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Multiple mycotoxin exposure assessment through human biomonitoring in an esophageal cancer case-control study in the Arsi-Bale districts of Oromia region of Ethiopia.

BACKGROUND: Esophageal cancer (EC) is a malignancy with a poor prognosis and a five-year survival rate of less than 20%. It is the ninth mos … , our result emphasizes the need to characterize the effect of mycotoxin co-exposure as part of the exposome and include it in risk assessment, since the current mycotoxin safety levels do not consider the additive or synergistic effects of mycotoxin co-exposure. Moreover, a prospective study design with regular sampling should be considered in this high i …

Early Respiratory Infection Burden and Atopic Dermatitis in Childhood.

IMPORTANCE: The exposome has been proposed to have a key role in the development of atopic dermatitis (AD). However, whether early-life infections are associated with AD risk remains unclear. OBJECTIVE: To investigate whether early infection burden and infection subtypes are associated with the risk of childhood AD. DESIGN, SETTING, AND PARTICIPANTS: A cohort study using data from children aged 0 to 10 years from the 2010 Danish Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010) birth cohort who were monitored for infection diagnoses, AD diagnosis, Scoring Atopic Dermatitis (…

Association of serum levels of typical organic pollutants with polycystic ovary syndrome (PCOS): a case-control study.

STUDY QUESTION: Is polycystic ovary syndrome (PCOS) associated with increased serum levels of typical organic pollutants? SUMMARY ANSWER: P … ccupation have been considered as an indicator of personal income. The PLS-DA model allowed a quasi-exposome analysis with over 60 kinds of typical organic pollutants; however, the possibility of other pollutants involved in the PCOS still could not be excluded. WIDER IMPLICATIONS OF THE FINDINGS: Our study identified that bodily retention of environmenta …

Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia.

Efforts to predict schizophrenia risk using biological data have been hampered by the heterogeneity of current 'clinical high-risk' (CHR-P) criteria, which pool phenomenologically and biologically distinct syndromes under a single label. In particular, the field has focused almost exclusively on 'ultra high-risk' (UHR) symptoms, while cognitive basic symptoms-despite their close alignment with schizophrenia's core features such as formal thought disorder-have remained under-used. To date, no study has directly compared brain signatures of different CHR-P definitions with respect to their simil

Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort.

BACKGROUND: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation … ng function and the onset of puberty, among European school-age children participating in the HELIX exposome cohort. METHODS: The study population included up to 1173 children, aged between 5 and 12 years, from study centres in the UK, France, Spain, Norway, Lithuania, and Greece. Telomere length was measured through qPCR, blood DNA methylation, and gene …

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.

IMPORTANCE: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human e … llected from April 1, 2003, to February 26, 2016, from mother-child pairs from the Human Early-Life Exposome project, a collaborative network of 6 ongoing, population-based prospective birth cohort studies from 6 European countries (France, Greece, Lithuania, Norway, Spain, and the UK). Data were analyzed from April 1, 2021, to January 31, 2022. EXPOSURES …

Changes in environmental exposures over decades may influence the genetic architecture of severe spermatogenic failure.

STUDY QUESTION: Do the genetic determinants of idiopathic severe spermatogenic failure (SPGF) differ between generations? SUMMARY ANSWER: O … precise understanding of conditions such as SPGF by considering the interactions between a variable exposome through different generations and genetic predisposition to complex diseases. STUDY FUNDING/COMPETING INTEREST(S): This work was supported by the "Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020)" (ref. PY20_00212, P20_00583), th …

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children.

IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to d … y, Spain, and the UK) between April 1, 2003, and February 26, 2016, as part of the Human Early Life Exposome (HELIX) project. Mothers and their singleton offspring were followed up until the children were aged 6 to 12 years. Data were analyzed between March 1 and August 2, 2019. EXPOSURES: Maternal fish intake during pregnancy (measured in times per week) …

От генов к окружающей среде: жизненный подход к профилактике педиатрических аутоиммунных заболеваний.

Аутоиммунные заболевания у детей, включая тип 1 Все более серьезной проблемой для здоровья людей во всем мире являются диабет, болезни селиака и детский артрит. Этот всплеск, слишком быстрый для того, чтобы его можно было объяснить только генетическими изменениями, подчеркивает важнейшую роль экологических факторов и подчеркивает настоятельную необходимость принятия активных превентивных мер. Этот обзор представляет собой комплексную, основанную на фактических данных основу для профилактики педиатрических аутоиммунных заболеваний по всему спектру услуг, начиная с первичной и заканчивая третичн

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… This article outlines a comprehensive, integrated framework that leverages advances in genomics and exposomics to identify and intervene in high-risk children. … Consequently, the reported ‘surge’ likely reflects a complex combination of genuine biological shifts in the pediatric exposome and improved detection capabilities in modern healthcare systems[ 6 ]. …

Immunologic tumor microenvironment modulators for turning cold tumors hot.

Tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment (TME). Hot tumors, characterized by heightened immune activity and responsiveness to immune checkpoint inhibitors (ICIs), stand in stark contrast to cold tumors, which lack immune infiltration and remain resistant to therapy. To overcome immune evasion mechanisms employed by tumor cells, novel immunologic modulators have emerged, particularly ICIs targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein

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… In this expansive view, these societal constructs also form a vital component of the exposome [ 185 , 186 , 187 , 188 ]. In the context of cancer and the response to therapies like ICB, recognizing the pivotal role played by the host‐intrinsic factors and exposome is paramount. … Both host‐intrinsic factors and host‐extrinsic factors (representing the exposome) are depicted. …

Methodological Development and Assessing Prescribing Determinants Through Cumulative Drug Exposure in Hospitalized Patients: Proof-of-Concept Retrospective Study.

BackgroundPreventing adverse drug reactions requires accurate monitoring of drug exposure throughout patient care. Conventional metrics, measured at admission or discharge, fail to capture the dynamic and cumulative nature of drug burden during hospitalization. Improving exposure assessment is essential to support clinical decision-making and medication safety. Clinical data warehouses (CDWs), which integrate detailed drug administration records, enable the retrospective reuse of hospital data to develop more granular and dynamic measures of in-hospital drug exposure.ObjectiveThis exploratory

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… Within this framework, pharmaceuticals represent a major, yet insufficiently characterized component of the chemical exposome, particularly regarding their longitudinal accumulation. … Smith MT de la Rosa R Daniels SI Using exposomics to assess cumulative risks and promote health Environ Mol Mutagen Dec 2015 56 9 715 723 doi 10.1002/em.21985 Medline 26475350 PMC4636923 34. …

Chained Risk Assessment for Life-Long Disease Burden of Early Exposures - Demonstration of Concept Using Prenatal Maternal Smoking.

Traditional risk factors and environmental exposures only explain less than half of the disease burden. The developmental origin of the health and disease (DOHaD) concept proposes that prenatal and early postnatal exposures increase disease susceptibility throughout life. The aim of this work is to demonstrate the application of the DOHaD concept in a chained risk assessment and to provide an estimate of later in life burden of disease related to maternal smoking. We conducted three systematic literature searches for meta-analysis and reviewed the literature reporting meta-analyses of long-ter

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… Biological Plausibility Application of epigenetics and exposome methods are in their infancy in environmental epidemiology. … The exposome: A new frontier for education. Am. Biol. Teach. 2016;78:542–548. doi: 10.1525/abt.2016.78.7.542. 4. Kuh D., Ben-Shlomo Y., Lynch J., Hallqvist J., Power C. Life course epidemiology. J. Epidemiol. Community Health. 2003;57:778–783. doi: 10.1136/jech.57.10.778. 5. Barker D.J. …

Полиаутоимунитет и множественные аутоиммунные синдромы: забытая клиническая проблема.

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… Notably, up to 25% of patients with one autoimmune disease may go on to develop additional autoimmune conditions.[ 2 ] Recent research highlights the role of the exposome – the cumulative burden of environmental exposures – and gut microbiome dysregulation in the pathogenesis of MAS. …

Сексуальные и гендерные аспекты в миелоиде и лимфоболическом лейкемии и множественной миеломе: от молекулярных механизмов к клиническим результатам.

Биологические и гендерные факторы оказывают значительное влияние на патогенез, прогресс и реакцию на гематологическое заболевание. В настоящем всеобъемлющем обзоре рассматриваются различия по признаку пола в острой миелоидной лейкемии, острой лимфоболической лейкемии, хронической миэлоидной лейкемии и множественной миеломе на основе систематического анализа рецензируемой литературы, опубликованной между 2014-2024 и идентифицировался с помощью структурированного поиска баз данных PubMed, Web of Science и MedLINE. Эпидемиологические данные свидетельствуют о более высокой частотности заболеваний

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… Exposomics as a tool to investigate differences in health and disease by sex and gender. Exposome. 2023;3:osad003. doi: 10.1093/exposome/osad003. 13. Miller V.M. Why are sex and gender important to basic physiology and translational and individualized medicine? Am. J. Physiol. Heart Circ. …

Bioengineered Humanoid-on-Chip Platforms: Tools for Evaluating the Effects of Environmental Exposure on Human Physiological Barriers.

UNLABELLED: Environmental pollutants; bioaerosols, chemicals and micro/nano-plastics (MNPs) can disrupt the mechano-biological processes of … vascular endothelial cell (BMVEC) barriers, and their OoC models to evaluate the effect of kinds of exposomes. We successfully characterized SPC+ AECs and CD31+ BMVECs with highly transepithelial electrical resistance values as a gold standart, IBA1+ microglia and CD31+ endothelial cells enriched, cortical plate structured advanced matured functional brain …

Diabetes and obesity: the role of stress in the development of cancer.

Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association. Managing diabetes and obesity is challenging as they both cause significant distress. The relationship between stress and cancer is interconnected, with anxi

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… Recently, there has been an increased focus on the concept of the “exposome” or “envirome [ 24 ]” It refers to all the exposures a person encounters from conception to death, including natural, social, and personal environments. … Dagnino, What is new in the exposome? Environ. Int. 143 , 105887 (2020) 25. R. Airaksinen, P. Rantakokko, J.G. Eriksson, P. Blomstedt, E. Kajantie, H. Kiviranta, Association between type 2 diabetes and exposure to persistent organic pollutants. Diab. Care 34 (9), 1972–1979 (2011) 26. V. …

Унификация одиссеи: искусственный интеллект для диагностирования и лечения редких заболеваний.

Подытожить текущие проблемы в диагностике и лечении редких заболеваний (РД), осветить последние достижения в области искусственного интеллекта (АИ) для РД и предложить модель будущего состояния лечения пациентов РД. Многодисциплинарный экспертный обзор с кратким изложением современных практических задач и мер по ограничению ставок в области РД-клиентов с учетом ключевых клинических и исследовательских соображений в отношении нормативных и экономических ограничений. 10,000 известные РД оказывают коллективное воздействие 1 В 10 Американцы, в целом 30 million Люди. Ежегодно на РД приходится свыше

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… Dynamic interactions between the host genome, microbiome, and exposome continually influence the state of health and disease [ 12 ]. … This would collect relevant spatial, temporal, and molecular data, for example the emerging fields of interactomics (total set of interactions among molecules) and exposomics (total lifetime environmental exposures) [ 12 ]. …

Сетевая биоинформатика Reveal Microenvironment-Driven Cell-Cell Communication in the Progress of Multieloma.

Секвенирование РНК в одной клетке (scRNAseq) фиксирует уникальные профили отдельных клеток и обнаруживает связь между клетками (CCC) посредством взаимодействия лиганда-рецептора (LR). Кроме того, он показывает механизмы сигнализации, лежащие в основе клеточной неоднородности и сложности реакции вниз по течению в здоровых и болезнетворных состояниях. В ходе этой работы мы разработали композитный вычислительный трубопровод для отслеживания структуры КХЦ в опухолей микроокружающей среды (TME) в процессе развития Multieloma (MM) в качестве тематического исследования. Three Обнародованные наборы да

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… However, along with genetic factors, tumour exposome, with all the environmental exposures that interact with the tumour and its microenvironment, shape cancer’s pathophysiology, disease initiation, progression, and response to treatment. … Collectively, CCC rewiring in crosstalk with tumour exposome will provide valuable insights into mechanisms that drive MM. …

Biological Therapy for Psoriasis in Cancer Patients: An 8-Year Retrospective Real-Life Study.

Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evidence on the safety of the use of biologic treatments in cancer patients with psoriasis, and the use of this therapeutic class in patients with a pre-existing or concomitan

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… Moreover, some studies have shown that psoriasis and cancer share the same exposome [ 9 , 10 ]. … Measuring the exposome: A powerful basis for evaluating environmental exposures and cancer risk. Environ. Mol. Mutagen. 2013;54:480–499. doi: 10.1002/em.21777. 10. Özdemir Ö. …

An overview of cancer health disparities: new approaches and insights and why they matter.

Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies greatly reduced cancer mortality among women and men and underserved communities in this country. Yet, disparities in cancer outcomes remain. Underserved populations continue to experience an excessive cancer burden. This burden is largely explained by health care disparities, lif

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… Mechanisms linking stress exposure to cancer metastasis and survival and disparate outcomes The concept of a public health exposome was developed for targeted community health intervention and includes exposure to stressors, their signaling, and the causes of the stress exposure ( 82 ). … Juarez, P.D. et al. (2014) The public health exposome: a population-based, exposure science approach to health disparities research. Int. J. Environ. Res. Public Health, 11, 12866–12895. 83. …