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Comparative Peripheral Blood Transcriptomic Profiles in Parkinson's Disease and Restless Legs Syndrome: An Exploratory Between-Cohort Analysis.

Restless legs syndrome (RLS) and RLS-like symptoms are frequently reported in Parkinson's disease (PD), but whether this clinical overlap reflects shared biology or convergent symptom expression remains uncertain. We performed an exploratory comparative analysis of peripheral blood mononuclear cell RNA-seq data from 17 drug-free patients with RLS and 60 patients with PD, most of whom were receiving dopaminergic treatment. Because the two cohorts were derived from independent datasets and no healthy control group was included, all findings were interpreted as relative PD-versus-RLS differences …

Pilot study of Pitolisant, a histamine-3 inverse agonist, as adjunct therapy for refractory restless legs syndrome.

BACKGROUND: Restless leg syndrome (RLS) treatments include iron, dopaminergics, gabapentinoids, and opioids, but symptoms often become refractory over time. Sedating antihistamines, which cross the blood-brain border, frequently exacerbate RLS. Pitolisant is a stimulant Histamine-3 inverse agonists that increases CNS histamine transmission. It is currently used to treat narcolepsy. METHODS: This open label trial titrated pitolisant to a maximum dose of 35.6 mg in the AM, in inadequately treated patients currently taking at least 1 RLS medication. Primary efficacy was the International RLS Rat

Evaluation of electrophysiological changes before and after pramipexole treatment in patients diagnosed with idiopathic restless legs syndrome.

BACKGROUND AND PURPOSE: Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, frequently accompanied by unplea-sant sensations. In this study, we aimed to determine the changes in electrophysiologi-cal tests including F-wave responses and H-reflex parameters in patients with idiopathic RLS after pramipexole medication. METHODS: This prospective study was con-ducted with twenty newly diagnosed, idiopathic RLS patients. The electrophysiological parameters, specifically F-wave duration (FWD), the duration of related compound muscle action…

Evaluating the adenosine hypothesis of restless legs syndrome and its implications for current and future treatment strategies.

INTRODUCTION: Restless Legs Syndrome (RLS) is a sensorimotor disorder linked to brain iron deficiency and dopaminergic dysfunction. Increasing evidence suggests that alterations in adenosine signaling may represent the missing link connecting dopaminergic and glutamatergic abnormalities. The 'adenosine hypothesis' proposes that brain iron deficiency induces a hypoadenosinergic state, primarily through adenosine A1 receptor downregulation, resulting in cortical hyperexcitability, hyperarousal, and periodic limb movements. AREAS COVERED: This critical perspective examines experimental, neurophy…

Прогнозы низкого качества сна в множестве склерозов: независимая роль тревоги и синдрома беспокойных ног.

ЦЕЛИ ИССЛЕДОВАНИЯ: Сповые расстройства широко распространены в множестве склерозов (МС) и оказывают значительное воздействие на качество жизни пациентов. Однако конкретные прогнозы низкого качества сна в НР остаются недостаточно изученными. Цель этого исследования заключалась в определении распространенности низкого качества сна и выявлении клинических и психологических факторов, независимо связанных с плохим сном у пациентов с синдромом MS. МЕТОДЫ: Это перекрестное обследование охватывало 103 пациента, зачислявшихся в систему НР в течение месячного периода набора. Качество сна оценивалось с п

Совпадение в аннотации оригинала
STUDY OBJECTIVES: Sleep disturbances are common in multiple sclerosis (MS) and significantly affect patients' quality of life. However, the … ty of life (all p < 0.01). Multivariate analysis revealed that anxiety symptoms and the presence of restless legs syndrome (RLS) were the only independent predictors of poor sleep quality. Depression, fatigue, disability, and neuropathic pain were not independent predictors after adjustment. CONCLUSIONS: Poor sleep is prevalent in MS and independently associated with a …

Повреждения сна в образце пациентов с множественным склерозом педиатрии: сосредоточьтесь на синдроме беспокойных ног.

Фон/цели: Согласно сообщениям, нарушения сна (SD) и синдром нержавеющих ног (RLS) широко распространены в случае множественного склероза (MS), однако данные о педиатрии-понтере MS (POMS) являются ограниченными. Целью этого исследования является оценка распространенности УР, в частности РСТ, в группе ПОМС и изучение сопутствующих клинических особенностей. Методы: Мы наняли пациентов ПОМС, которые посещали Центр ПОМС при Детской больнице Бамбино-Гессе в период с сентября 2021 и февраль 2023; они были оценены на предмет УР с использованием индекса качества сна Питтсбурга (PSQI) или шкалы неустойч

Совпадение в аннотации оригинала
Background/Objectives: Sleep disorders (SDs) and Restless Legs Syndrome (RLS) have been reported with high prevalence in Multiple Sclerosis (MS), but data on Pediatric-Onset MS (POMS) are scarce. This study aims to assess the prevalence of SDs, particularly RLS, in a POMS cohort and examine associated clinical features. Methods: We recruited POMS patients wh…

Exercise protects impairments in memory recognition in the iron-deficient male rat model of Restless Legs Syndrome.

Restless Legs Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs and is associated with decreased quality of life and sleep, and may result in cognitive changes. Physical exercise generates cognitive improvements and improves RLS symptoms. Our objective is to analyze recognition memory in the iron-deficient rodent model of RLS, and the effect of exercise. The animals (male Wistar rats) were distributed at 21 days of age into a control group (CTRL) (standard diet) or an ID group (iron-deficient diet). After performance classification (at 77 days of …

Prevalence of Current Restless Legs Syndrome Symptoms Among Patients Treated with Buprenorphine/Naloxone for Opioid Use Disorder.

OBJECTIVE: The purpose of this study was to determine the prevalence of Restless Legs Syndrome (RLS) in patients with Opioid Use Disorder (OUD) taking buprenorphine/naloxone maintenance therapy, and to assess symptom frequency, severity, and sleep disruption due to RLS. METHODS: Surveys inquired about demographic information, amount of time on maintenance treatment, previous drug use, current prescribed medications and alcohol use, and RLS symptoms. Participants were determined to have definite, probable, possible, or no RLS symptoms based on pre-established criteria from the Cambridge-Hopkin…

Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia.

OBJECTIVE: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM. METHODS: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗. RESULTS: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group an…

The Efficacy and Safety of Pharmacological Treatments for Restless Legs Syndrome: Systemic Review and Network Meta-Analysis.

Although various drugs are currently used for restless legs syndrome (RLS) in clinic, selecting appropriate drugs for patients is difficult. This network meta-analysis (NMA) aimed to compare the efficacy and safety of different drugs. After literature searching and screening, 46 trials, including 10,674 participants are included in this NMA. The pooled results showed that, compared with placebo, only levodopa is inefficient to relieve symptoms of RLS. Cabergoline decreases IRLS scores to the greatest extent among all drugs (MD -11.98, 95% CI -16.19 to -7.78). Additionally, pramipexole is super…

Which Factors in Spinocerebellar Ataxia Type 3 Patients Are Associated with Restless Legs Syndrome/Willis-Ekbom Disease?

There is evidence of a higher prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) in individuals with spinocerebellar ataxia type 3 (SCA3), although the factors underlying this association remain unknown. The present study aimed to determine the prevalence of RLS/WED in SCA3 patients and to investigate which factors of SCA3 patients are associated with presence of RLS/WED. From February to August of 2006, we carried out clinical interviews in 40 controls and 40 SCA3 patients, diagnosed and followed up at Faculty of Medicine of Ribeirão Preto, University of São Paulo. Twenty-sev…

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review.

Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on changes in RLS and/or PLMD. We conducted a systematic search looking for all relevant articles and then two reviewers read all article titles and abstracts to identify relevant studies. Eligible studies were scored for their quality as interventional trials. We found 855 abstracts …

Prevalence of restless legs syndrome in functional movement disorders: a case-control study from the Czech Republic.

OBJECTIVES: The prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Therefore, our objective was to evaluate possible association between FMD and RLS. DESIGN: Case-control study. SETTING: Movement Disorders Center, 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic. PARTICIPANTS: 96 consecutive patients with clinically established FMD (80 females, mean age (SD) 45.0 (13) years), and 76 matche…

Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD).

OBJECTIVES: Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are thought to center around a genetically mediated sensitivity to iron insufficiency. Previous studies have shown the effectiveness of short-term iron therapy in children with low iron storage. Little is known, however, about long-term iron treatment in children with RLS and PLMD. Therefore, we performed this study to assess the long-term effect of iron therapy in children with RLS and PLMD. METHODS: A retrospective chart review was performed for children who met the following criteria: A) diagnosed as having…

Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome.

STUDY OBJECTIVES: The aim of this study was to investigate the prevalence and characteristics of periodic limb movements during sleep (PLMS) in Korean patients with restless legs syndrome (RLS). METHODS: Unmedicated adult patients with idiopathic RLS (n = 354) who underwent polysomnography at three major sleep centers in tertiary hospitals were included. Characteristics of PLMS in RLS were analyzed using the time structure of polysomnographically recorded leg movements and periodicity indices (PIs). RLS severity and subjective sleep quality were assessed. RESULTS: Out of 354 patients with id…

The prevalence of restless legs syndrome in Edirne and its districts concomitant comorbid conditions and secondary complications.

We aimed to determine the prevalence and risk factors of restless legs syndrome in Edirne and its districts, located in Western Thrace, which is the most western part of Turkey. In this study, 4003 individuals who could communicate and agreed to participate in the study were evaluated. To obtain the data from the applicants in 30 Family Health Centres in Edirne and its districts, a face-to-face questionnaire that consisted of 54 questions was prepared by the researchers. The questionnaire included general information, questions to evaluate potential concomitant comorbid conditions and question…

Periodic limb movements during sleep and restless legs syndrome in patients with ASIA A spinal cord injury.

OBJECTIVE: To establish the occurrence of Periodic Leg Movements (PLM) and Restless Legs Syndrome (RLS) in Spinal Cord Injury (SCI) subjects. METHODS: In this study, twenty four patients were submitted to a full night polysomnography and were assessed with Epworth Sleepiness Scale and an adapted form of International Restless Legs Syndrome Scale Rating Scale (IRLS Rating Scale). Control Group (CG) was composed of 16 subjects, 50% of each sex, age: 24.38±4 years old. Spinal Cord Injury Group (SCIG) was composed of 8 subjects (29±5 years old) with a complete SCI (ASIA A) of about three and a ha…