Результаты поиска

Evaluation of dexmedetomidine and ketamine in combination with various opioids as injectable anesthetic combinations for castration in cats.

OBJECTIVE: To compare the efficacy and cardiorespiratory effects of dexmedetomidine-ketamine in combination with butorphanol, hydromorphone, … /kg [113.6 ?g/lb], IM) and the remainder received saline (0.9% NaCl) solution IM. All cats received meloxicam (0.2 mg/kg, SC) immediately prior to the conclusion of surgery. RESULTS: All drug combinations induced lateral recumbency, and intubation was achievable in 13 of 30 (43%) cats at 10 minutes after injection. Supplemental isoflurane was needed for th …

The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs.

The interaction between oral non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone administered concurrently for 30 days was studied in 18 healthy dogs divided into 3 groups of 6 dogs each: a drug-free negative control group (NC group) given 2 gelatin capsules; a group given meloxicam (0.1 mg/kg) and prednisolone (0.5 mg/kg) (MP group); and a group given a reduced dosage of ketoprofen (0.25 mg/kg, p.o.) and prednisolone (0.5 mg/kg, p.o.) (KP group). The dogs were periodically monitored by physical examinations, blood analyses, endoscopic examinations, fecal occult blood tests, renal …

Inducible cyclooxygenase and interleukin 6 gene expressions in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis.

BACKGROUND: Inflammation is believed to be related to the pathogenesis of nasal polyp (NP). Inducible cyclooxygenase (COX-2) and interleukin … L-6 and COX-2 mRNAs were produced in NPFs. Cytokines induced IL-6 and COX-2 mRNA synthesis in NPFs. Meloxicam (a specific COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA levels, and these effects could be reversed by exogenous prostaglandin E(2). In situ hybridization revealed that IL-6 and COX-2 mRNAs were detected primarily in fibrobla …

Local anaesthesia with lidocaine is insufficient for ovine tail docking: A randomised clinical trial.

BACKGROUND: Tail docking in sheep is a common management practice associated with significant pain and stress. Local anaesthesia with lidoca … expression scale. Plasma cortisol was measured at baseline and 1 h after docking. Rescue analgesia (meloxicam 0.5 mg/kg IM) was administered when pain scores ≥5. RESULTS: Six lambs in GS required rescue analgesia, whereas none in GX did (P = 0.02). Plasma cortisol increased significantly in GS compared to GX and to baseline (P < 0.05). Xylazine induced mil …

Molecular Characterization of Theileria annulata by HSP70 Gene of India and Management of Its Infection in Cattle: A Case Report.

A 3-year-old cow which suffered from anorexia and high fever for the last 2 days was investigated at farmer door step. Detailed examination … ne (Intas Pharmaceutical Pvt. Ltd., India; 2.50mg kg-1along with intra-muscular anti-pyrectic drugs Meloxicam and Paracetamol combination (Intas Pharmaceutical Pvt. Ltd., India;15 mg kg-1 q24)for 2 days and oral preparation of haematinics (Intas Pharmaceutical Pvt. Ltd., India; 50 ml q24) for 10 days. This is the first report on molecular detection of Theil …

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021.

BACKGROUND: We characterize outpatient prescribing trends of orthopedic surgery providers in the United States. MATERIALS AND METHODS: A re … m 1,300,279 (2013) to 1,796,419 (2021). Claims for celecoxib, diclofenac, ibuprofen, ketorolac, and meloxicam all significantly increased, whereas claims for etodolac, indomethacin, nabumetone, naproxen, piroxicam, and sulindac all significantly decreased (P<0.05). CONCLUSION: In line with national guidelines, claims for NSAIDs are increasing and claims fo …

Successful Treatment of Pneumothorax in a Dog With Sterile Pleural Fibrosis Caused by Chylothorax.

A 2-year-old, 12 kg, intact male crossbreed dog was presented with respiratory distress, exercise intolerance, and gagging. Plain thoracic r … Mild to moderate pleural effusion of non-chylic quality was present during the following 4 months. Meloxicam was administered for 4 months because of its anti-fibrotic and anti-inflammatory properties. Fifteen months later, thoracic radiographs revealed full radiologic expansion of the lungs with persistent mild pleural fibrosis. To the authors' knowledge, …

Dimethylthiourea ameliorates carbon tetrachloride-induced acute liver injury in ovariectomized mice.

AIMS: In order to clarify hepato-protective actions of estrogen, we examined the progress of carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in sham and ovariectomized (ovx) mice and the effects of dimethylthiourea (DMTU), a hydroxyl radical scavenger, and meloxicam (Melo), a selective cox-2 inhibitor, on the development of CCl4-induced ALI. MAIN METHODS: Female C57BL/6 J mice weighing 15-20 g were performed sham or ovx operation at 8 weeks of age. Blood and liver samples were collected 15 and 24 h after CCl4 administration. Sham and ovx mice were given DMTU, Melo or saline intra…

Inhibition by non-steroidal anti-inflammatory drugs of compound action potentials in frog sciatic nerve fibers.

AIMS: Although antinociception produced by non-steroidal anti-inflammatory drugs (NSAIDs) is partly attributed to nerve conduction inhibitio … ic acid-based (ketoprofen, naproxen, ibuprofen, loxoprofen and flurbiprofen) and enolic acid-based (meloxicam and piroxicam) NSAIDs had no effects on CAP peak amplitudes. SIGNIFICANCE: At least a part of antinociception produced by NSAIDs used as a dermatological drug to alleviate pain may be attributed to their inhibitory effects on nerve conduction, whic …

Duloxetine and Subacute Pain after Knee Arthroplasty when Added to a Multimodal Analgesic Regimen: A Randomized, Placebo-controlled, Triple-blinded Trial.

BACKGROUND: Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but there are insufficient data to recommend the use o … odal analgesic regimen including neuraxial anesthesia, epidural analgesia, an adductor canal block, meloxicam, and oxycodone/acetaminophen as needed. The primary outcome was the pain score (0 to 10 numeric rating scale) with ambulation on postoperative day 14. RESULTS: One hundred six patients were randomized and analyzed. On day 14, duloxetine had no effe …

Heartworm-positive dogs recover without complications from surgical sterilization using cardiovascular sparing anesthesia protocol.

Expedited home placement of heartworm-positive shelter dogs is desirable and may outweigh the perceived increase in anesthetic risk for pre- … for heartworm-positive dogs included acepromazine (0.01-0.05 mg/kg), butorphanol (0.1mg/kg IM) and meloxicam (0.2mg/kg IM), or carprofen (2mg/kg SQ) in the preanesthetic period; tiletamine/zolazepam (3-6 mg/kg IV) or ketamine/diazepam (3-6mg/kg/0.25-5mg/kg IV) to effect for induction; maintenance on isoflurane or sevoflurane and oxygen. A lidocaine testicu …

Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity.

It has been estimated that 10% of acute liver failure is due to "idiosyncratic hepatotoxicity". The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were included in this study: two overt hepatotoxicants (acetaminophen and carbon tetrachloride), two idiosyncratic hepatotoxicants (felbamate and dantrolene), and three non-hepatotoxicants (meloxicam, penicillin and metformin). Male Sprague-Dawley rats were orally gavaged with a single dose of vehicle, low …

Safety of celecoxib and nonselective nonsteroidal anti-inflammatory drugs in juvenile idiopathic arthritis: results of the Phase 4 registry.

BACKGROUND: This study aimed to assess long-term safety and developmental data on juvenile idiopathic arthritis (JIA) patients treated in ro … (nsNSAID, n = 219; celecoxib, n = 55) were observed for 410 patient-years of observation. Naproxen, meloxicam, and nabumetone were the most frequently used nsNSAIDs. At baseline, the celecoxib group was older, had a numerically longer median time since diagnosis, and a numerically higher proportion of patients with a history of gastrointestinal-related NSAI …

A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice.

Vasectomized mice are needed in the production of genetically-modified animals. The BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinemen … 48 h postsurgery. Data were obtained using automated behaviour recognition software (HomeCageScan). Meloxicam was administered either alone or combined with acetaminophen prior to surgery. A third group received only saline subcutaneously. Postsurgery behaviour changes were compared between groups at each time point. Exploratory behaviours such as rearing, …

Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature.

PURPOSE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with the use of nonsteroidal antiinflammatory drugs … isks reported with other NSAIDs are much lower. The risk with cyclooxygenase-2-selective NSAIDs and meloxicam is less clear, since all were introduced after the completion of the epidemiologic studies. SJS or TEN from NSAIDs and cyclooxygenase-2-selective NSAIDs appears to affect the same patient population as other medications that cause SJS or TEN. The ri …

Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells.

Cyclooxygenase-2 (COX-2) is reported to be an important cellular target for therapy in malignancies. The growth inhibitory effects of COX-2 … a cell lines, which expressed no COX-2 enzyme, etodolac more strongly induced apoptosis compared to meloxicam. Moreover, etodolac did not induce apoptosis to normal B-lymphocytes. For the pathway of etodolac-induced apoptosis, reduction of anti-apoptotic bcl-2 mRNA and Bcl-2 protein, activation of Caspase-9 and -3, down-regulation of caspase inhibitors, c-I …

Self-reported drug allergy in a general adult Portuguese population.

AIM: To estimate the prevalence of self-reported drug allergy in adults. METHODS: Cross-sectional survey of a general adult population from … (18.2%) and ibuprofen (18.2%) were the most frequently identified drugs, followed by nimesulide and meloxicam. Identification of the exact name of the involved drug was possible in less than one-third of the patients, more often within the NSAID group (59.5%). Women were significantly more likely to claim a drug allergy than men (10.2% vs. 5.3%). The most c …

Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors.

We investigated the regulation of COX-2 expression and activity by adenosine receptors in rat microglial cells. The selective adenosine A2a- … 80-increased PGE2 levels were inhibited by dexamethasone, by the nonsteroidal antiinflammatory drug meloxicam, and by the adenylyl cyclase inhibitor 9-(tetrahydro-2-furanyl)-9H-purine-6-amine (SQ22536). CGS21680 and NECA both increased intracellular cAMP levels in microglial cells. Dibutyryl cAMP as well as forskolin induced the release of PGE2. The results …

Successful treatment of suspected sciatic neuritis following canine total hip arthroplasty.

Sciatic neuritis is characterized by neuropathic pain with or without neurological deficits. There have been no previous reports of significant neuropathic pain or sciatic neuritis following total hip arthroplasty (THA) in dogs. This case report describes a male neutered Samoyed dog, aged 21 months and weighing 26 kg, with severe pain after THA that underwent revision surgery 2 days after the initial surgery. During the 36 hours after the initial surgery, analgesia was well managed with preventive and multimodal analgesic approaches (methadone, meloxicam, medetomidine infusion, epidural inject…

Диагноз колумборала Mycoplasma в молодом керу (Hemphaga novaeselandiae).

В начале лета в госпиталь дикой природы в Дунедине после падения из его гнезда и нахождения на земле был помещен дикий молодой человек (Hemphaga novaeselandiae). КЛИНИЧЕСКИЕ ВЕЩЕСТВА: Птица была понижена в весе, весила всего 391 г (ожидаемый вес > 450 г), и была уверена, что она находится в плохом состоянии в результате пальца грудной мышцы. Произошло двустороннее опухоль и окулярное опухоль с кажущимся материалом, блокирующим хоану. Образцы окулярного и хорового стока были собраны и представлены для молекулярного испытания. Для дальнейшей радиографической оценки потребовалась общая анестезия,

Совпадение в аннотации оригинала
CASE HISTORY: In early summer, a wild fledgling kererū (Hemiphaga novaeseelandiae) was admitted to a wildlife hospital in Dunedin after fall … lised for 48 hours with oral electrolytes and antimicrobial and analgesic therapy with doxycycline, meloxicam, and tramadol administered orally twice daily via crop tube and voriconazole administered once daily. Chloramphenicol was applied topically to the eyes twice daily. Subsequently, due to the severity of the gross and radiographic lesions, the likelih …