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Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… Search strategy and selection criteria A comprehensive literature search was initially performed using PubMed from database inception to May 15, 2026, with the following terms: “multiple sclerosis” AND (“gastrointestinal” OR “constipation” OR “fecal incontinence” OR “dyssynergic” OR “urinary” OR “detrusor … Transanal irrigation is the treatment of choice for fecal incontinence. Biofeedback therapy is indicated in patients with dyssynergic defecation or fecal incontinence. Lower urinary tract symptoms in MS can be due to storage or voiding phase dysfunction. …

[Pharmacological therapy of obesity].

Obesity is reaching epidemic proportions worldwide and it is correlated with various comorbidities, among which the most relevant are diabet … ects with orlistat are mainly gastrointestinal (fatty and oily stool, fecal urgency, oily spotting, fecal incontinence) and attenuate over time. Orlistat should be avoided in patients with chronic malabsorption and cholestasis. Rimonabant is a selective antagonist of cannabinoid type 1 receptor. This drug, by inhibiting the overactivation of the endocannabinoid syst …

Isolation of internal and external sphincter progenitor cells from the human anal sphincter with or without radiotherapy.

AIM: We aimed to isolate and propagate internal and external anal sphincter progenitor cells from the human anal sphincter, with or without radiotherapy, for tailored cell therapy of faecal incontinence. METHODS: Sphincter progenitor cells were isolated from normal internal and external anal sphincters collected from 10 patients with rectal cancer who had undergone abdominoperineal resection with (n = 6) or without (n = 4) preoperative chemoradiotherapy. The isolated cells and differentiated muscle fibres were identified using immunofluorescence assay, western blotting and reverse transcripti

The OBRA-87 nursing home regulations and implementation of the Resident Assessment Instrument: effects on process quality.

OBJECTIVE: To characterize changes in key aspects of process quality received by nursing home residents before and after the implementation of the national nursing home Resident Assessment Instrument (RAI) and other aspects of the Omnibus Budget Reconciliation Act (OBRA) nursing home reforms. DESIGN: A quasi-experimental study using a complex, multistage probability-based sample design, with data collected before (1990) and after (1993) implementation of the RAI and other OBRA provisions. SETTING AND PARTICIPANTS: Two independent cohorts (n > 2000) of residents in a random sample of 254 nurs

Predictors of institutionalization of dementia patients in mild and moderate stages: a 4-year prospective analysis.

BackgroundInstitutionalization is the most important milestone in the care of dementia patients. This study was aimed at identifying relevant predictors of institutionalization in a broad empirical context and interpreting them on the basis of the predictor model proposed by Luppa et al. [Dement Geriatr Cogn Disord 2008;26:65-78].MethodsAt the start of this study, 357 patients with mild to moderate dementia were examined by their general practitioners, and a telephone interview was conducted with their caregivers. Four years later, the outcomes 'institutionalization' and 'death' were determine

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… First, we checked the predictive influence of single items from the Barthel Index within the univariate analysis (e.g. urinary and fecal incontinence). … Incontinence Contrary to the findings of previous studies [ 40 , 43 , 87 , 88 ], urinary and fecal incontinence did not show a significant association with institutionalization in our study. …

Сопоставление клинических результатов между пиелоперфюзелями и микроволновой абсорбацией почечных клеток.

Справочная информация: Сопоставимость характерна для пациентов с множественным склерозом (МС), что повышает сложность лечения заболеваний и экономического бремени и ухудшает их прогноз и качество жизни. Не хватает реальных данных, позволяющих сопоставлять коморбиды и модели множественной смертности, характерные для лиц, охваченных системой страхования на коммерческой основе, и лиц, охваченных системой " Medicare " . Цель: Оценка структуры коморбидности и многоженства среди пациентов с НР в американской компании " Компромисс " и " Медикэр аппетит " . Методы: Это ре

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… Assessment of MS-Related Conditions and Symptoms Multiple sclerosis–related conditions and symptoms identified included abnormality of gait; ataxia, burning/numbness/tingling sensations, convulsions, depression, and fecal incontinence; fibromyalgia/myalgia and myositis, malaise and fatigue, optic neuritis … Abnormality of gait, urinary continence, ataxia, fecal incontinence, and trigeminal neuralgia were more common among Medicare Advantage beneficiaries 65 years and older (all P < .0001). Burning, numbness, and tingling sensations were more common among commercially insured patients ( P < .0001). …

Spinal Cord Compression As the Initial Manifestation of Relapsed Acute Myeloid Leukemia: A Case Report and Literature Review of a Rare Presentation.

Myeloid sarcoma (MS) is a solid mass of myeloid blasts outside the bone marrow (BM). Most cases occur in the setting of intramedullary acute myeloid leukemia (AML), but it can also present in the absence of overt BM disease, as a presentation of newly diagnosed or relapsed AML, or as a progression of myeloproliferative neoplasms or myelodysplastic syndromes. There are a few reports of spinal cord compression due to MS, and there is no consensus regarding its management. Here, we present a case of relapsed AML in the form of MS resulting in spinal cord compression and provide a comprehensive li

Aceruloplasminemia Презентация с выдающимися психиатрическими симптомами и нейродегенерацией: доклад по делу.

Aceruloplasminemia (ACP) часто имеет системные, психические и неврологические особенности. В этом случае сахарный диабет был диагностирован за несколько лет до психических симптомов, за которыми последовало неврологическое расстройство, что значительно задержало диагностику. Этот случай подчеркивает важность учета причин метаболизма и нейродегенеративного характера в нетипичных психиатрических представлениях и расширяет генетический спектр с помощью новой генной мутации CP.

Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan.

Aging is associated with complex immune dysfunction that contributes to the onset and progression of the "geriatric giants", including frailty, sarcopenia, cognitive decline, falls, and incontinence. Central to these conditions is immunosenescence, marked by thymic involution, the loss of naïve T cells, T-cell exhaustion, impaired B-cell class switch recombination, and increased autoreactivity. Concurrently, innate immunity deteriorates due to macrophage, neutrophil, and NK cell dysfunction, while chronic low-grade inflammation-or "inflammaging"-amplifies systemic decline. Key molecular pathwa

[Analysis of risk factors for long-term severe anastomotic complications following rectal cancer surgery].

Objective: To investigate the risk factors of long-term (>3 months) severe anastomotic complications after rectal cancer surgery. Methods: A … etastasis; (2) transverse colostomy due to non-anastomotic complications(e.g., radiation enteritis, fecal incontinence, anal pain); (3) extensive liver or lung metastasis; (4) loss to follow-up. This study defined long-term severe anastomotic complications as complications requiring readmission for transverse colostomy, including anastomotic leakage, sinus tract for …

Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study.

The interactions between the human bacterial microbiome and essential bodily functions are well established for organ systems such as the oral cavity, gut, and female reproductive tract. However, the urinary microbiome, particularly its viral component, remains largely unexplored. Emerging evidence suggests that the urinary microbiome may play a significant role in the development of overactive bladder syndrome (OAB). This study aims to fill this knowledge gap by investigating the potential link between the urethral virome and female overactive bladder syndrome, and by aligning these findings

Bile Acid Malabsorption as a Consequence of Cancer Treatment: Prevalence and Management in the National Leading Centre.

The aim was to establish prevalence of bile acid malabsorption (BAM) and management in patients who underwent treatment for malignancy. Retrospective evaluation of data in patients seen within six months (August 2019-January 2020) was carried out. Demographic, nuclear medicine (Selenium Homocholic Acid Taurine (SeHCAT) scan result), clinical (previous malignancy, type of intervention (medication, diet), response to intervention) and laboratory (vitamin D, vitamin B12 serum levels) data were searched. In total, 265 consecutive patients were reviewed. Out of those, 87/265 (33%) patients (57 fema

Differences between physician and patient preferences for cancer treatments: a systematic review.

BackgroundShared decision-making is useful to facilitate cancer treatment decisions. However, it is difficult to make treatment decisions when physician and patient preferences are different. This review aimed to summarize and compare the preferences for cancer treatments between physicians and patients.MethodsA systematic literature search was conducted on PubMed, Embase, PsycINFO, CINAHL and Scopus. Studies elicited and compared preferences for cancer treatments between physicians and patients were included. Information about the study design and preference measuring attributes or questions

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… DFS Degree of fecal incontinence, Degree of urinary dysfunction, Degree of sexual dysfunction Further therapies Worry about cancer recurrence Fifer, S. J. OS, Remission period Risk of SE Mode & frequency of administration Out of pocket (annual) Stenehjem, D. D. … M. | DFS | Degree of fecal incontinence, Degree of urinary dysfunction, Degree of sexual dysfunction | Further therapies | | Worry about cancer recurrence | Fifer, S. J. | OS, Remission period | Risk of SE | Mode & frequency of administration | Out of pocket (annual) | | Stenehjem, D. …

Developing tumor-specific PRO-CTCAE item sets: analysis of a cross-sectional survey in three German outpatient cancer centers.

BACKGROUND: To include the patient perspective in the assessment of adverse events in oncology, a patient-reported outcomes (PRO) version of the Common Terminology Criteria for Adverse Events (CTCAE) was developed by the US National Cancer Institute, the so called PRO-CTCAE. The objective of this study was the development of disease-specific PRO-CTCAE item sets for patients with breast cancer (BC), multiple myeloma (MM), and prostate cancer (PC). METHODS: The cross-sectional survey was conducted at three German outpatient cancer centers. Prevalence and importance of the 78 PRO-CTCAE symptoms

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… The item set by Feldmann et al. consists of 13 core outcome PRO-CTCAE symptoms (ability to achieve and maintain erection, decreased libido, inability to reach orgasm, urinary frequency, urinary urgency, urinary incontinence, painful urination, fecal incontinence, fatigue, hot flashes, feeling discouraged … Only fecal incontinence, concentration, and feeling discouraged are not included. Instead of feeling discouraged our item set includes the closely related symptom feeling anxious. …

Systematic review of patient-reported outcome item libraries in cancer research: an EORTC Quality of Life Group study.

BackgroundPatient-reported outcome (PRO) item libraries support flexible PRO assessment in cancer research by facilitating the development of customized item lists. However, little is known about the use of item lists in clinical research. This systematic review addresses this by assessing utilization of PRO item libraries and lists in oncology research.MethodsA systematic review of MEDLINE, Embase, and CINAHL identified cancer studies using PRO item libraries to develop item lists, regardless of study design, published between October 2021 and September 2025. Key features of item library usag

Antiobesity Medications for Older Adults-the New, the Good, the Bad, and the Unknown.

OBJECTIVE: Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non-modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be tailored to individual needs due to age-related metabolic and physiological changes. This review aimed to identify the suitability of seven FDA-approved AOMs in the treatment of obesity in older adults. METHODS: A review of AOMs was performed, focusing

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… In contrast, fecal incontinence is observed in up to 8.3% of older individuals and should be part of the evaluation when considering orlistat [ 23 , 28 , 30 ]. … Goode , et al., “ Fecal Incontinence in US Adults: Epidemiology and Risk Factors ,” Gastroenterology 137 , no. 2 ( 2009 ): 512 – 517 , 10.1053/j.gastro.2009.04.054 . 19410574 PMC2748224 31 A. B. Bansal , P. Patel , and Y. …

Царская нейромодия для нейрогенного Нижнего Уринарного тракта, Боул и Сексуальная дисфункция у пациентов с множественным склерозом: экспериментальное испытание.

АИСЮ: Мы представляем результаты two- Экспериментальное исследование с применением огнестрельного оружия для оценки целесообразности проведения двухзвукового выборочного контролируемого испытания (РКТ) с целью оценки эффективности нейромодуляции (СНМ) у пациентов с множественным склерозом (МС), страдающих нейрогеническим расстройством нижних мочевых путей (НЛУТД). МЕТОДЫ: Учитываемые темы с рефрактным NLUTD и EDS < 5 Прошла стадию испытания SNM. Те, кто показывают больше, чем 50% - усовершенствование переменных мочевого пузыря, получение имплантируемых импульсных генераторов (ИПГ) и произвольн

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… These results correspond with several published studies, which demonstrated efficacy of SNM in treating fecal incontinence and sexual dysfunction in patients with MS [ 5 , 6 , 18 , 22 , 23 ]. There is no consensus on how to measure the impact of the treatment of NLUTD on overall QoL. …

Нейроатомные корреляции пузырьков наполняют: активация симметрии оценки мета-анализа функциональных исследований в области нейронизации.

Ужасная континуальность зависит от сложного взаимодействия между хранением мочи и дезертирством с участием как спинных рефлексов, так и сверхспинных участков мозга для координации добровольного контроля за опорожнением. Несмотря на большое число исследований в области патофизиологии нейрогенного мочевого пузыря и его недержание, меньше известно о центральных корреляциях заполнения мочевого пузыря. Metods ALE (оценка вероятности активации) метаанализа, включая общее число 14 исследования 243 Участники в различных условиях заполнения мочевого пузыря в ходе функционального нейроимации были продем

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… Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence. Neurourol. Urodyn. 2010;29:213–240. doi: 10.1002/nau.20870. 67. …

Механические свойства мышечных мышц Лумбопелвича у женщин с множественным склерозом: перекрестное исследование под контролем.

Предыстория/цели: Сопоставление мышечных механических свойств (МПМ) у женщин с множественным склерозом (МС) и без него и изучение взаимосвязей между этими свойствами и социально-демографическими/клиническими характеристиками. Методы: Это межсекторальное исследование охватывало 22 женщины с НР и 22 женщины с матчными возрастами и БИ без НР. С помощью устройства MyotonPRO была произведена оценка ММП (частота, жесткость, обесцвечивание, релаксация и полость) тазового пола и поясничных мышц. Были также собраны социально-демографические и клинические данные, касающиеся здоровья тазового пола. Резул

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… These alterations may contribute to an increased prevalence of pelvic floor dysfunctions, such as urinary and fecal incontinence, when compared to healthy women. 2. Materials and Methods 2.1. …

Disorders of the Spinal Cord

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… The lesion may descend, resulting in LMN signs in the pelvic limbs, as well as urinary and fecal incontinence. Diagnosis Spinal radiographs may be suggestive of disc herniation or be normal. A. …