotechnol. 2015;10(4):370–9. doi: 10.1038/nnano.2015.17. 8. Lane DD, Black KCL, Raliya R, Reed N, Kotagiri N, Gilson R. et al. …

Management of Medication-Related Osteonecrosis of the Jaw (MRONJ) Using Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Photobiomodulation: A Retrospective Study.

BACKGROUND: The aim of this study was to compare retrospectively the effect of three different treatment protocols on the healing outcome in patients with established medication-related osteonecrosis of the jaw (MRONJ). METHODS: A total of 34 MRONJ patients were recruited from the Department database and were divided according to the treatment protocols in a study group (G1) and two control groups (G2 and G3). G1 was treated with antibiotic therapy, surgery, leukocyte- and platelet-rich fibrin (L-PRF), and photobiomodulation; G2 was treated with antibiotic therapy and surgery; G3 was treated

Совпадение в полном тексте источника
… Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: A preliminary study Oral Oncol. 2012 48 79 84 10.1016/j.oraloncology.2011.08.010 21940198 59. Posten W. Wrone D.A. Dover J.S. Arndt K.A. Silapunt S. Alam M. …

Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis.

BackgroundObjective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy.MethodsMEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) comparing prophylactic LLLT with placebo or no therapy in patients with cancer or undergoing hematopoietic stem cell transplantation (HSCT). All analyses used random effects models.ResultsEighteen RCTs (1144 patients) were included. Prophylactic LLLT reduced the overall risk of severe mu

Совпадение в полном тексте источника
… The search strategy included the following Medical Subject Heading terms: “mucositis”, “laser therapy”, “low-level laser therapy”, “phototherapy”, “light emitting diode”, “transplantation”, “chemotherapy” and “chemoradiotherapy”. …

Терапевтическое применение иммунобиологии в аутоиммунных и воспаленных заболеваниях.

Иммунобиологика или биологическая экспертиза революционизировали терапевтическую парадигму аутоиммунных и подстрекательских заболеваний путем выборочного целеопределения и модуляции дисрегулированных иммунных путей. По сравнению с обычными широкоспектральными иммунопрепрессантами биологика обеспечивает более конкретный и основанный на механизмах рациональный подход, зачастую связанный с повышением эффективности и сокращением неблагоприятных явлений. В этом обзоре содержится всеобъемлющий обзор репертуара терапевтической биологики, механизмов их действий, важнейших клинических испытаний и клини

Совпадение в полном тексте источника
… However, systemic therapies with adalimumab, infliximab, etanercept, efalizumab, or alefacept in combination with ultraviolet (UV) B phototherapy did not significantly affect overall cardiovascular risk [ 144 ]. … FDA approval in February 2017 under the brand name Siliq ® for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy. …

Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.

Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of biopharmaceutical markets in terms of approval and sales. They are the most profitable single product class, where they represent six of the top ten selling drugs. At the beginning of the 1990s, an in vitro antibody selection technology known as antibody phage display was developed by John McCafferty and Sir. Gregory Winter that enabled the discovery of human antibodies for diverse applications, particularly antibody-based drugs. They created c

Совпадение в полном тексте источника
… In 2017, this mAb has received approval from the US FDA to treat adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy ( 398 ) and is currently being evaluated in six active clinical trials at different phases. … Lxekizumab was initially approved in 2016 by the US FDA for moderate to severe plaque psoriasis treatment in adult patients who are eligible for systematic therapy or phototherapy. The FDA approval was further expanded in 2017 for the treatment of adults suffering from active PsA. …

Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.

Nanoparticles (NPs) provide a versatile toolkit for psychiatry and neurology by leveraging tunable size, surface chemistry, and payload control to overcome long-standing barriers in central nervous system (CNS) therapy. Lipid, polymeric, inorganic, and hybrid NPs can be engineered to traverse the blood-brain barrier (BBB) via receptor/transporter pathways, target specific cell types, and deliver sustained or stimuli-responsive release. Beyond drug delivery, NPs improve imaging, enable gene/RNA therapeutics, and support anti-inflammatory and neuroprotective strategies, advancing precision medic

Совпадение в полном тексте источника
… Novel therapeutic approaches NP-mediated phototherapy—including photothermal therapy (PTT) and photodynamic therapy (PDT)—offers a targeted approach to brain tumors. … Compared with surgery, radiotherapy, and chemotherapy, NP-enabled phototherapy can concentrate action within tumor tissue, reducing collateral damage and addressing some mechanisms of drug resistance [ 80 ]. …

Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects.

In recent years, antibody-based cancer therapy has emerged as one of the efficient therapeutic strategies, such as immune checkpoint inhibitors (ICIs), angiogenesis inhibitors, antibody-drug conjugates (ADCs), multi-specific antibodies, and chimeric antigen receptor T (CAR-T) cells, among others. To date, various drug delivery platforms have been developed to improve the bioavailability, delivery convenience, and reduced toxicity towards increased therapeutic efficacy of antibodies. Herein, we emphasize the clinical manifestations of various antibody-based tumor therapies, highlighting their m

Совпадение в полном тексте источника
… For antibody-based therapies, combination therapy can combine different antibodies or synergistic chemotherapy and phototherapy. …

The Effect of Er:YAG Laser Therapy as an Adjunct to Surgical Treatment Compared to Latter Alone in Managing Medication-Related Osteonecrosis of the Jaw: A Randomised Controlled Clinical Trial.

OBJECTIVE: The aim of this double-blind randomised controlled clinical trial was to assess the effectiveness of the Er:YAG laser as an adjunct to conventional surgical treatment compared to surgical treatment alone in managing medication-related osteonecrosis of the jaw (MRONJ). METHODS: Sixty-five patients diagnosed with stage II or III MRONJ were randomly allocated into 2 groups: a control group (n = 30) treated using conventional surgery alone and a test group (n = 35) treated using conventional surgery with adjunctive Er:YAG laser. All patients received 3-day preoperative and 14-day posto

Совпадение в полном тексте источника
… Use of phototherapy and Er-YAG laser in the management of mandible osteoradionecrosis: a case report. J Lasers Med Sci. 2023;14:e58. doi: 10.34172/jlms.2023.58. 78. Kiryk J., Matys J., Nikodem A., et al. …

Laser Devices and Autologous Platelet Concentrates in Prevention and Treatment of Medication-Related Osteonecrosis of the Jaws: A Systematic Review.

Background and Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a disease that affects many patients taking anti-angiogenic and antiresorptive medicines. Since the pathogenetic mechanism is still partially unknown, preventive strategies, as well as treatment alternatives, are needed. Therefore, the aim of this research is to describe the main evidence from the last 10 years of clinical trials regarding the use of auxiliary devices such as autologous platelet concentrates (APCs) and laser, other than their effects against MRONJ disease onset or therapy. Advantages in the heal

Совпадение в полном тексте источника
… Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: A preliminary study. Oral Oncol. 2012;48:79–84. doi: 10.1016/j.oraloncology.2011.08.010. 46. Valente N.A., Chatelain S., Alfonsi F., Mortellaro C., Barone A. …

Exploring the FGF/FGFR System in Ocular Tumors: New Insights and Perspectives.

Ocular tumors are a family of rare neoplasms that develop in the eye. Depending on the type of cancer, they mainly originate from cells localized within the retina, the uvea, or the vitreous. Even though current treatments (e.g., radiotherapy, transpupillary thermotherapy, cryotherapy, chemotherapy, local resection, or enucleation) achieve the control of the local tumor in the majority of treated cases, a significant percentage of patients develop metastatic disease. In recent years, new targeting therapies and immuno-therapeutic approaches have been evaluated. Nevertheless, the search for nov

Совпадение в полном тексте источника
… Primary tumors are successfully treated by brachytherapy or phototherapy, whereas enucleation is recommended only for severe cases with extensive intraocular growth [ 16 ]. …

Карта знаний транскраниальной магнитной стимуляции бессонницы: библиометрический и визуальный анализ.

Бессонница - это one :: наиболее распространенные нарушения сна, серьезно сказывающиеся на физическом и психическом здоровье человека, снижающие эффективность и бдительность работы и потенциально даже приводящие к несчастным случаям, усугубляющие тем самым экономическое бремя как отдельных лиц, так и общества. Первичное лечение бессонницы включает фармакологическую и нефармакологическую терапию. С учетом потенциальных побочных эффектов, связанных с фармакологической терапией, существует настоятельная необходимость в применении безопасных и эффективных нефармакологических мер. Такие технологии,

Совпадение в полном тексте источника
… Physical therapy mainly includes rTMS, phototherapy, and biofeedback therapy. …