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[Effect of CD4-positive T lymphocyte expression rate on pain control and prognosis in stage Ⅳ non-small cell lung cancer patients with cancerous pain].

Objective: To investigate the effect of CD4-positive T lymphocyte expression rate on the pain control and prognosis of stage Ⅳ non-small cell lung cancer (NSCLC) patients with cancerous pain. Methods: The clinical data of 128 stage Ⅳ NSCLC patients with cancerous pain who were admitted to the Affiliated Cancer Hospital of Zhengzhou University from January to December 2020 were retrospectively analyzed, including 92 males and 36 females, with a male-to-female ratio of 23∶9 and an average age of (56±21) years old. The expression rate of CD4-positive T lymphocytes in peripheral blood was routinel

Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer.

BACKGROUND: Morphine and other opioids are the mainstay of cancer pain management, yet considerable fears surrounding them present barriers to pain control. Research in groups already using opioids has examined their concerns, but there is little evidence about how patients react when first offered opioids. We explored the factors influencing the decision to accept or reject morphine when first offered to patients with cancer. PATIENTS AND METHODS: A qualitative in-depth interview study nested within a cancer pain management trial. Interviews were conducted with 18 patients (nine females), ag…

Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer.

Fatty acid amide hydrolase (FAAH) metabolizes the endocannabinoid anandamide, which has an important role in nociception. We investigated the role of common FAAH single-nucleotide polymorphisms (SNPs) in experimentally induced and postoperative pain. One thousand women undergoing surgery for breast cancer participated in the study. They were tested for cold (n = 900) and heat pain (n = 1000) sensitivity. After surgery, their pain intensities and analgesic consumption were carefully registered. FAAH genotyping was performed using MassARRAY platform and genome-wide chip (n = 926). Association be

Factors associated with the development of depression in chronic non-cancer pain patients following the onset of opioid treatment for pain.

BACKGROUND AND AIMS: Pharmaceutical opioid prescription rates are increasing globally, however knowledge of their long-term effects on mental health, in particular depression remains limited. This study aimed to identify factors associated with the onset of depression post-opioid use that differ to factors associated with depression post-pain. METHOD: Participants (N = 1418) were a national sample prescribed opioids for chronic non-cancer pain. Age at onset of depression, pain and commencement of opioid medications were collected via structured interview. RESULTS: Six in 10 (61%) reported li…

[Tractotomy and partial nucleotomy as a form of therapy in refractory pain of the trigeminal nerve and cancer pain in the head and neck area].

Persistent trigeminal neuralgia, herpes zoster neuralgia of the first division of the trigeminal nerve and pain caused by cancer situated in the head and neck pose frustrating problems for patients and physicians. Tractotomy and/or partial vertical nucleotomy of the subnucleus caudalis nervi trigemini offers a logical approach to the treatment of such pain, since these structures contain fibres of the Vth nerve, as well as the somatosensory fibres of the VIIth, IXth and Xth nerve. Tactile and some thermal sensitivity of the face is preserved and anaesthesia dolorosa and keratitis neuroparalyti

[The study of neuro-adrenolysis of pituitary gland on cancer pain and experimental approach to reveal its mechanism of pain relief].

Neuro-adrenolysis of the pituitary gland by injection of pure alcohol was done to control intractable pain associated with wide-spread cancer, and pituitary functions were measured before and after the injection. Of a series of 46 patients undergoing a total of 57 neuro-adrenolysis of the pituitary gland, 22 (38.6%) of these procedures obtained complete pain relief 22 (38.6%) showed improvement, and the remaining 13 (22.8%) no effect. Hormonal changes of pituitary gland were not same among the cases and there was no correlation between hormonal changes and the occurrence of pain relief. Experi

Determination of central pain modulation biomarkers to characterise patients with cancer and refractory pain: protocol for a cross-sectional study.

INTRODUCTION: Pain is one of the most prevalent and disabling oncological symptoms, but its underlying mechanisms remain poorly understood. … d modulation (QST and EEG) and the role of moderator variables to better characterise patients with cancer pain. METHODS AND ANALYSIS: This study protocol describes a multicentre, cross-sectional, case-control study that will include a minimum of 470 ambulatory patients with cancer, including 313 with oncological pain and 157 without pain. Participants will …

Pain interfering with daily life in patients with cancer: stronger associations with anxiety and emotional distress than with pain intensity.

PURPOSE: Pain interfering with daily life (PIDL) affects the quality of life of patients with cancer beyond pain intensity. This study was aimed at identifying clinical factors associated with PIDL, defined as pain interfering with mobility/posture, sleep, eating, or excretion. METHODS: This retrospective observational study included 1798 hospitalized patients with malignancy who underwent at least one pain assessment between 2016 and 2022, yielding 5394 assessments. Associations between PIDL and clinical variables-including demographics, primary malignancy site, number of assessments, surviv

Intravenous methadone in the management of acute postoperative pain in a chronic cancer pain patient: A case report and review of the literature.

KEY CLINICAL MESSAGE: The current landscape of literature highlights that there is insufficient well-powered and robust evidence to support … ve and postoperative space in the management of patients with complex pain regimens such as chronic cancer pain patients. Despite this, our case report and literature review highlight as a broad analgesic, intravenous methadone warrants consideration following more rigorous research and development of safe use guidelines into its use for this purpose.

Pilot Testing of a Multicomponent Cancer Pain-Cognitive Behavioral Therapy mHealth App for Patients With Advanced Cancer.

PURPOSE: Patients with advanced cancer often experience pain symptoms. Pain-cognitive behavioral therapy (pain-CBT) represents an effective … results support feasibility and acceptability of a pain-CBT intervention for patients with advanced cancer pain. Although exploratory analyses showed nonsignificant improvements in pain outcomes, qualitative findings indicate meaningful engagement and skill development. Future testing is needed to determine intervention efficacy.

Intrathecal cervical analgesia for cancer pain: a 12-year follow-up study in a comprehensive cancer center.

BACKGROUND: Intrathecal analgesia plays a key role for patients suffering refractory cancer pain. Nevertheless, intrathecal drug delivery systems (IDDS), requiring a cervical catheter tip implantation, have been poorly described in medical literature. AIMS: A monocentric retrospective follow-up study was designed to evaluate results of cervical IDDS for cancer pain. PATIENTS AND METHODS: From January 2010 to December 2022, all intrathecal-treated patients were prescribed a combined intrathecal analgesics regimen through a catheter placed in the cervical vertebral canal. Post-implant assessme…

Chronic cancer and non-cancer pain and opioid-induced hyperalgesia share common mechanisms: neuroinflammation and central sensitization.

Neuroinflammation, a peculiar form of inflammation that occurs in response to noxious stimuli in peripheral and central nervous system (CNS) … ing to pain chronicity. We describe the major neuroinflammatory mechanisms shared by cancer and non-cancer pain. Particular attention is given to two different chronic inflammatory painful diseases such as the complex regional pain syndrome and the rheumatoid arthritis as prototypes of neuroinflammatory diseases (gliopathies). In addition, we describe the com …

Cut points for mild, moderate, and severe pain among cancer and non-cancer patients: a literature review.

Defining cut points (CPs) for varying levels of pain intensity is important for assessing changes in patient's functional status, and guidin … erate pain category. Of 1,556 identified articles, 27 were included for review. Among patients with cancer pain, mild-moderate pain CPs ranged from 1 to 4 (mean, 3.5±1.08), with CP4 being the most recommended CP (80%). For moderate-severe pain, CPs ranged from 4 to 7 (mean, 6.2±0.92), and CP6 (50%) was the optimal CPs. Among patients with non-cancer pain, mil …

Neuropathic pain after breast cancer treatment and its impact on sleep quality one year after cancer diagnosis.

OBJECTIVES: Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce. Therefore, we aimed to assess the impact of breast cancer treatment-related NP on patients' sleep quality, during the first year after cancer diagnosis. MATERIALS AND METHODS: A total of 501 breast cancer patients were followed prospectively. Incident NP was identified through systematic evaluations after treatments and one year after enrolment. NP severity was quantified using the Brief Pain Inventory severity subscale and sleep quality was evaluated through the Pittsbu

Have We Improved Pain Control in Cancer Patients? A Multicenter Study of Ambulatory and Hospitalized Cancer Patients.

BACKGROUND: Pain in cancer patients is recognized as a major health problem, yet few studies of both inpatient and outpatient populations have been carried out. OBJECTIVE: The study objective was to assess the frequency, type, and characteristics of pain in adult cancer patients, including both inpatients and outpatients. METHODS: This cross-sectional study involved 1064 adult cancer patients (437 outpatients and 627 inpatients) from 44 hospitals and/or long-term-care centers in Catalonia, Spain. Cancer patients suffering from pain of any etiology for ≥2 weeks and/or under analgesic treatmen

Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice.

AIMS: Nonsteroidal anti-inflammatory drugs are a therapeutic modality for chronic cancer pain arising from bone metastases. Chronic administration of a cyclooxygenase (COX)-2 inhibitor is effective to bone cancer-related pain. However, adverse cardiovascular effects have limited COX-2 inhibitor therapy, and elucidation of better targets for blocking prostaglandin (PG) biosynthesis is necessary. Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that catalyzes isomerization of the endoperoxide PGH(2) to PGE(2). To investigate the validity of mPGES-1 as a therapeutic target, we evaluated…

When persistent idiopathic facial pain is not idiopathic: Facial pain attributed to lung cancer and comparative review of classification systems.

OBJECTIVE: Facial pain attributed to lung cancer (FPLC) is frequently misclassified as persistent idiopathic facial pain (PIFP). This study reviewed published cases, retrospectively applied existing criteria for PIFP to evaluate misclassification, characterized clinical features of FPLC, and proposed a diagnostic framework. METHODS: A structured search of MEDLINE, Embase, and Web of Science through December 13, 2025, identified 51 English-language case reports of orofacial or pharyngeal pain secondary to lung cancer. Thirty-three cases contained sufficient detail to allow retrospective applic

Personalized Pain Goal Achievement with Comparable Pain Intensity and Lower Palliative Care Referral in Adolescents and Young Adults with Cancer.

BACKGROUND: Adolescents and young adults (AYAs) with cancer usually receive high-intensity end-of-life care; however, early integration of specialized palliative care can mitigate this. OBJECTIVE: To examine personalized pain goal (PPG) achievement and palliative care visits for pain management among AYAs with cancer. DESIGN: Cross-sectional survey. SETTING/PATIENTS: Consecutively-enrolled outpatients and inpatients with cancer at a university hospital. MEASUREMENTS: Patient data and self-reported questionnaires were collected from medical records. RESULTS: Among 1226 patients with cancer

Identification of high-impact chronic pain among cancer survivors: a cross-sectional study using the Graded Chronic Pain Scale framework

PURPOSE: Chronic cancer-related pain is a prevalent and often under-recognized issue among individuals living with or after cancer. Clinically useful tools are needed to classify pain severity and impact and to identify those requiring targeted support. This study applied the Graded Chronic Pain Scale-Revised (GCPS-R) in a cohort of cancer survivors and examined differences in pain characteristics and psychosocial factors across GCPS-R subgroups. Secondly, the study compared pain characteristics in cancer survivors with high-impact chronic pain (HICP) to an age- and sex-matched sample of patie

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… The Graded Chronic Pain Scale–Revised (GCPS-R) was developed to classify chronic non-cancer pain as mild, bothersome, or high-impact based on pain severity and impact [ 8 , 10 ]. … This alignment enabled comparison of selected outcomes between cancer and non-cancer pain populations. All data were collected electronically and stored in accordance with data protection regulations. …

Life with Pain Revalued-A Therapist-Led Support Group for Patients with Chronic Non-Cancer Pain: A Pilot Feasibility Study.

Introduction. Chronic non-cancer pain is highly prevalent and profoundly diminishes quality of life. While pharmacological and interventional treatments are central, its psychosocial and spiritual dimensions remain under-addressed. This pilot study assessed the feasibility of a therapist-led support group intervention for patients with chronic non-cancer pain and explored preliminary psychospiritual outcomes. Methods. A two-arm, non-randomized pilot feasibility study was conducted among 58 outpatients of a university pain management clinic in Poland. Feasibility was assessed through recruitmen…