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Antiemetic Strategies in Patients Who Undergo Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is an integral part of the treatment strategy in patients with a hematological disorder. Chemotherapy-induced nausea and vomiting (CINV) is still an issue in patients who undergo HSCT. While several guidelines for the antiemetic therapy against CINV have been published, there is no detailed information about appropriate antiemetic drugs for each conditioning regimen in HSCT. Various studies reported that the triplet of 5-HT3RA, NK1RA, and dexamethasone appears useful in HSCT. However, each antiemetic has unique adverse effects or interactions with

Perspectives on returning to work of multiple myeloma patients: A qualitative interview study.

ObjectiveMultiple myeloma (MM) is a rare and incurable disease. Because new treatments improved survival rates, return to work (RTW) became more relevant to MM patients of working age. Also, (health care) experts may be confronted with specific obstacles in guiding MM patients' RTW. Therefore, we aimed to qualitatively explore perspectives and experiences of MM patients and (health care) experts regarding RTW and participation at work.MethodsSemi-structured interviews were conducted with patients (N = 9) and (health care) experts (N = 15). Interviews were transcribed verbatim and analysed usin

Ixazomib Improves Bone Remodeling and Counteracts sonic Hedgehog signaling Inhibition Mediated by Myeloma Cells.

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of plasma cells (PC) in the bone marrow (BM), leading to bone loss and BM failure. Osteolytic bone disease is a common manifestation observed in MM patients and represents the most severe cause of morbidity, leading to progressive skeletal damage and disabilities. Pathogenetic mechanisms of MM bone disease are closely linked to PCs and osteoclast (OCs) hyperactivity, coupled with defective osteoblasts (OBs) function that is unable to counteract bone resorption. The aim of the present study was to investigate t

Shared care follow-up of patients with B-cell neoplasms based on nurse-led telephone consultations and PRO-data: a feasibility study from the North Denmark Region.

BackgroundPatients with B-cell neoplasms in remission are monitored with regular physician visits at the hospital. The current standard foll … s requested by patients (n = 2) and patient-reported symptoms reviewed by the nurse (n = 1). The response rate to questionnaires was 98% (335/341). A total of 58/79 (74%) patients completed the Patient Feedback Form; 51/57 (89%) patients reported improved communication with health care professionals; and 50/57 (88%) patients reported improved recollect …

Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study.

BackgroundThis single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.Methods109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue

Psychometric properties of two physical activity questionnaires, the AQuAA and the PASE, in cancer patients.

BackgroundThis study aimed to evaluate the reliability and validity of two self-report physical activity (PA) questionnaires - the AQuAA (Activity Questionnaire for Adults and Adolescents) and PASE (Physical Activity Scale for the Elderly) - in cancer patients.MethodsTest-retest reliability was determined by administering the questionnaires twice within 5 days. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and smallest detectable difference (SDD) were calculated. Construct validity was determined by comparing the questionnaire results with ActiGraph acceleromete

Correlates of exercise motivation and behavior in a population-based sample of endometrial cancer survivors: an application of the Theory of Planned Behavior.

BackgroundDespite evidence of the benefits of exercise in cancer survivors, exercise participation rates tend to decline after treatments. Few studies have examined the determinants of exercise in less common cancer sites. In this study, we examined medical, demographic, and social cognitive correlates of exercise in endometrial cancer survivors using the Theory of Planned Behavior (TPB).MethodsA mailed survey was completed by 354 endometrial cancer survivors (1 to 10 years postdiagnosis) residing in Alberta, Canada. The study was cross-sectional. Exercise behavior was assessed using the Godin

Clinical applications of antibody-drug conjugates in advanced non-small cell lung cancer.

Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide, with non-small cell lung cancer (NSCLC) constituting the majority of cases. Current treatment modalities are constrained by significant limitations: conventional chemotherapy exhibits poor tumor selectivity and systemic toxicity, while monoclonal antibodies frequently demonstrate inadequate therapeutic efficacy. Antibody-drug conjugates (ADCs)-engineered biotherapeutics comprising tumor-targeting antibodies conjugated to potent cytotoxic agents through optimized linkers-have emerged as a transformative s

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… Cancer Discov . ( 2020 ) 10 : 688 – 701 . doi: 10.1158/2159-8290.CD-19-1014 , PMID: 32213540 PMC8292921 102 Ahn M-J Tanaka K Paz-Ares L Cornelissen R Girard N Pons-Tostivint E . … J Clin Oncol . ( 2024 ) 42 : 8548 . doi: 10.1200/JCO.2024.42.16_suppl.8548 123 Ahn MJ Lisberg A Paz-Ares L Cornelissen R Girard N Pons-Tostivint E . …

Health behaviour abilities profiles in patients with haematological malignancies and its influencing factors: a cross-sectional survey.

ObjectivesTo identify the latent profiles of health behaviour abilities among patients with haematological malignancies and to explore the underlying population heterogeneity and influencing factors.DesignA cross-sectional study conducted between October and December 2024.SettingData were collected from three provincial hospitals in China.ParticipantsA total of 486 hospitalised patients were recruited.Outcome measuresData were collected using a demographic questionnaire, the Sense of Coherence Scale-13, the Perceived Social Support Scale and the Self-rated Abilities for Health Practices Scale.

Decision Fatigue and Associated Factors Among Patients with Hematologic Malignancies: Implications for Patient-Centered Decision Support.

BACKGROUND: Patients with hematologic malignancies frequently face complex, repeated treatment decisions that may increase decision fatigue (DF) risk. However, evidence on DF and its correlates in this population remains scarce. This study aimed to investigate the level of DF and identify associated factors among patients with hematologic malignancies. METHODS: A cross-sectional study was conducted with 322 patients receiving treatment at a tertiary hospital in Anhui, China, between October 2024 and May 2025. Participants completed validated scales assessing DF, decision preparation, decision

Визуальное расстройство при множественном склерозе, связанном с постгенифицированной серой и белой материей: выше и выше.

Визуальное расстройство является одним из наиболее распространенных и нетрудоспособных проявлений множественного склероза (МС). Несмотря на то, что зрительная дисфункция, связанная с оптическим невритом и участием в работе мозговой системы, хорошо известна, зрительные нарушения, связанные с постгенетическими визуальными путями, включая оптические излучение и зрительные коры коры, относительно недостаточно изучены и недостаточно признаны в клинической практике. Увеличение числа свидетельств, полученных в результате продвинутого нейроимации, оптической томографии и нейропсихологического тестиров

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… Lesions involve not only potentially all white matter (with a predilection for periventricular and juxtacortical areas, optic nerve and spinal cord) but also subpial and leptomeningeal cortex, the thalamus, pons, and retina ( 4 ). …

Роль самосознания в самосознании с смягчающей ролью болезни у пациентов с множественным склерозом перенесена в больницу " Сина " .

Множественный склероз (MS) является хроническим нейродегенеративным расстройством, связанным с различными физическими и психологическими проблемами. Эффективное самообслуживание имеет важнейшее значение для регулирования симптомов и улучшения качества жизни. Такие психологические устои, как самосопоставление и восприятие болезней, являются ключевыми факторами, определяющими самоуправление в случае хронических заболеваний. ЦЕЛЬ: В этом исследовании изучалась роль самосопоставимости в поощрении самозаботы между пациентами с MS, при этом особое внимание уделялось посреднической роли восприятия за

Cancer-Related Alopecia Risk and Treatment.

Opinion statementCancer-related alopecia (CRA) presents a significant challenge for many patients undergoing cancer treatment, often affecting their psychological well-being and sense of identity. In my opinion, the optimal management of CRA requires a proactive, personalized approach that prioritizes both prevention and regrowth, while taking into account the type of cancer therapy, patient goals, and overall clinical context. For patients receiving chemotherapy, especially taxane- or anthracycline-based regimens, scalp cooling should be offered as a first-line preventative option whenever fe

Hematological cancer patients' social support, coping strategies, anxiety, depression and posttraumatic growth: a structural equation model.

ObjectivePosttraumatic growth (PTG), defined as positive psychological changes following traumatic events, has been observed in some hematological cancer patients during their disease course. These changes, encompassing shifts in life perspective, interpersonal relationships, and self-perception, are critical for psychological recovery. However, the interplay of social support, coping strategies, anxiety, and depression in shaping PTG remains unclear. Therefore, the aim of this study was to explore these associations in hematological cancer patients using a hypothetical model.MethodsFrom Augus

Анализ иммунологической памяти Джона Каннингема о мексиканском населении пациентов с множественным склерозом под лечением.

Фон/цели: Множественный склероз (MS) - это болезнь, характеризующаяся демиелинацией и аксонным повреждением центральной нервной системы. Несмотря на наблюдаемые преимущества, высокоэффективная терапия на основе ВИЧ-инфекции имеет негативные последствия, включая повышенный риск развития прогрессивной многофукальной лейкоэнцефалопатии (ПМП). Кроме того, риск возрастает, если пациент имеет антитела для вируса Джона Каннингема (JCV). Появляется ПМЛ редко, и в Мексике имеется лишь один доклад. Цель этого исследования состояла в том, чтобы определить и проанализировать иммунологическую память ОЖЦ у

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… Lombardo-Del Toro P., Bragado-Trigo I., Arroyo P., Tena-Cucala R., Bau L., Matas E., Muñoz-Vendrell A., Simó M., Pons-Escoda A., Martínez-Yélamos A., et al. Fingolimod-associated progressive multifocal leukoencephalopathy in a multiple sclerosis patient with a good response to filgrastim. J. …

IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients.

IntroductionHaematopoietic stem cell transplant (HSCT) in adults is an intensive medical procedure for a variety of haematological malignancies. Although there is a large body of evidence demonstrating the negative effects of HSCT on physical function and psychosocial parameters, there is limited evidence on the impact of HSCT on body composition and bone health. Further, aerobic and resistance-training exercise interventions aimed at improving physical function and patient-reported outcomes largely take place during the peritransplant and post-transplant period. Prehabilitative exercise, or e

Circulating sRANKL, Periostin, and Osteopontin as Biomarkers for the Assessment of Activated Osteoclastogenesis in Myeloma Related Bone Disease.

The hallmark of multiple myeloma is myeloma related bone disease. Interactions between myeloma plasma cells (MPCs), stromal cells, and the bone marrow (BM) microenvironment play a critical role in the pathogenesis of MBD. Bone remodeling is severely dysregulated with the prevalence of osteoclast activity. We aimed to assess circulating levels of sRANKL, periostin, and osteopontin as osteoclast activators in NDMM patients at diagnosis and in the course of treatment, correlations with clinical and laboratory data, and to evaluate their potential as additional biomarkers for the assessment of MBD

Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale.

PurposeThe aim of this study was to explore what methods should be used to determine the minimal important difference (MID) and minimal important change (MIC) in scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43.MethodsIn an international multi-centre study, patients with head and neck cancer completed the EORTC QLQ-HN43 before the onset of treatment (t1), three months after baseline (t2), and six months after baseline (t3). The methods explored for determining the MID were: (1) group comparisons based on performance statu

Assessment of Patient Reported Outcomes (PROs) in Outpatients Taking Oral Anticancer Drugs Included in the Real-Life Oncoral Program.

Background In previous studies, patient-reported outcomes (PROs) have been shown to improve survival in cancer patients. The aim of the present study was to assess symptoms potentially related to adverse events experienced by cancer outpatients treated by oral anticancer agents (OAAs) using PROs. Methods Between September 2018 and May 2019, outpatients starting OAAs were included in a 12-week follow-up to assess 15 symptoms listed in the National Cancer Institute PRO Common Terminology Criteria for Adverse Events, using a 5-point scale of severity or frequency. Patients were requested to alert

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.

PurposeStudy purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF.MethodsBalance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function ass