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Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer.

Bone metastatic prostate cancer (PCa) promotes mesenchymal stem cell (MSC) recruitment and their differentiation into osteoblasts. However, the effects of bone-marrow derived MSCs on PCa cells are less explored. Here, we report MSC-derived interleukin-28 (IL-28) triggers prostate cancer cell apoptosis via IL-28 receptor alpha (IL-28Rα)-STAT1 signaling. However, chronic exposure to MSCs drives the selection of prostate cancer cells that are resistant to IL-28-induced apoptosis and therapeutics such as docetaxel. Further, MSC-selected/IL-28-resistant prostate cancer cells grow at accelerated rat

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… Further analysis of the data were performed by the Moffitt biostatistics and bioinformatics shared resource. … Lynch were responsible for analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis). C. C. Lynch, J.J. McGuire, J.S. Frieling and C.H. Lo. were responsible for manuscript writing and editing. …

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intra

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… Zarour 1,2 1 Department of Medicine and Division of Hematology/Oncology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA; 2 Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA; 3 Department of Biostatistics, University of Pittsburgh … University of Manchester, Manchester, UK; 11 Dermatologische Klinik, University of Zurich, Zurich, Switzerland; 12 Division of Hematology and Oncology, Vanderbilt University School of Medicine, Nashville, TN, USA; 13 Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; 14 Department of Biostatistics …

Socioeconomic Deprivation and Health Care Use in Patients Enrolled in SWOG Cancer Clinical Trials.

ImportanceReducing acute care use is an important strategy for improving value. Patients with cancer are at risk for unplanned emergency department (ED) visits and hospital stays (HS). Clinical trial patients have homogeneous treatment; despite this, structural barriers to care may independently impact acute care use.ObjectiveTo examine whether ED visits and HS within 12 months of trial enrollment are more common among Medicare enrollees who live in areas of socioeconomic deprivation or have Medicaid insurance.Design, setting, and participantsThis cohort study included patients with cancer who

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… Approval to conduct this research was obtained from the Institutional Review Board of Cancer Research and Biostatistics in Seattle, Washington. …

Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases).

BackgroundSkeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities.MethodsWe retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal,

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… More precisely, it is a modified version of R commander designed to add statistical functions frequently used in biostatistics [9] . This study was approved by the Ethics Review Boards of our institution (B200070) and subjects were provided with information using opt-out methods. …

The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw.

BACKGROUND: Non-surgical treatment has generally been recommended for stage II medication-related osteonecrosis of the jaw (MRONJ) in preference to surgery. However, non-surgical treatment is not empirically effective. The aim of this study was to evaluate whether surgical or non-surgical treatment leads to better outcomes for stage II MRONJ. MATERIAL AND METHODS: In this retrospective study, surgery was performed in a total of 28 patients while 24 patients underwent non-surgical treatment. The outcomes of both treatment approaches after 6 months were evaluated and statistically compared. In

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… More precisely, it is a modified version of R commander designed to add statistical functions frequently used in biostatistics. …

The biology of stress in cancer: Applying the biobehavioral framework to adolescent and young adult oncology research.

The stress response influences the development and trajectory of cancer through a host of complex neuroimmune mechanisms. Basic, translational, and clinical research has elucidated these biobehavioral connections and offers a new paradigm for scientific investigation and patient care. Using a biobehavioral approach could offer new diagnostic and therapeutic opportunities in oncology, and this approach will be particularly impactful for adolescent and young adult (AYA) patients with cancer. To date, nearly all biobehavioral oncology research has been done in the adult population. And yet, AYAs

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… In biobehavioral AYA research, this could include stakeholders from immunology, genomics, pediatric oncology and transplant, psychology/psycho-oncology, social work, biostatistics, epidemiology, adolescent medicine, spiritual care, along with patients and caregivers, among others. …

The impact of radiation treatment planning technique on unplanned hospital admissions.

PurposeTreatment burdens and toxicities related to palliative radiation therapy (RT) may lead to unplanned hospital admissions (UHAs). The likelihood for these toxicities may be related to treatment technique. We compared rates of UHA between patients receiving nonconformal (2-dimensional) and conformal (3-dimensional or higher) radiation treatments to bone metastases involving the vertebral column.Methods and materialsWe retrospectively analyzed patients treated with RT for bone metastases at a single tertiary care center between 2010 and 2017. We compared rates of RT-related UHA within 90 da

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… The authors acknowledge the support of the Biostatistics Shared Resource Facility, Icahn School of Medicine at Mount Sinai, and NCI Cancer Center Support Grant P30 CA196521-01. Conflicts of interest: Dr. …

External validation of the Bayesian Estimated Tools for Survival (BETS) models in patients with surgically treated skeletal metastases.

BackgroundWe recently developed two Bayesian networks, referred to as the Bayesian-Estimated Tools for Survival (BETS) models, capable of estimating the likelihood of survival at 3 and 12 months following surgery for patients with operable skeletal metastases (BETS-3 and BETS-12, respectively). In this study, we attempted to externally validate the BETS-3 and BETS-12 models using an independent, international dataset.MethodsData were collected from the Scandinavian Skeletal Metastasis Registry for patients with extremity skeletal metastases surgically treated at eight major Scandinavian referr

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… Mithat Gönen (Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center) for his insight into Bayesian statistics, as well as Lionel Santibáñez and Rosalind Simmons for their editorial assistance. …

Estimating survival in patients with operable skeletal metastases: an application of a bayesian belief network.

BackgroundAccurate estimations of life expectancy are important in the management of patients with metastatic cancer affecting the extremities, and help set patient, family, and physician expectations. Clinically, the decision whether to operate on patients with skeletal metastases, as well as the choice of surgical procedure, are predicated on an individual patient's estimated survival. Currently, there are no reliable methods for estimating survival in this patient population. Bayesian classification, which includes bayesian belief network (BBN) modeling, is a statistical method that explore

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… Mithat Gönen (Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY) for his insight into both conventional and Bayesian statistics, as well as Isobel Lewis and Neha Kaul, whose dedication and organizational skills made this project possible. …

Serum C-C Motif Ligand 11/eotaxin-1 May Serve as a Candidate Biomarker for Postmenopausal Osteoporosis.

BACKGROUND: The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. OBJECTIVE: The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis. METHODS: A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85

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… analogue scale Ann Emerg Med 2001 38 639 43 11719742 10.1067/mem.2001.118012 18 Fairbank JC Pynsent PB The Oswestry Disability Index Spine 2000 25 2940 53 11074683 10.1097/00007632-200011150-00017 19 Chow S Shao J Wang H Sample Size Calculations in Clinical Research 2nd Ed 2008 Chapman & Hall/CRC Biostatistics …

Liver resection for hepatocellular carcinoma in patients with hematological malignancies.

BACKGROUND: Improvements in antimetabolite drugs have prolonged the survival of patient with hematological malignancies. However, these drugs may have hepatotoxic side effects and may induce acute liver failure, chronic liver fibrosis, cirrhosis, or even hepatocellular carcinoma (HCC). Although liver resection remains a curative option for HCC, its role in HCC with hematological malignancies has never been fully explored. METHODS: A retrospective review of 1725 patients who underwent curative liver resection for newly diagnosed HCC between 1994 and 2016 was conducted. Among these patients, 16

Levels of heavy metals in adolescents living in the industrialised area of Milazzo-Valle del Mela (northern Sicily).

In the Milazzo-Valle del Mela area, the presence of industrial plants and the oil refinery make local residents concerned for their health. For this reason, we evaluated the levels of heavy metals in 226 children aged 12-14 years, living in the 7 municipalities of the area. A control age-matched population (n = 29) living 45 km far from the industrial site was also enrolled. Arsenic, cadmium, chromium, mercury, nickel, and vanadium were analysed in 24 h urine samples, while lead concentration was evaluated in blood samples. A questionnaire regarding life style and risk perception was also admi

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… Technical Report Pure and Applied Chemistry 1997 69 1601 1611 15 Rosner B Fundamentals of Biostatistics 2011 7th edition Boston, Mass, USA Brooks/Cole 16 Nikić D Stojanović D Stanković A Cadmium in urine of children and adults from industrial areas Central European Journal of Public Health 2005 13 …

Снижение коэффициента деторождения при множественном склерозе с продромаальной фазы: свидетельства, полученные в результате исследования групп населения.

СОСТОЯНИЕ Множественного склероза (MS) совпадает с фертильным возрастом, и как улучшенные прогнозы, так и лечение могут влиять на коэффициент рождаемости у людей с MS (PwMS). ЦЕЛИ: Изучение показателей рождаемости с течением времени в ПТМС в сравнении с мерами контроля. МЕТОДЫ: В рамках этого когортного исследования были получены данные о ПМС. three Больницы на юго-востоке Норвегии. Клинические данные собирались в перспективе. Статистическое управление Норвегии представило информацию о годе рождения и семейном положении в системе контроля и контроля за возрастом, полом и местом проживания в во

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… Cathrine Brunborg, Research Support Services, Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway. Elisabeth Gulowsen Celius, Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. …

Unraveling the association between chronic inflammatory demyelinating polyradiculoneuropathy and peritoneal Dialysis.

BackgroundChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare disease seen in the general population and has been reported as showing an increased incidence in the peritoneal dialysis (PD) population, as documented in case reports.MethodsWe conducted a case-control study using data from the Taichung Veterans General Hospital electric medical record database from the years 2010 to 2023. We defined cases as CIDP with End-stage kidney disease (ESKD) and controls as without CIDP. A logistic regression analysis was used to investigate the association between CIDP and dialysis

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… Supplementary Material 1 Acknowledgements The authors gratefully acknowledge Yu-Min Chou, and Ching-Ching Hsiao for retrieving the data from the Taichung Veterans General Hospital database and Jung-Peng Chen from Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital …

Множественная выживаемость миеломы в Новом Южном Уэльсе, Австралия, в период лечения 2020.

ЦЕЛЬ: В Австралии наблюдаются относительно высокие показатели заболеваемости миеломой (ММ) и смертности. За последние десятилетия улучшение положения в области лечения от болезней, связанных с беременностью и родами, привело к улучшению показателей выживания в странах с высоким уровнем дохода; однако отчетность в Австралии носит ограниченный характер. Мы изучили временные тенденции в области выживания ММ в масштабах всего населения 3 - продолжительность лечения в Новом Южном Уэльсе (НЮУ), Австралия.МЕТОДЫ: Лица, имеющие диагноз MM в регистре рака НЮУ 1985 и 2015 с жизненно важными последующими

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… Chiang CL Introduction to stochastic processes in biostatistics 99 th ed John Wiley & Sons 1968 24. Ederer F Heise H Instructions to IMB 650 programmers in processing survival computations. Methodological note No. 10, end results evaluation section Bethesda National Cancer Institute 1959 25. …

A polygenic risk score for multiple myeloma risk prediction.

There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53-4.6

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… Dominic Edelmann (Division of Biostatistics, DKFZ) for helpful advice about data analysis. Author contributions DC and FC conceived and designed the study. CP performed labwork. CP, FC, AM, and DC performed data quality control and statistical analyses. FC, AM, and DC drafted the manuscript. …

Long term renal survival in patients undergoing T-Cell depleted versus conventional hematopoietic stem cell transplants.

Calcineurin inhibitor (CNI)-sparing T-cell depleted (TCD) hematopoietic stem cell transplants (HSCTs) are presumed to be less nephrotoxic than conventional HSCTs. We evaluated incidence and risk factors for kidney failure and chronic kidney disease (CKD) in 231 TCD and 212 conventional HSCT recipients. Kidney failure required a median glomerular filtration rate (GFR) 2 for ⩾100 days anytime after 180-days post-HSCT. Two-year cumulative incidence (CI) of kidney failure was 42% in the conventional versus 31% in the TCD group (P=0.005). TCD, age, acute kidney injury and number of toxic CNI levels

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… Biostatistics Descriptive statistics were used to summarize patient and treatment characteristics by transplant type (conventional and TCD). Differences across groups were assessed using either Wilcoxon rank-sum tests or Fisher’s exact tests as appropriate. …

Prognostic pan-cancer and single-cancer models: A large-scale analysis using a real-world clinico-genomic database.

Prognostic models in oncology have a profound impact on personalized cancer care and patient profiling, but tend to be heterogeneously developed and implemented in narrow patient cohorts. Here, we develop and benchmark multiple machine learning models to predict survival in pan-cancer and 16 single-cancer settings using a de-identified clinico-genomic database of 28,079 US patients with cancer. We identify key predictors of cancer prognosis, including 15 shared across seven or more cancer types, revealing strong consistency in cancer prognostic factors. We demonstrate that pan-cancer models ge

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… Biostatistics . 2017 ; 18 ( 2 ): 352 – 69 . doi: 10.1093/biostatistics/kxw047 28025180 78 Corporation M , Weston S . doParallel: Foreach Parallel Adaptor for the “parallel” Package . 2020 . 79 Microsoft WS. foreach: Provides Foreach Looping Construct [Internet]. 2020. …

Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study.

ObjectivesTo estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015.MethodsVital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology.ResultsIn 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs

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… Elisabete Weiderpass, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Community Medicine, Faculty of Health Sciences, University … Naohiro Yonemoto, MPH, Department of Biostatistics, School of Public Health, Kyoto University, Kyoto, Japan. Maysaa El Sayed Zaki, PhD, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Bassel Zein, MS, Department of Neuroscience, Georgetown University, Washington DC, United States. …

Proceedings of the CIMAGO Meeting - Challenges in Oncobiology Coimbra, 31st january 2020.

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… Biotechnology, University of Coimbra, Portugal; 4 Faculty of Pharmacy, University of Coimbra, Portugal; 5 Department of Pathology, Centro Hospitalar e Universitário de Coimbra, Portugal; 6 Department of Urology and Renal Transplantation, Centro Hospital e Universitário de Coimbra, Portugal; 7 Laboratory of Biostatistics … Institute for Clinical and Biomedical Research – Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra and CIBB Center for Innovative Biomedicine and Biotechnology, Coimbra, Portugal; 3 CACC-Clinical Academic Center of Coimbra, Portugal; 4 Laboratory of Biostatistics …