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Therapeutic strategies against cancer cachexia.

Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems es

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… cachexia. 27 Pre-clinical studies have shown that ghrelin administration to cachectic tumor-bearing animals results in an improvement in both appetite and body weight, together with an improvement in lean body mass. 28 In addition, ghrelin administration to rats prevents cisplatin-induced mechanical hyperalgesia … Ghrelin Prevents Cisplatin-Induced Mechanical Hyperalgesia and Cachexia. Endocrinology 2008;149:455-460. 30. Yakabi K, Sadakane C, Noguchi M, et al. Reduced Ghrelin Secretion in the Hypothalamus of Rats due to Cisplatin-Induced Anorexia. Endocrinology 2010;151:3773-3782. 31. …

Cutaneous adverse events following CAR T-cell therapy in hematologic malignancies.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Less frequent AEs included acneiform rash, skin erythema and hyperalgesia, mucocutaneous ulcer, and other skin and subcutaneous tissue disorders (Table S1 ). All cutaneous AEs were grade 1 ( n = 16, 70%) or grade 2 ( n = 7, 30%). …

Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification.

PurposeChemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in CIPN are largely ineffective, with unfavorable side-effects. The capsaicin 8% patch (capsaicin 179 mg patch) is approved for the treatment of neuropathic pain: a single topical cutaneous application can produce effective pain relief for up to 12 weeks. We assessed the therapeutic potential of capsaicin 8% patch in patients with painful CIPN, and its mechanism of action.Patients and methods16 patients with chronic painful CIPN (mea

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… Transient receptor potential vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice. Mol Pain . 2010;6:15. doi: 10.1186/1744-8069-6-15 27. Siau C, Xiao W, Bennett GJ. … Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy. Neurosci Lett . 2011;495(2):93–97. doi: 10.1016/j.neulet.2011.03.035 34. Galeotti N, Vivoli E, Bilia AR, Vincieri FF, Ghelardini C. St. …

Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.

Interleukin (IL)-1β and IL-18 play critical roles in the induction of chronic pain hypersensitivity. Their inactive forms are activated by caspase-1. However, little is known about the mechanism underlying the activation of pro-caspase-1. There is increasing evidence that cathepsin B (CatB), a typical lysosomal cysteine protease, is involved in the pro-caspase-1 activation and the subsequent maturation of IL-1β and IL-18. In this context, CatB is considered to be an important molecular target to control chronic pain. However, no information is currently available about the role of CatB in chro

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

Peripheral cannabinoid receptors exert a powerful inhibitory control over pain initiation, but the endocannabinoid signal that normally engages this intrinsic analgesic mechanism is unknown. To address this question, we developed a peripherally restricted inhibitor (URB937) of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of the endocannabinoid anandamide. URB937 suppressed FAAH activity and increased anandamide levels outside the rodent CNS. Despite its inability to access brain and spinal cord, URB937 attenuated behavioral responses indicative of persistent pa

Регулирование причиняемой раком боли в хосписе и паллиативном уходе.

Раковая боль в костях (CIBP) one - наиболее распространенные симптомы инвалидности, встречающиеся в хосписе и паллиативном уходе. Метастазы костей особенно часто встречаются у пациентов с множественной миеломой, раком груди и раком простаты, и они могут вызывать непрерывную фоновую боль, боль, связанную с движением, патологический перелом, злокачественное сжатие спинного мозга и гиперкальцемию злокачественности. CIBP является результатом сложного взаимодействия ноцицептивных, подстрекательских и нейропатических механизмов, обусловленных взаимодействием опухолей со стромой и центральной сенсиби

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… Repetitive peripheral input subsequently induces central sensitization within the spinal dorsal horn through glutamatergic transmission and N-methyl-D-aspartate receptor activation, producing wind-up, hyperalgesia, and movement-evoked pain that may be disproportionate to the immediate structural stimulus …

Диагностика множественных склерозов: из материалов Конференции Национального общества по проблемам множественных склерозов.

28-летняя чернокожая женщина имела как типичные, так и нетипичные особенности множественного склероза в условиях многоженства, включая психиатрическую историю, осложняющие диагностику и лечение. Этот случай иллюстрирует важность дифференциального диагноза и продольного контроля, прежде чем брать на себя обязательство по профилактике заболеваний. Особое внимание уделяется принятию решений в отношении индивидуального лечения.

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… Neurologic examination was remarkable for hyperalgesia to pinprick and temperature sensation in the right hemibody below the neck, including upper and lower extremities and the trunk. She also complained of dyspnea and pleuritic chest pain and was noted to have sinus tachycardia. …

Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics.

Pain is one of the most frequent reasons for seeking dental care and significantly influences patient comfort, treatment acceptance, and clinical outcomes. Effective management of dental pain requires accurate diagnosis, timely intervention, and the rational use of analgesics supported by evidence-based clinical decision-making. Recognizing the need for structured guidance for everyday dental practice, the Indian Society of Periodontology has developed Good Clinical Practice Recommendations on Pain Management and the Use of Analgesics in Dental Clinics. These recommendations were formulated by

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… In reversible pulpitis, the pain response is increased (hyperalgesia) and outlasts the stimulus, usually by<10 s. In irreversible pulpitis, application of ethyl chloride results in excruciating pain that outlasts the stimulus for more than 10 s b. … Nondental issues such as systemic diseases (leukemia), medication side effects, referred pain from headaches, and self-inflicted trauma RECOGNIZING REFERRED OR NONODONTOGENIC PAIN “Referred pain” occurs in an area far from the primary lesion and is sometimes associated with secondary hyperalgesia and …

Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy.

Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for hematologic malignancy, has effective anti-cancer activity but often causes severe peripheral neuropathy. Although bortezomib-induced peripheral neuropathy (BIPN) is a dose-limiting toxicity, there are no recommended therapeutics for its prevention or treatment. One of the most critical problems is a lack of knowledge about pathological mechanisms of BIPN. Here, we summarize the known mechanisms of BIPN based on preclinical evidence, including morphological abnormalities, involvement of non-neuronal cells, oxid

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… Although the common feature of these models is mechanical hypersensitivity (hyperalgesia and/or allodynia), these animals show no alteration of heat sensitivity [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. … Furthermore, systemic administration of the reactive oxygen species (ROS) scavenger phenyl-N-tert-butylnitrone attenuated existing mechanical hyperalgesia induced by bortezomib [ 17 ]. 5.2. Involvement of TRPA1 Channel Several studies have implicated TRPA1 in bortezomib-induced neuropathic pain. …

Unveiling the Role of CCL3: A Driver of CIPN in Colon Cancer Patients?

Cancer neuroscience is an emerging field revealing how malignancies interact with the nervous system to shape disease progression and symptom burden. In colorectal cancer (CRC), increasing evidence suggests a direct interplay between tumor cells and peripheral sensory neurons, contributing not only to cancer progression but also to chemotherapy-induced side effects such as peripheral neuropathy. Chemokines, particularly CCL3, appear to be key players in this bidirectional communication. This literature review aims to critically examine the role of CCL3 in CRC and chemotherapy-induced periphera

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… Overall, the findings of this study reveal the role of CCL3 in the sensitization of TRPV1-mediated signaling and therefore in thermal hyperalgesia. Zhang et al. also found that CCL3 affects pain perception [ 77 ]. … TRPV1 | Not implicated in CRC. | Sensitization of nociceptive neurons via CCL3–CCR1 signaling increases TRPV1 activity. | CCL3 activates PLC–PKC pathway, phosphorylating TRPV1 and enhancing thermal hyperalgesia. …

Refractory postherpetic neuralgia in a multiple myeloma patient with lenalidomide maintenance therapy: a case report.

Herpes zoster is not common in multiple myeloma (MM) patients treated with lenalidomide-based regimens. We report an MM patient in his late 60s who received lenalidomide as maintenance treatment and whose condition was complicated with refractory postherpetic neuralgia. The patient received antiviral treatment and analgesia immediately after the diagnosis of herpes zoster. Two months later, the patient received acupuncture, radiofrequency treatment, and even spinal cord stimulation, which failed to relieve the pain. Consequently, we performed high-resolution magnetic resonance imaging of the c

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… In PHN, abnormal sensory symptoms such as hyperalgesia, allodynia, sensory loss, and pruritus are also common. 1 These symptoms can sometimes last for many years, thus severely interfering with sleep, disturbing the patient’s mood, and negatively affecting their quality of life. …

Ultralow-Dose Adjunctive Methadone with Slow Titration, Considering Long Half-Life, for Outpatients with Cancer-Related Pain.

Background: The unique properties of methadone make it attractive for use in cancer pain. The use of very low initial doses of adjunctive methadone is a promising strategy given its simplicity and potentially reduced risk profile. Objective: To understand if an ultralow-dose (ULD) methadone protocol (1 mg by mouth daily initial dose with gradual titration) can improve pain control in outpatients with cancer-related pain not responsive to previous opioids and/or nonopioid analgesics. We also sought to assess if the use of ULD methadone resulted in improvement in mood and sleep among other outco

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… Arout CA, Edens E, Petrakis IL, Sofuoglu M: Targeting opioid-induced hyperalgesia in clinical treatment: Neurobiological considerations. CNS Drugs 2015;29:465–486 6. Morley JS, Makin MK: The use of methadone in cancer pain poorly responsive to other opioids. Pain Reviews 1998;5:51–58 7. …

The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.

BackgroundPain is a common side effect of cancer or cancer treatment that negatively impacts biopsychosocial wellbeing and quality of life. Exercise is a potential intervention to manage pain that is safe and has multiple benefits. The objective was to determine the role of exercise in cancer pain management.MethodsWe completed a systematic review and meta-analysis of exercise interventions in adults with any type or stage of cancer by searching Ovid MEDLINE®, Embase, APA PsycInfo, the Cochrane Central Register of Controlled Trials, CINAHL, and SPORTDiscus. We included experimental and quasi-e

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… However, no significant changes in widespread pressure pain hyperalgesia were found Cantarero-Vilanueva 2017; Spain Intervention: 57.52 ± 8.05 Control: 62.31 ± 7.93 Colorectal Off treatment A secondary analysis of a randomized controlled clinical trial. … However, no significant changes in widespread pressure pain hyperalgesia were found Cantarero-Vilanueva 2017; Spain | Intervention: 57.52 ± 8.05 Control: 62.31 ± 7.93 | Colorectal | Off treatment | A secondary analysis of a randomized controlled clinical trial. …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

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… 30766) 16 migraine.mp. (47906) 17 Fibromyalgia/ (10384) 18 fibromyalg*.mp. (14910) 19 complex regional pain syndromes/or exp causalgia/or exp reflex sympathetic dystrophy/ (6060) 20 (complex regional pain syndromes or causalgia).mp. (2965) 21 Pain, Intractable/ (6431) 22 Phantom Limb/ (2128) 23 Hyperalgesia … 82237) 16 migraine.mp. (90595) 17 fibromyalgia/ (26870) 18 fibromyalg*.mp. (29046) 19 reflex sympathetic dystrophy.mp. (2431) 20 (complex regional pain syndromes or causalgia).mp. (1400) 21 intractable pain/ (5737) 22 phantom limb.mp. or agnosia/or phantom pain/or amputation stump/ (8957) 23 hyperalgesia …

Cerebral lesions in the central pain matrix are associated with headache in multiple sclerosis.

Headache is very frequent in multiple sclerosis. However, the question whether headache is just coincidental or may be secondary due to inflammatory cerebral multiple sclerosis lesions is yet to be clarified. This study intended to evaluate the distribution of cerebral lesion sites and the potential presence of specific lesion clusters in patients with multiple sclerosis and comorbid headache using voxel-based lesion symptom mapping (VLSM). Patients with multiple sclerosis and headache were prospectively identified and included in a university neurological center between 2017 and 2023. Only pa

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… Especially the left hippocampus, as affected in our study, is responsible for the development of hyperalgesia and the emergence of persistent pain 42 , 43 . Hence, we hypothesize that lesions in the hippocampus may promote headache by disinhibition of central inhibitory pain mechanisms 32 . …

Effect of recombinant human nerve growth factor treatment on corneal nerve regeneration in patients with neurotrophic keratopathy.

IntroductionNeurotrophic Keratopathy (NK) is a neurodegenerative corneal disease that results in diminished corneal sensation. Previous studies have found that Cenegermin 0.002%, a recombinant human nerve growth factor (rhNGF), improves corneal epithelial healing in stage 2 and 3 NK patients. However, rhNGF effect on corneal sensation and nerve regeneration has not been well established. Thus, this study aims to analyze the effect of rhNGF on corneal nerve regeneration using in vivo confocal microscopy (IVCM) and on corneal sensitivity in NK patients.MethodsThis is a retrospective, longitudina

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… This creates an increased sensitivity to noxious stimuli, called sensitization, which can result in allodynia and hyperalgesia ( Kerstman et al., 2013 ). In addition, neurodegeneration processes are triggered by the interaction between neuronal and glial cells ( Lobsiger and Cleveland, 2007 ). … Animal studies have demonstrated that NGF decreases allodynia and hyperalgesia by decreasing glial reactions elicited by peripheral nerve damage, and reversing neuromodulation at molecular and morphological level of peripheral sensory neurons ( Colangelo et al., 2008 ; Cirillo et al., 2010 ). …

Neurophysiological Mechanisms Related to Pain Management in Bone Tumors.

BackgroundPrimary and metastatic bone tumor incidence has increased in the previous years. Pain is a common symptom and is one of the most important related factors to the decrease of quality of life in patients with bone tumor. Different pain management strategies are not completely effective and many patients afflicted by cancer pain cannot be controlled properly. In this sense, we need to elucidate the neurophysiology of cancer-induced pain, contemplating other components such as inflammation, neuropathies and cognitive components regarding bone tumors, and thus pave the way for novel thera

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… The pain produced is typically perceived as burning, tingling or ‘electric’ in character and can be combined with allodynia - in which non-painful stimuli evoke pain - and hyperalgesia. … Yoneda et al . propose that the acidic environment, due to elevated aerobic glycolysis known as the “Warburg effect”, generates a large amount of H+, and can activate nociceptors resulting in hyperalgesia at both the central and peripheral nervous levels [ 12 , 41 ]. …

Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis.

PurposeCancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis.Patients and methodsFifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neuroph

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… tissues, thereby exerting analgesic effects. 15 For example, electroacupuncture has been found to alleviate pain by reducing Na + channel currents in animal models, 16 and stimulation of the “Zusanli (ST36)” acupoint has been shown to reduce acid-sensing ion channel currents, alleviating mechanical hyperalgesia … Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain . J Biomed Sci . 2011 ; 18 : 1 – 10 . doi: 10.1186/1423-0127-18-82 22070775 PMC3233511 18. Qu Z , Liu L , Yang Y , et al. …

Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior.

Tuberous sclerosis is a developmental genetic disorder caused by mutations in TSC1, which results in epilepsy, autism, and intellectual disability. The cause of these neurological deficits remains unresolved. Imaging studies suggest that the thalamus may be affected in tuberous sclerosis patients, but this has not been experimentally interrogated. We hypothesized that thalamic deletion of Tsc1 at distinct stages of mouse brain development would produce differential phenotypes. We show that mosaic Tsc1 deletion within thalamic precursors at embryonic day (E) 12.5 disrupts thalamic circuitry and

Alendronate improves QOL of postmenopausal women with osteoporosis.

PURPOSE: Postmenopausal osteoporosis causes bone fracture as well as pain, physical, psychological and socially adverse effects, which affects a patient's quality of life (QOL). The effect of alendronate on QOL was investigated compared with that of alfacalcidol in post-menopausal osteoporotic women. PATIENTS AND METHODS: A total of 44 postmenopausal osteoporotic women (mean age 69.8 years) with back or joint pain, although capable of walking, were randomly assigned to two groups; group A (n=25) received 5 mg/day of alendronate, and group B (n=19) received 0.5 microg/day of alfacalcidol, for

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… In the study, bisphosphonates suppressed inflammatory hyperalgesia by inhibiting the effect of osteoclasts in the animal model. There are limitations in the present study. …